NO303544B1 - FremgangsmÕte for fremstilling av et polypeptid med Ún eller flere av de hematopoietiske biologiske egenskaper til granulocyttkolonistimulerende faktor (hpG-CSF) - Google Patents
FremgangsmÕte for fremstilling av et polypeptid med Ún eller flere av de hematopoietiske biologiske egenskaper til granulocyttkolonistimulerende faktor (hpG-CSF) Download PDFInfo
- Publication number
- NO303544B1 NO303544B1 NO871679A NO871679A NO303544B1 NO 303544 B1 NO303544 B1 NO 303544B1 NO 871679 A NO871679 A NO 871679A NO 871679 A NO871679 A NO 871679A NO 303544 B1 NO303544 B1 NO 303544B1
- Authority
- NO
- Norway
- Prior art keywords
- csf
- hpg
- cells
- ser
- polypeptide
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 48
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 48
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 46
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 title claims abstract description 21
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims description 45
- 230000003394 haemopoietic effect Effects 0.000 title claims description 7
- 230000004071 biological effect Effects 0.000 title abstract description 12
- 238000002360 preparation method Methods 0.000 title description 6
- 210000004027 cell Anatomy 0.000 claims abstract description 108
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 37
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 238000002955 isolation Methods 0.000 claims description 9
- 230000009471 action Effects 0.000 claims description 5
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims description 5
- 230000031018 biological processes and functions Effects 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000001900 immune effect Effects 0.000 abstract description 7
- 125000000539 amino acid group Chemical group 0.000 abstract description 6
- 241000894006 Bacteria Species 0.000 abstract description 4
- 230000000704 physical effect Effects 0.000 abstract description 3
- 108091029865 Exogenous DNA Proteins 0.000 abstract description 2
- 238000000338 in vitro Methods 0.000 abstract description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 239000013600 plasmid vector Substances 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 53
- 108090000623 proteins and genes Proteins 0.000 description 39
- 239000002299 complementary DNA Substances 0.000 description 32
- 239000012634 fragment Substances 0.000 description 31
- 239000000047 product Substances 0.000 description 30
- 108020004414 DNA Proteins 0.000 description 29
- 241000588724 Escherichia coli Species 0.000 description 25
- 230000000694 effects Effects 0.000 description 22
- 239000013598 vector Substances 0.000 description 22
- 108020004705 Codon Proteins 0.000 description 20
- 239000000463 material Substances 0.000 description 20
- 239000013612 plasmid Substances 0.000 description 20
- 239000002609 medium Substances 0.000 description 19
- 230000027455 binding Effects 0.000 description 16
- 238000002474 experimental method Methods 0.000 description 15
- 238000009396 hybridization Methods 0.000 description 15
- 235000018102 proteins Nutrition 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 15
- 241000276498 Pollachius virens Species 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 241001529936 Murinae Species 0.000 description 13
- 108091034117 Oligonucleotide Proteins 0.000 description 13
- 238000010276 construction Methods 0.000 description 13
- 230000004069 differentiation Effects 0.000 description 13
- 208000032839 leukemia Diseases 0.000 description 13
- 108020004999 messenger RNA Proteins 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 239000007983 Tris buffer Substances 0.000 description 12
- 150000001413 amino acids Chemical class 0.000 description 12
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 11
- 210000002798 bone marrow cell Anatomy 0.000 description 10
- 239000008188 pellet Substances 0.000 description 10
- 108091008146 restriction endonucleases Proteins 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 9
- 239000011324 bead Substances 0.000 description 9
- 238000012163 sequencing technique Methods 0.000 description 9
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 8
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 8
- 239000013604 expression vector Substances 0.000 description 8
- 210000003714 granulocyte Anatomy 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 108700026495 N-Myc Proto-Oncogene Proteins 0.000 description 7
- 102000055056 N-Myc Proto-Oncogene Human genes 0.000 description 7
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 7
- 239000000427 antigen Substances 0.000 description 7
- 102000036639 antigens Human genes 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004962 mammalian cell Anatomy 0.000 description 7
- 210000003643 myeloid progenitor cell Anatomy 0.000 description 7
- 210000000440 neutrophil Anatomy 0.000 description 7
- 239000001632 sodium acetate Substances 0.000 description 7
- 235000017281 sodium acetate Nutrition 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 229940104230 thymidine Drugs 0.000 description 7
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 6
- 206010005003 Bladder cancer Diseases 0.000 description 6
- 101100007328 Cocos nucifera COS-1 gene Proteins 0.000 description 6
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 6
- 229940024606 amino acid Drugs 0.000 description 6
- 230000003321 amplification Effects 0.000 description 6
- 210000002960 bfu-e Anatomy 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 230000000813 microbial effect Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 238000003199 nucleic acid amplification method Methods 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 5
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 5
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 5
- 238000007792 addition Methods 0.000 description 5
- 230000029087 digestion Effects 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000002741 site-directed mutagenesis Methods 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical group O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 4
- 238000000376 autoradiography Methods 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000012228 culture supernatant Substances 0.000 description 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- 210000002540 macrophage Anatomy 0.000 description 4
- 208000025113 myeloid leukemia Diseases 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000014616 translation Effects 0.000 description 4
- 238000011144 upstream manufacturing Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 3
- 102000003951 Erythropoietin Human genes 0.000 description 3
- 108090000394 Erythropoietin Proteins 0.000 description 3
- 108700024394 Exon Proteins 0.000 description 3
- 108010002386 Interleukin-3 Proteins 0.000 description 3
- 102100039064 Interleukin-3 Human genes 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
- 102000005348 Neuraminidase Human genes 0.000 description 3
- 108010006232 Neuraminidase Proteins 0.000 description 3
- 238000012300 Sequence Analysis Methods 0.000 description 3
- 108020004682 Single-Stranded DNA Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 235000004279 alanine Nutrition 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 201000001531 bladder carcinoma Diseases 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 229940009976 deoxycholate Drugs 0.000 description 3
- KXGVEGMKQFWNSR-LLQZFEROSA-M deoxycholate Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-M 0.000 description 3
- 231100000673 dose–response relationship Toxicity 0.000 description 3
- 229940105423 erythropoietin Drugs 0.000 description 3
- 239000013613 expression plasmid Substances 0.000 description 3
- 239000012894 fetal calf serum Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 108010085617 glycopeptide alpha-N-acetylgalactosaminidase Proteins 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 102000046157 human CSF2 Human genes 0.000 description 3
- 230000008105 immune reaction Effects 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 210000001237 metamyelocyte Anatomy 0.000 description 3
- 210000001616 monocyte Anatomy 0.000 description 3
- 210000003887 myelocyte Anatomy 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- 238000010188 recombinant method Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 229940016590 sarkosyl Drugs 0.000 description 3
- 108700004121 sarkosyl Proteins 0.000 description 3
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 3
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- YXQDRIRSAHTJKM-IMJSIDKUSA-N Cys-Ser Chemical group SC[C@H](N)C(=O)N[C@@H](CO)C(O)=O YXQDRIRSAHTJKM-IMJSIDKUSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- 229930010555 Inosine Natural products 0.000 description 2
- 239000007760 Iscove's Modified Dulbecco's Medium Substances 0.000 description 2
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 238000000636 Northern blotting Methods 0.000 description 2
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 2
- 108091000080 Phosphotransferase Proteins 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 238000002105 Southern blotting Methods 0.000 description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000003277 amino acid sequence analysis Methods 0.000 description 2
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000003969 blast cell Anatomy 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000005757 colony formation Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 238000002523 gelfiltration Methods 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 description 2
- 229940025294 hemin Drugs 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 229960003786 inosine Drugs 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 108700024542 myc Genes Proteins 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 230000009871 nonspecific binding Effects 0.000 description 2
- 239000002751 oligonucleotide probe Substances 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000000813 peptide hormone Substances 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 102000020233 phosphotransferase Human genes 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 210000004765 promyelocyte Anatomy 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 238000011451 sequencing strategy Methods 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- 238000001890 transfection Methods 0.000 description 2
- 230000014621 translational initiation Effects 0.000 description 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 1
- 108010013043 Acetylesterase Proteins 0.000 description 1
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 101000904962 Arabidopsis thaliana Histone H2B.6 Proteins 0.000 description 1
- 208000002109 Argyria Diseases 0.000 description 1
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 description 1
- 108010051152 Carboxylesterase Proteins 0.000 description 1
- 102000013392 Carboxylesterase Human genes 0.000 description 1
- 229920013669 Clearsite Polymers 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001646716 Escherichia coli K-12 Species 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 101000824878 Gallus gallus Somatotropin Proteins 0.000 description 1
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 1
- 229920000209 Hexadimethrine bromide Polymers 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000910338 Homo sapiens Carbonic anhydrase 9 Proteins 0.000 description 1
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 description 1
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 description 1
- 101001033279 Homo sapiens Interleukin-3 Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 206010024305 Leukaemia monocytic Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 241000282346 Meles meles Species 0.000 description 1
- 241000699673 Mesocricetus auratus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101000931108 Mus musculus DNA (cytosine-5)-methyltransferase 1 Proteins 0.000 description 1
- 230000004988 N-glycosylation Effects 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 230000004989 O-glycosylation Effects 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 102000015731 Peptide Hormones Human genes 0.000 description 1
- 108010038988 Peptide Hormones Proteins 0.000 description 1
- 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 description 1
- 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 description 1
- 102100030852 Run domain Beclin-1-interacting and cysteine-rich domain-containing protein Human genes 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- 108700009124 Transcription Initiation Site Proteins 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- 238000005571 anion exchange chromatography Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 125000000837 carbohydrate group Chemical group 0.000 description 1
- 239000011545 carbonate/bicarbonate buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000007248 cellular mechanism Effects 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 108010004215 chloroacetate esterase Proteins 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 101150034144 ci gene Proteins 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 230000002281 colonystimulating effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000003636 conditioned culture medium Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000002327 eosinophilic effect Effects 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000001641 gel filtration chromatography Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
- 210000000777 hematopoietic system Anatomy 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 102000044890 human EPO Human genes 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000012454 limulus amebocyte lysate test Methods 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 210000003593 megakaryocyte Anatomy 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- KRZWEBVPFGCYMY-UHFFFAOYSA-M methylmercury(1+);hydroxide Chemical compound [OH-].[Hg+]C KRZWEBVPFGCYMY-UHFFFAOYSA-M 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000006894 monocytic leukemia Diseases 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 210000004206 promonocyte Anatomy 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 108020004418 ribosomal RNA Proteins 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical group OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 238000012868 site-directed mutagenesis technique Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO954199A NO954199D0 (no) | 1985-08-23 | 1995-10-20 | DNA-sekvens som koder for et polypeptidprodukt |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76895985A | 1985-08-23 | 1985-08-23 | |
| US06/835,548 US4810643A (en) | 1985-08-23 | 1986-03-03 | Production of pluripotent granulocyte colony-stimulating factor |
| PCT/US1986/001708 WO1987001132A1 (en) | 1985-08-23 | 1986-08-22 | Production of pluripotent granulocyte colony-stimulating factor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO871679D0 NO871679D0 (no) | 1987-04-22 |
| NO871679L NO871679L (no) | 1987-04-22 |
| NO303544B1 true NO303544B1 (no) | 1998-07-27 |
Family
ID=27118107
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO871679A NO303544B1 (no) | 1985-08-23 | 1987-04-22 | FremgangsmÕte for fremstilling av et polypeptid med Ún eller flere av de hematopoietiske biologiske egenskaper til granulocyttkolonistimulerende faktor (hpG-CSF) |
| NO19982132A NO314902B1 (no) | 1985-08-23 | 1998-05-11 | Biologisk funksjonelt plasmid eller virus-DNA-vektor som koder for en analog av granulocyttkolonistimulerende faktor (hpG-CSF), samtprokaryot eller eukaryot vertscelle |
| NO20032250A NO318755B1 (no) | 1985-08-23 | 2003-05-19 | Anvendelse av et hpG-CSF-polypeptid til fremstilling av et medikament for a stanse proliferasjon av leukemiceller |
| NO2003008C NO2003008I1 (no) | 1985-08-23 | 2003-11-13 | Fremgangsmaate for fremstilling av et polypeptid med én eller flere av de hematopoietiske biologiskeegenskaper til grnulocyttkolonistimulerende faktor(hpg-csf) |
| NO2003010C NO2003010I2 (no) | 1985-08-23 | 2003-12-09 | Pegfilgrastim |
| NO20045548A NO20045548L (no) | 1985-08-23 | 2004-12-17 | Fremgangsmate for fremstilling av et hpG-CSF-polypeptidprodukt, samt anvendelse derav til fremstilling av et medikament for induksjon av proliferasjonen av humane benmargsceller |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19982132A NO314902B1 (no) | 1985-08-23 | 1998-05-11 | Biologisk funksjonelt plasmid eller virus-DNA-vektor som koder for en analog av granulocyttkolonistimulerende faktor (hpG-CSF), samtprokaryot eller eukaryot vertscelle |
| NO20032250A NO318755B1 (no) | 1985-08-23 | 2003-05-19 | Anvendelse av et hpG-CSF-polypeptid til fremstilling av et medikament for a stanse proliferasjon av leukemiceller |
| NO2003008C NO2003008I1 (no) | 1985-08-23 | 2003-11-13 | Fremgangsmaate for fremstilling av et polypeptid med én eller flere av de hematopoietiske biologiskeegenskaper til grnulocyttkolonistimulerende faktor(hpg-csf) |
| NO2003010C NO2003010I2 (no) | 1985-08-23 | 2003-12-09 | Pegfilgrastim |
| NO20045548A NO20045548L (no) | 1985-08-23 | 2004-12-17 | Fremgangsmate for fremstilling av et hpG-CSF-polypeptidprodukt, samt anvendelse derav til fremstilling av et medikament for induksjon av proliferasjonen av humane benmargsceller |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US4810643A (xx) |
| EP (1) | EP0237545B2 (xx) |
| JP (11) | JP2527365B2 (xx) |
| KR (1) | KR880700071A (xx) |
| CN (1) | CN1020924C (xx) |
| AT (1) | ATE332375T1 (xx) |
| AU (1) | AU6334686A (xx) |
| CA (1) | CA1341537C (xx) |
| CY (1) | CY1642A (xx) |
| DE (1) | DE3650788T2 (xx) |
| DK (1) | DK174980B1 (xx) |
| ES (1) | ES2001883A6 (xx) |
| FI (3) | FI105191B (xx) |
| GR (1) | GR862185B (xx) |
| HK (1) | HK1029600A1 (xx) |
| IL (1) | IL79805A (xx) |
| MX (1) | MX9202992A (xx) |
| NL (1) | NL930127I1 (xx) |
| NO (6) | NO303544B1 (xx) |
| NZ (1) | NZ217334A (xx) |
| PT (1) | PT83242B (xx) |
| SA (1) | SA92130186B1 (xx) |
| SG (2) | SG48964A1 (xx) |
| WO (1) | WO1987001132A1 (xx) |
Families Citing this family (339)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU594014B2 (en) * | 1984-03-21 | 1990-03-01 | Research Corporation Technologies, Inc. | Recombinant DNA molecules |
| US5718893A (en) * | 1984-04-15 | 1998-02-17 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
| EP0215126B1 (en) * | 1985-02-08 | 1991-07-31 | Chugai Seiyaku Kabushiki Kaisha | Human granulocyte colony stimulating factor |
| US5532341A (en) | 1985-03-28 | 1996-07-02 | Sloan-Kettering Institute For Cancer Research | Human pluripotent hematopoietic colony stimulating factor |
| US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US6004548A (en) | 1985-08-23 | 1999-12-21 | Amgen, Inc. | Analogs of pluripotent granulocyte colony-stimulating factor |
| NZ218336A (en) * | 1985-12-09 | 1991-08-27 | Kirin Amgen Inc | Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf) |
| DK203187A (da) * | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
| GR871067B (en) * | 1986-07-18 | 1987-11-19 | Chugai Pharmaceutical Co Ltd | Process for producing stable pharmaceutical preparation containing granulocyte colony stimulating factor |
| US5186931A (en) * | 1986-08-06 | 1993-02-16 | Ajinomoto Co., Inc. | Composition and method for supporting bone marrow transplantation |
| JPH01500483A (ja) * | 1986-08-11 | 1989-02-23 | シタス コーポレイション | Ｇ‐ｃｓｆ及びそのミューテインの発現 |
| JPH0618781B2 (ja) * | 1986-10-18 | 1994-03-16 | 中外製薬株式会社 | 感染症治療剤 |
| US6238889B1 (en) * | 1986-12-16 | 2001-05-29 | Dsm N.V. | Molecular cloning and expression of the Pro8 isoform of human IL-3 |
| US5362853A (en) * | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| JP2618618B2 (ja) * | 1988-03-04 | 1997-06-11 | 協和醗酵工業株式会社 | 抗ｇ−ｃｓｆ誘導体、ｎｄ２８モノクローナル抗体 |
| DK174044B1 (da) | 1986-12-23 | 2002-05-06 | Kyowa Hakko Kogyo Kk | Polypeptid afledt fra human granulocytkolonistimulerende faktor, og fremgangsmåde til fremstilling deraf, DNA kodende for nævnte polypeptid, rekombinant plasmid indeholdende nævnte DNA, og mikroorganismer indeholdende nævnte rekombinante plasmid....... |
| US5194592A (en) * | 1986-12-23 | 1993-03-16 | Kyowa Hakko Kogyo Co. Ltd. | Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor |
| US5714581A (en) * | 1986-12-23 | 1998-02-03 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US6384194B1 (en) * | 1987-12-16 | 2002-05-07 | Dsm N.V. | Expression and purification of human interleukin-3 and muteins thereof |
| GB2213821B (en) * | 1987-12-23 | 1992-01-02 | British Bio Technology | Synthetic human granulocyte colony stimulating factor gene |
| US5599690A (en) * | 1988-02-01 | 1997-02-04 | Amgen Inc. | Control of norleucine incorporation into recombinant proteins |
| CA1329119C (en) * | 1988-03-29 | 1994-05-03 | Milton David Goldenberg | Cytotoxic therapy |
| US20030232010A2 (en) * | 1988-03-29 | 2003-12-18 | Immunomedics, Inc. | Improved cytotoxic therapy |
| EP0347041A3 (en) * | 1988-05-13 | 1990-11-22 | Amgen Inc. | Compositions and method for treating or preventing infections in animals |
| US5070013A (en) * | 1988-05-31 | 1991-12-03 | Schering Corporation | Immunochemical assay for human granulocyte-macrophage colony stimulating factor |
| US5082774A (en) * | 1988-08-30 | 1992-01-21 | The General Hospital Corporation | Recombinant human nerve growth factor |
| US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
| US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
| US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| ATE135370T1 (de) * | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
| AU5355790A (en) * | 1989-04-19 | 1990-11-16 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
| US6254861B1 (en) * | 1989-05-23 | 2001-07-03 | Chandra Choudhury | Hematopoietic growth factor derived from T lymphocytes |
| US5635386A (en) * | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5605822A (en) * | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
| US5763266A (en) * | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
| WO1990015877A2 (en) * | 1989-06-15 | 1990-12-27 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing cells |
| US6203976B1 (en) | 1989-07-18 | 2001-03-20 | Osi Pharmaceuticals, Inc. | Methods of preparing compositions comprising chemicals capable of transcriptional modulation |
| US5776502A (en) | 1989-07-18 | 1998-07-07 | Oncogene Science, Inc. | Methods of transcriptionally modulating gene expression |
| US5665543A (en) * | 1989-07-18 | 1997-09-09 | Oncogene Science, Inc. | Method of discovering chemicals capable of functioning as gene expression modulators |
| US5580722A (en) * | 1989-07-18 | 1996-12-03 | Oncogene Science, Inc. | Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease |
| EP0648501A1 (en) * | 1989-10-10 | 1995-04-19 | Amgen Inc. | Compositions comprising G-CSF for treating or preventing infections in canine and feline animals |
| CA2025181A1 (en) * | 1989-10-12 | 1991-04-13 | William G. Weisburg | Nucleic acid probes and methods for detecting fungi |
| US20040181044A1 (en) * | 1989-10-16 | 2004-09-16 | Zsebo Krisztina M. | Method of stimulating growth of epithelial cells by administering stem cell factor |
| HU220234B (hu) * | 1989-10-16 | 2001-11-28 | Amgen Inc. | Eljárás stem sejtek működését befolyásoló faktorok előállitására |
| ZA907921B (en) | 1989-10-16 | 1991-08-28 | Amgen Inc | Stem cell factor |
| US6852313B1 (en) | 1989-10-16 | 2005-02-08 | Amgen Inc. | Method of stimulating growth of melanocyte cells by administering stem cell factor |
