CA2106301C
(en)
|
1991-03-18 |
1999-04-06 |
Chi-Huey Wong |
Oligosaccharide enzyme substrates and inhibitors: method and compositions
|
JPH07500248A
(ja)
*
|
1991-10-15 |
1995-01-12 |
ザ スクリップス リサーチ インスティテュート |
糖ヌクレオチドの酵素的フコシル化合成によるフコシル化炭水化物の生産、及びGDP−フコースのin situ 再生
|
US5559103A
(en)
*
|
1993-07-21 |
1996-09-24 |
Cytel Corporation |
Bivalent sialyl X saccharides
|
EP0671409A3
(de)
*
|
1994-03-11 |
1996-06-12 |
Hoechst Ag |
Malonsäurederivate mit antiadhäsiven Eigenschaften.
|
DE4408248A1
(de)
*
|
1994-03-11 |
1995-09-14 |
Hoechst Ag |
Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung
|
IT1268954B1
(it)
*
|
1994-03-11 |
1997-03-18 |
Fidia Advanced Biopolymers Srl |
Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
|
US5922577A
(en)
*
|
1995-04-11 |
1999-07-13 |
Cytel Corporation |
Enzymatic synthesis of glycosidic linkages
|
US5728554A
(en)
*
|
1995-04-11 |
1998-03-17 |
Cytel Corporation |
Enzymatic synthesis of glycosidic linkages
|
US6030815A
(en)
*
|
1995-04-11 |
2000-02-29 |
Neose Technologies, Inc. |
Enzymatic synthesis of oligosaccharides
|
US5876980A
(en)
*
|
1995-04-11 |
1999-03-02 |
Cytel Corporation |
Enzymatic synthesis of oligosaccharides
|
WO1997037682A1
(en)
*
|
1996-04-10 |
1997-10-16 |
Cytel Corporation |
Nucleic acids encoding gdp-fucose pyrophosphorylase
|
AU736993B2
(en)
|
1997-01-16 |
2001-08-09 |
Novo Nordisk A/S |
Practical in vitro sialylation of recombinant glycoproteins
|
US5952203A
(en)
|
1997-04-11 |
1999-09-14 |
The University Of British Columbia |
Oligosaccharide synthesis using activated glycoside derivative, glycosyl transferase and catalytic amount of nucleotide phosphate
|
EP1903114A3
(de)
|
1997-12-01 |
2008-07-23 |
Neose Technologies, Inc. |
Enzymatische Synthese von Gangliosiden
|
JP2002526549A
(ja)
|
1998-10-06 |
2002-08-20 |
マサチューセッツ インスティテュート オブ テクノロジー |
オリゴ糖の合成、それに関する試薬及び合成法
|
US6699705B2
(en)
|
1999-02-01 |
2004-03-02 |
National Research Council Of Canada |
Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
|
US6503744B1
(en)
|
1999-02-01 |
2003-01-07 |
National Research Council Of Canada |
Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
|
US6949372B2
(en)
*
|
1999-03-02 |
2005-09-27 |
The Johns Hopkins University |
Engineering intracellular sialylation pathways
|
AU3388400A
(en)
|
1999-03-02 |
2000-09-21 |
Human Genome Sciences, Inc. |
Human glycosylation enzymes
|
AUPP913999A0
(en)
*
|
1999-03-12 |
1999-04-01 |
Biota Scientific Management Pty Ltd |
Novel chemical compounds and their use
|
US6395559B1
(en)
|
1999-05-04 |
2002-05-28 |
Orchid Biosciences, Inc. |
Multiple fluid sample processor with single well addressability
|
ATE378421T1
(de)
*
|
1999-05-24 |
2007-11-15 |
Abaron Biosciences Inc |
Glycosyltransferase inhibitoren
|
EP1189643A1
(de)
|
1999-06-30 |
2002-03-27 |
Novartis AG |
Ophthalmischer formkörper
|
KR100349696B1
(ko)
*
|
1999-06-30 |
2002-08-22 |
주식회사 하이닉스반도체 |
화학적 팽창 공정을 이용한 반도체 소자의 금속배선 형성을 위한 대머신 구조 형성방법
|
FI19992070A
(fi)
|
1999-09-28 |
2001-03-28 |
Jari Natunen |
Uudet fukosyloidut oligosakkaridit ja menetelmä niiden valmistamiseksi
|
JP4599505B2
(ja)
*
|
2000-03-03 |
2010-12-15 |
明治乳業株式会社 |
