TW202448941A - 細胞傷害誘導治療劑 - Google Patents

細胞傷害誘導治療劑 Download PDF

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TW202448941A
TW202448941A TW113106078A TW113106078A TW202448941A TW 202448941 A TW202448941 A TW 202448941A TW 113106078 A TW113106078 A TW 113106078A TW 113106078 A TW113106078 A TW 113106078A TW 202448941 A TW202448941 A TW 202448941A
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antibody
amino acid
variable region
chain
acid sequence
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TW113106078A
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Chinese (zh)
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根津淳一
成田敦
石黑敬弘
櫻井実香
白岩宙丈
廣庭奈緒香
井川智之
川合由美子
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日商中外製藥股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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TW113106078A 2014-09-26 2015-09-25 細胞傷害誘導治療劑 TW202448941A (zh)

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JP2014-197315 2014-09-26
JP2014197315 2014-09-26

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TW113106078A TW202448941A (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW109115002A TWI724889B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW111142937A TWI860574B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW106114767A TWI717507B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW108130499A TWI716979B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW110103660A TWI860447B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW104131736A TWI597290B (zh) 2014-09-26 2015-09-25 Cell injury-inducing therapeutic agent

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TW109115002A TWI724889B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW111142937A TWI860574B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW106114767A TWI717507B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW108130499A TWI716979B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW110103660A TWI860447B (zh) 2014-09-26 2015-09-25 細胞傷害誘導治療劑
TW104131736A TWI597290B (zh) 2014-09-26 2015-09-25 Cell injury-inducing therapeutic agent

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US (4) US9975966B2 (enExample)
EP (2) EP3199628A4 (enExample)
JP (6) JP5941230B1 (enExample)
KR (4) KR20230101934A (enExample)
CN (2) CN113388038A (enExample)
AU (2) AU2015322543B2 (enExample)
BR (2) BR112017006061B1 (enExample)
CA (1) CA2960650C (enExample)
CL (3) CL2017000704A1 (enExample)
CO (1) CO2017004002A2 (enExample)
CR (2) CR20210331A (enExample)
EA (1) EA201790674A1 (enExample)
IL (2) IL250685B2 (enExample)
MA (1) MA40764A (enExample)
MX (2) MX2017003503A (enExample)
MY (1) MY187049A (enExample)
PE (1) PE20170704A1 (enExample)
PH (1) PH12017500507A1 (enExample)
RU (1) RU2743464C2 (enExample)
SA (1) SA517381167B1 (enExample)
SG (2) SG11201701119RA (enExample)
TW (7) TW202448941A (enExample)
UA (1) UA121661C2 (enExample)
WO (1) WO2016047722A1 (enExample)

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