ES2507091T3 - Nanofiltración de soluciones del factor VII para eliminar virus - Google Patents

Nanofiltración de soluciones del factor VII para eliminar virus Download PDF

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Publication number
ES2507091T3
ES2507091T3 ES04804635.3T ES04804635T ES2507091T3 ES 2507091 T3 ES2507091 T3 ES 2507091T3 ES 04804635 T ES04804635 T ES 04804635T ES 2507091 T3 ES2507091 T3 ES 2507091T3
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ES
Spain
Prior art keywords
factor vii
nanofiltration
polypeptides
eliminate viruses
solutions
Prior art date
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Active
Application number
ES04804635.3T
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English (en)
Inventor
Jesper Christensen
Erik Halkjaer
Turid Preuss
Thomas Budde Hansen
Lene Vaedele Madsen Tomoda
Nina Johansen
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Novo Nordisk Health Care AG
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Novo Nordisk Health Care AG
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Application filed by Novo Nordisk Health Care AG filed Critical Novo Nordisk Health Care AG
Application granted granted Critical
Publication of ES2507091T3 publication Critical patent/ES2507091T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13061—Methods of inactivation or attenuation
    • C12N2740/13063—Methods of inactivation or attenuation by chemical treatment

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un método para retirar virus de una composición líquida del factor VII recombinante, donde dicha composición comprende uno o más polipéptidos del factor VII, donde la concentración de los polipéptidos del factor VII está comprendida en el intervalo de 0.01 a 5 mg/mL y donde la forma activada de los polipéptidos del factor VII representa un 50-100% de la masa del polipéptido o de los polipéptidos del factor FVII en la composición; donde dicho método comprende someter dicha solución a nanofiltración utilizando un nanofiltro que tiene un tamaño de poro de 80 nm como máximo.

Description

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Claims (1)

  1. imagen1
ES04804635.3T 2003-12-01 2004-12-01 Nanofiltración de soluciones del factor VII para eliminar virus Active ES2507091T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200301775 2003-12-01
DK200301775 2003-12-01
PCT/EP2004/053206 WO2005054275A2 (en) 2003-12-01 2004-12-01 Nanofiltration of factor vii solutions to remove virus

Publications (1)

Publication Number Publication Date
ES2507091T3 true ES2507091T3 (es) 2014-10-14

Family

ID=34639198

Family Applications (2)

Application Number Title Priority Date Filing Date
ES19186952T Active ES2926359T3 (es) 2003-12-01 2004-12-01 Filtración de virus de composiciones líquidas del Factor VII
ES04804635.3T Active ES2507091T3 (es) 2003-12-01 2004-12-01 Nanofiltración de soluciones del factor VII para eliminar virus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES19186952T Active ES2926359T3 (es) 2003-12-01 2004-12-01 Filtración de virus de composiciones líquidas del Factor VII

Country Status (14)

Country Link
US (8) US20070142625A1 (es)
EP (3) EP1711513B1 (es)
JP (3) JP4874806B2 (es)
KR (1) KR101234170B1 (es)
CN (3) CN1890257A (es)
AU (1) AU2004294403A1 (es)
BR (1) BRPI0416950B8 (es)
CA (1) CA2545474A1 (es)
DK (1) DK1711513T3 (es)
ES (2) ES2926359T3 (es)
PL (1) PL1711513T3 (es)
PT (1) PT1711513E (es)
RU (1) RU2472804C2 (es)
WO (1) WO2005054275A2 (es)

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WO2012090067A1 (en) 2010-12-30 2012-07-05 Lfb Biotechnologies Glycols as pathogen inactivating agents
SG193564A1 (en) 2011-03-25 2013-10-30 Genentech Inc Novel protein purification methods
MY173835A (en) 2012-06-21 2020-02-24 Baxter Int Virus filtration of cell culture media
TWI641382B (zh) * 2013-01-31 2018-11-21 韓美藥品股份有限公司 於包含因子ｖｉｉ之組成物中使病毒失活之方法
RU2526494C1 (ru) * 2013-03-19 2014-08-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Челябинская государственная медицинская академия" Министерства здравоохранения Российской Федерации" (ГБОУ ВПО ЧелГМА Минздрава России) Способ удаления вируса иммунодефицита человека из спермы мужчины
CN105722523B (zh) * 2013-11-15 2022-06-14 豪夫迈·罗氏有限公司 使用环保洗涤剂的病毒灭活方法
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Also Published As

Publication number Publication date
PL1711513T3 (pl) 2014-12-31
US20200248150A1 (en) 2020-08-06
CN106916802A (zh) 2017-07-04
US20070142625A1 (en) 2007-06-21
CN1890257A (zh) 2007-01-03
US20190032026A1 (en) 2019-01-31
EP3594222A1 (en) 2020-01-15
WO2005054275A2 (en) 2005-06-16
EP1711513B1 (en) 2014-07-02
AU2004294403A1 (en) 2005-06-16
US20080274534A1 (en) 2008-11-06
US20170022482A1 (en) 2017-01-26
PT1711513E (pt) 2014-10-02
JP2011173889A (ja) 2011-09-08
BRPI0416950B8 (pt) 2021-05-25
KR20070001887A (ko) 2007-01-04
WO2005054275A3 (en) 2005-09-09
JP5666359B2 (ja) 2015-02-12
BRPI0416950B1 (pt) 2019-05-28
US20120115204A1 (en) 2012-05-10
KR101234170B1 (ko) 2013-02-18
CN106916802B (zh) 2022-03-25
DK1711513T3 (da) 2014-09-15
JP2012021007A (ja) 2012-02-02
EP1711513A2 (en) 2006-10-18
RU2006118024A (ru) 2008-01-10
EP2275432A1 (en) 2011-01-19
US20150299685A1 (en) 2015-10-22
RU2472804C2 (ru) 2013-01-20
CA2545474A1 (en) 2005-06-16
BRPI0416950A (pt) 2007-02-13
US20220064605A1 (en) 2022-03-03
JP4874806B2 (ja) 2012-02-15
US9102762B2 (en) 2015-08-11
EP3594222B1 (en) 2022-08-03
JP2007537994A (ja) 2007-12-27
CN102351953A (zh) 2012-02-15
BRPI0416950A8 (pt) 2019-01-22
CN102351953B (zh) 2017-05-10
ES2926359T3 (es) 2022-10-25

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