N−アセチル−β−ヘキソサミニド誘導体の製造方法
|
JP4060079B2
(ja)
*
|
2000-03-31 |
2008-03-12 |
ミシガン ステイト ユニバーシティー |
オキシム又はイミンからの1,5―ジデオキシ―1,5−イミノヘキシトールの製法
|
US6586207B2
(en)
|
2000-05-26 |
2003-07-01 |
California Institute Of Technology |
Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
|
US7863020B2
(en)
*
|
2000-06-28 |
2011-01-04 |
Glycofi, Inc. |
Production of sialylated N-glycans in lower eukaryotes
|
CA2457794A1
(en)
|
2001-08-29 |
2003-03-06 |
Neose Technologies, Inc. |
Novel synthetic ganglioside derivatives and compositions thereof
|
EP1438387A4
(de)
*
|
2001-09-14 |
2004-10-13 |
Momenta Pharmaceuticals Inc |
Verfahren zur herstellung von glycomolekülen mit verstärkten aktivitäten und verwendungen davon
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
PT2279753E
(pt)
|
2001-10-10 |
2016-01-15 |
Novo Nordisk As |
Remodelação e glicoconjugação de péptidos
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
EP2305311A3
(de)
|
2001-10-10 |
2011-07-20 |
BioGeneriX AG |
Glykokonjugation von Peptiden
|
AUPR879501A0
(en)
*
|
2001-11-09 |
2001-12-06 |
Biota Scientific Management Pty Ltd |
Novel chemical compounds and their use
|
US6852485B1
(en)
|
2002-01-22 |
2005-02-08 |
California State University Fullerton Foundation |
Method for identifying a compound for the treatment of microorganism infections by inhibiting energy storage and utilization in pathogens
|
CA2493258C
(en)
|
2002-07-23 |
2015-10-20 |
Neose Technologies, Inc. |
Synthesis of oligosaccharides, glycolipids, and glycoproteins using bacterial glycosyltransferases
|
EP1636248A4
(de)
|
2002-12-16 |
2006-09-06 |
Halozyme Inc |
Humanes chondroitinase-glycoprotein(chasegp), verfahren zu seiner herstellung und dieses enthaltendepharmazeutische zusammensetzungen
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
PL1603541T5
(pl)
|
2003-03-05 |
2013-06-28 |
Halozyme Inc |
Rozpuszczalna glikoproteina o aktywności hialuronidazy (sHASEGP), sposób jej wytwarzania, zastosowanie i zawierające ją kompozycje farmaceutyczne
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
EP1603932B1
(de)
|
2003-03-06 |
2012-10-03 |
Seneb Biosciences Inc. |
Verfahren und zusammensetzungen für die enzymatische synthese von gangliosiden
|
CA2522345A1
(en)
|
2003-04-09 |
2004-11-18 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
WO2005000862A2
(en)
*
|
2003-06-24 |
2005-01-06 |
Isis Innovation Limited |
Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
ES2501642T3
(es)
|
2004-02-04 |
2014-10-02 |
Ratiopharm Gmbh |
Métodos de replegamiento de glicosiltransferasas de mamífero
|
US20050287639A1
(en)
|
2004-05-17 |
2005-12-29 |
California Institute Of Technology |
Methods of incorporating amino acid analogs into proteins
|
WO2006050247A2
(en)
|
2004-10-29 |
2006-05-11 |
Neose Technologies, Inc. |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
WO2006074467A2
(en)
|
2005-01-10 |
2006-07-13 |
Neose Technologies, Inc. |
Glycopegylated granulocyte colony stimulating factor
|
US20070154992A1
(en)
|
2005-04-08 |
2007-07-05 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
EP1891231A4
(de)
|
2005-05-25 |
2011-06-22 |
Novo Nordisk As |
