EA201590962A1 - Новые соединения - Google Patents

Новые соединения

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Publication number
EA201590962A1
EA201590962A1 EA201590962A EA201590962A EA201590962A1 EA 201590962 A1 EA201590962 A1 EA 201590962A1 EA 201590962 A EA201590962 A EA 201590962A EA 201590962 A EA201590962 A EA 201590962A EA 201590962 A1 EA201590962 A1 EA 201590962A1
Authority
EA
Eurasian Patent Office
Prior art keywords
new connections
therapy
relates
present
heterocyclic compounds
Prior art date
Application number
EA201590962A
Other languages
English (en)
Other versions
EA028507B1 (ru
Inventor
Лилиан Алькара
Роберт Эндрю Хилд
Джонатан Марк Саттон
Элизабетта Армани
Кармелида Капальди
Original Assignee
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50030225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201590962(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. filed Critical КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Publication of EA201590962A1 publication Critical patent/EA201590962A1/ru
Publication of EA028507B1 publication Critical patent/EA028507B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/08—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/20—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/19—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/02—Formic acid
    • C07C53/06—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к гетероциклическим соединениям, которые представляют собой пиримидиноновые производные, обладающие ингибирующими человеческую нейтрофил-эластазу свойствами, и их применению в терапии.
EA201590962A 2012-12-18 2013-12-16 Соединения EA028507B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12197767 2012-12-18
EP13158757 2013-03-12
PCT/EP2013/076672 WO2014095700A1 (en) 2012-12-18 2013-12-16 Novel compounds

Publications (2)

Publication Number Publication Date
EA201590962A1 true EA201590962A1 (ru) 2015-10-30
EA028507B1 EA028507B1 (ru) 2017-11-30

Family

ID=50030225

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590962A EA028507B1 (ru) 2012-12-18 2013-12-16 Соединения

Country Status (33)

Country Link
US (2) US9365577B2 (ru)
EP (1) EP2935274B1 (ru)
JP (1) JP6390919B2 (ru)
KR (1) KR102197721B1 (ru)
CN (1) CN104870449B (ru)
AU (1) AU2013363783B2 (ru)
BR (1) BR112015014438B1 (ru)
CA (1) CA2895352C (ru)
CL (1) CL2015001678A1 (ru)
CY (1) CY1122368T1 (ru)
DK (1) DK2935274T3 (ru)
EA (1) EA028507B1 (ru)
ES (1) ES2700226T3 (ru)
GE (1) GEP20186885B (ru)
HK (1) HK1212985A1 (ru)
HR (1) HRP20182007T1 (ru)
IL (1) IL239447B (ru)
LT (1) LT2935274T (ru)
MX (1) MX2015007379A (ru)
NZ (1) NZ709153A (ru)
PE (1) PE20151084A1 (ru)
PH (1) PH12015501043B1 (ru)
PL (1) PL2935274T3 (ru)
PT (1) PT2935274T (ru)
RS (1) RS58129B1 (ru)
SA (1) SA515360612B1 (ru)
SG (2) SG11201504737RA (ru)
SI (1) SI2935274T1 (ru)
TN (1) TN2015000276A1 (ru)
TW (1) TWI675837B (ru)
UA (1) UA118021C2 (ru)
WO (1) WO2014095700A1 (ru)
ZA (1) ZA201504331B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
CA2933725A1 (en) * 2013-12-16 2015-06-25 Chiesi Farmaceutici S.P.A. Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors
US9487528B2 (en) * 2014-06-09 2016-11-08 Chiesi Farmaceutici S.P.A. Compounds
PL3154977T3 (pl) 2014-06-12 2018-10-31 Chiesi Farmaceutici S.P.A. Nowe związki
US9475779B2 (en) 2014-07-31 2016-10-25 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9657015B2 (en) 2014-07-31 2017-05-23 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
US9890169B2 (en) 2015-12-14 2018-02-13 Chiesi Farmaceutici S.P.A. Triazolinone compounds as HNE inhibitors
EP3464269B1 (en) 2016-05-31 2020-04-01 Chiesi Farmaceutici S.p.A. Heterocyclic compounds for use in the treatment of a hne related disease
EP3464268B1 (en) 2016-05-31 2020-03-11 Chiesi Farmaceutici S.p.A. Novel compounds
JP6990663B2 (ja) 2016-05-31 2022-01-13 シエッシ ファーマスーティシ エス．ピー．エー． ヒト好中球エラスターゼ阻害剤としてのイミダゾロン化合物
AU2019373948B2 (en) 2018-10-30 2023-11-16 Chiesi Farmaceutici S.P.A. Apparatus to administer drugs to mechanically ventilated patients
US20220331244A1 (en) 2019-09-24 2022-10-20 Chiesi Farmaceutici S.P.A. Novel carrier particles for dry powder formulations for inhalation
WO2023118252A1 (en) 2021-12-22 2023-06-29 Chiesi Farmaceutici S.P.A. Triazolone derivative salt as neutrophil elastase inhibitor
AR128054A1 (es) 2021-12-22 2024-03-20 Chiesi Farm Spa Sal derivada de triazolona como inhibidor de elastasa de neutrófilos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
KR20000005039A (ko) * 1996-03-28 2000-01-25 그레이엄 브레레톤, 레슬리 에드워즈 호중구 엘라스타제 억제제로서의 피롤로피롤론 유도체
GB0608844D0 (en) * 2006-05-04 2006-06-14 Argenta Discovery Ltd Enzyme inhibitors
DE102009004197A1 (de) * 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung
GB201004179D0 (en) * 2010-03-12 2010-04-28 Pulmagen Therapeutics Inflamma Enzyme inhibitors
GB201004178D0 (en) * 2010-03-12 2010-04-28 Pulmagen Therapeutics Inflamma Enzyme inhibitors
RU2622643C2 (ru) * 2011-09-14 2017-06-19 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные тетрагидротриазолопиримидина в качестве ингибиторов нейтрофильной эластазы человека

