MX2009003400A - Compuestos antidiabeticos. - Google Patents
Compuestos antidiabeticos.Info
- Publication number
- MX2009003400A MX2009003400A MX2009003400A MX2009003400A MX2009003400A MX 2009003400 A MX2009003400 A MX 2009003400A MX 2009003400 A MX2009003400 A MX 2009003400A MX 2009003400 A MX2009003400 A MX 2009003400A MX 2009003400 A MX2009003400 A MX 2009003400A
- Authority
- MX
- Mexico
- Prior art keywords
- peptidomimetics
- antidiabetic compounds
- glp
- sub
- found
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Abstract
La presente invención proporciona nuevos peptidomiméticos de fórmula (I), que principalmente actúan como secretagogos de insulina dependiente de glucosa. Por otra parte, se encontró que estos peptidomiméticos muestran actividad antagonista respecto al receptor del glucagón y también actividad agonista respecto al receptor del GLP-1. A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-B (I).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1632MU2006 | 2006-10-03 | ||
IN1965MU2006 | 2006-11-30 | ||
IN423MU2007 | 2007-03-06 | ||
PCT/IN2007/000457 WO2008062457A2 (en) | 2006-10-03 | 2007-09-28 | Antidiabetic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003400A true MX2009003400A (es) | 2009-04-28 |
Family
ID=39430173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003400A MX2009003400A (es) | 2006-10-03 | 2007-09-28 | Compuestos antidiabeticos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US8841413B2 (es) |
EP (1) | EP2084182B1 (es) |
JP (1) | JP5247708B2 (es) |
AU (1) | AU2007323035B2 (es) |
CA (1) | CA2665033C (es) |
DK (1) | DK2084182T3 (es) |
MX (1) | MX2009003400A (es) |
NZ (1) | NZ576023A (es) |
WO (1) | WO2008062457A2 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8883963B2 (en) * | 2007-12-11 | 2014-11-11 | Cadila Healthcare Limited | Peptidomimetics with glucagon antagonistic and GLP 1 agonistic activities |
UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
MX2011005874A (es) * | 2008-12-05 | 2011-06-27 | Glaxo Group Ltd | Metodos para seleccionar polipeptidos resistentes a proteasa. |
GB0917072D0 (en) | 2009-09-29 | 2009-11-11 | Univ Ulster | Peptide analogues of glucagon for diabetes therapy |
EP2491054A2 (en) | 2009-10-22 | 2012-08-29 | Cadila Healthcare Limited | Short chain peptidomimetics based orally active glp-1 agonist and glucagon receptor antagonist |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
DE102010015123A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi-Aventis Deutschland Gmbh | Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
CA2822556A1 (en) | 2010-12-30 | 2012-07-05 | Enanta Pharmaceuticals, Inc | Macrocyclic hepatitis c serine protease inhibitors |
SG191759A1 (en) | 2010-12-30 | 2013-08-30 | Enanta Pharm Inc | Phenanthridine macrocyclic hepatitis c serine protease inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
US11173135B2 (en) | 2016-03-17 | 2021-11-16 | Thiogenesis Therapeutics, Inc. | Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders |
US10988514B2 (en) | 2016-04-01 | 2021-04-27 | University Of Washington | Polypeptdes capable of forming homo-oligomers with modular hydrogen bond network-mediated specificity and their design |
CA3076392A1 (en) | 2017-09-20 | 2019-03-28 | Thiogenesis Therapeutics, Inc. | Methods for the treatment of cysteamine sensitive disorders |
CN111171135B (zh) * | 2018-11-12 | 2023-04-07 | 天津药物研究院有限公司 | 具有双重受体激动作用的胰高血糖素衍生肽及其用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040005664A1 (en) * | 2000-04-25 | 2004-01-08 | Millennium Pharmaceuticals, Inc. | Novel 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 molecules and uses therefor |
US6864069B2 (en) * | 2001-10-05 | 2005-03-08 | Bayer Pharmaceuticals Corporation | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use |
JP2005514337A (ja) | 2001-10-18 | 2005-05-19 | ブリストル−マイヤーズ スクイブ カンパニー | ヒトグルカゴン様ペプチド−1模倣体、並びに糖尿病および関連疾患の処置におけるその使用 |
TW200611704A (en) * | 2004-07-02 | 2006-04-16 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
KR20080021636A (ko) * | 2005-05-05 | 2008-03-07 | 카딜라 핼쓰캐어 리미티드 | Glp-1 아고니스트인 신규 화합물 |
-
2007
- 2007-09-28 MX MX2009003400A patent/MX2009003400A/es active IP Right Grant
- 2007-09-28 US US12/311,448 patent/US8841413B2/en not_active Expired - Fee Related
- 2007-09-28 CA CA2665033A patent/CA2665033C/en not_active Expired - Fee Related
- 2007-09-28 AU AU2007323035A patent/AU2007323035B2/en not_active Ceased
- 2007-09-28 NZ NZ576023A patent/NZ576023A/en not_active IP Right Cessation
- 2007-09-28 WO PCT/IN2007/000457 patent/WO2008062457A2/en active Application Filing
- 2007-09-28 DK DK07866718.5T patent/DK2084182T3/da active
- 2007-09-28 JP JP2009531015A patent/JP5247708B2/ja not_active Expired - Fee Related
- 2007-09-28 EP EP07866718.5A patent/EP2084182B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2007323035B2 (en) | 2011-11-24 |
US20130225488A1 (en) | 2013-08-29 |
WO2008062457A8 (en) | 2008-08-07 |
US8841413B2 (en) | 2014-09-23 |
WO2008062457A2 (en) | 2008-05-29 |
JP2010505820A (ja) | 2010-02-25 |
CA2665033C (en) | 2013-10-01 |
CA2665033A1 (en) | 2008-05-29 |
JP5247708B2 (ja) | 2013-07-24 |
WO2008062457A3 (en) | 2008-10-02 |
EP2084182B1 (en) | 2013-08-28 |
EP2084182A2 (en) | 2009-08-05 |
DK2084182T3 (da) | 2013-11-04 |
NZ576023A (en) | 2012-06-29 |
AU2007323035A1 (en) | 2008-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |