CN1635901B - 肽的重构和糖缀合的方法 - Google Patents
肽的重构和糖缀合的方法 Download PDFInfo
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- CN1635901B CN1635901B CN02820073XA CN02820073A CN1635901B CN 1635901 B CN1635901 B CN 1635901B CN 02820073X A CN02820073X A CN 02820073XA CN 02820073 A CN02820073 A CN 02820073A CN 1635901 B CN1635901 B CN 1635901B
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- peptide
- glycosyl
- independently
- mannose
- polysaccharide
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- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
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- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
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- C12Y302/01021—Beta-glucosidase (3.2.1.21)
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Abstract
Description
蛋白质 | 来源 | 末端Gal1 摩尔/摩尔 | NeuAc整合2 摩尔/摩尔 | % Rxn3 | 其他特征 |
ATIII4 | Genzyme Transgenics | 102 | 104 | 117 | 无 |
ATIII4 | Genzyme Transgenics | 102 | 1.3 | 108 | SDS-凝胶:蛋白质纯度 FACs:糖类糖形式 |
脱唾液酸化-胎 球蛋白 | Sigma | 802 | 905 | 116 | 无 |
脱唾液酸化 -AAAT5 | PPL | 7 | 7.0 | 100 | SDS-凝胶:蛋白质纯度 |
Claims (36)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510483413.4A CN105131104B (zh) | 2001-10-10 | 2002-10-09 | 肽的重构和糖缀合 |
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US32852301P | 2001-10-10 | 2001-10-10 | |
US60/328,523 | 2001-10-11 | ||
US34469201P | 2001-10-19 | 2001-10-19 | |
US60/344,692 | 2001-10-19 | ||
US33430101P | 2001-11-28 | 2001-11-28 | |
US33423301P | 2001-11-28 | 2001-11-28 | |
US60/334,233 | 2001-11-28 | ||
US60/334,301 | 2001-11-28 | ||
US38729202P | 2002-06-07 | 2002-06-07 | |
US60/387,292 | 2002-06-07 | ||
US39177702P | 2002-06-25 | 2002-06-25 | |
US60/391,777 | 2002-06-25 | ||
US39659402P | 2002-07-17 | 2002-07-17 | |
US60/396,594 | 2002-07-17 | ||
US40424902P | 2002-08-16 | 2002-08-16 | |
US60/404,249 | 2002-08-16 | ||
US40752702P | 2002-08-28 | 2002-08-28 | |
US60/407,527 | 2002-08-28 | ||
PCT/US2002/032263 WO2003031464A2 (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
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CN201510483413.4A Division CN105131104B (zh) | 2001-10-10 | 2002-10-09 | 肽的重构和糖缀合 |
CN2011100354568A Division CN102180944A (zh) | 2001-10-10 | 2002-10-09 | 肽的重构和糖缀合 |
CN200910145812.4A Division CN101724075B (zh) | 2001-10-10 | 2002-10-09 | 肽的重构和糖缀合 |
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CN1635901A CN1635901A (zh) | 2005-07-06 |
CN1635901B true CN1635901B (zh) | 2012-03-28 |
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CN02820073XA Expired - Lifetime CN1635901B (zh) | 2001-10-10 | 2002-10-09 | 肽的重构和糖缀合的方法 |
CN200910145812.4A Expired - Lifetime CN101724075B (zh) | 2001-10-10 | 2002-10-09 | 肽的重构和糖缀合 |
CN2011100354568A Pending CN102180944A (zh) | 2001-10-10 | 2002-10-09 | 肽的重构和糖缀合 |
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CN200910145812.4A Expired - Lifetime CN101724075B (zh) | 2001-10-10 | 2002-10-09 | 肽的重构和糖缀合 |
CN2011100354568A Pending CN102180944A (zh) | 2001-10-10 | 2002-10-09 | 肽的重构和糖缀合 |
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US (3) | US7416858B2 (zh) |
EP (7) | EP2042196B1 (zh) |
JP (8) | JP5232352B2 (zh) |
CN (3) | CN1635901B (zh) |
AU (2) | AU2002360264B2 (zh) |
BE (1) | BE2014C004I2 (zh) |
BR (1) | BRPI0213207B1 (zh) |
CA (1) | CA2462930C (zh) |
DK (2) | DK1578771T3 (zh) |
ES (9) | ES2556338T3 (zh) |
FR (1) | FR14C0007I2 (zh) |
HK (4) | HK1149513A1 (zh) |
IL (3) | IL161251A0 (zh) |
LU (1) | LU92359I2 (zh) |
MX (1) | MXPA04003333A (zh) |
NL (1) | NL300912I2 (zh) |
NZ (1) | NZ532027A (zh) |
PT (2) | PT2279753E (zh) |
SG (2) | SG177002A1 (zh) |
WO (1) | WO2003031464A2 (zh) |
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WO2001002017A2 (en) * | 1999-07-02 | 2001-01-11 | F. Hoffmann-La Roche Ag | Erythropoietin conjugates with polyethylenglycol |
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