| US7144731B2 (en) * | 1989-10-16 | 2006-12-05 | Amgen Inc. | SCF antibody compositions and methods of using the same |
| EP1241258A3 (en) * | 1989-10-16 | 2003-12-10 | Amgen Inc. | Stem cell factor |
| US5214133A (en) * | 1989-11-17 | 1993-05-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SCL: a hematopoietic growth and differentiation factor |
| US5132212A (en) * | 1989-11-17 | 1992-07-21 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Scl gene, and a hematopoietic growth and differentiation factor encoded thereby |
| JPH04218000A (ja) * | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| US5147799A (en) * | 1990-04-25 | 1992-09-15 | Isia Bursuker | Repopulation of macrophages and granulocytes using transforming growth factor-beta |
| GB9107846D0 (en) * | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
| US5399345A (en) * | 1990-05-08 | 1995-03-21 | Boehringer Mannheim, Gmbh | Muteins of the granulocyte colony stimulating factor |
| US5258367A (en) * | 1990-06-29 | 1993-11-02 | University Of Florida | Uteroferrin and rose proteins for stimulating hematopoietic cells |
| IE912365A1 (en) * | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| JPH05506673A (ja) * | 1991-02-22 | 1993-09-30 | アムジエン・インコーポレーテツド | 迅速な創傷の治癒を促進するためのｇｍ―ｃｓｆ及びｇ―ｃｓｆの使用 |
| DE69233336T2 (de) * | 1991-02-26 | 2005-03-31 | Astrazeneca Ab | Vektor |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US5772992A (en) * | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
| US7091319B1 (en) | 1992-11-24 | 2006-08-15 | Bauer S Christopher | IL-3 variant hematopoiesis fusion protein |
| US6361976B1 (en) | 1992-11-24 | 2002-03-26 | S. Christopher Bauer | Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production |
| US6153183A (en) * | 1992-11-24 | 2000-11-28 | G. D. Searle & Company | Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production |
| US6361977B1 (en) | 1992-11-24 | 2002-03-26 | S. Christopher Bauer | Methods of using multivariant IL-3 hematopoiesis fusion protein |
| US6057133A (en) * | 1992-11-24 | 2000-05-02 | G. D. Searle | Multivariant human IL-3 fusion proteins and their recombinant production |
| US6413509B1 (en) | 1992-11-24 | 2002-07-02 | S. Christopher Bauer | Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors |
| US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
| US6403076B1 (en) | 1992-11-24 | 2002-06-11 | S. Christopher Bauer | Compositions for increasing hematopoiesis with interleukin-3 mutants |
| AU2007200247B2 (en) * | 1993-01-28 | 2011-03-10 | Amgen Inc. | G-CSF analog compositions |
| US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| DE69435224D1 (de) | 1993-09-15 | 2009-09-10 | Novartis Vaccines & Diagnostic | Rekombinante Alphavirus-Vektoren |
| US5874075A (en) * | 1993-10-06 | 1999-02-23 | Amgen Inc. | Stable protein: phospholipid compositions and methods |
| US20050059149A1 (en) * | 1993-11-22 | 2005-03-17 | Bauer S. Christopher | Methods of ex-vivo expansion of hematopoeitic cells using multivariant IL-3 hematopoiesis chimera proteins |
| CA2139385C (en) * | 1994-02-04 | 2001-12-25 | Gottfried Alber | Products containing g-csf and tnf binding protein |
| US6242417B1 (en) | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
| US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
| EP0755263A4 (en) * | 1994-03-31 | 2005-02-09 | Amgen Inc | COMPOUNDS AND METHODS FOR STIMULATING MEGAKARYOCYTE GROWTH AND THEIR DIFFERENTIATION |
| US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
| US5536495A (en) * | 1994-04-15 | 1996-07-16 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
| US20030053982A1 (en) * | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US6100070A (en) * | 1995-10-05 | 2000-08-08 | G. D. Searle & Co. | G-CSF receptor agonists |
| US6066318A (en) * | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
| JP4383530B2 (ja) | 1996-04-05 | 2009-12-16 | ノバルティス バクシンズ アンド ダイアグノスティックス， インコーポレーテッド | 細胞巨大分子合成の阻害が減少したアルファウイルスベクター |
| CA2266656A1 (en) | 1996-09-17 | 1998-03-26 | Chiron Corporation | Compositions and methods for treating intracellular diseases |
| US6162426A (en) * | 1997-05-05 | 2000-12-19 | La Gamma; Edmund F. | Use of G-CSF to enhance the immune system in neonates |
| US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
| US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
| US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
| ES2297889T3 (es) * | 1997-07-14 | 2008-05-01 | Bolder Biotechnology, Inc. | Derivados de hormona de crecimiento y proteinas relacionadas. |
| US6753165B1 (en) * | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| US6017876A (en) | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
| JP4891477B2 (ja) * | 1997-10-02 | 2012-03-07 | マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー．ヴェー． | 血管新生及び／または既存細動脈網から側枝動脈及び／または他の動脈の発達の調節に関する方法 |
| US20020034819A1 (en) * | 1998-02-23 | 2002-03-21 | Alan K. Smith | Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses |
| US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
| CN1101403C (zh) * | 1998-07-13 | 2003-02-12 | 金磊 | 粒细胞集落刺激因子的制备 |
| US6979442B1 (en) | 1998-08-17 | 2005-12-27 | Pfizer Inc. | Stabilized protein compositions |
| US5999474A (en) | 1998-10-01 | 1999-12-07 | Monolithic System Tech Inc | Method and apparatus for complete hiding of the refresh of a semiconductor memory |
| US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| US6451346B1 (en) * | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
| CA2360347C (en) | 1998-12-31 | 2013-05-07 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| JP4092081B2 (ja) | 1999-01-06 | 2008-05-28 | ゼンコー・インコーポレイテッド | 顆粒球形成活性を有するｇ−ｃｓｆ変異体相当核酸およびタンパク質 |
| US7208473B2 (en) * | 1999-01-06 | 2007-04-24 | Xencor, Inc. | Nucleic acids and protein variants of hG-CSF with granulopoietic activity |
| US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| DE60041386D1 (de) | 1999-01-19 | 2009-03-05 | Molecular Insight Pharm Inc | Konjugate des granulozyten-kolonie stimulierenden faktors zur gezielten bildgebung von infektionen und entzündungen |
| HU228488B1 (en) * | 1999-01-29 | 2013-03-28 | Amgen Inc | Gcsf conjugates |
| US6365583B1 (en) | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| KR100356140B1 (ko) * | 1999-07-08 | 2002-10-19 | 한미약품공업 주식회사 | 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법 |
| US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| AU784195B2 (en) | 1999-11-12 | 2006-02-16 | Baxter Biotech Technology S.A.R.L. | Reduced side-effect hemoglobin compositions |
| US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| US6831158B2 (en) * | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| AR027509A1 (es) | 2000-01-10 | 2003-04-02 | Maxygen Aps | Conjugados g-csf |
| CA2337661A1 (en) | 2000-02-29 | 2001-08-29 | Pfizer Products Inc. | Stabilized granulocyte colony stimulating factor |
| CN1420776A (zh) * | 2000-03-31 | 2003-05-28 | 塞尔基因公司 | 环氧合酶－2活性的抑制 |
| US6926898B2 (en) | 2000-04-12 | 2005-08-09 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
| CA2421760A1 (en) * | 2000-09-08 | 2002-03-14 | Massachusetts Institute Of Technology | G-csf analog compositions and methods |
| US20020150979A1 (en) * | 2000-10-04 | 2002-10-17 | Naokazu Naitou | Process for producing a protein |
| DE60130799T2 (de) * | 2000-11-30 | 2008-07-17 | Children's Medical Center Corp., Boston | Synthese von 4-aminothalidomid enantiomeren |
| EP1229045A1 (en) * | 2001-02-01 | 2002-08-07 | Institut Curie | Universal carrier for targeting molecules to Gb3 receptor expressing cells |
| WO2002069232A2 (en) | 2001-02-19 | 2002-09-06 | Merck Patent Gmbh | Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity |
| FR2820979B1 (fr) | 2001-02-22 | 2004-03-12 | Didier Pourquier | Nouvelle application therapeutique du g-csf |
| US6956023B1 (en) | 2001-04-19 | 2005-10-18 | University Of Florida | Materials and methods for providing nutrition to neonates |
