ECSP077217A - Inhibidores de proteasa peptidomimeticos - Google Patents
Inhibidores de proteasa peptidomimeticosInfo
- Publication number
- ECSP077217A ECSP077217A EC2007007217A ECSP077217A ECSP077217A EC SP077217 A ECSP077217 A EC SP077217A EC 2007007217 A EC2007007217 A EC 2007007217A EC SP077217 A ECSP077217 A EC SP077217A EC SP077217 A ECSP077217 A EC SP077217A
- Authority
- EC
- Ecuador
- Prior art keywords
- hcv
- inhibitors
- infection
- relates
- patient
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a compuestos peptidomiméticos útiles como inhibidores de proteasa (1), en particular como inhibidores de serina proteasa y más particularmente como inhibidores de la proteasa NS3 de la hepatitis C; a intermedios de los mismos; a su preparación incluyendo nuevos procedimientos estereoselectivos para los intermedios. La invención también se refiere a composiciones farmacéuticas y a procedimientos para usar los compuestos para inhibir la proteasa del HCV o tratar un paciente que padece una infección por HCV o estados fisiológicos relacionados con la infección. Además se proporcionan combinaciones farmacéuticas que comprenden, además de uno o más inhibidores de serina proteasa del HCV, uno o más interferones que presentan actividad frente al HCV y/o uno o más compuestos que tienen actividad frente al HCV y un vehículo farmacéuticamente aceptable, y procedimientos para tratar o prevenir una infección por HCV en un paciente usando las composiciones. La presente invención también se refiere a un kit o envase farmacéutico para tratar o prevenir una infección por HCV en un paciente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22939800P | 2000-08-31 | 2000-08-31 | |
US27764101P | 2001-03-21 | 2001-03-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP077217A true ECSP077217A (es) | 2007-04-26 |
Family
ID=26923261
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2003004493A ECSP034493A (es) | 2000-08-31 | 2003-02-25 | Inhibidores de proteasa peptidomimeticos |
EC2007007217A ECSP077217A (es) | 2000-08-31 | 2007-01-31 | Inhibidores de proteasa peptidomimeticos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2003004493A ECSP034493A (es) | 2000-08-31 | 2003-02-25 | Inhibidores de proteasa peptidomimeticos |
Country Status (37)
Country | Link |
---|---|
US (5) | US7820671B2 (es) |
EP (9) | EP2368878A1 (es) |
JP (4) | JP4689938B2 (es) |
KR (10) | KR20080096718A (es) |
CN (7) | CN1869061B (es) |
AR (1) | AR030591A1 (es) |
AT (2) | ATE483686T1 (es) |
AU (2) | AU2001288318B2 (es) |
BR (1) | BR0113666A (es) |
CA (2) | CA2419607C (es) |
CL (1) | CL2010000330A1 (es) |
CY (2) | CY1109216T1 (es) |
CZ (1) | CZ2003595A3 (es) |
DE (4) | DE60138717D1 (es) |
DK (2) | DK1878720T3 (es) |
DZ (1) | DZ3438A1 (es) |
EA (2) | EA011547B1 (es) |
EC (2) | ECSP034493A (es) |
ES (4) | ES2325481T3 (es) |
HK (3) | HK1163061A1 (es) |
HR (1) | HRP20030139B8 (es) |
HU (1) | HUP0300855A3 (es) |
IL (6) | IL154671A0 (es) |
LU (1) | LU91960I2 (es) |
MX (1) | MXPA03001780A (es) |
NO (4) | NO329929B1 (es) |
NZ (2) | NZ541302A (es) |
PE (1) | PE20020474A1 (es) |
PL (1) | PL211019B1 (es) |
PT (1) | PT1320540E (es) |
SI (1) | SI1320540T1 (es) |
SK (1) | SK2492003A3 (es) |
SV (1) | SV2003000617A (es) |
TW (6) | TW201022244A (es) |
UA (2) | UA81600C2 (es) |
WO (1) | WO2002018369A2 (es) |
ZA (1) | ZA200301641B (es) |
Families Citing this family (237)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA979327B (en) * | 1996-10-18 | 1998-05-11 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease. |
US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
ATE297946T1 (de) * | 2000-04-03 | 2005-07-15 | Vertex Pharma | Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
CA2410579C (en) | 2000-05-26 | 2010-04-20 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses |
US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
DK1385870T3 (da) | 2000-07-21 | 2010-07-05 | Schering Corp | Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus |
BR0112666A (pt) | 2000-07-21 | 2003-06-10 | Schering Corp | Peptìdeos como inibidores de ns3-serina protease de vìrus da hepatite c |
SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
GB2368339B (en) | 2000-10-26 | 2002-09-18 | Yissum Res Dev Co | Complex incorporating a plurality of antioxidants |
AU2002348414B2 (en) * | 2001-10-24 | 2009-10-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine protease, particularly hepatitis C virus NS3-NS4A protease, incorporating a fused ring system |
US7119072B2 (en) | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
US7091184B2 (en) | 2002-02-01 | 2006-08-15 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor tri-peptides |
US6642204B2 (en) | 2002-02-01 | 2003-11-04 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor tri-peptides |
EP2468744A2 (en) * | 2002-04-11 | 2012-06-27 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
AU2003299519A1 (en) * | 2002-05-20 | 2004-05-04 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
ES2469569T3 (es) | 2002-06-28 | 2014-06-18 | Idenix Pharmaceuticals, Inc. | Prof�rmacos de nucle�sidos modificados en 2' y 3' para el tratamiento de infecciones de Flaviviridae |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
AU2003277891A1 (en) * | 2002-09-23 | 2004-04-08 | Medivir Ab | Hcv ns-3 serine protease inhibitors |
US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
AU2011203054B2 (en) * | 2003-04-11 | 2012-04-26 | Vertex Pharmaceuticals, Incorporated | Inhibitors of Serine Proteases, Particularly HCV NS3-NS4A Protease |
EP2332935A1 (en) * | 2003-04-11 | 2011-06-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
EP1613620A1 (en) * | 2003-04-11 | 2006-01-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
BRPI0410456B8 (pt) | 2003-05-21 | 2021-05-25 | Boehringer Ingelheim Int | compostos inibidores de hepatite c, composição farmacêutica, uso dos mesmos, bem como artigo de fabricação |
RU2358979C2 (ru) | 2003-05-30 | 2009-06-20 | Фармассет, Инк. | Модифицированные фторированные аналоги нуклеозида |
EP2368900A3 (en) | 2003-07-18 | 2012-07-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
TWI359147B (en) * | 2003-09-05 | 2012-03-01 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv n |
TW200518669A (en) * | 2003-09-12 | 2005-06-16 | Vertex Pharma | Animal model for protease activity and liver damage |
AU2004274468B2 (en) | 2003-09-18 | 2009-07-23 | Vertex Pharmaceuticals, Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
CN1906208B (zh) * | 2003-10-10 | 2011-03-30 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 |
AU2004282148A1 (en) | 2003-10-10 | 2005-04-28 | Vertex Pharmaceuticals Incoporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
US20060003942A1 (en) * | 2003-10-27 | 2006-01-05 | Roger Tung | Combinations for HCV treatment |
EP1944042A1 (en) | 2003-10-27 | 2008-07-16 | Vertex Pharmceuticals Incorporated | Combinations for HCV treatment |
