EA201600418A1 - Новые иммуноконъюгаты - Google Patents
Новые иммуноконъюгатыInfo
- Publication number
- EA201600418A1 EA201600418A1 EA201600418A EA201600418A EA201600418A1 EA 201600418 A1 EA201600418 A1 EA 201600418A1 EA 201600418 A EA201600418 A EA 201600418A EA 201600418 A EA201600418 A EA 201600418A EA 201600418 A1 EA201600418 A1 EA 201600418A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- immunoconjugates
- application
- application describes
- contain
- describes
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 6
- 239000012634 fragment Substances 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000012636 effector Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2319/00—Fusion polypeptide
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- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
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Abstract
В целом, в заявке описаны антигенспецифические иммуноконъюгаты, предназначенные для введения эффекторных фрагментов, которые влияют на клеточную активность. Более конкретно, в заявке описаны новые иммуноконъюгаты, которые содержат первый антигенсвязывающий фрагмент, Fc-домен и единичный эффекторный фрагмент. Кроме того, в заявке описаны полинуклеотиды, кодирующие указанные иммуноконъюгаты, и векторы и клетки-хозяева, которые содержат указанные полинуклеотиды. В заявке описаны также способы получения иммуноконъюгатов, предлагаемых в изобретении, и способы применения указанных иммуноконъюгатов для лечения заболевания.
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EA201600418A EA034251B1 (ru) | 2011-04-29 | 2012-04-26 | Новые иммуноконъюгаты |
EA201301208A EA025851B1 (ru) | 2011-04-29 | 2012-04-26 | Новые иммуноконъюгаты |
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