| EP2280074A3 (en) | 2001-07-05 | 2011-06-22 | Novartis Vaccines and Diagnostics, Inc. | Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof |
| US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
| JP4444652B2 (ja) | 2001-07-11 | 2010-03-31 | マキシゲン・ホールディングズ・リミテッド | Ｇ−ｃｓｆ結合体 |
| US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| US6987102B2 (en) | 2001-07-31 | 2006-01-17 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| US20030104996A1 (en) * | 2001-08-30 | 2003-06-05 | Tiansheng Li | L-methionine as a stabilizer for NESP/EPO in HSA-free formulations |
| CN102180944A (zh) | 2001-10-10 | 2011-09-14 | 诺和诺德公司 | 肽的重构和糖缀合 |
| AU2004236174B2 (en) | 2001-10-10 | 2011-06-02 | Novo Nordisk A/S | Glycopegylation methods and proteins/peptides produced by the methods |
| ZA200700168B (en) | 2001-10-10 | 2010-02-24 | Novo Nordisk As | Remodeling and glycoconjugation of peptides |
| SI21102A (sl) | 2001-12-19 | 2003-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika |
| ES2500918T3 (es) | 2001-12-21 | 2014-10-01 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina e interferón beta |
| KR20030062854A (ko) * | 2002-01-21 | 2003-07-28 | 주식회사 엘지생명과학 | 분비형 벡터를 이용한 효모에서의 재조합 단백질의 제조방법 |
| KR100508358B1 (ko) * | 2002-03-20 | 2005-08-17 | 주식회사 바이오폴리메드 | 생체적합성 고분자가 시스테인 잔기에 화학양론적으로 결합된 ｇ-ｃｓｆ의 제조 방법 |
| US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| EP1497437A4 (en) | 2002-05-01 | 2005-11-16 | Cell Genesys Inc | LENTIVIRAL VECTOR PARTICLES RESISTANT TO THE INACTIVATION OF A COMPLEMENT |
| US7323479B2 (en) * | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| US20100129363A1 (en) * | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
| US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| USRE48890E1 (en) | 2002-05-17 | 2022-01-11 | Celgene Corporation | Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation |
| NZ536908A (en) | 2002-05-17 | 2008-09-26 | Celgene Corp | Treating or preventing cancer comprising administering an effective amount of cytokine inhibitory drug plus a second active ingredient |
| EP1505973B1 (en) | 2002-05-17 | 2010-03-03 | Celgene Corporation | Combinations for treating multiple myeloma |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US7081443B2 (en) | 2002-05-21 | 2006-07-25 | Korea Advanced Institutes Of Science And Technology (Kaist) | Chimeric comp-ang1 molecule |
| AU2002345829A1 (en) * | 2002-06-24 | 2004-01-06 | Dr. Reddy's Laboratories Ltd. | Process for preparing g-csf |
| SI21273A (sl) * | 2002-07-31 | 2004-02-29 | LEK farmacevtska dru�ba d.d. | Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina |
| WO2004020462A1 (ja) | 2002-08-27 | 2004-03-11 | Fujii, Nobutaka | Ｃｘｃｒ４拮抗薬およびその用途 |
| WO2004022593A2 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| US8404717B2 (en) * | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes using lenalidomide |
| US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| US8404716B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| EP1900369A1 (en) | 2002-10-15 | 2008-03-19 | Celgene Corporation | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes |
| KR20050056247A (ko) * | 2002-10-15 | 2005-06-14 | 셀진 코포레이션 | 골수형성이상증후군의 치료 및 관리를 위한 선택적인사이토킨 저해 약물의 사용 방법 및 이를 포함하는 조성물 |
| KR20090048520A (ko) | 2002-11-06 | 2009-05-13 | 셀진 코포레이션 | 암 및 다른 질환의 치료 및 관리를 위한 선택적 시토킨 억제 약물의 사용 방법 및 그 조성물 |
| KR20050086780A (ko) * | 2002-11-26 | 2005-08-30 | 안트로제네시스 코포레이션 | 세포요법제, 세포요법제 단위 및 이를 이용한 치료방법 |
| US7785601B2 (en) * | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| US7695723B2 (en) * | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| WO2004058287A2 (en) * | 2002-12-31 | 2004-07-15 | Axaron Bioscience Ag | Methods of treating neurological conditions with hematopoeitic growth factors |
| EP1601248A4 (en) * | 2003-02-13 | 2010-01-27 | Anthrogenesis Corp | USE OF UMBILICAL CORD BLOOD FOR TREATING INDIVIDUALS WITH DISEASE, DISORDER OR PATHOLOGY |
| ES2436606T3 (es) | 2003-03-12 | 2014-01-03 | Celgene Corporation | Compuestos de 7-amido-isoindolilo y sus usos farmacéuticos |
| CA2521979A1 (en) * | 2003-04-09 | 2004-10-28 | University Of Utah Research Foundation | Compositions and methods related to production of erythropoietin |
| MXPA05011353A (es) * | 2003-04-22 | 2005-11-28 | Anormed Inc | Compuestos heterociclicos que se unen al receptor de quimiocina con eficacia mejorada. |
| US7501518B2 (en) * | 2003-04-22 | 2009-03-10 | Genzyme Corporation | Methods of making 2,6-diaryl piperidine derivatives |
| WO2005018663A1 (en) * | 2003-08-22 | 2005-03-03 | The Council Of The Queensland Institute Of Medical Research | G-csf derivative for inducing immunological tolerance |
| UA83504C2 (xx) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Поліморфні форми 3-(4-аміно-1-оксо-1,3-дигідроізоіндол-2-іл)піперидин-2,6-діону$полиморфные формы 3-(4-амино-1-оксо-1,3-дигидроизоиндол-2-ил) пиперидин-2,6-диона |
| US7220407B2 (en) * | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
| OA13284A (en) * | 2003-11-06 | 2007-01-31 | Corporation Celgene | Methods and compositions using thalidomide for thetreatment and management of cancers and other dis eases. |
| EP1694328A4 (en) * | 2003-12-02 | 2010-02-17 | Celgene Corp | METHOD AND COMPOSITIONS FOR THE TREATMENT AND SUPPLY OF HEMOGLOBINOPATHY AND ANEMIA |
| CA2552241C (en) | 2003-12-30 | 2013-10-01 | Durect Corporation | Co-polymeric devices for controlled release of active agents |
| US8906676B2 (en) * | 2004-02-02 | 2014-12-09 | Ambrx, Inc. | Modified human four helical bundle polypeptides and their uses |
| SE0400942D0 (sv) * | 2004-04-08 | 2004-04-08 | Henrik Arnberg | Composition and method |
| US20080213213A1 (en) * | 2004-04-14 | 2008-09-04 | Zeldis Jerome B | Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione |
| US20080199422A1 (en) * | 2004-04-14 | 2008-08-21 | Celgene Corporation | Method for the Treatment of Myelodysplastic Syndromes Using 1-Oxo-2-(2,6-Dioxopiperidin-3-Yl-)-4-Methylisoindoline |
| EP1586334A1 (en) * | 2004-04-15 | 2005-10-19 | TRASTEC scpa | G-CSF conjugates with peg |
| AU2005273968A1 (en) * | 2004-08-09 | 2006-02-23 | Alios Biopharma Inc. | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
| US7597884B2 (en) * | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| CA2577046A1 (en) * | 2004-08-13 | 2006-02-23 | Anormed Inc. | Chemokine combinations to mobilize progenitor/stem cells |
| US20120225044A9 (en) * | 2004-09-07 | 2012-09-06 | Zymequest, Inc. | Compositions and methods for prolonging survival of platelets |
| ES2376777T3 (es) | 2004-09-07 | 2012-03-16 | Velico Medical, Inc. | Aparato para prolongar la supervivencia de plaquetas |
| US7691365B2 (en) | 2004-09-28 | 2010-04-06 | Aprogen, Inc. | Methods of using chimeric coiled coil molecule to treat ischemic disease |
| GB0505353D0 (en) | 2005-03-16 | 2005-04-20 | Chem Technologies Ltd E | Treatment process for concrete |
| EP1814583A2 (en) | 2004-11-01 | 2007-08-08 | Novartis Vaccines and Diagnostics, Inc. | Combination approaches for generating immune responses |
| EP1817047B1 (en) | 2004-11-05 | 2012-02-08 | Northwestern University | Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders |
| WO2006067170A1 (en) * | 2004-12-23 | 2006-06-29 | Laboratoires Serono S.A. | G-csf polypeptides and uses thereof |
| EP1858543B1 (en) | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylated granulocyte colony stimulating factor |
| WO2006081249A2 (en) | 2005-01-25 | 2006-08-03 | Cell Therapeutics, Inc. | Conjugates of biologically active proteins having a modified in vivo half-life |
| US20060270707A1 (en) * | 2005-05-24 | 2006-11-30 | Zeldis Jerome B | Methods and compositions using 4-[(cyclopropanecarbonylamino)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione for the treatment or prevention of cutaneous lupus |
| CN101193658B (zh) * | 2005-06-01 | 2011-08-31 | 马克西根控股公司 | 聚乙二醇化g-csf多肽及其产生方法 |
| EP1739179A1 (en) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