AU2004285019B9 (en) | 2003-10-27 | 2011-11-24 | Vertex Pharmaceuticals Incorporated | HCV NS3-NS4A protease resistance mutants |
WO2005043118A2 (en) | 2003-10-27 | 2005-05-12 | Vertex Pharmaceuticals Incorporated | Drug discovery method |
CN100509784C (zh) * | 2003-12-11 | 2009-07-08 | 先灵公司 | 丙型肝炎病毒ns3/ns4a丝氨酸蛋白酶的抑制剂 |
CA2549851C (en) | 2004-01-21 | 2012-09-11 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis c virus |
CA2554999A1 (en) * | 2004-02-04 | 2005-08-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
RS51394B (en) * | 2004-02-27 | 2011-02-28 | Schering Corporation | SUMPOR COMPOUNDS AS INHIBITORS OF NS3 SERINE PROTEASE HEPATITIS C VIRUS |
KR20060124725A (ko) | 2004-02-27 | 2006-12-05 | 쉐링 코포레이션 | C형 간염 바이러스 ns3 프로테아제의 억제제 |
EP1737821B1 (en) * | 2004-02-27 | 2009-08-05 | Schering Corporation | 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease |
US7173057B2 (en) * | 2004-02-27 | 2007-02-06 | Schering Corporation | Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus |
EP1765283A4 (en) * | 2004-06-08 | 2012-11-28 | Vertex Pharma | PHARMACEUTICAL COMPOSITIONS |
CA2573346C (en) | 2004-07-20 | 2011-09-20 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor peptide analogs |
UY29016A1 (es) | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
AU2005291918A1 (en) * | 2004-10-01 | 2006-04-13 | Vertex Pharmaceuticals Incorporated | HCV NS3-NS4A protease inhibition |
TW201424733A (zh) | 2004-10-29 | 2014-07-01 | Vertex Pharma | 劑量型式 |
NZ561681A (en) | 2005-03-21 | 2011-01-28 | Virobay Inc | Alpha ketoamide compounds as cysteine protease inhibitors |
US20070015803A1 (en) * | 2005-04-12 | 2007-01-18 | Romark Laboratories L.C. | Methods for treating diseases through interruption of protein maturation, compounds that inhibit the function of molecular chaperones such as protein disulfide isomerases or interfere with glycosylation, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
AP2007004245A0 (en) | 2005-05-13 | 2007-12-31 | Virochem Pharma Inc | Compounds and methods for the treatment or prevention of flavivirus infections |
US20060276404A1 (en) * | 2005-06-02 | 2006-12-07 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
WO2006130553A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Hcv protease inhibitors |
AU2006252519B2 (en) | 2005-06-02 | 2012-08-30 | Merck Sharp & Dohme Corp. | HCV protease inhibitors in combination with food |
NZ563365A (en) | 2005-06-02 | 2011-02-25 | Schering Corp | Combination of HCV protease inhibitors with a surfactant |
US7608592B2 (en) | 2005-06-30 | 2009-10-27 | Virobay, Inc. | HCV inhibitors |
PE20070210A1 (es) | 2005-07-29 | 2007-04-16 | Tibotec Pharm Ltd | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
PL1912997T3 (pl) | 2005-07-29 | 2012-02-29 | Tibotec Pharm Ltd | Makrocykliczne inhibitory wirusa zapalenia wątroby typu C |
MY139988A (en) | 2005-07-29 | 2009-11-30 | Tibotec Pharm Ltd | Macrocylic inhibitors of hepatitis c virus |
CN101273027B (zh) | 2005-07-29 | 2015-12-02 | 爱尔兰詹森科学公司 | 丙型肝炎病毒的大环抑制剂 |
JO2768B1 (en) | 2005-07-29 | 2014-03-15 | تيبوتيك فارماسيوتيكالز ليمتد | Large cyclic inhibitors of hepatitis C virus |
EP1919899B1 (en) | 2005-07-29 | 2011-01-19 | Tibotec Pharmaceuticals | Macrocyclic inhibitors of hepatitis c virus |
PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
WO2007014924A1 (en) | 2005-07-29 | 2007-02-08 | Tibotec Pharmaceuticals Ltd. | Macrocyclic inhibitors of hepatitis c virus |
ES2401661T3 (es) * | 2005-08-02 | 2013-04-23 | Vertex Pharmaceuticals Incorporated | Inhibidores de serina proteasas |
US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
KR20130038947A (ko) | 2005-08-19 | 2013-04-18 | 버텍스 파마슈티칼스 인코포레이티드 | 방법 및 중간체 |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
EP2392590A3 (en) | 2005-11-11 | 2012-03-14 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
JP3975226B2 (ja) * | 2006-01-11 | 2007-09-12 | 生化学工業株式会社 | シクロアルキルカルボニルアミノ酸誘導体及びその製造方法 |
AU2007205578B2 (en) * | 2006-01-11 | 2012-06-28 | Seikagaku Corporation | Cycloalkylcarbonylamino acid ester derivative and process for producing the same |
JP4047365B2 (ja) * | 2006-01-11 | 2008-02-13 | 生化学工業株式会社 | シクロアルカンカルボキサミド誘導体及びその製造方法 |
JP5260062B2 (ja) * | 2006-01-20 | 2013-08-14 | 株式会社カネカ | β−アミノ−α−ヒドロキシ酸アミド誘導体の製造法 |
CA2643688A1 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
MX2008011429A (es) | 2006-03-06 | 2008-09-18 | Abbott Lab | Composiciones y metodos de uso de ritonavir para tratar hcv. |
KR20080112303A (ko) * | 2006-03-16 | 2008-12-24 | 버텍스 파마슈티칼스 인코포레이티드 | 중수소화 c형 간염 프로테아제 억제제 |
EP1993993A1 (en) | 2006-03-16 | 2008-11-26 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for preparing steric compounds |
WO2007109605A2 (en) | 2006-03-20 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
CA2647158C (en) * | 2006-03-23 | 2012-07-31 | Schering Corporation | Combinations of hcv protease inhibitor(s) and cyp3a4 inhibitor(s), and methods of treatment related thereto |
WO2007120595A2 (en) * | 2006-04-11 | 2007-10-25 | Novartis Ag | Amines for the treatment of hcv |
BRPI0710878A2 (pt) | 2006-04-11 | 2015-03-31 | Novartis Ag | Compostos orgânicos e seus usos |
RU2419626C2 (ru) | 2006-05-23 | 2011-05-27 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы |
DE102006059317A1 (de) | 2006-07-04 | 2008-01-10 | Evonik Degussa Gmbh | Verfahren zur Herstellung von β-Amino-α-hydroxy-carbonsäureamiden |
EP1886685A1 (en) | 2006-08-11 | 2008-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition |
US20120220520A1 (en) * | 2006-10-17 | 2012-08-30 | Van T Klooster Gerben Albert Eleutherius | Bioavailable combinations for hcv treatment |
EA201101492A1 (ru) | 2006-11-15 | 2012-09-28 | Вирокем Фарма Инк. | Аналоги тиофена для лечения или предупреждения флавивирусных инфекций |
JP2010510192A (ja) | 2006-11-17 | 2010-04-02 | テイボテク・フアーマシユーチカルズ・リミテツド | C型肝炎ウイルスの大環状阻害剤 |
CA2673111A1 (en) | 2006-12-07 | 2008-06-19 | Schering Corporation | Ph sensitive matrix formulation |
WO2008074035A1 (en) * | 2006-12-27 | 2008-06-19 | Abbott Laboratories | Hcv protease inhibitors and uses thereof |
WO2008095058A1 (en) * | 2007-02-01 | 2008-08-07 | Taigen Biotechnology Co. Ltd. | Hcv protease inhibitors |
CN105254637A (zh) | 2007-02-08 | 2016-01-20 | 爱尔兰詹森科学公司 | 嘧啶取代的大环抑制剂 |
EA016327B1 (ru) | 2007-02-09 | 2012-04-30 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы |
CA2679426A1 (en) | 2007-02-27 | 2008-09-04 | Luc Farmer | Inhibitors of serine proteases |
KR20090115970A (ko) * | 2007-02-27 | 2009-11-10 | 버텍스 파마슈티칼스 인코포레이티드 | 공-결정 및 그를 포함하는 제약 조성물 |
WO2008127613A1 (en) * | 2007-04-11 | 2008-10-23 | Scynexis, Inc. | New pharmaceutical compositions |
EP2494991A1 (en) | 2007-05-04 | 2012-09-05 | Vertex Pharmaceuticals Incorporated | Combination therapy for the treatment of HCV infection |
US20100254942A1 (en) * | 2007-08-03 | 2010-10-07 | Biotron Limited | Hepatitis c antiviral compositions and methods |
