BR122018009866B8 - métodos para preparar compostos de éter aminocicloexílico e compostos intermediários - Google Patents

métodos para preparar compostos de éter aminocicloexílico e compostos intermediários

Info

Publication number
BR122018009866B8
BR122018009866B8 BR122018009866A BR122018009866A BR122018009866B8 BR 122018009866 B8 BR122018009866 B8 BR 122018009866B8 BR 122018009866 A BR122018009866 A BR 122018009866A BR 122018009866 A BR122018009866 A BR 122018009866A BR 122018009866 B8 BR122018009866 B8 BR 122018009866B8
Authority
BR
Brazil
Prior art keywords
compounds
methods
aminocyclohexyl ether
preparing
ether compounds
Prior art date
Application number
BR122018009866A
Other languages
English (en)
Other versions
BR122018009866B1 (pt
Inventor
Zolotoy Alexander
G M Barrett Anthony
Plouvier Bertrand
Ta Hung Chou Doug
Jung Grace
N Beatch Gregory
Zhu Jeff
Siu Leung Choi Lewis
J A Walker Michael
Wall Richard
L Yong Sandro
Sheng Tao
Liu Yuzhong
Original Assignee
Cardiome Pharma Corp
Correvio Int Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiome Pharma Corp, Correvio Int Sarl filed Critical Cardiome Pharma Corp
Publication of BR122018009866B1 publication Critical patent/BR122018009866B1/pt
Publication of BR122018009866B8 publication Critical patent/BR122018009866B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

são revelados compostos de éter aminocicloexílico. os compostos da presente invenção podem ser incorporados em composições e kits. a presente invenção também revela os métodos para preparar os ditos compostos, e usos para os compostos e as composições, incluindo o tratamento de arritmia.
BR122018009866A 2003-05-02 2003-10-31 métodos para preparar compostos de éter aminocicloexílico e compostos intermediários BR122018009866B8 (pt)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US46715903P 2003-05-02 2003-05-02
US60/467,159 2003-05-02
US47608303P 2003-06-04 2003-06-04
US60/476,083 2003-06-04
US47591203P 2003-06-05 2003-06-05
US47644703P 2003-06-05 2003-06-05
US47588403P 2003-06-05 2003-06-05
US60/475,912 2003-06-05
US60/475,884 2003-06-05
US60/476,447 2003-06-05
US48965903P 2003-07-23 2003-07-23
US60/489,659 2003-07-23
US49339203P 2003-08-07 2003-08-07
US60/493,392 2003-08-07
BRPI0318278 2003-10-31
PCT/US2003/034655 WO2004099137A1 (en) 2003-05-02 2003-10-31 Aminocyclohexyl ether compounds and uses thereof

Publications (2)

Publication Number Publication Date
BR122018009866B1 BR122018009866B1 (pt) 2018-12-18
BR122018009866B8 true BR122018009866B8 (pt) 2021-07-27

Family

ID=33437310

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0318278A BRPI0318278B8 (pt) 2003-05-02 2003-10-31 Compostos de éter aminocicloexílico, composição compreendendo ditos compostos, usos dos mesmos e método para modular a atividade do canal iônico em um ambiente in vitro
BR122018009866A BR122018009866B8 (pt) 2003-05-02 2003-10-31 métodos para preparar compostos de éter aminocicloexílico e compostos intermediários

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0318278A BRPI0318278B8 (pt) 2003-05-02 2003-10-31 Compostos de éter aminocicloexílico, composição compreendendo ditos compostos, usos dos mesmos e método para modular a atividade do canal iônico em um ambiente in vitro

Country Status (21)

