YU31004A - Mimetici humanog glukagonu sličnog peptida-1 i njihova upotreba u lečenju dijabetesa i srodnih stanja - Google Patents
Mimetici humanog glukagonu sličnog peptida-1 i njihova upotreba u lečenju dijabetesa i srodnih stanjaInfo
- Publication number
- YU31004A YU31004A YU31004A YUP31004A YU31004A YU 31004 A YU31004 A YU 31004A YU 31004 A YU31004 A YU 31004A YU P31004 A YUP31004 A YU P31004A YU 31004 A YU31004 A YU 31004A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- peptide
- glp
- mimics
- treatment
- human glucagon
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Predmetni pronalazak obezbedjuje nove peptidne mimetike humanog glukagonu sličnog peptida-1 koji imitiraju biološku aktivnost nativnog GLP-1 peptida i tako su korisni za lečenje ili prevenciju oboljenja ili poremećaja udruženih sa aktivnošću GLP-1. Predmetni pronalazak, dalje, obezbedjuje nove, hemijski modifikovane peptide koji ne samo što stimulišu sekreciju insulina u dijabetesu tipa II, nego takodje izaziavju i druge korisne insulinotropne odgovore. Ovi sintetski peptidni mimetici GLP-1 ispoljavaju povećanu stabilnost prema proteolizi što ih čini idealnim terapeutskim kandidatima za oralnu ili parenteralnu primenu.[The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Further, the present invention provides novel, chemically modified peptides that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 mimics exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34201501P | 2001-10-18 | 2001-10-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU31004A true YU31004A (sh) | 2006-08-17 |
Family
ID=23339970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU31004A YU31004A (sh) | 2001-10-18 | 2002-10-18 | Mimetici humanog glukagonu sličnog peptida-1 i njihova upotreba u lečenju dijabetesa i srodnih stanja |
Country Status (21)
Country | Link |
---|---|
US (3) | US7238670B2 (sh) |
EP (1) | EP1572892A4 (sh) |
JP (1) | JP2005514337A (sh) |
KR (1) | KR20040054729A (sh) |
CN (1) | CN1630709A (sh) |
AU (1) | AU2002348469B2 (sh) |
BR (1) | BR0213377A (sh) |
CA (1) | CA2463908A1 (sh) |
GE (1) | GEP20063908B (sh) |
HR (1) | HRP20040343A2 (sh) |
HU (1) | HUP0700151A2 (sh) |
IL (1) | IL160917A0 (sh) |
IS (1) | IS7185A (sh) |
MX (1) | MXPA04003553A (sh) |
NO (1) | NO20041203L (sh) |
NZ (1) | NZ531788A (sh) |
PL (1) | PL377687A1 (sh) |
RU (1) | RU2353625C2 (sh) |
WO (1) | WO2003033671A2 (sh) |
YU (1) | YU31004A (sh) |
ZA (1) | ZA200402846B (sh) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
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YU31004A (sh) | 2001-10-18 | 2006-08-17 | Bristol-Myers Squibb Company | Mimetici humanog glukagonu sličnog peptida-1 i njihova upotreba u lečenju dijabetesa i srodnih stanja |
US7238671B2 (en) | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
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-
2002
- 2002-10-18 YU YU31004A patent/YU31004A/sh unknown
- 2002-10-18 MX MXPA04003553A patent/MXPA04003553A/es active IP Right Grant
- 2002-10-18 EP EP02782185A patent/EP1572892A4/en not_active Withdrawn
- 2002-10-18 HU HU0700151A patent/HUP0700151A2/hu unknown
- 2002-10-18 BR BRPI0213377-6A patent/BR0213377A/pt not_active IP Right Cessation
- 2002-10-18 GE GE5582A patent/GEP20063908B/en unknown
- 2002-10-18 AU AU2002348469A patent/AU2002348469B2/en not_active Ceased
- 2002-10-18 US US10/273,975 patent/US7238670B2/en not_active Expired - Lifetime
- 2002-10-18 RU RU2004114836/04A patent/RU2353625C2/ru not_active IP Right Cessation
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- 2002-10-18 IL IL16091702A patent/IL160917A0/xx unknown
- 2002-10-18 KR KR10-2004-7005731A patent/KR20040054729A/ko not_active Application Discontinuation
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- 2002-10-18 NZ NZ531788A patent/NZ531788A/en unknown
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- 2004-04-15 ZA ZA200402846A patent/ZA200402846B/en unknown
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US20030195157A1 (en) | 2003-10-16 |
RU2004114836A (ru) | 2005-04-10 |
IL160917A0 (en) | 2004-08-31 |
NZ531788A (en) | 2008-01-31 |
JP2005514337A (ja) | 2005-05-19 |
EP1572892A2 (en) | 2005-09-14 |
CA2463908A1 (en) | 2003-04-24 |
KR20040054729A (ko) | 2004-06-25 |
MXPA04003553A (es) | 2004-07-22 |
WO2003033671A2 (en) | 2003-04-24 |
AU2002348469B2 (en) | 2008-03-13 |
IS7185A (is) | 2004-03-16 |
GEP20063908B (en) | 2006-08-25 |
HRP20040343A2 (en) | 2005-08-31 |
WO2003033671A3 (en) | 2005-12-29 |
US7238670B2 (en) | 2007-07-03 |
US20100210552A1 (en) | 2010-08-19 |
RU2353625C2 (ru) | 2009-04-27 |
BR0213377A (pt) | 2006-05-23 |
HUP0700151A2 (en) | 2007-05-29 |
NO20041203L (no) | 2004-06-10 |
US20070287670A1 (en) | 2007-12-13 |
ZA200402846B (en) | 2005-08-16 |
CN1630709A (zh) | 2005-06-22 |
EP1572892A4 (en) | 2007-08-22 |
PL377687A1 (pl) | 2006-02-06 |
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