EP0238655A4 - Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells. - Google Patents
Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells.Info
- Publication number
- EP0238655A4 EP0238655A4 EP19860906562 EP86906562A EP0238655A4 EP 0238655 A4 EP0238655 A4 EP 0238655A4 EP 19860906562 EP19860906562 EP 19860906562 EP 86906562 A EP86906562 A EP 86906562A EP 0238655 A4 EP0238655 A4 EP 0238655A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- polypeptides
- processes
- producing
- stimulating factor
- colony stimulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78341485A | 1985-10-03 | 1985-10-03 | |
US783414 | 1985-10-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0238655A1 EP0238655A1 (en) | 1987-09-30 |
EP0238655A4 true EP0238655A4 (en) | 1989-09-11 |
Family
ID=25129176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19860906562 Withdrawn EP0238655A4 (en) | 1985-10-03 | 1986-10-03 | Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0238655A4 (en) |
JP (1) | JPS63502795A (en) |
AU (2) | AU606585B2 (en) |
DK (1) | DK282887A (en) |
WO (1) | WO1987002060A1 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5837229A (en) * | 1985-02-05 | 1998-11-17 | Chiron Corporation | Uses of recombinant colony stimulating factor-1 |
US5422105A (en) * | 1985-02-05 | 1995-06-06 | Cetus Oncology Corporation | Use of recombinant colony stimulating factor 1 |
US5556620A (en) * | 1985-02-05 | 1996-09-17 | Cetus Oncology Corporation | Use of recombinant colony stimulating factor-1 to enhance wound healing |
US5104650A (en) * | 1985-02-05 | 1992-04-14 | Cetus Corporation | Uses of recombinant colony stimulating factor-1 |
US5242811A (en) * | 1985-03-26 | 1993-09-07 | Biogen, Inc. | Production of human somatomedin C |
DE3712985A1 (en) * | 1987-04-16 | 1988-11-03 | Hoechst Ag | BIFUNCTIONAL PROTEINS |
DE3545568A1 (en) * | 1985-12-21 | 1987-07-16 | Hoechst Ag | GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE |
EP0276846A3 (en) * | 1987-01-29 | 1989-07-26 | Zymogenetics, Inc. | Colony-stimulating factor derivatives |
JPS6420097A (en) * | 1987-03-02 | 1989-01-24 | Sumitomo Chemical Co | Human granulocyte-macrophage colony stimulating factor |
WO1988010310A1 (en) * | 1987-06-25 | 1988-12-29 | Immunex Corporation | Bovine granulocyte-macrophage colony stimulating factor |
IE63514B1 (en) * | 1987-07-17 | 1995-05-03 | Schering Biotech Corp | Expression vectors for the production of human granulocyte-macrophage colony stimulation factor in a mammalian cell host |
JPH03502322A (en) * | 1987-10-30 | 1991-05-30 | イミュネックス・コーポレーション | Non-glycosylated analogs of human colony-stimulating factor |
GB2212159B (en) * | 1987-11-13 | 1992-01-22 | British Bio Technology | Synthetic gene for human granulocyte/macrophage colony stimulating factor. |
EP0413721A4 (en) * | 1988-04-21 | 1991-11-13 | Medvet Science Pty. Ltd. | Human gm-csf variants |
AU3578189A (en) * | 1988-04-27 | 1989-11-24 | Immunomedics Inc. | Improved radiotherapy |
MY105798A (en) * | 1989-01-30 | 1995-01-30 | Schering Corp | Treatment of leukocyte dysfunction with gm-csf. |
AU704486B2 (en) * | 1994-03-04 | 1999-04-22 | Ludwig Institute For Cancer Research | Animals with targeted gene disruption |
US6979442B1 (en) | 1998-08-17 | 2005-12-27 | Pfizer Inc. | Stabilized protein compositions |
NZ532027A (en) | 2001-10-10 | 2008-09-26 | Neose Technologies Inc | Remodeling and glycoconjugation of peptides |
US10138283B2 (en) | 2008-07-23 | 2018-11-27 | Ambrx, Inc. | Modified bovine G-CSF polypeptides and their uses |
AR083006A1 (en) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | FORMULATIONS FOR THE STIMULATING FACTOR OF COLONIES OF GRANULOCITS (G-CSF) BOVINE AND VARIANTS OF THE SAME |
JP6698854B2 (en) * | 2016-09-16 | 2020-05-27 | キッセイ薬品工業株式会社 | Genetically modified cell and method for producing the same |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0212914A2 (en) * | 1985-08-06 | 1987-03-04 | Immunex Corporation | Amplifying the expression of recombinant DNA products |
EP0228018A2 (en) * | 1985-12-21 | 1987-07-08 | Hoechst Aktiengesellschaft | GM-CSF protein, its derivatives, preparation of such proteins and their use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6030654B2 (en) * | 1980-12-31 | 1985-07-17 | 株式会社林原生物化学研究所 | Method for producing human colony stimulating factor |
UA39161C2 (en) * | 1984-07-06 | 2001-06-15 | Новартіс Аг | Recombinant protein of GM-CSF for increase in productION of granylocytes and macrophages by patients, vector and cdna coding it |
ZA856108B (en) * | 1984-10-29 | 1986-10-29 | Immunex Corp | Cloning of human granulocyte-macrophage colony simulating factor gene |
KR920003822B1 (en) * | 1984-11-20 | 1992-05-15 | 쉐링 바이오텍 코포레이션 | Polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity |
-
1986
- 1986-10-03 EP EP19860906562 patent/EP0238655A4/en not_active Withdrawn
- 1986-10-03 WO PCT/US1986/002106 patent/WO1987002060A1/en not_active Application Discontinuation
- 1986-10-03 AU AU65493/86A patent/AU606585B2/en not_active Ceased
- 1986-10-03 JP JP50583986A patent/JPS63502795A/en active Pending
-
1987
- 1987-06-02 DK DK282887A patent/DK282887A/en not_active Application Discontinuation
-
1990
- 1990-11-05 AU AU65781/90A patent/AU630516B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0212914A2 (en) * | 1985-08-06 | 1987-03-04 | Immunex Corporation | Amplifying the expression of recombinant DNA products |
EP0228018A2 (en) * | 1985-12-21 | 1987-07-08 | Hoechst Aktiengesellschaft | GM-CSF protein, its derivatives, preparation of such proteins and their use |
Non-Patent Citations (2)
Title |
---|
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 82, no. 18, September 1985, pages 6250-6254, Washington, US; M.A. CANTRELL et al.: "Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor" * |
See also references of WO8702060A1 * |
Also Published As
Publication number | Publication date |
---|---|
DK282887D0 (en) | 1987-06-02 |
AU630516B2 (en) | 1992-10-29 |
AU6549386A (en) | 1987-04-24 |
WO1987002060A1 (en) | 1987-04-09 |
AU606585B2 (en) | 1991-02-14 |
JPS63502795A (en) | 1988-10-20 |
EP0238655A1 (en) | 1987-09-30 |
DK282887A (en) | 1987-07-30 |
AU6578190A (en) | 1991-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19870625 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: BIOGEN, INC. |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19890911 |
|
17Q | First examination report despatched |
Effective date: 19900920 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19921120 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: DELAMARTER, JOHN Inventor name: ERNST, JOACHIM, F. |