PT2279755E - Remodelação e glicoconjugação do factor de crescimento de fibroblastos (fgf) - Google Patents

Remodelação e glicoconjugação do factor de crescimento de fibroblastos (fgf) Download PDF

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Publication number
PT2279755E
PT2279755E PT100129394T PT10012939T PT2279755E PT 2279755 E PT2279755 E PT 2279755E PT 100129394 T PT100129394 T PT 100129394T PT 10012939 T PT10012939 T PT 10012939T PT 2279755 E PT2279755 E PT 2279755E
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PT
Portugal
Prior art keywords
glycoconjugation
remodelling
fgf
growth factor
fibroblast growth
Prior art date
Application number
PT100129394T
Other languages
English (en)
Portuguese (pt)
Inventor
Shawn De Frees
David Zopf
Robert Bayer
David Hakes
Caryn Bowe
Xi Chen
Original Assignee
Ratiopharm Gmbh
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Filing date
Publication date
Application filed by Ratiopharm Gmbh filed Critical Ratiopharm Gmbh
Publication of PT2279755E publication Critical patent/PT2279755E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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