JP5443360B2 (ja) | 2007-08-30 | 2014-03-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | 共結晶体およびそれを含む医薬組成物 |
CA2699280A1 (en) | 2007-09-14 | 2009-03-26 | Schering Corporation | Method of treating hepatitis c patients |
US20090082366A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched telaprevir |
MX2010003916A (es) | 2007-10-10 | 2010-05-05 | Novartis Ag | Espiro-pirrolidinas y su uso contra infeccion por el virus de hepatitis c (hcv) y por el virus de inmunodeficiencia humana (vih). |
EP2215076A4 (en) | 2007-10-24 | 2012-05-02 | Virobay Inc | COMPOUNDS CAPABLE OF INHIBITING CATHEPSIN S PROTEASE AND HCV REPLICATION |
US20090111757A1 (en) * | 2007-10-25 | 2009-04-30 | Taigen Biotechnology Co., Ltd. | Hcv protease inhibitors |
BRPI0821836A2 (pt) | 2007-12-24 | 2015-06-16 | Tibotec Pharm Ltd | Indóis macrocíclicos como inibidores do vírus da hepatite c |
DE102008009761A1 (de) | 2008-02-19 | 2009-08-27 | Bayer Materialscience Ag | Verfahren zur Herstellung von Isocyanaten |
EP2101173A1 (en) | 2008-03-14 | 2009-09-16 | Vivalis | In vitro method to determine whether a drug candidate active against a target protein is active against a variant of said protein |
CN101580535B (zh) * | 2008-05-16 | 2012-10-03 | 太景生物科技股份有限公司 | 丙型肝炎病毒蛋白酶抑制剂 |
ES2438576T3 (es) | 2008-06-24 | 2014-01-17 | Codexis, Inc. | Procesos biocatalíticos para la preparación de compuestos de prolina bicíclica fusionada considerablemente pura estereoméricamente |
US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
WO2010014744A1 (en) * | 2008-07-29 | 2010-02-04 | The Scripps Research Institute | Inhibitors of hepatitis c virus infection |
US8188137B2 (en) | 2008-08-15 | 2012-05-29 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
KR20110098779A (ko) | 2008-12-03 | 2011-09-01 | 프레시디오 파마슈티칼스, 인코포레이티드 | Hcv ns5a의 억제제 |
EP2373172B1 (en) | 2008-12-03 | 2013-07-17 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
GB0900914D0 (en) | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
WO2010093843A2 (en) | 2009-02-12 | 2010-08-19 | Vertex Pharmaceuticals Incorporated | Hcv combination therapies |
BRPI1012282A2 (pt) | 2009-03-27 | 2015-09-22 | Presidio Pharmaceuticals Inc | inibidores de anel fundidos da hepatite c. |
US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
AR077138A1 (es) | 2009-06-23 | 2011-08-03 | Gilead Sciences Inc | Composiciones farmaceuticas utiles para tratar el vhc |
JP5702388B2 (ja) | 2009-09-15 | 2015-04-15 | タイゲン バイオテクノロジー カンパニー,リミテッド | Hcvプロテアーゼ阻害剤 |
TWI404269B (zh) * | 2009-09-18 | 2013-08-01 | Advanced Connectek Inc | High speed plug connector |
UA108211C2 (uk) | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
AU2010326225A1 (en) | 2009-11-25 | 2012-06-07 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
CA2784748A1 (en) * | 2009-12-18 | 2011-06-23 | Idenix Pharmaceuticals, Inc. | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
MX2012007420A (es) | 2009-12-24 | 2012-07-23 | Vertex Pharma | Analogos para el tratamiento o prevencion de infecciones de flavivirus. |
US20110178107A1 (en) * | 2010-01-20 | 2011-07-21 | Taigen Biotechnology Co., Ltd. | Hcv protease inhibitors |
AU2011209051B2 (en) | 2010-01-27 | 2015-01-15 | AB Pharma Ltd. | Polyheterocyclic compounds highly potent as HCV inhibitors |
RU2012136824A (ru) | 2010-01-29 | 2014-03-10 | Вертекс Фармасьютикалз Инкорпорейтед | Способы лечения вирусной инфекции гепатита с |
WO2011112516A1 (en) | 2010-03-08 | 2011-09-15 | Ico Therapeutics Inc. | Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides |
JP2013522377A (ja) | 2010-03-24 | 2013-06-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染を処置または予防するためのアナログ |
EP2550262A1 (en) | 2010-03-24 | 2013-01-30 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
EP2550267A1 (en) | 2010-03-24 | 2013-01-30 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
TW201141857A (en) | 2010-03-24 | 2011-12-01 | Vertex Pharma | Analogues for the treatment or prevention of flavivirus infections |
TWI515000B (zh) | 2010-04-01 | 2016-01-01 | 伊迪尼克製藥公司 | 用於治療病毒感染之化合物及醫藥組合物 |
EP2575866A4 (en) | 2010-05-24 | 2013-10-16 | Presidio Pharmaceuticals Inc | HCV NS5A INHIBITORS |
AU2011261349A1 (en) | 2010-06-03 | 2012-12-06 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
WO2011156545A1 (en) | 2010-06-09 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Viral dynamic model for hcv combination therapy |
EP2582717A2 (en) | 2010-06-15 | 2013-04-24 | Vertex Pharmaceuticals Incorporated | Hcv ns5b polymerase mutants |
AU2011276526A1 (en) | 2010-06-28 | 2013-01-10 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
WO2012006070A1 (en) | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
WO2012006060A1 (en) | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
TW201208704A (en) | 2010-07-14 | 2012-03-01 | Vertex Pharma | Palatable pharmaceutical composition |
AR082619A1 (es) | 2010-08-13 | 2012-12-19 | Hoffmann La Roche | Inhibidores del virus de la hepatitis c |
EP2606041A2 (en) | 2010-08-17 | 2013-06-26 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flaviviridae viral infections |
AU2011305655B2 (en) | 2010-09-22 | 2015-11-05 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
BR112013008510A2 (pt) | 2010-10-08 | 2016-07-05 | Novartis Ag | vitamina e formulações de inibidores de sulfamida ns3 |
US20140308242A1 (en) | 2010-10-21 | 2014-10-16 | Vertex Pharmaceuticals Incorporated | Biomarkers for hcv infected patients |
BR112013009789A2 (pt) | 2010-10-26 | 2016-07-19 | Presidio Pharmaceuticals Inc | inibidores do vírus da hepatite c |
WO2012109646A1 (en) | 2011-02-11 | 2012-08-16 | Vertex Pharmaceuticals Incorporated | Treatment of hcv in hiv infection patients |
WO2012107589A1 (en) | 2011-02-11 | 2012-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of hcv infections |
WO2012123298A1 (en) | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Antiviral compounds |
JP2014514295A (ja) | 2011-03-31 | 2014-06-19 | アイディニックス ファーマシューティカルズ インコーポレイテッド | ウイルス感染の治療のための化合物および薬学的組成物 |
WO2012151319A1 (en) | 2011-05-02 | 2012-11-08 | Virobay, Inc. | Cathepsin inhibitors for the treatment of bone cancer and bone cancer pain |
EP2707347A1 (en) | 2011-05-13 | 2014-03-19 | Vertex Pharmaceuticals Inc. | Processes and intermediates |
WO2012171332A1 (zh) | 2011-06-16 | 2012-12-20 | 爱博新药研发(上海)有限公司 | 抑制丙型肝炎病毒的大环状杂环化合物及其制备和应用 |
CN103732242A (zh) | 2011-06-23 | 2014-04-16 | 迪格纳生物技术公司 | 用与IFN-α2b组合的IFN-α5在患者群体中治疗慢性丙型肝炎 |
US20120328565A1 (en) | 2011-06-24 | 2012-12-27 | Brinkman John A | Antiviral compounds |
WO2013016499A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Methods for preparation of thiophene compounds |
AR087345A1 (es) | 2011-07-26 | 2014-03-19 | Vertex Pharma | Metodos para la preparacion de compuestos de tiofeno |
CA2847892A1 (en) | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
WO2013049382A2 (en) | 2011-09-27 | 2013-04-04 | Kansas State University Research Foundation | Broad-spectrum antivirals against 3c or 3c-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses |
MX2014003705A (es) | 2011-10-10 | 2014-07-22 | Hoffmann La Roche | Compuestos antivirales. |
US9079929B2 (en) | 2011-10-14 | 2015-07-14 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors |
ES2572908T3 (es) | 2011-10-14 | 2016-06-03 | Bristol-Myers Squibb Company | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIa |
HUE034857T2 (en) | 2011-10-14 | 2018-03-28 | Bristol Myers Squibb Co | Substituted tetrahydroisoquinoline compounds are inhibitors of factor XIA |
BR112014005617A2 (pt) | 2011-10-21 | 2017-06-13 | Abbvie Inc | tratamento de combinação (por exemplo, com abt-072 ou abt -333) de daas para uso no tratamento de hcv |
US8466159B2 (en) * | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
ES2572329B1 (es) | 2011-10-21 | 2017-08-24 | Abbvie Inc. | Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para uso en el tratamientodel vhc |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
JP5923181B2 (ja) | 2011-12-16 | 2016-05-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Hcvns5aの阻害剤 |
SI2794629T1 (sl) | 2011-12-20 | 2017-10-30 | Riboscience Llc | 2'4'-difluoro-2'-metil substituirani nukleozidni derivati k0t zaviralci replikacije hcv-rna |
AU2012357986B2 (en) | 2011-12-20 | 2017-02-02 | Riboscience Llc | 4'-Azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication |
AU2012360905B2 (en) | 2011-12-28 | 2017-04-27 | Janssen Sciences Ireland Uc | Hetero-bicyclic derivatives as HCV inhibitors |
WO2013116339A1 (en) | 2012-01-31 | 2013-08-08 | Vertex Pharmaceuticals Incorporated | High potency formulations of vx-950 |
ITMI20120192A1 (it) | 2012-02-13 | 2013-08-14 | Dipharma Francis Srl | Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi |
US8999922B2 (en) * | 2012-02-16 | 2015-04-07 | Rqx Pharmaceuticals, Inc. | Linear peptide antibiotics |
CN104185624B (zh) | 2012-02-24 | 2016-10-12 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒化合物 |
ITMI20120359A1 (it) | 2012-03-07 | 2013-09-08 | Dipharma Francis Srl | Procedimento per la preparazione di intermedi utili nella preparazione di un inibitore delle proteasi virali |
ITMI20120391A1 (it) * | 2012-03-13 | 2013-09-14 | Dipharma Francis Srl | Procedimento per la sintesi di un intermedio ciclopropilammidico utile nella preparazione di un inibitore delle proteasi virali |
WO2013136265A1 (en) | 2012-03-13 | 2013-09-19 | Dipharma Francis S.R.L. | Synthesis of an intermediate of an antiviral compound |
WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
EP2844249A4 (en) | 2012-05-02 | 2016-03-09 | Univ Kansas State | MACROCYCLIC AND PEPTIDOMIMETIC COMPOUNDS AS VIRUZIDES AGAINST 3C OR 3C LIKE PROTEASES OF PICORNIVERS, CALICIVIRES AND CORONA VIRUSES |
ITMI20120800A1 (it) * | 2012-05-10 | 2013-11-11 | Dipharma Francis Srl | Procedimento per la preparazione di un intermedio utile nella preparazione di un inibitore delle proteasi virali |
CN103450066B (zh) * | 2012-05-30 | 2017-03-15 | 博瑞生物医药(苏州)股份有限公司 | 特拉匹韦中间体的制备方法 |
WO2013178682A2 (en) | 2012-05-30 | 2013-12-05 | Chemo Ibérica, S.A. | Multicomponent process for the preparation of bicyclic compounds |
US20140010783A1 (en) | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
WO2014015217A1 (en) | 2012-07-19 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Biomarkers for hcv infected patients |
WO2014033667A1 (en) | 2012-08-30 | 2014-03-06 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir |
WO2014045263A2 (en) * | 2012-09-24 | 2014-03-27 | Dr. Reddy's Laboratories Limited | Process for preparation of intermediates of telaprevir |
EP2906541B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
EP2906551B1 (en) | 2012-10-12 | 2018-02-28 | Bristol-Myers Squibb Company | Crystalline forms of a factor xia inhibitor |
WO2014059202A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
WO2014068265A1 (en) | 2012-10-29 | 2014-05-08 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
ITMI20122036A1 (it) | 2012-11-29 | 2014-05-30 | Dipharma Francis Srl | Sintesi di un intermedio di un composto antivirale |
WO2014096374A1 (en) | 2012-12-21 | 2014-06-26 | Sandoz Ag | Process for the synthesis of pyrrolidines and pyrroles |
CN105073726B (zh) | 2013-01-23 | 2017-05-31 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒三唑衍生物 |
CN103113288B (zh) * | 2013-02-04 | 2015-05-20 | 苏州永健生物医药有限公司 | 一种八氢环戊烯并[c]吡咯羧酸衍生物的合成方法 |
WO2014134251A1 (en) | 2013-02-28 | 2014-09-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
WO2014135422A1 (en) | 2013-03-05 | 2014-09-12 | F. Hoffmann-La Roche Ag | Antiviral compounds |
JP6479763B2 (ja) | 2013-03-25 | 2019-03-06 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 第xia因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン |
ITMI20130706A1 (it) | 2013-04-30 | 2014-10-31 | Dipharma Francis Srl | Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi |
US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
SG11201509427RA (en) | 2013-05-16 | 2015-12-30 | Riboscience Llc | 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives |
BR112015028764B1 (pt) | 2013-05-16 | 2022-09-27 | Riboscience Llc | Derivados de nucleosídeo de 4-fluoro-2-metil substituídos como inibidores de replicação de rna do hcv |
CN104163851B (zh) * | 2013-05-20 | 2019-03-05 | 湘北威尔曼制药股份有限公司 | 氟代的α-羰基类HCV NS3/4A丝氨酸蛋白酶抑制剂 |
CN103288671B (zh) * | 2013-06-20 | 2014-10-29 | 上海步越化工科技有限公司 | 一种(3s)-3-氨基-n-环丙基-2-羟基己酰胺盐酸盐的合成方法 |
WO2014203224A1 (en) | 2013-06-21 | 2014-12-24 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir and its intermediates |
WO2014203208A1 (en) | 2013-06-21 | 2014-12-24 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir and intermediates thereof |
CN104292146B (zh) * | 2013-06-24 | 2017-04-26 | 上海医药工业研究院 | 特拉匹韦中间体及其制备方法 |
CN104558106B (zh) * | 2013-10-19 | 2019-12-10 | 广东东阳光药业有限公司 | 一种治疗丙肝药物的制备方法 |
CN104610272B (zh) * | 2013-11-05 | 2017-03-29 | 上海唐润医药科技有限公司 | 环状黄酮或异黄酮类化合物及其用途 |
EP2899207A1 (en) | 2014-01-28 | 2015-07-29 | Amikana.Biologics | New method for testing HCV protease inhibition |
CN106132962B (zh) | 2014-01-31 | 2018-09-07 | 百时美施贵宝公司 | 作为凝血因子xia抑制剂的具有芳族p2’基团的大环化合物 |
NO2760821T3 (es) | 2014-01-31 | 2018-03-10 | ||
CN104926712B (zh) * | 2014-03-20 | 2018-03-23 | 上海医药工业研究院 | 合成特拉匹韦的中间体及其制备方法 |
CN104926831A (zh) * | 2014-03-20 | 2015-09-23 | 上海医药工业研究院 | 合成特拉匹韦的中间体及其制备方法 |
US10240427B2 (en) | 2014-07-07 | 2019-03-26 | Halliburton Energy Services, Inc. | Downhole tools comprising aqueous-degradable sealing elements |
ES2714283T3 (es) | 2014-09-04 | 2019-05-28 | Bristol Myers Squibb Co | Macrociclos de diamida que son inhibidores de FXIa |
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
WO2017148964A1 (en) | 2016-03-04 | 2017-09-08 | F. Hoffmann-La Roche Ag | New trifluoromethylpropanamide derivatives as htra1 inhibitors |
JP2019507176A (ja) | 2016-03-04 | 2019-03-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Htra1阻害剤としての新規ジフルオロケタミド誘導体 |