Glykopegylierter faktor ix
|
US7820422B2
(en)
|
2005-06-16 |
2010-10-26 |
Centre National De La Recherche Scientifique (Cnrs) |
Efficient production of oligosaccharides using metabolically engineered microorganisms
|
CA2618769C
(en)
|
2005-08-11 |
2014-03-04 |
National Research Council Of Canada |
Orf11 from campylobacter jejuni is a sialate-o-acetyltransferase
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
WO2007024743A2
(en)
|
2005-08-19 |
2007-03-01 |
Centocor, Inc. |
Proteolysis resistant antibody preparations
|
AU2006304463A1
(en)
*
|
2005-10-17 |
2007-04-26 |
Health Research, Inc. |
Specific acceptors for tranferases to saccharides and method for obtaining and using same
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
PT1999259E
(pt)
|
2006-03-03 |
2014-09-24 |
California Inst Of Techn |
Incorporação sítio-específica de aminoácidos em moléculas
|
CA2653748A1
(en)
|
2006-05-02 |
2007-11-15 |
Allozyne, Inc. |
Non-natural amino acid substituted polypeptides
|
AR078117A1
(es)
|
2006-06-20 |
2011-10-19 |
Protech Pharma S A |
Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina
|
EP2049144B8
(de)
|
2006-07-21 |
2015-02-18 |
ratiopharm GmbH |
Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen
|
DE602007013588D1
(de)
|
2006-10-03 |
2011-05-12 |
Centre Nat Rech Scient |
Fermentative produktion von sialinsäure (neu5ac) mit hoher ausbeute
|
EP2054521A4
(de)
|
2006-10-03 |
2012-12-19 |
Novo Nordisk As |
Verfahren zur reinigung von polypeptid-konjugate
|
DK2068907T3
(en)
|
2006-10-04 |
2018-01-15 |
Novo Nordisk As |
GLYCEROL BOND PEGYLED SUGAR AND GLYCOPE Peptides
|
EP1911850A1
(de)
*
|
2006-10-09 |
2008-04-16 |
Centre National De La Recherche Scientifique (Cnrs) |
Verfahren zur Herstellung von 6-thio-sialierten Glykoproteinen und Glycokonjugaten
|
BRPI0809607A2
(pt)
*
|
2007-04-02 |
2014-09-30 |
Theracos Inc |
Composto, composição farmacêutica, combinação farmacêutica, e, método para tratar uma doença
|
CN101796063B
(zh)
|
2007-04-03 |
2017-03-22 |
拉蒂奥法姆有限责任公司 |
使用糖聚乙二醇化g‑csf的治疗方法
|
PL2137655T3
(pl)
|
2007-04-16 |
2012-12-31 |
Momenta Pharmaceuticals Inc |
Zdefiniowane produkty glikoproteinowe i powiązane sposoby
|
EP2170919B8
(de)
|
2007-06-12 |
2016-01-20 |
ratiopharm GmbH |
Verbessertes verfahren zur herstellung von nukleotidzuckern
|
WO2009006613A1
(en)
*
|
2007-07-03 |
2009-01-08 |
Children's Hospital & Research Center At Oakland |
Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting
|
US8999954B2
(en)
*
|
2007-07-03 |
2015-04-07 |
Childern's Hospital & Research Center at Oakland |
Inhibitors of polysialic acid de-N-acetylase and methods for using the same
|
WO2009006620A1
(en)
|
2007-07-03 |
2009-01-08 |
Children's Hospital & Research Center At Oakland |
Oligosialic acid derivatives, methods of manufacture, and immunological uses
|
US20100260751A1
(en)
|
2007-09-28 |
2010-10-14 |
Raju T Shantha |
Methods and Structural Conformations of Antibody Preparations with Increased Resistance to Proteases
|
JP4826824B2
(ja)
*
|
2007-12-03 |
2011-11-30 |
クミアイ化学工業株式会社 |
オリゴ糖
|
AU2009219232B2
(en)
|
2008-02-27 |
2014-02-27 |
Novo Nordisk A/S |
