MX374906B - Nuevos inmunoconjugados - Google Patents

Nuevos inmunoconjugados

Info

Publication number
MX374906B
MX374906B MX2018003540A MX2018003540A MX374906B MX 374906 B MX374906 B MX 374906B MX 2018003540 A MX2018003540 A MX 2018003540A MX 2018003540 A MX2018003540 A MX 2018003540A MX 374906 B MX374906 B MX 374906B
Authority
MX
Mexico
Prior art keywords
immunoconjugates
methods
present
relates
polynucleotides
Prior art date
Application number
MX2018003540A
Other languages
English (en)
Inventor
Ast Oliver
Christian Klein
Ekkehard Moessner
Pablo Umana
Peter Bruenker
Ralf Hosse
Thomas Hofer
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46022216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX374906(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of MX374906B publication Critical patent/MX374906B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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Abstract

La presente invención en general está relacionada con inmunoconjugados específicos de antígeno para la liberación selectiva de porciones efectoras que influyen en la actividad celular. Más específicamente, la invención proporciona nuevos inmunoconjugados que comprenden una primera porción de unión a antígeno, un dominio Fc y una única porción efectora. Además, la presente invención está relacionada con los polinucleótidos que codifican tales inmunoconjugados, y con los vectores y células huésped que comprenden tales polinucleótidos. La invención además está relacionada con los métodos para producir los inmunoconjugados de la invención, y con los métodos de utilización de estos inmunoconjugados en el tratamiento de una enfermedad.
MX2018003540A 2011-04-29 2012-04-26 Nuevos inmunoconjugados MX374906B (es)

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