WO2017189978A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
EP3472151A4 (en) | 2016-06-21 | 2020-03-04 | Orion Ophthalmology LLC | CARBOCYCLIC PROLINAMIDE DERIVATIVES |
EP3472130B1 (en) | 2016-06-21 | 2022-02-16 | Orion Ophthalmology LLC | Aliphatic prolinamide derivatives |
KR102595723B1 (ko) | 2016-06-21 | 2023-10-27 | 오리온 옵탈몰로지 엘엘씨 | 헤테로시클릭 프롤린아미드 유도체 |
WO2018036942A1 (en) * | 2016-08-23 | 2018-03-01 | F. Hoffmann-La Roche Ag | New difluoroketamide derivatives as htra1 inhibitors |
SG11202002431SA (en) | 2017-09-21 | 2020-04-29 | Riboscience Llc | 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication |
CN109337537B (zh) * | 2018-09-26 | 2022-10-25 | 河北晨阳工贸集团有限公司 | 一种起重机专用单组分水性面漆及其制备方法 |
CN110668538B (zh) * | 2019-09-20 | 2021-10-22 | 济南大学 | 一种聚合氯化钛的制备方法 |
CN114057702B (zh) * | 2020-07-31 | 2022-09-30 | 四川大学 | 一种新型冠状病毒主蛋白酶的抑制剂及其制备方法和用途 |
CN115960088A (zh) * | 2020-07-31 | 2023-04-14 | 四川大学 | 一种新型冠状病毒主蛋白酶的抑制剂及其制备方法和用途 |
WO2023149981A1 (en) * | 2022-02-07 | 2023-08-10 | Purdue Research Foundation | Compounds for the treatment of sars |
CN114703003B (zh) * | 2022-04-14 | 2023-04-28 | 上海绿晟环保科技有限公司 | 一种负载碳量子点的纳米材料润滑添加剂及其制备方法 |
CN115417790A (zh) * | 2022-10-09 | 2022-12-02 | 山东大学 | 一类新型偶氮类发泡剂及合成方法 |
Family Cites Families (163)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3719667A (en) | 1970-08-24 | 1973-03-06 | Lilly Co Eli | Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters |
US3840556A (en) | 1971-05-28 | 1974-10-08 | Lilly Co Eli | Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby |
DE3226768A1 (de) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
DE3211676A1 (de) | 1982-03-30 | 1983-10-06 | Hoechst Ag | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
FR2570695A1 (fr) * | 1984-09-27 | 1986-03-28 | Synthelabo | Diphenylazomethines a chaine ramifiee ou cyclique, leur preparation et leur application en therapeutique |
FR2575753B1 (fr) | 1985-01-07 | 1987-02-20 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5496927A (en) | 1985-02-04 | 1996-03-05 | Merrell Pharmaceuticals Inc. | Peptidase inhibitors |
EP0204571B1 (en) * | 1985-06-07 | 1992-01-22 | Ici Americas Inc. | Selected difluoro derivatives |
US4835168A (en) | 1985-12-16 | 1989-05-30 | Eli Lilly And Company | Thiadiazole antiviral agents |
US5231084A (en) | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
US5736520A (en) | 1988-10-07 | 1998-04-07 | Merrell Pharmaceuticals Inc. | Peptidase inhibitors |
NZ235155A (en) | 1989-09-11 | 1993-04-28 | Merrell Dow Pharma | Peptidase substrates in which the carboxy terminal group has been replaced by a tricarbonyl radical |
US5371072A (en) * | 1992-10-16 | 1994-12-06 | Corvas International, Inc. | Asp-Pro-Arg α-keto-amide enzyme inhibitors |
ES2150933T3 (es) | 1992-12-22 | 2000-12-16 | Lilly Co Eli | Inhibidores de la proteasa vih utiles para el tratamiento del sida. |
PT727419E (pt) | 1992-12-29 | 2002-08-30 | Abbott Lab | Compostos intermediarios para a preparacao de inibidores da protease retroviral |
US5384410A (en) | 1993-03-24 | 1995-01-24 | The Du Pont Merck Pharmaceutical Company | Removal of boronic acid protecting groups by transesterification |
US5656600A (en) * | 1993-03-25 | 1997-08-12 | Corvas International, Inc. | α-ketoamide derivatives as inhibitors of thrombosis |
US5672582A (en) | 1993-04-30 | 1997-09-30 | Merck & Co., Inc. | Thrombin inhibitors |
IL110752A (en) | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
US5559158A (en) | 1993-10-01 | 1996-09-24 | Abbott Laboratories | Pharmaceutical composition |
US5468858A (en) | 1993-10-28 | 1995-11-21 | The Board Of Regents Of Oklahoma State University Physical Sciences | N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents |
IL111991A (en) | 1994-01-28 | 2000-07-26 | Abbott Lab | Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent |
IL113196A0 (en) | 1994-03-31 | 1995-06-29 | Bristol Myers Squibb Co | Imidazole derivatives and pharmaceutical compositions containing the same |
US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5847135A (en) | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5861267A (en) | 1995-05-01 | 1999-01-19 | Vertex Pharmaceuticals Incorporated | Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity |
US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
JPH09124691A (ja) * | 1995-08-25 | 1997-05-13 | Green Cross Corp:The | ペプチド化合物およびそれを含有する医薬組成物 |
JP2000500760A (ja) | 1995-11-23 | 2000-01-25 | メルク シヤープ エンド ドーム リミテツド | スピロピペリジン誘導体およびタキキニン拮抗薬としてのその使用 |
US6054472A (en) | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
ZA972195B (en) | 1996-03-15 | 1998-09-14 | Du Pont Merck Pharma | Spirocycle integrin inhibitors |
CZ298463B6 (cs) | 1996-04-23 | 2007-10-10 | Vertex Pharmaceuticals Incorporated | Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují |
US6127422A (en) | 1996-05-06 | 2000-10-03 | Eli Lilly And Company | Anti-viral method |
US5990276A (en) | 1996-05-10 | 1999-11-23 | Schering Corporation | Synthetic inhibitors of hepatitis C virus NS3 protease |
EP0907659A1 (en) | 1996-05-10 | 1999-04-14 | Schering Corporation | Synthetic inhibitors of hepatitis c virus ns3 protease |
EP0898584A4 (en) | 1996-05-17 | 2002-01-02 | Datacard Corp | CURABLE SURFACE COMPOSITION AND METHODS FOR USE |
EP0913389A4 (en) * | 1996-06-28 | 2000-02-02 | Nippon Chemiphar Co | CYCLOPROPYLGLYCINE DERIVATIVES AND AGONISTS OF THE L-GLUTAMATE RECEPTOR TYPE OF METABOLITE REGULATION |
US6245919B1 (en) | 1996-06-28 | 2001-06-12 | Haruhiko Shinozaki | Cyclopropylglycine derivatives and agonists for metabotronic L-glutamate receptors |
US6153579A (en) | 1996-09-12 | 2000-11-28 | Vertex Pharmaceuticals, Incorporated | Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex |
EP0929554B1 (en) | 1996-09-25 | 2006-03-15 | MERCK SHARP & DOHME LTD. | Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists |
ATE250048T1 (de) | 1996-10-08 | 2003-10-15 | Univ Colorado State Res Found | Katalytische asymmetrische epoxidierung |
ZA979327B (en) | 1996-10-18 | 1998-05-11 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease. |
GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
DE19648011A1 (de) | 1996-11-20 | 1998-05-28 | Bayer Ag | Cyclische Imine |
WO1998040381A1 (en) | 1997-03-14 | 1998-09-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
GB9707659D0 (en) | 1997-04-16 | 1997-06-04 | Peptide Therapeutics Ltd | Hepatitis C NS3 Protease inhibitors |
GB9708484D0 (en) | 1997-04-25 | 1997-06-18 | Merck Sharp & Dohme | Therapeutic agents |
GB9711114D0 (en) | 1997-05-29 | 1997-07-23 | Merck Sharp & Dohme | Therapeutic agents |
CA2294562C (en) | 1997-08-11 | 2005-07-26 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor peptide analogues |
US6767991B1 (en) | 1997-08-11 | 2004-07-27 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C inhibitor peptides |
ATE291032T1 (de) | 1997-08-11 | 2005-04-15 | Boehringer Ingelheim Ca Ltd | Hepatitis c inhibitor peptide |
