KR20150002782A - Ampk를 활성화시키는 인돌 및 인다졸 화합물 - Google Patents

Ampk를 활성화시키는 인돌 및 인다졸 화합물 Download PDF

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KR20150002782A
KR20150002782A KR20147031394A KR20147031394A KR20150002782A KR 20150002782 A KR20150002782 A KR 20150002782A KR 20147031394 A KR20147031394 A KR 20147031394A KR 20147031394 A KR20147031394 A KR 20147031394A KR 20150002782 A KR20150002782 A KR 20150002782A
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alkyl
alkoxy
hydroxy
independently
carbonyl
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사밋 쿠마르 바따차랴
킴벌리 오키피 카메론
매튜 스캇 다울링
데이빗 크리스토퍼 에브너
딜리니 프라사디니 페르난도
케빈 제임스 필립스키
다니엘 웨이 셩 쿵
에스더 쳉 인 리
애론 크리스토퍼 스미스
메이후아 마이크 투
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화이자 인코포레이티드
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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  • Animal Behavior & Ethology (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR20147031394A 2012-04-10 2013-04-01 Ampk를 활성화시키는 인돌 및 인다졸 화합물 Ceased KR20150002782A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261622129P 2012-04-10 2012-04-10
US61/622,129 2012-04-10
PCT/IB2013/052604 WO2013153479A2 (en) 2012-04-10 2013-04-01 Indole and indazole compounds that activate ampk

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KR20150002782A true KR20150002782A (ko) 2015-01-07

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KR20147031394A Ceased KR20150002782A (ko) 2012-04-10 2013-04-01 Ampk를 활성화시키는 인돌 및 인다졸 화합물

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EP (1) EP2836490B1 (enExample)
JP (1) JP6026642B2 (enExample)
KR (1) KR20150002782A (enExample)
CN (1) CN104245688A (enExample)
AP (1) AP2014007983A0 (enExample)
AR (1) AR090633A1 (enExample)
AU (1) AU2013246552A1 (enExample)
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MX379846B (es) 2015-06-18 2025-03-11 89Bio Ltd Derivados de 4-bencil y 4-benzoil piperidina sustituidos.
WO2017011917A1 (en) * 2015-07-23 2017-01-26 Thrasos Therapeutics Inc. Methods for treating and preventing polycystic kidney diseases (pkd) using amp-activated protein kinase (ampk) modulators and activators
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CN115650985B (zh) 2016-04-15 2024-08-02 癌症研究科技有限公司 作为ret激酶抑制剂的杂环化合物
HUE057838T2 (hu) 2016-06-07 2022-06-28 Jacobio Pharmaceuticals Co Ltd SHP2 inhibitorokként hasznos új heterociklusos származékok
US20190350955A1 (en) 2016-06-30 2019-11-21 Inserm (Institut National De La Sante Et De La Recherche Medicale Methods and pharmaceutical compositions for the treatment of cardiomyopathies
JOP20190042B1 (ar) 2016-09-30 2021-08-17 Vertex Pharma مُعدِّل‏ لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل
JOP20190125B1 (ar) 2016-12-09 2022-03-14 Vertex Pharma مُعدِّل‏ لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل
TWI664175B (zh) 2017-03-23 2019-07-01 大陸商北京加科思新藥研發有限公司 用於作為shp2抑制劑之新穎雜環衍生物
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US11434201B2 (en) 2017-08-02 2022-09-06 Vertex Pharmaceuticals Incorporated Processes for preparing pyrrolidine compounds
US10654829B2 (en) 2017-10-19 2020-05-19 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of CFTR modulators
CA3085006A1 (en) 2017-12-08 2019-06-13 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
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LT2836490T (lt) 2017-08-10
US20130267493A1 (en) 2013-10-10
ES2637238T3 (es) 2017-10-11
TWI465431B (zh) 2014-12-21
CN104245688A (zh) 2014-12-24
SI2836490T1 (sl) 2017-08-31
CY1119194T1 (el) 2018-02-14
CR20140411A (es) 2014-10-14
US20150038484A1 (en) 2015-02-05
DK2836490T3 (en) 2017-07-31
AU2013246552A1 (en) 2014-09-25
EA201491592A1 (ru) 2015-03-31
RS56290B1 (sr) 2017-12-29
CU20140118A7 (es) 2014-11-27
ECSP14020545A (es) 2017-07-31
TN2014000420A1 (fr) 2016-03-30
CA2869692C (en) 2016-08-02
JP2015512931A (ja) 2015-04-30
EA028564B1 (ru) 2017-12-29
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MX2014012330A (es) 2015-01-12
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PH12014502280A1 (en) 2014-12-15

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