UA93662C2 - Гетерологический пептидилированный глюкагон-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением или инсулинонезависимым сахарным диабетом - Google Patents

Гетерологический пептидилированный глюкагон-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением или инсулинонезависимым сахарным диабетом Download PDF

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UA93662C2
UA93662C2 UAA200706704A UAA200706704A UA93662C2 UA 93662 C2 UA93662 C2 UA 93662C2 UA A200706704 A UAA200706704 A UA A200706704A UA A200706704 A UAA200706704 A UA A200706704A UA 93662 C2 UA93662 C2 UA 93662C2
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Вольфганг Глезнер
Радмила Миканович
Шенг-Хунг Рейнбоу Чанг
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Эли Лилли Энд Компани
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)

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Abstract

Изобретение относится к гетерологическому пептидилированному белку, в состав которого входит первый полипептид, сшитый со вторым полипептидом, где первым полипептидом является соединение GLP-1 (глюкагон-1-подобный пептид), а второй полипептид выбран среди человеческого альбумина, аналогов человеческого альбумина и фрагментов человеческого альбумина. Заявленные белки имеют продленный период полувыведения из организма. Изобретение также относится к фармацевтической композиции, которая содержит данные белки, и применению заявленного гетерологического пептидилированного белка для изготовления лекарственного средства для лечения пациентов, страдающих ожирением и/или инсулинонезависимым сахарным диабетом.
UAA200706704A 2000-12-07 2001-11-29 Гетерологический пептидилированный глюкагон-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением или инсулинонезависимым сахарным диабетом UA93662C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25195400P 2000-12-07 2000-12-07

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UA93662C2 true UA93662C2 (ru) 2011-03-10

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ID=22954069

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Application Number Title Priority Date Filing Date
UAA200706704A UA93662C2 (ru) 2000-12-07 2001-11-29 Гетерологический пептидилированный глюкагон-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением или инсулинонезависимым сахарным диабетом
UA2003065280A UA81897C2 (ru) 2000-12-07 2001-11-29 Гетерологический пептидилированный глюкагон-1-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением и/или инсулиннезависимым диабетом

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UA2003065280A UA81897C2 (ru) 2000-12-07 2001-11-29 Гетерологический пептидилированный глюкагон-1-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением и/или инсулиннезависимым диабетом

Country Status (30)

Country Link
US (1) US7271149B2 (ru)
EP (2) EP1355942B1 (ru)
JP (2) JP2004528014A (ru)
KR (2) KR100942864B1 (ru)
CN (2) CN1483041A (ru)
AT (2) ATE406384T1 (ru)
AU (2) AU2002226897B2 (ru)
BR (1) BR0116024A (ru)
CA (2) CA2716959A1 (ru)
CY (2) CY1108485T1 (ru)
CZ (2) CZ306180B6 (ru)
DE (2) DE60135581D1 (ru)
DK (2) DK1355942T3 (ru)
EA (1) EA005584B1 (ru)
EC (1) ECSP064643A (ru)
ES (2) ES2328510T3 (ru)
HK (1) HK1061411A1 (ru)
HR (1) HRP20030455A2 (ru)
HU (2) HU229218B1 (ru)
IL (3) IL155812A0 (ru)
MX (1) MXPA03005036A (ru)
NO (3) NO331273B1 (ru)
NZ (1) NZ525577A (ru)
PL (2) PL209550B1 (ru)
PT (2) PT1724284E (ru)
SI (2) SI1355942T1 (ru)
SK (2) SK288342B6 (ru)
UA (2) UA93662C2 (ru)
WO (1) WO2002046227A2 (ru)
ZA (1) ZA200303642B (ru)

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DK1724284T3 (da) 2009-11-02
ES2311560T3 (es) 2009-02-16
IL155812A0 (en) 2003-12-23
HUP0302529A3 (en) 2009-03-30
SK288342B6 (en) 2016-03-01
NZ525577A (en) 2005-05-27
SK6702003A3 (en) 2004-08-03
HUP1300326A2 (en) 2003-10-28
NO332221B1 (no) 2012-07-30
PL209550B1 (pl) 2011-09-30
SK288088B6 (sk) 2013-06-03
EA005584B1 (ru) 2005-04-28
CZ20031602A3 (cs) 2006-04-12
CA2434237C (en) 2012-05-15
SI1724284T1 (sl) 2009-12-31
CA2716959A1 (en) 2002-06-13
WO2002046227A3 (en) 2003-04-24
DK1355942T3 (da) 2008-11-17
EP1355942B1 (en) 2008-08-27
BR0116024A (pt) 2005-12-13
EA200300644A1 (ru) 2003-12-25
EP1355942A2 (en) 2003-10-29
CA2434237A1 (en) 2002-06-13
NO20032565L (no) 2003-08-01
CZ308214B6 (cs) 2020-03-04
DE60135581D1 (de) 2008-10-09

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