Country Link
US (3) US20070099983A1 (pt)
EP (3) EP1666459B1 (pt)
JP (2) JP4919661B2 (pt)
KR (1) KR101059379B1 (pt)
AT (2) ATE529401T1 (pt)
AU (2) AU2003287378B2 (pt)
BR (2) BRPI0318278B8 (pt)
CA (1) CA2524323C (pt)
CY (1) CY1105137T1 (pt)
DE (1) DE60305200T2 (pt)
DK (1) DK1560812T3 (pt)
ES (2) ES2375820T3 (pt)
IL (2) IL171653A (pt)
NO (1) NO334094B1 (pt)
NZ (1) NZ543921A (pt)
PL (1) PL227937B1 (pt)
PT (1) PT1560812E (pt)
RU (1) RU2478617C2 (pt)
SG (2) SG2010079697A (pt)
SI (1) SI1560812T1 (pt)
WO (1) WO2004099137A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA00009593A (es) 1998-04-01 2004-03-10 Nortran Pharmaceuticals Inc Compuestos de eter aminociclohexilico y sus usos.
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
US7057053B2 (en) * 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
NZ543921A (en) * 2003-05-02 2008-11-28 Cardiome Pharma Corp Aminocyclohexyl ether compounds and uses thereof
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
US20080063707A1 (en) * 2003-05-02 2008-03-13 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
US7674820B2 (en) 2003-08-07 2010-03-09 Cardiome Pharma Corp. Ion channel modulating activity I
US7345087B2 (en) * 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
CA2561733A1 (en) * 2004-04-01 2005-10-13 Cardiome Pharma Corp. Pegylated ion channel modulating compounds
CA2561819A1 (en) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
WO2005097087A2 (en) * 2004-04-01 2005-10-20 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
JP5583325B2 (ja) * 2004-11-08 2014-09-03 カーディオム ファーマ コーポレイション イオンチャネル調節化合物の投与レジメ
WO2006088525A1 (en) * 2004-11-18 2006-08-24 Cardiome Pharma Corp. Synthetic process for aminocyclohexyl ether compounds
US20090005576A1 (en) * 2005-01-12 2009-01-01 Astellas Pharma Inc. Production Method of Optically Active Cyclohexane Ether Compounds
BRPI0612138B8 (pt) * 2005-06-15 2021-05-25 Cardiome Pharma Corp compostos éter aminocicloexílicos e método para fazer os mesmos
US7973176B2 (en) * 2005-08-23 2011-07-05 Kaneka Corporation Process for production of aralkyloxypyrrolidine derivative
JP2007131597A (ja) * 2005-11-11 2007-05-31 Toray Fine Chemicals Co Ltd ベンジルオキシピロリジン誘導体の製造方法
JP5004067B2 (ja) * 2005-10-31 2012-08-22 東レ・ファインケミカル株式会社 ベンジルオキシ含窒素環状化合物の製造法
CA2627502C (en) * 2005-10-31 2014-04-01 Toray Fine Chemicals Co., Ltd. Process for production of benzyloxypyrrolidine derivative, and process for production of hydrochloride salt powder of optically active benzyloxypyrrolidine derivative
JP5004073B2 (ja) * 2006-06-13 2012-08-22 東レ・ファインケミカル株式会社 光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体及びその製造法
EA200971025A1 (ru) * 2007-05-04 2010-04-30 Кардиом Фарма Корп. Пероральные композиции с регулируемым высвобождением соединений, модулирующих ионные каналы, и связанные с ними способы предупреждения аритмии
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
EP2605772B1 (en) 2010-08-16 2016-06-22 Cardiome International AG Process for preparing aminocyclohexyl ether compounds
WO2016016424A1 (de) * 2014-08-01 2016-02-04 Covestro Deutschland Ag Copolycarbonat-zusammensetzungen mit cyclischen und linearen oligomeren und verbesserten optischen eigenschaften

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2954380A (en) * 1958-11-26 1960-09-27 Us Vitamin Pharm Corp Piperazinocyclohexyl esters
US3218328A (en) * 1963-02-18 1965-11-16 U S Vitamin & Pharmacentical C Heterocyclic amino phenoxyacetic acids, acid addition salts and quaternary ammonium salts thereof
DE2259260A1 (de) 1972-12-04 1974-06-06 Merck Patent Gmbh Neue amine
US4145435A (en) * 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds
US4179501A (en) * 1976-11-12 1979-12-18 The Upjohn Company Analgesic N-(2-aminocycloaliphatic)azidobenzamides
DE2658401A1 (de) 1976-12-23 1978-07-06 Merck Patent Gmbh Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4598087A (en) * 1983-12-06 1986-07-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4656182A (en) 1983-12-06 1987-04-07 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
DE3517901A1 (de) * 1984-05-18 1985-12-12 Glaxo Group Ltd., London Aminocyclopentylether, ihre herstellung und pharmazeutische formulierung
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
WO1987002584A1 (en) 1985-10-25 1987-05-07 The Upjohn Company Cis-n-(2-aminocycloaliphatic)benzene acetamide and -benzamide anticonvulsants
US5059620A (en) * 1985-12-27 1991-10-22 The Du Pont Merck Pharmaceutical Company Aryl substituted aminomethyl benzene derivatives
US4855316A (en) * 1988-02-18 1989-08-08 Warner-Lambert Company 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds
AU626949B2 (en) 1988-12-06 1992-08-13 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US5051428A (en) * 1988-12-06 1991-09-24 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
JPH02270864A (ja) 1989-04-12 1990-11-05 Asahi Glass Co Ltd フルオロカルバサイクリックヌクレオシドおよびその製造法
US5428031A (en) 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
ZA929008B (en) 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
CA2058502A1 (en) 1991-12-27 1993-06-28 David C. Horwell 2-amino-mono-methoxycyclohexyl amides useful as analgesics
EP0552386A1 (en) 1992-01-13 1993-07-28 Warner-Lambert Company 2-Amino-3 or 6-methoxycyclohexyl amide derivatives
AU668932B2 (en) 1992-03-26 1996-05-23 University Of British Columbia, The Method of blocking sodium channels or neuronal tissue
US5506257A (en) * 1992-03-26 1996-04-09 University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
GB9220286D0 (en) 1992-09-25 1992-11-11 Merck Sharp & Dohme Therapeutic agents
US5451596A (en) 1992-12-29 1995-09-19 Rhone Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
US5747278A (en) * 1993-05-21 1998-05-05 California Institute Of Technology DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
US5492825A (en) * 1993-08-06 1996-02-20 The Regents Of The University Of California Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
DE69429524T2 (de) 1993-09-24 2002-08-08 The University Of British Columbia, Vancouver Aminocyclohexylester und ihre anwendung
GB9406043D0 (en) * 1994-03-26 1994-05-18 Smithkline Beecham Plc Compounds
US5441946A (en) 1994-04-14 1995-08-15 Rhone-Poulenc-Rorer Pharmaceuticals, Inc. Phosphonate derivatives of lipophilic amines
WO1996004274A1 (en) * 1994-08-02 1996-02-15 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives
AU3354895A (en) * 1994-09-19 1996-04-09 Fujisawa Pharmaceutical Co., Ltd. Novel medicinal use of 5ht3 antagonist
US5556990A (en) 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
DK0801683T3 (da) 1995-02-03 2002-06-17 Basf Ag Racematspaltning af primære og sekundære heteroatomsubstituerede aminer ved enzymkatalyseret acylering
DE19703816A1 (de) 1996-01-25 1997-08-07 Schering Ag Verbesserte konzentrierte Injektions- und Infusionslösungen für die intravasale Anwendung
US5646151A (en) 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
EP0912505A4 (en) 1996-06-27 2001-10-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US5935945A (en) * 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US6180632B1 (en) * 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
TW536401B (en) 1997-09-03 2003-06-11 Cardiome Pharma Corp A pharmaceutical composition of N,N-bis(phenylcarbamoylmethyl)dimethylammomum chloride and derivatives for the treatment of pain
AU9248698A (en) 1997-09-26 1999-04-23 Nortran Pharmaceuticals Inc. Mixtures of enantiomers of aminocyclohexylamides to produce simultaneous analgesia with local anaesthesia or antiarrhythmia
JP3773644B2 (ja) * 1998-01-06 2006-05-10 芝府エンジニアリング株式会社 接点材料
US6013830A (en) 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
MXPA00009593A (es) 1998-04-01 2004-03-10 Nortran Pharmaceuticals Inc Compuestos de eter aminociclohexilico y sus usos.
US6624761B2 (en) * 1998-12-11 2003-09-23 Realtime Data, Llc Content independent data compression method and system
WO2000047547A2 (en) 1999-02-12 2000-08-17 Nortran Pharmaceuticals Inc. Cycloalkyl amine compounds and uses thereof
US6979685B1 (en) * 1999-02-12 2005-12-27 Cardiome Pharma Corp. Cycloalkyl amine compounds and uses thereof
WO2000051981A1 (en) 1999-03-04 2000-09-08 Nortran Pharmaceuticals Inc. Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics
US7507545B2 (en) * 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
CA2268590A1 (en) * 1999-04-12 2000-10-12 Nortran Pharmaceuticals Inc. Ion channel modulating compounds and uses thereof
US6150357A (en) 1999-05-10 2000-11-21 Merck & Co., Inc. Potassium channel agonists
AU2001273942B2 (en) * 2000-04-20 2005-09-01 F. Hoffmann-La Roche Ag Pyrrolidine and piperidine derivatives and their use for the treament of neurodegenerative disorders
CA2311483A1 (en) 2000-06-12 2001-12-12 Gregory N Beatch IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF
US6521619B2 (en) * 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US6498170B2 (en) * 2000-07-17 2002-12-24 Wyeth Cyclamine sulfonamides as β-3 adrenergic receptor agonists
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
AU2003248647A1 (en) * 2002-06-14 2003-12-31 Johnson Matthey Pharmaceutical Materials, Inc. Stereoselective synthesis of 1,2-disubstituted cycloalkyls
AU2003251937A1 (en) 2002-07-12 2004-02-02 Cardiome Inc. Mutations of voltage-gated potassium channels
US7345086B2 (en) * 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
CA2524034A1 (en) 2003-05-02 2004-11-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
NZ543921A (en) 2003-05-02 2008-11-28 Cardiome Pharma Corp Aminocyclohexyl ether compounds and uses thereof
US20060094880A9 (en) * 2003-06-04 2006-05-04 Barrett Anthony G M Synthetic process for trans-aminocyclohexyl ether compounds
US7674820B2 (en) * 2003-08-07 2010-03-09 Cardiome Pharma Corp. Ion channel modulating activity I
US7345087B2 (en) * 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US20070197632A1 (en) 2003-10-31 2007-08-23 Cardiome Pharma Corp Aminocyclohexyl ether compounds and uses thereof