US6183121B1 (en) | 1997-08-14 | 2001-02-06 | Vertex Pharmaceuticals Inc. | Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets |
US20040058982A1 (en) | 1999-02-17 | 2004-03-25 | Bioavailability System, Llc | Pharmaceutical compositions |
US20020017295A1 (en) | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
WO1999028482A2 (en) | 1997-11-28 | 1999-06-10 | Schering Corporation | Single-chain recombinant complexes of hepatitis c virus ns3 protease and ns4a cofactor peptide |
AU3376699A (en) | 1998-03-31 | 1999-10-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
US6518305B1 (en) * | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
US6251583B1 (en) | 1998-04-27 | 2001-06-26 | Schering Corporation | Peptide substrates for HCV NS3 protease assays |
GB9812523D0 (en) | 1998-06-10 | 1998-08-05 | Angeletti P Ist Richerche Bio | Peptide inhibitors of hepatitis c virus ns3 protease |
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
AR022061A1 (es) * | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
DE19836514A1 (de) | 1998-08-12 | 2000-02-17 | Univ Stuttgart | Modifikation von Engineeringpolymeren mit N-basischen Gruppe und mit Ionenaustauschergruppen in der Seitenkette |
US6117639A (en) | 1998-08-31 | 2000-09-12 | Vertex Pharmaceuticals Incorporated | Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity |
US6025516A (en) | 1998-10-14 | 2000-02-15 | Chiragene, Inc. | Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes |
DE60039377D1 (de) | 1999-02-09 | 2008-08-21 | Pfizer Prod Inc | Zusammensetzungen basischer Arzneistoffe mit verbesserter Bioverfügbarkeit |
US20020042046A1 (en) | 1999-02-25 | 2002-04-11 | Vertex Pharmaceuticals, Incorporated | Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex |
EE200100492A (et) | 1999-03-19 | 2002-12-16 | Vertex Pharmaceuticals Incorporated | Ensüümi IMPDH inhibiitorid |
US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
US7122627B2 (en) | 1999-07-26 | 2006-10-17 | Bristol-Myers Squibb Company | Lactam inhibitors of Hepatitis C virus NS3 protease |
US20020183249A1 (en) | 1999-08-31 | 2002-12-05 | Taylor Neil R. | Method of identifying inhibitors of CDC25 |
US6774212B2 (en) | 1999-12-03 | 2004-08-10 | Bristol-Myers Squibb Pharma Company | Alpha-ketoamide inhibitors of hepatitis C virus NS3 protease |
US6365380B2 (en) * | 2000-02-23 | 2002-04-02 | Pcbu Services, Inc. | Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst |
AU2001245356A1 (en) | 2000-02-29 | 2001-09-12 | Bristol-Myers Squibb Pharma Company | Inhibitors of hepatitis c virus ns3 protease |
ATE297946T1 (de) | 2000-04-03 | 2005-07-15 | Vertex Pharma | Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease |
IL151934A0 (en) | 2000-04-05 | 2003-04-10 | Schering Corp | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising n-cyclic p2 moieties |
NZ521456A (en) | 2000-04-19 | 2004-07-30 | Schering Corp | Macrocyclic NS3-Serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties |
EP2289887A3 (en) | 2000-06-30 | 2011-07-06 | Seikagaku Corporation | Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them |
US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
DK1385870T3 (da) | 2000-07-21 | 2010-07-05 | Schering Corp | Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus |
WO2002008251A2 (en) | 2000-07-21 | 2002-01-31 | Corvas International, Inc. | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
AR034127A1 (es) | 2000-07-21 | 2004-02-04 | Schering Corp | Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento |
BR0112666A (pt) | 2000-07-21 | 2003-06-10 | Schering Corp | Peptìdeos como inibidores de ns3-serina protease de vìrus da hepatite c |
AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
US6939692B2 (en) | 2000-09-12 | 2005-09-06 | Degussa Ag | Nucleotide sequences coding for the pknB gene |
US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
DE60119968T2 (de) | 2000-11-20 | 2007-01-18 | Bristol-Myers Squibb Co. | Hepatitis c tripeptid inhibitoren |
IL155842A0 (en) | 2000-12-12 | 2003-12-23 | Schering Corp | Diaryl peptides as ns3-serine protease inhibitors of hepatitis c virus |
US6653295B2 (en) | 2000-12-13 | 2003-11-25 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus NS3 protease |
AU2002230764A1 (en) | 2000-12-13 | 2002-06-24 | Bristol-Myers Squibb Pharma Company | Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors |
HUP0400726A3 (en) | 2001-01-22 | 2007-05-29 | Merck & Co Inc | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
GB0102342D0 (en) | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
WO2002061149A2 (en) | 2001-01-30 | 2002-08-08 | Vertex Pharmaceuticals Incorporated | A quantitative assay for nucleic acids |
EP1381673B1 (en) | 2001-03-27 | 2009-05-13 | Vertex Pharmaceuticals Incorporated | Compositions and methods useful for hcv infection |
GB0107924D0 (en) | 2001-03-29 | 2001-05-23 | Angeletti P Ist Richerche Bio | Inhibitor of hepatitis C virus NS3 protease |
US7034178B2 (en) | 2001-07-03 | 2006-04-25 | Altana Pharma Ag | Process for the production of 3-phenylisoserine |
KR100926244B1 (ko) | 2001-07-11 | 2009-11-12 | 버텍스 파마슈티칼스 인코포레이티드 | 브릿지된 바이사이클릭 세린 프로테아제 억제제 |
US7029561B2 (en) | 2001-07-25 | 2006-04-18 | The United States Of America As Represented By The Secretary Of Commerce | Fluidic temperature gradient focusing |
JP2003055389A (ja) | 2001-08-09 | 2003-02-26 | Univ Tokyo | 錯体及びそれを用いたエポキシドの製法 |
US6824769B2 (en) | 2001-08-28 | 2004-11-30 | Vertex Pharmaceuticals Incorporated | Optimal compositions and methods thereof for treating HCV infections |
AU2002348414B2 (en) | 2001-10-24 | 2009-10-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine protease, particularly hepatitis C virus NS3-NS4A protease, incorporating a fused ring system |
EP1458693A4 (en) | 2001-11-14 | 2005-02-09 | Teva Pharma | Amorphous and crystalline forms of losartan potassium and method for making same |
CA2369711A1 (en) | 2002-01-30 | 2003-07-30 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis c virus |
AR038375A1 (es) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
CA2369970A1 (en) | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor tri-peptides |
US7091184B2 (en) | 2002-02-01 | 2006-08-15 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor tri-peptides |
US6642204B2 (en) | 2002-02-01 | 2003-11-04 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor tri-peptides |
EP2468744A2 (en) | 2002-04-11 | 2012-06-27 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
US8093380B2 (en) | 2002-08-01 | 2012-01-10 | Pharmasset, Inc. | Compounds with the bicyclo[4.2.1]nonane system for the treatment of Flaviviridae infections |
US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
CA2413705A1 (en) | 2002-12-06 | 2004-06-06 | Raul Altman | Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions |
US7601709B2 (en) | 2003-02-07 | 2009-10-13 | Enanta Pharmaceuticals, Inc. | Macrocyclic hepatitis C serine protease inhibitors |
US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US20040180815A1 (en) | 2003-03-07 | 2004-09-16 | Suanne Nakajima | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors |
CA2516328A1 (en) | 2003-02-18 | 2004-09-02 | Pfizer Inc. | Inhibitors of hepatitis c virus, compositions and treatments using the same |
CA2516018C (en) | 2003-03-05 | 2011-08-23 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor peptide analogs |
JP4550824B2 (ja) | 2003-03-05 | 2010-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | C型肝炎抑制化合物 |
EP2332935A1 (en) | 2003-04-11 | 2011-06-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
EP1613620A1 (en) | 2003-04-11 | 2006-01-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
BRPI0410456B8 (pt) | 2003-05-21 | 2021-05-25 | Boehringer Ingelheim Int | compostos inibidores de hepatite c, composição farmacêutica, uso dos mesmos, bem como artigo de fabricação |
EP2368900A3 (en) | 2003-07-18 | 2012-07-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
WO2005018330A1 (en) | 2003-08-18 | 2005-03-03 | Pharmasset, Inc. | Dosing regimen for flaviviridae therapy |
TWI359147B (en) | 2003-09-05 | 2012-03-01 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv n |
TW200518669A (en) | 2003-09-12 | 2005-06-16 | Vertex Pharma | Animal model for protease activity and liver damage |
AU2004274468B2 (en) | 2003-09-18 | 2009-07-23 | Vertex Pharmaceuticals, Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
US6933760B2 (en) | 2003-09-19 | 2005-08-23 | Intel Corporation | Reference voltage generator for hysteresis circuit |
AU2004274051A1 (en) | 2003-09-22 | 2005-03-31 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
AU2004282148A1 (en) | 2003-10-10 | 2005-04-28 | Vertex Pharmaceuticals Incoporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
AR045870A1 (es) | 2003-10-11 | 2005-11-16 | Vertex Pharma | Terapia de combinacion para la infeccion de virus de hepatitis c |
US20060003942A1 (en) | 2003-10-27 | 2006-01-05 | Roger Tung | Combinations for HCV treatment |
AU2004285019B9 (en) | 2003-10-27 | 2011-11-24 | Vertex Pharmaceuticals Incorporated | HCV NS3-NS4A protease resistance mutants |
WO2005043118A2 (en) | 2003-10-27 | 2005-05-12 | Vertex Pharmaceuticals Incorporated | Drug discovery method |
KR20060122872A (ko) | 2003-10-28 | 2006-11-30 | 버텍스 파마슈티칼스 인코포레이티드 | 피셔-핑크형 합성 및 후속 아실화에 의한4,5-디알킬-3-아실-피롤-2-카복실산 유도체의 제조 |
US20050119318A1 (en) | 2003-10-31 | 2005-06-02 | Hudyma Thomas W. | Inhibitors of HCV replication |
US7132504B2 (en) | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP1689857A1 (en) | 2003-12-01 | 2006-08-16 | Vertex Pharmaceuticals Incorporated | Compositions comprising fetal liver cells and methods useful for hcv infection |
CA2549851C (en) | 2004-01-21 | 2012-09-11 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis c virus |
CA2554999A1 (en) | 2004-02-04 | 2005-08-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
US7582770B2 (en) | 2004-02-20 | 2009-09-01 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US20050187192A1 (en) | 2004-02-20 | 2005-08-25 | Kucera Pharmaceutical Company | Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses |
EP1737821B1 (en) | 2004-02-27 | 2009-08-05 | Schering Corporation | 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease |
US7381827B2 (en) | 2004-03-12 | 2008-06-03 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
US20050249702A1 (en) | 2004-05-06 | 2005-11-10 | Schering Corporation | (1R,2S,5S)-N-[(1S)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide as inhibitor of hepatitis C virus NS3/NS4a serine protease |
EP1765283A4 (en) | 2004-06-08 | 2012-11-28 | Vertex Pharma | PHARMACEUTICAL COMPOSITIONS |
CA2577812A1 (en) | 2004-08-27 | 2006-03-09 | Schering Corporation | Acylsulfonamide compounds as inhibitors of hepatitis c virus ns3 serine protease |
US7863274B2 (en) | 2005-07-29 | 2011-01-04 | Concert Pharmaceuticals Inc. | Deuterium enriched analogues of tadalafil as PDE5 inhibitors |
ES2401661T3 (es) | 2005-08-02 | 2013-04-23 | Vertex Pharmaceuticals Incorporated | Inhibidores de serina proteasas |
KR20130038947A (ko) | 2005-08-19 | 2013-04-18 | 버텍스 파마슈티칼스 인코포레이티드 | 방법 및 중간체 |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
CA2643688A1 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
EP1993993A1 (en) | 2006-03-16 | 2008-11-26 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for preparing steric compounds |
KR20080112303A (ko) | 2006-03-16 | 2008-12-24 | 버텍스 파마슈티칼스 인코포레이티드 | 중수소화 c형 간염 프로테아제 억제제 |
WO2007109605A2 (en) | 2006-03-20 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
TW200812611A (en) | 2006-03-20 | 2008-03-16 | Vertex Pharma | Pharmaceutical compositions |
JP2009538912A (ja) | 2006-05-31 | 2009-11-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | インターロイキン−1β変換酵素阻害剤の経口制御放出剤形 |
CA2679426A1 (en) | 2007-02-27 | 2008-09-04 | Luc Farmer | Inhibitors of serine proteases |
-
2001
- 2001-08-30 SV SV2001000617A patent/SV2003000617A/es not_active Application Discontinuation
- 2001-08-31 TW TW099107493A patent/TW201022244A/zh unknown
- 2001-08-31 DE DE60138717T patent/DE60138717D1/de not_active Expired - Lifetime
- 2001-08-31 KR KR1020087025506A patent/KR20080096718A/ko not_active Application Discontinuation
- 2001-08-31 ES ES01968040T patent/ES2325481T3/es not_active Expired - Lifetime
- 2001-08-31 EA EA200300318A patent/EA011547B1/ru not_active IP Right Cessation
- 2001-08-31 EP EP10185148A patent/EP2368878A1/en not_active Withdrawn
- 2001-08-31 DK DK07012485.4T patent/DK1878720T3/da active
- 2001-08-31 CN CN2006100803265A patent/CN1869061B/zh not_active Expired - Fee Related
- 2001-08-31 DZ DZ013438A patent/DZ3438A1/fr active
- 2001-08-31 ES ES07012485T patent/ES2352804T3/es not_active Expired - Lifetime
- 2001-08-31 CN CN200910149350.3A patent/CN101693672B/zh not_active Expired - Fee Related
- 2001-08-31 AU AU2001288318A patent/AU2001288318B2/en not_active Ceased
- 2001-08-31 EP EP10185722A patent/EP2371839A1/en not_active Withdrawn
- 2001-08-31 NZ NZ541302A patent/NZ541302A/en not_active IP Right Cessation
- 2001-08-31 UA UA2003021834A patent/UA81600C2/uk unknown
- 2001-08-31 CN CN2011103464269A patent/CN102504014A/zh active Pending
- 2001-08-31 CA CA2419607A patent/CA2419607C/en not_active Expired - Fee Related
- 2001-08-31 KR KR1020087025503A patent/KR100968295B1/ko not_active IP Right Cessation
- 2001-08-31 AT AT07012485T patent/ATE483686T1/de not_active IP Right Cessation
- 2001-08-31 TW TW099107492A patent/TWI359145B/zh not_active IP Right Cessation
- 2001-08-31 EP EP07012485A patent/EP1878720B1/en not_active Expired - Lifetime
- 2001-08-31 TW TW097127487A patent/TWI339661B/zh not_active IP Right Cessation
- 2001-08-31 KR KR1020117015737A patent/KR20110088600A/ko not_active Application Discontinuation
- 2001-08-31 CN CNB018150551A patent/CN100522991C/zh not_active Expired - Fee Related