| DE102005033250A1 (de) | 2005-07-15 | 2007-01-18 | Bioceuticals Arzneimittel Ag | Verfahren zur Reinigung von G-CSF |
| KR100735784B1 (ko) * | 2005-07-20 | 2007-07-06 | 재단법인 목암생명공학연구소 | 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물 |
| WO2007019331A2 (en) * | 2005-08-04 | 2007-02-15 | Nektar Therapeutics Al, Corporation | Conjugates of a g-csf moiety and a polymer |
| US8580814B2 (en) * | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| US20080138295A1 (en) * | 2005-09-12 | 2008-06-12 | Celgene Coporation | Bechet's disease using cyclopropyl-N-carboxamide |
| US20070155791A1 (en) * | 2005-12-29 | 2007-07-05 | Zeldis Jerome B | Methods for treating cutaneous lupus using aminoisoindoline compounds |
| US20100035941A1 (en) * | 2006-02-24 | 2010-02-11 | Bridger Gary J | Methods for increasing blood flow and/or promoting tissue regeneration |
| DE202006020194U1 (de) | 2006-03-01 | 2007-12-06 | Bioceuticals Arzneimittel Ag | G-CSF-Flüssigformulierung |
| WO2007102814A2 (en) * | 2006-03-07 | 2007-09-13 | Regenetech, Inc. | Recombinant mammalian molecules and method for production thereof |
| GB0605684D0 (en) * | 2006-03-21 | 2006-05-03 | Sicor Biotech Uab | Method For Purifying Granulocyte-Colony Stimulating Factor |
| US20100196336A1 (en) | 2006-05-23 | 2010-08-05 | Dongsu Park | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
| US8124773B2 (en) | 2006-06-12 | 2012-02-28 | Sunesis Pharmaceuticals, Inc. | 1,8-naphthyridine compounds for the treatment of cancer |
| HUE026693T2 (hu) * | 2006-08-02 | 2016-07-28 | Sunesis Pharmaceuticals Inc | (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil) -1,8-naftiridin-3-karbonsav és cytarabin (Ara-C) kombinált alkalmazása leukémia kezelésére |
| CL2007002218A1 (es) * | 2006-08-03 | 2008-03-14 | Celgene Corp Soc Organizada Ba | Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa. |
| US20100178271A1 (en) * | 2006-08-07 | 2010-07-15 | Genzyme Corporation | Combination Therapy |
| EP2094274A4 (en) | 2006-12-21 | 2011-05-11 | Biokine Therapeutics Ltd | T-140 PEPTIDE ANALOGUE WITH CXCR4 SUPERAGONIST ACTIVITY FOR BONE MARROW RECOVERY |
| WO2008096370A2 (en) * | 2007-02-05 | 2008-08-14 | Natco Pharma Limited | An efficient and novel purification method of recombinant hg-csf |
| AU2008247815B2 (en) * | 2007-05-02 | 2012-09-06 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
| CN101801942B (zh) * | 2007-07-17 | 2013-03-27 | 美国艾森生物科学公司 | 杂环化合物和作为抗癌剂的用途 |
| US7893045B2 (en) | 2007-08-07 | 2011-02-22 | Celgene Corporation | Methods for treating lymphomas in certain patient populations and screening patients for said therapy |
| EP2185689A2 (en) | 2007-08-09 | 2010-05-19 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
| RS53404B (en) | 2007-08-27 | 2014-10-31 | Ratiopharm Gmbh | LIQUID FORMULATION OF G-CSF CONJUGATES |
| BRPI0815280A2 (pt) | 2007-08-27 | 2018-11-27 | Biogenerix Ag | medicamento que compreende uma formulação líquida aquosa de g-csf, receptáculo para a administração de medicamentos líquidos, seringa ou ampola, kit para a administração parenteral de g-csf |
| WO2009046015A2 (en) * | 2007-09-30 | 2009-04-09 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
| KR100921226B1 (ko) | 2007-10-04 | 2009-10-12 | 학교법인 선목학원 | 사람 혈액의 과립구집락자극인자(ｈＧ-ＣＳＦ) 유전자를 내장하는 레트로바이러스 발현벡터 및 이에 의해 형질전환된 가금 |
| GB2455204B (en) * | 2007-11-28 | 2010-07-14 | Smart Tube Inc | Devices, systems and methods for the collection, stimulation, stabilization and analysis of a biological sample |
| WO2009075841A2 (en) | 2007-12-10 | 2009-06-18 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
| CN103694337B (zh) | 2008-02-08 | 2016-03-02 | Ambrx公司 | 经修饰瘦素多肽和其用途 |
| RU2010148803A (ru) * | 2008-04-30 | 2012-06-10 | Ньютрон Роу (Bm) | Способы применения кортикотропин-рилизинг фактора для лечения рака |
| NZ623495A (en) | 2008-05-15 | 2015-08-28 | Celgene Corp | Oral formulations of cytidine analogs and methods of use thereof |
| UA118536C2 (uk) * | 2008-07-23 | 2019-02-11 | Амбркс, Інк. | Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування |
| WO2010092571A2 (en) | 2009-02-11 | 2010-08-19 | Yeda Research And Development Co. Ltd. | Short beta-defensin-derived peptides |
| CN102448472A (zh) | 2009-05-25 | 2012-05-09 | 国立大学法人东京工业大学 | 包含与中枢神经细胞的增殖和分化相关的核因子的药物组合物 |
| JP5715622B2 (ja) | 2009-06-14 | 2015-05-07 | バイオカイン セラピューティックス リミテッド | 血小板レベルを増大させるためのペプチド療法 |
| EP3366692A1 (en) | 2009-06-22 | 2018-08-29 | Amgen, Inc | Refolding proteins using a chemically controlled redox state |
| KR20120124353A (ko) | 2009-06-24 | 2012-11-13 | 스티븐 에반스-프레케 | 암 치료를 위해 코르티코트로핀 방출인자를 사용하는 방법 |
| EP2445924B2 (en) | 2009-06-25 | 2023-12-13 | Amgen Inc. | Capture purification processes for proteins expressed in a non-mammalian system |
| TW201120037A (en) * | 2009-10-26 | 2011-06-16 | Sunesis Pharmaceuticals Inc | Compounds and methods for treatment of cancer |
| US20110129858A1 (en) * | 2009-11-27 | 2011-06-02 | Changhua Christian Hospital | Prognosis Biomarker for Evaluating the Cure Level of Stroke Patient and a Method thereof |
| CN107674121A (zh) | 2009-12-21 | 2018-02-09 | Ambrx 公司 | 经过修饰的牛促生长素多肽和其用途 |
| PT2341061E (pt) | 2009-12-31 | 2013-11-05 | Arven Ilac Sanayi Ve Ticaret As | Um processo novo para a preparação de g-csf (fator de estimulação de colónias de granulócitos) |
| CA2789249A1 (en) * | 2010-02-19 | 2011-08-25 | Long Mao | Heterocyclic compounds and uses as anticancer agents |
| ES2639398T3 (es) | 2010-03-04 | 2017-10-26 | Pfenex Inc. | Método para producir proteína de interferón recombinante soluble sin desnaturalización |
| JP2013522236A (ja) | 2010-03-12 | 2013-06-13 | セルジーン コーポレイション | レナリドミドを使用する非ホジキンリンパ腫の治療方法、並びに予測因子としての遺伝子及びタンパク質バイオマーカー |
| US8455218B2 (en) | 2010-04-01 | 2013-06-04 | Pfenex, Inc. | Methods for G-CSF production in a Pseudomonas host cell |
| EP2600901B1 (en) * | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
| PT2621519T (pt) | 2010-09-28 | 2017-10-04 | Aegerion Pharmaceuticals Inc | Polipéptido de fusão de leptina-abd com duração de ação melhorada |
| US20140031325A1 (en) | 2010-12-06 | 2014-01-30 | Celgene Corporation | Combination therapy with lenalidomide and a cdk inhibitor for treating multiple myeloma |
| MX2013006020A (es) | 2011-01-31 | 2013-10-01 | Celgene Corp | Composicion farmaceutica de analogos de citidina y metodos para su uso. |
| CN103561744A (zh) | 2011-03-11 | 2014-02-05 | 细胞基因公司 | 3-(5-氨基-2-甲基-4-氧代喹唑啉-3(4h)-基)哌啶-2,6-二酮在治疗免疫相关性和炎症性疾病中的用途 |
| TWI601722B (zh) | 2011-03-11 | 2017-10-11 | 西建公司 | ３-（５-胺基-２-甲基-４-氧基-４ｈ-喹唑啉-３-基）-六氫吡啶-２，６-二酮之固體型式及其醫藥組合物及用途 |
| US9365640B2 (en) | 2011-04-29 | 2016-06-14 | Celgene Corporation | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
| US9320777B2 (en) | 2011-05-13 | 2016-04-26 | Bolder Biotechnology, Inc. | Methods and use of growth hormone supergene family protein analogs for treatment of radiation exposure |
| EP2771294B1 (en) | 2011-10-25 | 2017-12-13 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US10350139B2 (en) | 2011-10-25 | 2019-07-16 | Corning Incorporated | Pharmaceutical glass packaging assuring pharmaceutical sterility |
| JP6162709B2 (ja) | 2011-11-01 | 2017-07-12 | セルジーン コーポレイション | シチジンアナログの経口製剤を使用して癌を治療する方法 |
| US8889630B2 (en) | 2011-12-23 | 2014-11-18 | Carlos Lopez | Method for hair regrowth using Granulocyte-Colony Stimulating Factor |
| HUP1200171A1 (hu) | 2012-03-19 | 2013-09-30 | Richter Gedeon Nyrt | Módszerek polipeptidek elõállítására |
| HUP1200172A2 (en) | 2012-03-19 | 2013-10-28 | Richter Gedeon Nyrt | Methods for refolding g-csf from inclusion bodies |
| WO2013155347A1 (en) | 2012-04-11 | 2013-10-17 | Izumi Raquel | Bruton's tyrosine kinase inhibitors for hematopoietic mobilization |
| EP2841084B1 (en) | 2012-04-24 | 2018-05-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist peptide for use in the treatment of large cell lung cancer |
| JP6318152B2 (ja) | 2012-06-29 | 2018-04-25 | セルジーン コーポレイション | セレブロン関連タンパク質を利用して薬物効能を決定する方法 |
