RU2251544C2 - N-замещенные 2-цианпирролидины - Google Patents

N-замещенные 2-цианпирролидины Download PDF

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Publication number
RU2251544C2
RU2251544C2 RU2001118826/04A RU2001118826A RU2251544C2 RU 2251544 C2 RU2251544 C2 RU 2251544C2 RU 2001118826/04 A RU2001118826/04 A RU 2001118826/04A RU 2001118826 A RU2001118826 A RU 2001118826A RU 2251544 C2 RU2251544 C2 RU 2251544C2
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RU
Russia
Prior art keywords
amino
adamantyl
acetyl
alkyl
formula
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RU2001118826/04A
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English (en)
Russian (ru)
Other versions
RU2001118826A (ru
Inventor
Эдуин Бернард ВИЛЛХОЕР (US)
Эдуин Бернард ВИЛЛХОЕР
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2001118826A publication Critical patent/RU2001118826A/ru
Application granted granted Critical
Publication of RU2251544C2 publication Critical patent/RU2251544C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2001118826/04A 1998-12-10 1999-12-09 N-замещенные 2-цианпирролидины RU2251544C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20906898A 1998-12-10 1998-12-10
US09/209,068 1998-12-10
US09/209068 1998-12-10

Publications (2)

Publication Number Publication Date
RU2001118826A RU2001118826A (ru) 2003-06-10
RU2251544C2 true RU2251544C2 (ru) 2005-05-10

Family

ID=22777194

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001118826/04A RU2251544C2 (ru) 1998-12-10 1999-12-09 N-замещенные 2-цианпирролидины

Country Status (34)

Country Link
US (1) US6166063A (OSRAM)
EP (1) EP1137635B1 (OSRAM)
JP (2) JP3681110B2 (OSRAM)
KR (2) KR100509311B1 (OSRAM)
CN (1) CN1160330C (OSRAM)
AR (1) AR023719A1 (OSRAM)
AT (1) ATE307112T1 (OSRAM)
BR (1) BRPI9915985B8 (OSRAM)
CA (1) CA2350609C (OSRAM)
CO (1) CO5150173A1 (OSRAM)
CY (3) CY1105355T1 (OSRAM)
CZ (1) CZ299151B6 (OSRAM)
DE (3) DE122008000017I1 (OSRAM)
DK (1) DK1137635T3 (OSRAM)
ES (1) ES2251847T3 (OSRAM)
FR (1) FR08C0005I2 (OSRAM)
HK (1) HK1040394B (OSRAM)
HU (1) HU226769B1 (OSRAM)
ID (1) ID28796A (OSRAM)
IL (2) IL143091A0 (OSRAM)
LU (2) LU91409I2 (OSRAM)
MY (1) MY123244A (OSRAM)
NL (2) NL300333I2 (OSRAM)
NO (3) NO318741B1 (OSRAM)
NZ (1) NZ511935A (OSRAM)
PE (1) PE20001317A1 (OSRAM)
PL (1) PL199443B1 (OSRAM)
RU (1) RU2251544C2 (OSRAM)
SK (1) SK286635B6 (OSRAM)
TR (1) TR200101478T2 (OSRAM)
TW (1) TW509674B (OSRAM)
UY (1) UY25843A1 (OSRAM)
WO (1) WO2000034241A1 (OSRAM)
ZA (1) ZA200104581B (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2443687C2 (ru) * 2006-04-03 2012-02-27 Матрикс Лэборетериз Лтд. Новые ингибиторы дипептидилпептидазы iv, способы их получения и содержащие их фармацевтические композиции
RU2628573C2 (ru) * 2015-11-27 2017-08-21 Общество с ограниченной ответственностью "Аллель Центр Инновационных Биотехнологий" Ингибитор дипептидилпептидазы-4 для лечения сахарного диабета 2-го типа

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