- 2001-08-31 KR KR1020087025504A patent/KR20080104383A/ko not_active Application Discontinuation
- 2001-08-31 KR KR1020077029814A patent/KR100945975B1/ko not_active IP Right Cessation
- 2001-08-31 TW TW090121629A patent/TWI319763B/zh not_active IP Right Cessation
- 2001-08-31 TW TW099107489A patent/TWI378927B/zh not_active IP Right Cessation
- 2001-08-31 BR BR0113666-6A patent/BR0113666A/pt not_active IP Right Cessation
- 2001-08-31 CN CN2009101474875A patent/CN101633636B/zh not_active Expired - Fee Related
- 2001-08-31 JP JP2002523884A patent/JP4689938B2/ja not_active Expired - Lifetime
- 2001-08-31 CA CA2697205A patent/CA2697205C/en not_active Expired - Fee Related
- 2001-08-31 WO PCT/US2001/026008 patent/WO2002018369A2/en active Application Filing
- 2001-08-31 KR KR1020087025505A patent/KR20080104384A/ko not_active Application Discontinuation
- 2001-08-31 KR KR1020097022810A patent/KR20090120013A/ko not_active Application Discontinuation
- 2001-08-31 AT AT01968040T patent/ATE431358T1/de active
- 2001-08-31 ES ES07012483.9T patent/ES2450815T3/es not_active Expired - Lifetime
- 2001-08-31 CN CN200910149349A patent/CN101696232A/zh active Pending
- 2001-08-31 SI SI200130924T patent/SI1320540T1/sl unknown
- 2001-08-31 CZ CZ2003595A patent/CZ2003595A3/cs unknown
- 2001-08-31 UA UAA200710133A patent/UA99895C2/uk unknown
- 2001-08-31 PE PE2001000876A patent/PE20020474A1/es active IP Right Grant
- 2001-08-31 HU HU0300855A patent/HUP0300855A3/hu unknown
- 2001-08-31 EP EP01968040A patent/EP1320540B9/en not_active Expired - Lifetime
- 2001-08-31 DE DE20122915U patent/DE20122915U1/de not_active Expired - Lifetime
- 2001-08-31 MX MXPA03001780A patent/MXPA03001780A/es active IP Right Grant
- 2001-08-31 EP EP20100185155 patent/EP2368901A1/en not_active Withdrawn
- 2001-08-31 PT PT01968040T patent/PT1320540E/pt unknown
- 2001-08-31 EA EA200701869A patent/EA017556B1/ru not_active IP Right Cessation
- 2001-08-31 KR KR1020107007135A patent/KR20100043293A/ko not_active Application Discontinuation
- 2001-08-31 EP EP10185132.7A patent/EP2368877B1/en not_active Expired - Lifetime
- 2001-08-31 AU AU8831801A patent/AU8831801A/xx active Pending
- 2001-08-31 PL PL365836A patent/PL211019B1/pl unknown
- 2001-08-31 ES ES10185132.7T patent/ES2489115T3/es not_active Expired - Lifetime
- 2001-08-31 SK SK249-2003A patent/SK2492003A3/sk unknown
- 2001-08-31 AR ARP010104168A patent/AR030591A1/es active IP Right Grant
- 2001-08-31 IL IL15467101A patent/IL154671A0/xx unknown
- 2001-08-31 EP EP07012483.9A patent/EP1958956B1/en not_active Expired - Lifetime
- 2001-08-31 EP EP07012484A patent/EP1876173A1/en not_active Withdrawn
- 2001-08-31 US US10/344,112 patent/US7820671B2/en not_active Expired - Fee Related
- 2001-08-31 CN CN2013100240570A patent/CN103232381A/zh active Pending
- 2001-08-31 KR KR1020037002880A patent/KR100876472B1/ko not_active IP Right Cessation
- 2001-08-31 KR KR1020107007138A patent/KR20100042296A/ko active Application Filing
- 2001-08-31 DE DE60143233T patent/DE60143233D1/de not_active Expired - Lifetime
- 2001-08-31 TW TW099107488A patent/TWI359144B/zh not_active IP Right Cessation
- 2001-08-31 NZ NZ569670A patent/NZ569670A/en not_active IP Right Cessation
- 2001-08-31 EP EP07111000A patent/EP1849797A3/en not_active Withdrawn
- 2001-08-31 DK DK01968040.4T patent/DK1320540T5/da active
-
2003
- 2003-02-25 EC EC2003004493A patent/ECSP034493A/es unknown
- 2003-02-25 HR HRP20030139AA patent/HRP20030139B8/hr not_active IP Right Cessation
- 2003-02-27 IL IL154671A patent/IL154671A/en not_active IP Right Cessation
- 2003-02-27 ZA ZA200301641A patent/ZA200301641B/en unknown
- 2003-02-27 NO NO20030928A patent/NO329929B1/no not_active IP Right Cessation
- 2003-11-19 HK HK12103079.4A patent/HK1163061A1/xx not_active IP Right Cessation
- 2003-11-19 HK HK03108422.8A patent/HK1057758A1/xx not_active IP Right Cessation
- 2003-11-19 HK HK08104142.1A patent/HK1114090A1/xx not_active IP Right Cessation
-
2007
- 2007-01-31 EC EC2007007217A patent/ECSP077217A/es unknown
- 2007-05-30 JP JP2007143124A patent/JP2007284444A/ja active Pending
- 2007-08-30 IL IL185644A patent/IL185644A0/en unknown
-
2008
- 2008-09-08 US US12/231,982 patent/US8252923B2/en not_active Expired - Fee Related
-
2009
- 2009-07-20 CY CY20091100765T patent/CY1109216T1/el unknown
-
2010
- 2010-01-18 NO NO20100093A patent/NO20100093L/no not_active Application Discontinuation
- 2010-04-07 CL CL2010000330A patent/CL2010000330A1/es unknown
- 2010-07-12 NO NO20100999A patent/NO330807B1/no not_active IP Right Cessation
- 2010-10-25 JP JP2010238165A patent/JP5269035B2/ja not_active Expired - Fee Related
-
2011
- 2011-10-24 IL IL215892A patent/IL215892A/en not_active IP Right Cessation
- 2011-10-24 IL IL215891A patent/IL215891A/en not_active IP Right Cessation
- 2011-10-24 IL IL215890A patent/IL215890A0/en unknown
- 2011-11-10 US US13/293,812 patent/US20120064034A1/en not_active Abandoned
-
2012
- 2012-03-19 LU LU91960C patent/LU91960I2/fr unknown
- 2012-03-19 DE DE201212000015 patent/DE122012000015I1/de active Pending
- 2012-03-19 CY CY2012007C patent/CY2012007I1/el unknown
- 2012-04-03 NO NO2012006C patent/NO2012006I1/no unknown
- 2012-05-28 JP JP2012120678A patent/JP2012197289A/ja active Pending
- 2012-07-03 US US13/541,436 patent/US8529882B2/en not_active Expired - Fee Related
-
2014
- 2014-06-17 US US14/306,778 patent/US20140294763A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP077217A (es) | Inhibidores de proteasa peptidomimeticos | |
ATE413411T1 (de) | Substituierte cycloalkyl p1' hepatitis c virus inhibitoren | |
MX2007004783A (es) | Inhibidores de la proteasa del virus de la hepatitis c, y composiciones y tratamientos que los usan. | |
DE60217114D1 (de) | Verbrückte bizyklische serinproteaseinhibitoren | |
ATE481106T1 (de) | Heterocyclische sulfonamid-hepatitis-c-virus- hemmer | |
ECSP045223A (es) | Composiciones farmacéuticas para inhibidores de proteasa viral de la hepatitis c | |
ATE327246T1 (de) | Hepatitis c tripeptid inhibitoren | |
EP1441720B8 (en) | Inhibitors of serine protease, particularly hepatitis c virus ns3-ns4a protease, incorporating a fused ring system | |
ECSP045191A (es) | "nuevos péptidos como inhibidores de la proteasa serina ns3 del virus de la hepatitis c" | |
HUP0400456A2 (hu) | Hepatitis C vírus N-ciklikus P2 csoportokat tartalmazó makrociklusos NS3-szerin proteáz inhibitorai és ezeket tartalmazó gyógyszerkészítmények | |
IS7533A (is) | Lifrarbólgu C-veirutálmar | |
TW200612898A (en) | Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same | |
ATE512976T1 (de) | Hemmer des hepatitis-c-virus | |
MY148123A (en) | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease | |
ES2240446T3 (es) | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. | |
CY1110437T1 (el) | Χρηση παραγωγων καστανοσπερμινης για την θεραπεια της ηπατιτιδας c | |
TH124102A (th) | สารยับยั้งเปปไทโดไมเมทิคโปรทีเอส |