EA201791843A2 - Способы повышения эффективности folr1 терапии рака - Google Patents
Способы повышения эффективности folr1 терапии ракаInfo
- Publication number
- EA201791843A2 EA201791843A2 EA201791843A EA201791843A EA201791843A2 EA 201791843 A2 EA201791843 A2 EA 201791843A2 EA 201791843 A EA201791843 A EA 201791843A EA 201791843 A EA201791843 A EA 201791843A EA 201791843 A2 EA201791843 A2 EA 201791843A2
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- increasing
- efficiency
- cancer therapy
- folr1
- Prior art date
Links
- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102100035139 Folate receptor alpha Human genes 0.000 title 1
- 238000011275 oncology therapy Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 102000053180 human FOLR1 Human genes 0.000 abstract 1
- 238000002626 targeted therapy Methods 0.000 abstract 1
Classifications
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Biophysics (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
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Abstract
Представляются способы повышения возможности успеха при таргетной терапии рака, направленной против человеческого рецептора фолата 1. Наборы включают реагенты для использования с помощью дополнительно предусмотренных способов.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161471007P | 2011-04-01 | 2011-04-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201791843A2 true EA201791843A2 (ru) | 2017-12-29 |
EA201791843A3 EA201791843A3 (ru) | 2018-05-31 |
Family
ID=46932392
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791843A EA201791843A3 (ru) | 2011-04-01 | 2012-03-30 | Способы повышения эффективности folr1 терапии рака |
EA201391351A EA028805B1 (ru) | 2011-04-01 | 2012-03-30 | Способы повышения эффективности folr1 терапии рака |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201391351A EA028805B1 (ru) | 2011-04-01 | 2012-03-30 | Способы повышения эффективности folr1 терапии рака |
Country Status (29)
Country | Link |
---|---|
US (4) | US8709432B2 (ru) |
EP (4) | EP2694106B1 (ru) |
JP (6) | JP6018621B2 (ru) |
KR (6) | KR20230013283A (ru) |
CN (3) | CN108743965A (ru) |
AU (4) | AU2012236219B2 (ru) |
BR (1) | BR112013025415B1 (ru) |
CA (2) | CA2831426C (ru) |
CY (1) | CY1119960T1 (ru) |
DK (1) | DK2694106T3 (ru) |
EA (2) | EA201791843A3 (ru) |
ES (2) | ES2965109T3 (ru) |
HK (1) | HK1254759A1 (ru) |
HR (1) | HRP20180358T1 (ru) |
HU (1) | HUE036172T2 (ru) |
IL (5) | IL303208A (ru) |
LT (1) | LT2694106T (ru) |
ME (1) | ME03025B (ru) |
MX (3) | MX346555B (ru) |
MY (2) | MY186591A (ru) |
NO (1) | NO2893540T3 (ru) |
PL (1) | PL2694106T3 (ru) |
PT (1) | PT2694106T (ru) |
RS (1) | RS56916B1 (ru) |
SG (2) | SG193514A1 (ru) |
SI (1) | SI2694106T1 (ru) |
TR (1) | TR201802659T4 (ru) |
UA (2) | UA125636C2 (ru) |
WO (1) | WO2012135675A2 (ru) |
Families Citing this family (42)
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CN102448500A (zh) | 2009-06-03 | 2012-05-09 | 免疫基因公司 | 轭合方法 |
NZ724971A (en) | 2010-02-24 | 2019-06-28 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
EA201991268A3 (ru) | 2011-03-29 | 2020-01-31 | Иммуноджен, Инк. | Получение конъюгатов "майтансиноид-антитело" одностадийным способом |
KR20230013283A (ko) * | 2011-04-01 | 2023-01-26 | 이뮤노젠 아이엔씨 | Folr1 암 치료의 효능을 증가시키기 위한 방법 |
PL2890717T3 (pl) | 2012-08-31 | 2020-08-10 | Immunogen, Inc. | Testy i zestawy diagnostyczne do wykrywania receptora folianu |
RU2018122734A (ru) | 2012-10-04 | 2018-07-24 | Иммуноджен, Инк. | Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент-цитотоксический агент |
WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
AU2013355931B2 (en) | 2012-12-07 | 2019-03-14 | Kyowa Kirin Co., Ltd. | Anti-FOLR1 antibody |
SG11201504887TA (en) | 2012-12-21 | 2015-07-30 | Bioalliance Cv | Hydrophilic self-immolative linkers and conjugates thereof |
US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
CN105308072A (zh) * | 2013-05-14 | 2016-02-03 | 伊缪诺金公司 | 抗folr1免疫缀合物给药方案 |
AU2014312086B2 (en) * | 2013-08-30 | 2020-03-12 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
JP6463744B2 (ja) * | 2013-10-08 | 2019-02-06 | イミュノジェン, インコーポレイテッド | 抗folr1免疫抱合体投薬レジメン |
US20150297744A1 (en) * | 2014-03-28 | 2015-10-22 | Immunogen, Inc. | Anti-FOLR1 Immunoconjugate Dosing Regimens |
JP2017528418A (ja) * | 2014-06-20 | 2017-09-28 | バイオアライアンス コマンディテール フェンノートシャップ | 抗葉酸受容体アルファ(fra)抗体−薬物コンジュゲート及びその使用方法 |
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US9381256B2 (en) | 2014-09-03 | 2016-07-05 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
CN116514903A (zh) | 2014-09-03 | 2023-08-01 | 伊缪诺金公司 | 细胞毒性苯并二氮杂䓬衍生物 |
DK3221355T3 (da) | 2014-11-20 | 2020-12-07 | Hoffmann La Roche | Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler CD3 og folatreceptor 1 (FolR1) samt PD-1-aksebindende antagonister |
JP6768786B2 (ja) * | 2015-07-30 | 2020-10-14 | エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc. | 最適な癌療法のためのFR−αおよびGARTタンパク質の定量 |
MA42844A (fr) * | 2015-09-17 | 2018-07-25 | Immunogen Inc | Combinaisons thérapeutiques comprenant des immunoconjugués anti-folr1 |
US20170189548A1 (en) | 2015-11-25 | 2017-07-06 | Immunogen, Inc. | Pharmaceutical formulations and methods of use thereof |
CN108713026B (zh) | 2016-01-08 | 2023-01-06 | 美国全心医药生技股份有限公司 | 四价抗psgl-1抗体及其用途 |
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- 2021-08-31 US US17/463,156 patent/US20220143208A1/en active Pending
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2022
- 2022-02-10 JP JP2022019315A patent/JP2022062219A/ja not_active Withdrawn
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