SG11201509427RA - 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives - Google Patents

4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives

Info

Publication number
SG11201509427RA
SG11201509427RA SG11201509427RA SG11201509427RA SG11201509427RA SG 11201509427R A SG11201509427R A SG 11201509427RA SG 11201509427R A SG11201509427R A SG 11201509427RA SG 11201509427R A SG11201509427R A SG 11201509427RA SG 11201509427R A SG11201509427R A SG 11201509427RA
Authority
SG
Singapore
Prior art keywords
azido
deoxy
fluoro substituted
substituted nucleoside
nucleoside derivatives
Prior art date
Application number
SG11201509427RA
Inventor
Mark Smith
Klaus G Klumpp
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of SG11201509427RA publication Critical patent/SG11201509427RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
SG11201509427RA 2013-05-16 2014-05-15 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives SG11201509427RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824034P 2013-05-16 2013-05-16
PCT/US2014/038288 WO2014193663A1 (en) 2013-05-16 2014-05-15 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives

Publications (1)

Publication Number Publication Date
SG11201509427RA true SG11201509427RA (en) 2015-12-30

Family

ID=51895939

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201509427RA SG11201509427RA (en) 2013-05-16 2014-05-15 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives

Country Status (19)

Country Link
US (2) US9249176B2 (en)
EP (1) EP2996696A4 (en)
JP (1) JP2016519146A (en)
KR (1) KR20160039154A (en)
CN (1) CN105307661A (en)
AU (1) AU2014272055A1 (en)
BR (1) BR112015028765A2 (en)
CA (1) CA2912684A1 (en)
CL (1) CL2015003358A1 (en)
CR (1) CR20150649A (en)
EA (1) EA201592185A1 (en)
HK (2) HK1217295A1 (en)
MA (1) MA38678A1 (en)
MX (1) MX2015015781A (en)
PE (1) PE20160119A1 (en)
PH (1) PH12015502589A1 (en)
SG (1) SG11201509427RA (en)
WO (1) WO2014193663A1 (en)
ZA (1) ZA201509055B (en)

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MA38678A1 (en) * 2013-05-16 2017-07-31 Riboscience Llc Nucleoside derivatives 4'-azido, 3'-deoxy-3'-fluoro substituted
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CN109562113A (en) 2016-05-10 2019-04-02 C4医药公司 Loop coil degron body for target protein degradation
CN109641874A (en) 2016-05-10 2019-04-16 C4医药公司 C for target protein degradation3The glutarimide degron body of carbon connection
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
AR112702A1 (en) * 2017-09-21 2019-11-27 Riboscience Llc 4'-FLUORO-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS HCV RNA REPLICATION INHIBITORS

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Also Published As

Publication number Publication date
MA38678A1 (en) 2017-07-31
EA201592185A1 (en) 2016-05-31
ZA201509055B (en) 2017-03-29
JP2016519146A (en) 2016-06-30
US9694028B2 (en) 2017-07-04
PE20160119A1 (en) 2016-02-24
PH12015502589A1 (en) 2016-02-29
US9249176B2 (en) 2016-02-02
HK1217295A1 (en) 2017-01-06
CA2912684A1 (en) 2014-12-04
US20160220596A1 (en) 2016-08-04
CN105307661A (en) 2016-02-03
KR20160039154A (en) 2016-04-08
BR112015028765A2 (en) 2017-07-25
CL2015003358A1 (en) 2016-10-14
AU2014272055A1 (en) 2015-12-24
MX2015015781A (en) 2016-06-02
US20140341848A1 (en) 2014-11-20
EP2996696A4 (en) 2016-12-21
HK1219901A1 (en) 2017-04-21
WO2014193663A1 (en) 2014-12-04
CR20150649A (en) 2016-03-09
EP2996696A1 (en) 2016-03-23

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