| US9732144B2 (en) | 2012-07-05 | 2017-08-15 | Ohio State Innovation Foundation | Infectious bursal disease (IBDV) vaccine compositions |
| WO2014022759A1 (en) | 2012-08-03 | 2014-02-06 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
| MX359508B (es) | 2012-08-09 | 2018-09-28 | Celgene Corp | Sales y formas solidas de (s)-3-(4-((4-(morfolinometil) bencil) oxi)-1-oxoisoindolin-2-il) piperidin-2,6-diona y composiciones que comprenden y metodos para utilizar las mismas. |
| NZ628078A (en) | 2012-08-09 | 2017-01-27 | Celgene Corp | Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
| US9587281B2 (en) | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| US9694015B2 (en) | 2012-09-10 | 2017-07-04 | Celgene Corporation | Methods for the treatment of locally advanced breast cancer |
| US9968627B2 (en) | 2013-03-26 | 2018-05-15 | Celgene Corporation | Solid forms comprising 4-amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one and a coformer, compositions and methods of use thereof |
| AU2014248263A1 (en) | 2013-04-02 | 2015-10-15 | Celgene Corporation | Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers |
| US9717648B2 (en) | 2013-04-24 | 2017-08-01 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9713572B2 (en) | 2013-04-24 | 2017-07-25 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9603775B2 (en) | 2013-04-24 | 2017-03-28 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9717649B2 (en) | 2013-04-24 | 2017-08-01 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9700486B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9707153B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9839579B2 (en) | 2013-04-24 | 2017-12-12 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9849066B2 (en) | 2013-04-24 | 2017-12-26 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9700485B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9707155B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| CA2913490A1 (en) | 2013-06-06 | 2014-12-11 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for identification, assessment, prevention, and treatment of cancer using pd-l1 isoforms |
| EP2815749A1 (en) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
| EP3757130A1 (en) | 2013-09-26 | 2020-12-30 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| WO2015057992A1 (en) | 2013-10-16 | 2015-04-23 | Izumi Raquel | Btk inhibitors for hematopoietic mobilization |
| WO2015073727A1 (en) | 2013-11-13 | 2015-05-21 | Aequus Biopharma, Inc. | Engineered glycoproteins and uses thereof |
| CA2935804A1 (en) | 2014-01-14 | 2015-07-23 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms |
| US20150359810A1 (en) | 2014-06-17 | 2015-12-17 | Celgene Corporation | Methods for treating epstein-barr virus (ebv) associated cancers using oral formulations of 5-azacytidine |
| ES2843973T3 (es) | 2014-06-27 | 2021-07-21 | Celgene Corp | Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3 |
| US9499514B2 (en) | 2014-07-11 | 2016-11-22 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| HUE061382T2 (hu) | 2014-08-22 | 2023-06-28 | Celgene Corp | Eljárás myeloma multiplex kezelésére immunomoduláló vegyületekkel, antestekkel kombinálva |
| US20180086808A1 (en) | 2015-03-16 | 2018-03-29 | Arven Ilac Sanayi Ve Ticaret A.S. | A process for preparing g-csf (granulocyte colony stimulating factor) |
| WO2016167291A1 (ja) | 2015-04-13 | 2016-10-20 | 国立研究開発法人産業技術総合研究所 | 環状化サイトカイン及びその製法 |
| EP3313818B1 (en) | 2015-06-26 | 2023-11-08 | Celgene Corporation | Methods for the treatment of kaposi's sarcoma or kshv-induced lymphoma using immunomodulatory compounds, and uses of biomarkers |
| KR20180063881A (ko) | 2015-07-16 | 2018-06-12 | 바이오카인 테라퓨틱스 리미티드 | 암 치료용 조성물 및 방법 |
| WO2017040387A2 (en) | 2015-08-31 | 2017-03-09 | Technovax, Inc. | Human respiratory syncytial virus (hrsv) virus-like particles (vlps) based vaccine |
| US11229683B2 (en) | 2015-09-18 | 2022-01-25 | Bolder Biotechnology, Inc. | Hematopoietic growth factor proteins and analogs thereof and angiotensin converting enzyme inhibitors for treatment of radiation exposure |
| EP3362074B1 (en) | 2015-10-16 | 2023-08-09 | President and Fellows of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
| EP3365359A1 (en) | 2015-10-19 | 2018-08-29 | Sandoz AG | Method for producing a recombinant protein with reduced impurities |
| EP3365360A1 (en) | 2015-10-19 | 2018-08-29 | Sandoz AG | Improved coding sequence for human g-csf |
| CN109069486A (zh) | 2015-12-14 | 2018-12-21 | X4 制药有限公司 | 治疗癌症的方法 |
| WO2017106328A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3393468B1 (en) | 2015-12-22 | 2022-09-14 | X4 Pharmaceuticals, Inc. | Methods for treating immunodeficiency disease |
| US10830762B2 (en) | 2015-12-28 | 2020-11-10 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases |
| CN108712904B (zh) | 2016-01-08 | 2022-08-02 | 细胞基因公司 | 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的固体形式以及其药物组合物和用途 |
| ES2832475T3 (es) | 2016-01-08 | 2021-06-10 | Celgene Corp | Compuestos antiproliferativos y sus composiciones farmacéuticas y usos |
| EA037508B1 (ru) | 2016-01-08 | 2021-04-06 | Селджин Корпорейшн | Композиции 2-(4-хлорфенил)-n-((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-5-ил)метил)-2,2-дифторацетамида |
| KR102033920B1 (ko) | 2016-02-23 | 2019-10-18 | 바이오라인알엑스 리미티드 | 급성 골수성 백혈병을 치료하는 방법 |
| US20210309965A1 (en) | 2016-03-21 | 2021-10-07 | Dana-Farber Cancer Institute, Inc. | T-cell exhaustion state-specific gene expression regulators and uses thereof |
| AU2017240050B2 (en) | 2016-04-01 | 2021-12-16 | Signal Pharmaceuticals, Llc | Solid forms of (1s,4s)-4-(2-(((3S4R)-3-fluorotetrahydro-2H-pyran-4-yl) amino)-8-((2,4,6-trichlorophenyl) amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use |
| WO2017173206A1 (en) | 2016-04-01 | 2017-10-05 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| WO2017177230A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3443107A1 (en) | 2016-04-13 | 2019-02-20 | Synthetic Genomics, Inc. | Recombinant arterivirus replicon systems and uses thereof |
| ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
| WO2017223229A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| JP6994767B2 (ja) | 2016-06-21 | 2022-01-14 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
| WO2018013689A1 (en) | 2016-07-13 | 2018-01-18 | Celgene Corporation | Solid dispersions and solid forms comprising 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, method of preparation and use thereof |
| WO2018013693A1 (en) | 2016-07-13 | 2018-01-18 | Celgene Corporation | Solid dispersions and cocrystals comprising 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione compositions and methods of use thereof |
| WO2018075235A1 (en) | 2016-10-17 | 2018-04-26 | Synthetic Genomics, Inc. | Recombinant virus replicon systems and uses thereof |
| EP3548625B1 (en) | 2016-12-05 | 2024-06-26 | Janssen Pharmaceuticals, Inc. | Compositions and methods for enhancing gene expression |
| WO2018165142A1 (en) | 2017-03-07 | 2018-09-13 | Celgene Corporation | Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
| SG11201911929XA (en) | 2017-06-21 | 2020-01-30 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| RS64029B1 (sr) | 2017-06-30 | 2023-03-31 | Celgene Corp | Kompozicije i postupci za upotrebu 2-(4-hlorfenil)-n-((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-5-il)metil)-2,2-difluoracetamida |
| AU2018345647A1 (en) | 2017-10-04 | 2020-04-16 | Celgene Corporation | Compositions and methods of use of cis-4-(2-{((3S,4R)-3-fluorooxan-4-yl) amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide |
| CN111417634A (zh) | 2017-10-04 | 2020-07-14 | 细胞基因公司 | 用于制备顺式-4-[2-{[(3s,4r)-3-氟噁烷-4-基]氨基}-8-(2,4,6-三氯苯胺基)-9h-嘌呤-9-基]-1-甲基环己烷-1-甲酰胺的方法 |
| CA3077215A1 (en) * | 2017-10-11 | 2019-04-18 | Elanco Us Inc. | Porcine g-csf variants and their uses |
