RU2016150386A - Гетероциклические модуляторы транспортеров атф-связывающей кассеты - Google Patents
Гетероциклические модуляторы транспортеров атф-связывающей кассеты Download PDFInfo
- Publication number
- RU2016150386A RU2016150386A RU2016150386A RU2016150386A RU2016150386A RU 2016150386 A RU2016150386 A RU 2016150386A RU 2016150386 A RU2016150386 A RU 2016150386A RU 2016150386 A RU2016150386 A RU 2016150386A RU 2016150386 A RU2016150386 A RU 2016150386A
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- RU
- Russia
- Prior art keywords
- atp
- binding cassette
- cassette transporters
- heterocyclic modulators
- pharmaceutically acceptable
- Prior art date
Links
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 title 1
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 title 1
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 230000002924 anti-infective effect Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003172 expectorant agent Substances 0.000 claims 1
- 229940066491 mucolytics Drugs 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Claims (5)
1. Комбинация фармацевтически приемлемого носителя и соединения формулы
или его фармацевтически приемлемой соли, и дополнительного терапевтического средства или его фармацевтически приемлемой соли.
2. Комбинация по п.1, где дополнительное терапевтическое средство представляет собой муколитическое средство, бронхолитическое средство, антибиотик, противоинфекционное средство, противовоспалительное средство, модулятор трансмембранного регулятора муковисцидоза (CFTR) или питательное вещество.
3. Комбинация по п.2, где дополнительное терапевтическое средство представляет собой модулятор CFTR.
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RU2012123372A RU2608610C2 (ru) | 2005-11-08 | 2012-06-05 | Гетероциклические модуляторы транспортеров атф-связывающей кассеты |
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