UA93662C2 - Гетерологический пептидилированный глюкагон-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением или инсулинонезависимым сахарным диабетом - Google Patents
Гетерологический пептидилированный глюкагон-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением или инсулинонезависимым сахарным диабетом Download PDFInfo
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- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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Abstract
Изобретение относится к гетерологическому пептидилированному белку, в состав которого входит первый полипептид, сшитый со вторым полипептидом, где первым полипептидом является соединение GLP-1 (глюкагон-1-подобный пептид), а второй полипептид выбран среди человеческого альбумина, аналогов человеческого альбумина и фрагментов человеческого альбумина. Заявленные белки имеют продленный период полувыведения из организма. Изобретение также относится к фармацевтической композиции, которая содержит данные белки, и применению заявленного гетерологического пептидилированного белка для изготовления лекарственного средства для лечения пациентов, страдающих ожирением и/или инсулинонезависимым сахарным диабетом.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25195400P | 2000-12-07 | 2000-12-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA93662C2 true UA93662C2 (ru) | 2011-03-10 |
Family
ID=22954069
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200706704A UA93662C2 (ru) | 2000-12-07 | 2001-11-29 | Гетерологический пептидилированный глюкагон-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением или инсулинонезависимым сахарным диабетом |
UA2003065280A UA81897C2 (ru) | 2000-12-07 | 2001-11-29 | Гетерологический пептидилированный глюкагон-1-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением и/или инсулиннезависимым диабетом |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2003065280A UA81897C2 (ru) | 2000-12-07 | 2001-11-29 | Гетерологический пептидилированный глюкагон-1-подобный белок и его применение для изготовления лекарственного средства для лечения пациентов, страдающих ожирением и/или инсулиннезависимым диабетом |
Country Status (30)
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US (1) | US7271149B2 (ru) |
EP (2) | EP1355942B1 (ru) |
JP (2) | JP2004528014A (ru) |
KR (2) | KR100942864B1 (ru) |
CN (2) | CN1483041A (ru) |
AT (2) | ATE406384T1 (ru) |
AU (2) | AU2002226897B2 (ru) |
BR (1) | BR0116024A (ru) |
CA (2) | CA2716959A1 (ru) |
CY (2) | CY1108485T1 (ru) |
CZ (2) | CZ306180B6 (ru) |
DE (2) | DE60135581D1 (ru) |
DK (2) | DK1355942T3 (ru) |
EA (1) | EA005584B1 (ru) |
EC (1) | ECSP064643A (ru) |
ES (2) | ES2328510T3 (ru) |
HK (1) | HK1061411A1 (ru) |
HR (1) | HRP20030455A2 (ru) |
HU (2) | HU229218B1 (ru) |
IL (3) | IL155812A0 (ru) |
MX (1) | MXPA03005036A (ru) |
NO (3) | NO331273B1 (ru) |
NZ (1) | NZ525577A (ru) |
PL (2) | PL209550B1 (ru) |
PT (2) | PT1724284E (ru) |
SI (2) | SI1355942T1 (ru) |
SK (2) | SK288342B6 (ru) |
UA (2) | UA93662C2 (ru) |
WO (1) | WO2002046227A2 (ru) |
ZA (1) | ZA200303642B (ru) |
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ATE439592T1 (de) * | 1998-12-10 | 2009-08-15 | Bristol Myers Squibb Co | Proteingerüste für antikörper-nachahmer und andere bindende proteine |
US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
DE60006100T2 (de) | 1999-05-17 | 2004-07-01 | Conjuchem, Inc., Montreal | Lang wirkende insulinotrope peptide |
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EP2990417A1 (en) | 2001-12-21 | 2016-03-02 | Human Genome Sciences, Inc. | Albumin insulin fusion protein |
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2001
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