Also Published As

Publication number Publication date
SI1560812T1 (sl) 2006-10-31
DE60305200D1 (de) 2006-06-14
IL216579A0 (en) 2012-01-31
IL216579A (en) 2015-02-26
BRPI0318278B8 (pt) 2024-01-09
SG2010079697A (en) 2016-09-29
NO20055130D0 (no) 2005-11-02
RU2008104198A (ru) 2009-08-10
EP1666459A2 (en) 2006-06-07
EP2298735A1 (en) 2011-03-23
EP1560812A1 (en) 2005-08-10
EP1666459A3 (en) 2006-09-20
WO2004099137A1 (en) 2004-11-18
BR0318278A (pt) 2006-05-23
RU2478617C2 (ru) 2013-04-10
EP1560812B1 (en) 2006-05-10
KR101059379B1 (ko) 2011-08-26
JP2006525227A (ja) 2006-11-09
IL171653A (en) 2013-06-27
HK1091814A1 (zh) 2007-01-26
ES2375820T3 (es) 2012-03-06
CA2524323A1 (en) 2004-11-18
JP2007077162A (ja) 2007-03-29
ATE529401T1 (de) 2011-11-15
DK1560812T3 (da) 2006-09-04
PL227937B1 (pl) 2018-01-31
JP4919661B2 (ja) 2012-04-18
DE60305200T2 (de) 2007-05-10
CY1105137T1 (el) 2010-03-03
BRPI0318278B1 (pt) 2018-11-06
AU2011201015B2 (en) 2012-02-02
PT1560812E (pt) 2006-09-29
AU2011201015A1 (en) 2011-03-31
ES2264776T3 (es) 2007-01-16
KR20060057531A (ko) 2006-05-26
SG167670A1 (en) 2011-01-28
ATE325789T1 (de) 2006-06-15
US20070254945A1 (en) 2007-11-01
NO334094B1 (no) 2013-12-09
PL378918A1 (pl) 2006-06-12
NZ543921A (en) 2008-11-28
US20070099983A1 (en) 2007-05-03
AU2003287378B2 (en) 2010-12-16
BR122018009866B1 (pt) 2018-12-18
US20110004006A1 (en) 2011-01-06
NO20055130L (no) 2005-12-01
EP1666459B1 (en) 2011-10-19
CA2524323C (en) 2012-05-15
AU2003287378A1 (en) 2004-11-26
US8163938B2 (en) 2012-04-24
US7767830B2 (en) 2010-08-03

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