RU2651892C2 - Нуклеозидфосфорамидаты в качестве противовирусных агентов - Google Patents
Нуклеозидфосфорамидаты в качестве противовирусных агентов Download PDFInfo
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- RU2651892C2 RU2651892C2 RU2009139968K RU2009139968K RU2651892C2 RU 2651892 C2 RU2651892 C2 RU 2651892C2 RU 2009139968 K RU2009139968 K RU 2009139968K RU 2009139968 K RU2009139968 K RU 2009139968K RU 2651892 C2 RU2651892 C2 RU 2651892C2
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- Prior art keywords
- alkyl
- methyl
- alkenyl
- phenyl
- alkynyl
- Prior art date
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- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000002264 triphosphate group Chemical group [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- 125000005454 tryptophanyl group Chemical group 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US90931507P | 2007-03-30 | 2007-03-30 | |
| US60/909,315 | 2007-03-30 | ||
| US98230907P | 2007-10-24 | 2007-10-24 | |
| US60/982,309 | 2007-10-24 | ||
| US12/053,015 US7964580B2 (en) | 2007-03-30 | 2008-03-21 | Nucleoside phosphoramidate prodrugs |
| US12/053,015 | 2008-03-21 | ||
| PCT/US2008/058183 WO2008121634A2 (en) | 2007-03-30 | 2008-03-26 | Nucleoside phosphoramidate prodrugs |
Publications (1)
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| RU2651892C2 true RU2651892C2 (ru) | 2018-04-24 |
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| RU2009139968K RU2651892C2 (ru) | 2007-03-30 | 2008-03-26 | Нуклеозидфосфорамидаты в качестве противовирусных агентов |
| RU2009139968A RU2651892C3 (ru) | 2007-03-30 | 2008-03-26 | Нуклеозидфосфорамидаты в качестве противовирусных агентов |
| RU2012152811/04A RU2012152811A (ru) | 2007-03-30 | 2012-12-07 | Нуклеозидфосфорамидаты в качестве противовирусных агентов |
| RU2018103329A RU2018103329A (ru) | 2007-03-30 | 2018-01-30 | Нуклеозидфосфорамидаты в качестве противовирусных агентов |
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| RU2009139968A RU2651892C3 (ru) | 2007-03-30 | 2008-03-26 | Нуклеозидфосфорамидаты в качестве противовирусных агентов |
| RU2012152811/04A RU2012152811A (ru) | 2007-03-30 | 2012-12-07 | Нуклеозидфосфорамидаты в качестве противовирусных агентов |
| RU2018103329A RU2018103329A (ru) | 2007-03-30 | 2018-01-30 | Нуклеозидфосфорамидаты в качестве противовирусных агентов |
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| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| AU2001272923A1 (en) | 2000-05-26 | 2001-12-11 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses |
| JP2004532184A (ja) | 2001-01-22 | 2004-10-21 | メルク エンド カムパニー インコーポレーテッド | Ｒｎａ依存性ｒｎａウィルスポリメラーゼ阻害薬としてのヌクレオシド誘導体 |
| CN1849142A (zh) | 2002-11-15 | 2006-10-18 | 埃迪尼克斯(开曼)有限公司 | 2′－支链核苷和黄病毒突变 |
| KR100883703B1 (ko) | 2003-05-30 | 2009-02-12 | 파마셋 인코포레이티드 | 변형 불소화 뉴클레오시드 유사체 |
| EP1827460A4 (en) | 2004-12-09 | 2012-03-14 | Univ Minnesota | NUCLEOSIDE WITH ANTIVIRAL AND ANTI-CANCER EFFECT |
| GB0623493D0 (en) | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
| US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| US20090318380A1 (en) | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
| CN102046626A (zh) | 2008-04-23 | 2011-05-04 | 吉里德科学公司 | 用于抗病毒治疗的carba-核苷类似物 |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
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| CN102753563A (zh) * | 2008-12-23 | 2012-10-24 | 吉利德制药有限责任公司 | 核苷类似物 |
| MX2011006891A (es) * | 2008-12-23 | 2011-10-06 | Pharmasset Inc | Fosforamidatos de nucleosidos. |
| BRPI1005401A2 (pt) | 2009-02-06 | 2019-04-02 | Rfs Pharma, Llc | pro-farmácos de purina nucleosídeo monofosfato para o tratamento de câncer e infecções virais |
| AP2011005929A0 (en) * | 2009-03-20 | 2011-10-31 | Alios Biopharma Inc | Substituted nucleoside and nucleotide analogs. |
| NZ619205A (en) | 2009-05-13 | 2015-04-24 | Gilead Pharmasset Llc | Antiviral compounds |
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| AU2016200676B2 (en) * | 2009-05-20 | 2017-06-01 | Gilead Sciences, Inc. | N-[(2'R)-2 '-deoxy-2'-fluoro-2'-methyl-p-phenyl-5'-uridylyl] -L-alanine 1-methylethyl ester and process for its production |
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| US8927513B2 (en) | 2009-07-07 | 2015-01-06 | Alnylam Pharmaceuticals, Inc. | 5′ phosphate mimics |
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| WO2011133212A1 (en) * | 2010-04-20 | 2011-10-27 | New York University | Methods, compounds and pharmaceutical compositions for treating anxiety and mood disorders |
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