Conjugated Factor VIII molecules
|
WO2010111530A1
(en)
|
2009-03-25 |
2010-09-30 |
Seneb Biosciences, Inc. |
Glycolipids as treatment for disease
|
US20100248365A1
(en)
*
|
2009-03-27 |
2010-09-30 |
Zacharon Pharmaceuticals, Inc. |
Ganglioside biosynthesis modulators
|
PL2442831T3
(pl)
*
|
2009-06-16 |
2016-06-30 |
Glythera Ltd |
Materiały i sposoby dotyczące glikozylacji polipeptydu terapeutycznego
|
EP2494061B1
(de)
|
2009-10-29 |
2017-01-25 |
Janssen Biotech, Inc. |
Antikörperglycosylierungsvarianten
|
EP2556163B1
(de)
|
2010-04-07 |
2016-08-10 |
Momenta Pharmaceuticals, Inc. |
Verfahren zur quantifizierung von "high mannose"-glycoformen
|
ES2634669T3
(es)
|
2011-02-08 |
2017-09-28 |
Halozyme, Inc. |
Composición y formulación lipídica de una enzima de degradación de hialuronano y uso de la misma para el tratamiento de la hiperplasia benigna de próstata
|
CN103782168B
(zh)
|
2011-03-12 |
2016-03-16 |
动量制药公司 |
在糖蛋白产品中包含n-乙酰己糖胺的n-聚醣
|
US20130011378A1
(en)
|
2011-06-17 |
2013-01-10 |
Tzung-Horng Yang |
Stable formulations of a hyaluronan-degrading enzyme
|
WO2013063155A2
(en)
|
2011-10-24 |
2013-05-02 |
Halozyme, Inc. |
Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
|
SI3130347T1
(sl)
|
2011-12-30 |
2020-02-28 |
Halozyme, Inc. |
Variante polipeptida PH20, formulacije in uporabe le-teh
|
US9695244B2
(en)
|
2012-06-01 |
2017-07-04 |
Momenta Pharmaceuticals, Inc. |
Methods related to denosumab
|
TWI510627B
(zh)
*
|
2012-08-20 |
2015-12-01 |
Academia Sinica |
寡醣之大規模酵素合成
|
EP2855533A4
(de)
|
2013-03-15 |
2015-11-25 |
Momenta Pharmaceuticals Inc |
Verfahren in zusammenhang mit ctla4-fc-fusionsproteinen
|
US20160106860A1
(en)
|
2013-05-02 |
2016-04-21 |
Glykos Finland Oy |
Conjugates of a glycoprotein or a glycan with a toxic payload
|
US10464996B2
(en)
|
2013-05-13 |
2019-11-05 |
Momenta Pharmaceuticals, Inc. |
Methods for the treatment of neurodegeneration
|
WO2014210397A1
(en)
*
|
2013-06-26 |
2014-12-31 |
Academia Sinica |
Rm2 antigens and use thereof
|
EP3058084A4
(de)
|
2013-10-16 |
2017-07-05 |
Momenta Pharmaceuticals, Inc. |
Sialylierte glycoproteine
|
WO2016077567A1
(en)
*
|
2014-11-12 |
2016-05-19 |
Tumorend, Llc |
Compositions, methods and treatments for inhibiting cell adhesion and virus binding and penetration
|
EP3559250A1
(de)
|
2016-12-21 |
2019-10-30 |
H. Hoffnabb-La Roche Ag |
Wiederverwendung von enzymen im in-vitro-glyco-engineering von antikörpern
|
BR112019010294A2
(pt)
|
2016-12-21 |
2019-09-03 |
Hoffmann La Roche |
método para a produção enzimática de um anticorpo, anticorpo e formulação farmacêutica
|
WO2018114877A1
(en)
|
2016-12-21 |
2018-06-28 |
F. Hoffmann-La Roche Ag |
In vitro glycoengineering of antibodies
|
CN106632531B
(zh)
*
|
2017-01-03 |
2019-02-22 |
河南科技学院 |
一种α-2,3羟乙酰唾液酸乳果糖的制备方法
|
BR112020013198A2
(pt)
|
2017-12-29 |
2020-12-01 |
Glycomimetics, Inc. |
inibidores heterobifuncionais de e-selectina e galectina-3
|
EP3902797A1
(de)
|
2018-12-27 |
2021-11-03 |
GlycoMimetics, Inc. |
Galectin-3-hemmende c-glycoside
|
WO2020139962A1
(en)
|
2018-12-27 |
2020-07-02 |
Glycomimetics, Inc. |
Heterobifunctional inhibitors of e-selectin and galectin-3
|