MX359508B - Sales y formas solidas de (s)-3-(4-((4-(morfolinometil) bencil) oxi)-1-oxoisoindolin-2-il) piperidin-2,6-diona y composiciones que comprenden y metodos para utilizar las mismas. - Google Patents

Sales y formas solidas de (s)-3-(4-((4-(morfolinometil) bencil) oxi)-1-oxoisoindolin-2-il) piperidin-2,6-diona y composiciones que comprenden y metodos para utilizar las mismas.

Info

Publication number
MX359508B
MX359508B MX2015001636A MX2015001636A MX359508B MX 359508 B MX359508 B MX 359508B MX 2015001636 A MX2015001636 A MX 2015001636A MX 2015001636 A MX2015001636 A MX 2015001636A MX 359508 B MX359508 B MX 359508B
Authority
MX
Mexico
Prior art keywords
salts
oxoisoindolin
morpholinomethyl
dione
piperidine
Prior art date
Application number
MX2015001636A
Other languages
English (en)
Other versions
MX2015001636A (es
Inventor
M Cohen Benjamin
Li Ying
Xu Jean
F Traverse John
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49054882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX359508(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2015001636A publication Critical patent/MX2015001636A/es
Publication of MX359508B publication Critical patent/MX359508B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Se describen sales y formas sólidas de 3-(4-((4-(morfolinometil)be ncil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona, o un estereoisómero de las mismas. También se describen composiciones que comprenden y métodos para utilizar las sales y formas sólidas.
MX2015001636A 2012-08-09 2013-08-08 Sales y formas solidas de (s)-3-(4-((4-(morfolinometil) bencil) oxi)-1-oxoisoindolin-2-il) piperidin-2,6-diona y composiciones que comprenden y metodos para utilizar las mismas. MX359508B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261681484P 2012-08-09 2012-08-09
PCT/US2013/054064 WO2014025964A2 (en) 2012-08-09 2013-08-08 Salts and solid forms of (s)-3-(4-((4-morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and compositions comprising and methods of using the same

Publications (2)

Publication Number Publication Date
MX2015001636A MX2015001636A (es) 2015-08-14
MX359508B true MX359508B (es) 2018-09-28

Family

ID=49054882

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015001636A MX359508B (es) 2012-08-09 2013-08-08 Sales y formas solidas de (s)-3-(4-((4-(morfolinometil) bencil) oxi)-1-oxoisoindolin-2-il) piperidin-2,6-diona y composiciones que comprenden y metodos para utilizar las mismas.
MX2021006091A MX2021006091A (es) 2012-08-09 2015-02-05 Sales y formas solidas de (s)-3-(4-((4-(morfolinometil)bencil)oxi) -1-oxoisoindolin-2-il)piperidin-2,6-diona y composiciones que comprenden y metodos para utilizar las mismas.

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MX2021006091A MX2021006091A (es) 2012-08-09 2015-02-05 Sales y formas solidas de (s)-3-(4-((4-(morfolinometil)bencil)oxi) -1-oxoisoindolin-2-il)piperidin-2,6-diona y composiciones que comprenden y metodos para utilizar las mismas.

Country Status (37)

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US (7) US9221788B2 (es)
EP (3) EP3524598B1 (es)
JP (4) JP6419072B2 (es)
KR (1) KR20150041123A (es)
CN (2) CN104703978B (es)
AR (1) AR094997A1 (es)
AU (1) AU2013299631B2 (es)
BR (1) BR112015001874A2 (es)
CA (1) CA2878954C (es)
CL (1) CL2015000291A1 (es)
CR (1) CR20150050A (es)
CY (1) CY1121592T1 (es)
DK (1) DK2882737T3 (es)
EA (1) EA201590330A1 (es)
EC (1) ECSP15004234A (es)
ES (2) ES2723277T3 (es)
HK (1) HK1211576A1 (es)
HR (1) HRP20190398T1 (es)
HU (1) HUE042685T2 (es)
IL (1) IL236922A0 (es)
IN (1) IN2015DN00885A (es)
LT (1) LT2882737T (es)
MX (2) MX359508B (es)
NZ (1) NZ628030A (es)
PE (1) PE20150617A1 (es)
PH (1) PH12015500275A1 (es)
PL (1) PL2882737T3 (es)
PT (1) PT2882737T (es)
RS (1) RS58548B1 (es)
SA (1) SA515360022B1 (es)
SG (1) SG11201500999WA (es)
SI (1) SI2882737T1 (es)
TR (1) TR201904785T4 (es)
TW (1) TW201408657A (es)
UA (1) UA114521C2 (es)
WO (1) WO2014025964A2 (es)
ZA (1) ZA201500326B (es)

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