NO329929B1 - Ny forbindelse samt anvendelser derav og farmasoytisk preparat - Google Patents
Ny forbindelse samt anvendelser derav og farmasoytisk preparat Download PDFInfo
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- NO329929B1 NO329929B1 NO20030928A NO20030928A NO329929B1 NO 329929 B1 NO329929 B1 NO 329929B1 NO 20030928 A NO20030928 A NO 20030928A NO 20030928 A NO20030928 A NO 20030928A NO 329929 B1 NO329929 B1 NO 329929B1
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- Prior art keywords
- hcv
- compound
- replicon
- interferon
- rna
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Classifications
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
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- C07—ORGANIC CHEMISTRY
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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- Crystallography & Structural Chemistry (AREA)
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- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US22939800P | 2000-08-31 | 2000-08-31 | |
US27764101P | 2001-03-21 | 2001-03-21 | |
PCT/US2001/026008 WO2002018369A2 (fr) | 2000-08-31 | 2001-08-31 | Inhibiteurs peptidomimetiques de protease |
Publications (3)
Publication Number | Publication Date |
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NO20030928D0 NO20030928D0 (no) | 2003-02-27 |
NO20030928L NO20030928L (no) | 2003-04-16 |
NO329929B1 true NO329929B1 (no) | 2011-01-24 |
Family
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Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
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NO20030928A NO329929B1 (no) | 2000-08-31 | 2003-02-27 | Ny forbindelse samt anvendelser derav og farmasoytisk preparat |
NO20100093A NO20100093L (no) | 2000-08-31 | 2010-01-18 | Peptidomimetiske protease-inhibitorer |
NO20100999A NO330807B1 (no) | 2000-08-31 | 2010-07-12 | Nye forbindelser, farmasoytisk preparat og anvendelse derav |
NO2012006C NO2012006I1 (no) | 2000-08-31 | 2012-04-03 | Telaprevir og enhver terapeutisk ekvivalent form derav som er beskyttet av basispatentet, slik som farmasøytisk akseptable salter og/eller solvater avtelaprevir eller solvater av slike salter |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
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NO20100093A NO20100093L (no) | 2000-08-31 | 2010-01-18 | Peptidomimetiske protease-inhibitorer |
NO20100999A NO330807B1 (no) | 2000-08-31 | 2010-07-12 | Nye forbindelser, farmasoytisk preparat og anvendelse derav |
NO2012006C NO2012006I1 (no) | 2000-08-31 | 2012-04-03 | Telaprevir og enhver terapeutisk ekvivalent form derav som er beskyttet av basispatentet, slik som farmasøytisk akseptable salter og/eller solvater avtelaprevir eller solvater av slike salter |
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US (5) | US7820671B2 (fr) |
EP (9) | EP2368878A1 (fr) |
JP (4) | JP4689938B2 (fr) |
KR (10) | KR20100042296A (fr) |
CN (7) | CN103232381A (fr) |
AR (1) | AR030591A1 (fr) |
AT (2) | ATE431358T1 (fr) |
AU (2) | AU8831801A (fr) |
BR (1) | BR0113666A (fr) |
CA (2) | CA2419607C (fr) |
CL (1) | CL2010000330A1 (fr) |
CY (2) | CY1109216T1 (fr) |
CZ (1) | CZ2003595A3 (fr) |
DE (4) | DE20122915U1 (fr) |
DK (2) | DK1878720T3 (fr) |
DZ (1) | DZ3438A1 (fr) |
EA (2) | EA011547B1 (fr) |
EC (2) | ECSP034493A (fr) |
ES (4) | ES2489115T3 (fr) |
HK (3) | HK1114090A1 (fr) |
HR (1) | HRP20030139B8 (fr) |
HU (1) | HUP0300855A3 (fr) |
IL (6) | IL154671A0 (fr) |
LU (1) | LU91960I2 (fr) |
MX (1) | MXPA03001780A (fr) |
NO (4) | NO329929B1 (fr) |
NZ (2) | NZ541302A (fr) |
PE (1) | PE20020474A1 (fr) |
PL (1) | PL211019B1 (fr) |
PT (1) | PT1320540E (fr) |
SI (1) | SI1320540T1 (fr) |
SK (1) | SK2492003A3 (fr) |
SV (1) | SV2003000617A (fr) |
TW (6) | TW201022244A (fr) |
UA (2) | UA99895C2 (fr) |
WO (1) | WO2002018369A2 (fr) |
ZA (1) | ZA200301641B (fr) |
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US7863274B2 (en) | 2005-07-29 | 2011-01-04 | Concert Pharmaceuticals Inc. | Deuterium enriched analogues of tadalafil as PDE5 inhibitors |
CN101277950B (zh) | 2005-08-02 | 2013-03-27 | 弗特克斯药品有限公司 | 丝氨酸蛋白酶抑制剂 |
PL1934179T4 (pl) | 2005-08-19 | 2014-03-31 | Vertex Pharma | Sposoby i związki pośrednie |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
EP1991229A2 (fr) | 2006-02-27 | 2008-11-19 | Vertex Pharmaceuticals Incorporated | Co-cristaux et compositions pharmaceutiques les comprenant |
MX2008011868A (es) | 2006-03-16 | 2008-12-15 | Vertex Pharma | Inhibidores deuterados de la proteasa de la hepatitis c. |
KR101398259B1 (ko) | 2006-03-16 | 2014-05-26 | 버텍스 파마슈티칼스 인코포레이티드 | 입체 화합물의 제조 방법 및 이를 위한 중간체 |
EP2001498A4 (fr) | 2006-03-20 | 2013-01-23 | Vertex Pharma | Compositions pharmaceutiques |
RS20090406A (en) | 2006-03-20 | 2010-12-31 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
CA2653625A1 (fr) | 2006-05-31 | 2007-12-13 | Vertex Pharmaceuticals Incorporated | Formulations a liberation controlee |
CA2679426A1 (fr) | 2007-02-27 | 2008-09-04 | Luc Farmer | Inhibiteurs de serine proteases |
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