| BR112020009055A2 (pt) | 2017-11-06 | 2020-11-03 | Rapt Therapeutics, Inc. | moduladores de receptor de quimiocina para tratamento de câncer positivo para vírus epstein barr |
| US11389531B2 (en) | 2017-12-19 | 2022-07-19 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines |
| US11021692B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Hepatitis B virus (HBV) vaccines and uses thereof |
| EA202091516A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv) |
| CN111902163B (zh) | 2018-01-19 | 2024-02-13 | 杨森制药公司 | 使用重组复制子系统诱导和增强免疫应答 |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| US20230078755A1 (en) | 2018-12-19 | 2023-03-16 | Shy Therapeutics, Llc | Compounds that Interact with the RAS Superfamily for the Treatment of Cancers, Inflammatory Diseases, Rasopathies, and Fibrotic Disease |
| WO2020234742A1 (en) | 2019-05-20 | 2020-11-26 | Lupin Limited | Granulocyte colony stimulating factor purification |
| MX2022005371A (es) | 2019-11-05 | 2022-08-04 | Celgene Corp | Terapia de combinacion con 2-(4-clorofenil)-n-((2-(2,6-dioxopiperi din-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida. |
| US20230227466A1 (en) | 2020-06-18 | 2023-07-20 | Shy Therapeutics, Llc | Substituted thienopyrimidines that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| AR129053A1 (es) | 2022-04-14 | 2024-07-10 | Bristol Myers Squibb Co | Nuevos compuestos gspt1 y métodos de uso de los nuevos compuestos |
| WO2024064646A1 (en) | 2022-09-20 | 2024-03-28 | Celgene Corporation | Salts and solid forms of (s)- or racemic 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and methods of using the same |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4358535A (en) * | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
| US4394443A (en) * | 1980-12-18 | 1983-07-19 | Yale University | Method for cloning genes |
| US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
| JPS6023777A (ja) * | 1983-07-15 | 1985-02-06 | 鶴海合成炉材株式会社 | 低融点金属用溶解保持手許炉 |
| WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
| US4710473A (en) * | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
| NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| JPS60206066A (ja) * | 1984-03-29 | 1985-10-17 | Toshiba Corp | 固体撮像装置 |
| JPS60209638A (ja) * | 1984-04-03 | 1985-10-22 | Diesel Kiki Co Ltd | デイ−ゼル機関用電子式ガバナ |
| JPS60217150A (ja) * | 1984-04-13 | 1985-10-30 | マツダ株式会社 | 塗装を施した繊維強化ウレタン成形品 |
| JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
| EP0215126B1 (en) * | 1985-02-08 | 1991-07-31 | Chugai Seiyaku Kabushiki Kaisha | Human granulocyte colony stimulating factor |
| JPH0615477B2 (ja) * | 1985-02-08 | 1994-03-02 | 中外製薬株式会社 | 感染防禦剤 |
| JPH01110629A (ja) * | 1985-04-05 | 1989-04-27 | Chugai Pharmaceut Co Ltd | 感染防禦剤 |
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| JPS63500636A (ja) * | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ |
| JPS62236497A (ja) * | 1985-09-17 | 1987-10-16 | Chugai Pharmaceut Co Ltd | 顆粒球コロニー刺激因子活性を有する糖蛋白質の製造方法 |
| ATE67517T1 (de) * | 1985-09-30 | 1991-10-15 | Chugai Pharmaceutical Co Ltd | Menschlicher granulozyten-colony stimulierender faktor. |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| JP2976258B2 (ja) * | 1992-07-07 | 1999-11-10 | 株式会社名機製作所 | ホットプレスの断熱材取付け構造 |
-
1986
- 1986-03-03 US US06/835,548 patent/US4810643A/en not_active Expired - Lifetime
- 1986-08-22 KR KR870700352A patent/KR880700071A/ko not_active Application Discontinuation
- 1986-08-22 AU AU63346/86A patent/AU6334686A/en not_active Abandoned
- 1986-08-22 NZ NZ217334A patent/NZ217334A/en unknown
- 1986-08-22 SG SG1996004322A patent/SG48964A1/en unknown
- 1986-08-22 EP EP86905530A patent/EP0237545B2/en not_active Expired - Lifetime
- 1986-08-22 IL IL79805A patent/IL79805A/xx not_active IP Right Cessation
- 1986-08-22 WO PCT/US1986/001708 patent/WO1987001132A1/en active IP Right Grant
- 1986-08-22 AT AT00101091T patent/ATE332375T1/de not_active IP Right Cessation
- 1986-08-22 GR GR862185A patent/GR862185B/el unknown
- 1986-08-22 PT PT83242A patent/PT83242B/pt unknown
- 1986-08-22 DE DE3650788T patent/DE3650788T2/de not_active Expired - Lifetime
- 1986-08-23 CN CN86106234A patent/CN1020924C/zh not_active Expired - Lifetime
- 1986-08-23 ES ES8601318A patent/ES2001883A6/es not_active Expired
- 1986-08-25 CA CA000516737A patent/CA1341537C/en not_active Expired - Lifetime
-
1987
- 1987-04-16 FI FI871700A patent/FI105191B/fi not_active IP Right Cessation
- 1987-04-22 DK DK198702044A patent/DK174980B1/da not_active IP Right Cessation
- 1987-04-22 NO NO871679A patent/NO303544B1/no not_active IP Right Cessation
-
1989
- 1989-05-02 JP JP1113512A patent/JP2527365B2/ja not_active Expired - Lifetime
- 1989-05-02 JP JP1113513A patent/JPH0231675A/ja active Granted
-
1991
- 1991-05-17 JP JP3141402A patent/JP2660178B2/ja not_active Expired - Lifetime
- 1991-09-27 JP JP3277149A patent/JP2660179B2/ja not_active Expired - Lifetime
-
1992
- 1992-03-26 SG SG358/92A patent/SG35892G/en unknown
- 1992-06-18 MX MX9202992A patent/MX9202992A/es unknown
- 1992-10-21 SA SA92130186A patent/SA92130186B1/ar unknown
- 1992-11-06 CY CY1642A patent/CY1642A/xx unknown
-
1993
- 1993-07-01 NL NL930127C patent/NL930127I1/nl unknown
-
1995
- 1995-05-26 US US08/452,135 patent/US5582823A/en not_active Expired - Lifetime
- 1995-06-02 US US08/459,298 patent/US5580755A/en not_active Expired - Lifetime
-
1996
- 1996-03-12 JP JP8055077A patent/JP2718426B2/ja not_active Expired - Lifetime
- 1996-07-11 US US08/678,692 patent/US5676941A/en not_active Expired - Fee Related
- 1996-07-15 US US08/679,897 patent/US5830705A/en not_active Expired - Fee Related
-
1997
- 1997-02-18 JP JP9033849A patent/JP2952203B2/ja not_active Expired - Lifetime
-
1998
- 1998-05-11 NO NO19982132A patent/NO314902B1/no active Protection Beyond IP Right Term
-
1999
- 1999-02-12 JP JP11034848A patent/JP3115561B2/ja not_active Expired - Lifetime
-
2000
- 2000-01-04 FI FI20000014A patent/FI107540B/fi not_active IP Right Cessation
- 2000-03-08 JP JP2000064219A patent/JP2000279185A/ja active Pending
- 2000-12-12 HK HK00107970A patent/HK1029600A1/xx not_active IP Right Cessation
-
2001
- 2001-02-21 FI FI20010334A patent/FI110576B/fi not_active IP Right Cessation
-
2002
- 2002-03-28 JP JP2002092947A patent/JP2002315578A/ja active Pending
-
2003
- 2003-05-19 NO NO20032250A patent/NO318755B1/no not_active IP Right Cessation
- 2003-11-13 NO NO2003008C patent/NO2003008I1/no unknown
- 2003-11-26 JP JP2003394905A patent/JP2004041242A/ja not_active Withdrawn
- 2003-12-09 NO NO2003010C patent/NO2003010I2/no not_active IP Right Cessation
-
2004
- 2004-12-17 NO NO20045548A patent/NO20045548L/no unknown
-
2006
- 2006-01-11 JP JP2006004052A patent/JP2006101889A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO303544B1 (no) | FremgangsmÕte for fremstilling av et polypeptid med Ún eller flere av de hematopoietiske biologiske egenskaper til granulocyttkolonistimulerende faktor (hpG-CSF) | |
| US4999291A (en) | Production of human pluripotent granulocyte colony-stimulating factor | |
| US6004548A (en) | Analogs of pluripotent granulocyte colony-stimulating factor | |
| EP1018552B1 (en) | Production of pluripotent granulocyte colony-stimulating factor | |
| AU727724B2 (en) | Production of pluripotent granulocyte colony-stimulating factor | |
| BG63065B2 (bg) | Аналози на плурипотентен гранулоцитен колония- стимулиращ фактор | |
| AU1110101A (en) | Production of pluripotent granulocyte colony-stimulating factor | |
| BG63285B2 (bg) | Получаване на човешки плурипотентен гранулоцитен колония - стимулиращ фактор | |
| AU2004202013A1 (en) | Production of pluripotent granulocyte colony-stimulating factor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SPCF | Filing of supplementary protection certificate |
Free format text: PRODUCT NAME: PEGFILGRASTIM; NAT. REG. NO/DATE: NO , EU/1/02/22 20030513; FIRST REG. NO/DATE: EP , EU/01/02/2 20020827 Spc suppl protection certif: 2003008 Filing date: 20031113 |
|
| MK1K | Patent expired |