Also Published As

Publication number Publication date
PL2935274T3 (pl) 2019-04-30
PT2935274T (pt) 2018-12-05
KR20150095692A (ko) 2015-08-21
NZ709153A (en) 2019-01-25
CN104870449B (zh) 2018-11-06
MX2015007379A (es) 2015-09-23
EP2935274B1 (en) 2018-10-03
BR112015014438B1 (pt) 2023-02-14
RS58129B1 (sr) 2019-02-28
US9828382B2 (en) 2017-11-28
WO2014095700A1 (en) 2014-06-26
IL239447B (en) 2018-06-28
CN104870449A (zh) 2015-08-26
US9365577B2 (en) 2016-06-14
HRP20182007T1 (hr) 2019-01-25
JP2016507488A (ja) 2016-03-10
SG10201703484YA (en) 2017-06-29
KR102197721B1 (ko) 2021-01-05
GEP20186885B (en) 2018-08-10
AU2013363783B2 (en) 2018-02-08
SG11201504737RA (en) 2015-07-30
PH12015501043A1 (en) 2015-07-27
EA028507B1 (ru) 2017-11-30
US20140171414A1 (en) 2014-06-19
SA515360612B1 (ar) 2018-01-04
PH12015501043B1 (en) 2015-07-27
CY1122368T1 (el) 2020-07-31
AU2013363783A1 (en) 2015-07-02
UA118021C2 (uk) 2018-11-12
CL2015001678A1 (es) 2015-10-23
EP2935274A1 (en) 2015-10-28
ES2700226T3 (es) 2019-02-14
CA2895352C (en) 2022-05-17
PE20151084A1 (es) 2015-08-07
IL239447A0 (en) 2015-07-30
HK1212985A1 (zh) 2016-06-24
TW201437210A (zh) 2014-10-01
US20160251362A1 (en) 2016-09-01
TN2015000276A1 (fr) 2016-10-03
SI2935274T1 (sl) 2018-12-31
BR112015014438A2 (pt) 2017-07-11
DK2935274T3 (en) 2018-11-26
ZA201504331B (en) 2016-11-30
TWI675837B (zh) 2019-11-01
CA2895352A1 (en) 2014-06-26
JP6390919B2 (ja) 2018-09-19
LT2935274T (lt) 2018-12-10

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