AU2002239277A1 - Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof - Google Patents

Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof

Info

Publication number
AU2002239277A1
AU2002239277A1 AU2002239277A AU3927702A AU2002239277A1 AU 2002239277 A1 AU2002239277 A1 AU 2002239277A1 AU 2002239277 A AU2002239277 A AU 2002239277A AU 3927702 A AU3927702 A AU 3927702A AU 2002239277 A1 AU2002239277 A1 AU 2002239277A1
Authority
AU
Australia
Prior art keywords
pharmaceutical compositions
adenylyl cyclase
based inhibitors
adenine
adenine based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002239277A
Inventor
Kim Kane-Maguire
Daniel E Levy
Charles Marlowe
Robert M. Scarborough Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COR Therapeutics Inc
Original Assignee
COR Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by COR Therapeutics Inc filed Critical COR Therapeutics Inc
Publication of AU2002239277A1 publication Critical patent/AU2002239277A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2002239277A 2000-11-20 2001-11-20 Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof Abandoned AU2002239277A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24946500P 2000-11-20 2000-11-20
US60/249,465 2000-11-20
PCT/US2001/043294 WO2002040481A2 (en) 2000-11-20 2001-11-20 Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof

Publications (1)

Publication Number Publication Date
AU2002239277A1 true AU2002239277A1 (en) 2002-05-27

Family

ID=22943575

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002239277A Abandoned AU2002239277A1 (en) 2000-11-20 2001-11-20 Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof

Country Status (3)

Country Link
US (1) US6887880B2 (en)
AU (1) AU2002239277A1 (en)
WO (1) WO2002040481A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060252774A1 (en) * 2002-05-02 2006-11-09 Vatner Stephen F Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases
AU2004233863B2 (en) 2003-04-24 2010-06-17 Incyte Holdings Corporation Aza spiro alkane derivatives as inhibitors of metalloproteases
US20070225303A1 (en) * 2004-03-26 2007-09-27 Haruhisa Ogita 8-Oxoadenine Compound
TWI414525B (en) * 2004-03-26 2013-11-11 Dainippon Sumitomo Pharma Co 9-substituted-8-oxoadenine compound
US8138172B2 (en) 2006-07-05 2012-03-20 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of TLR7
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
WO2009063446A2 (en) 2007-11-13 2009-05-22 Oridion Medical (1987) Ltd. Medical system, apparatus and method
WO2008114006A1 (en) * 2007-03-19 2008-09-25 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7) modulators
PT2132209E (en) * 2007-03-19 2014-04-15 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators
PE20081887A1 (en) * 2007-03-20 2009-01-16 Dainippon Sumitomo Pharma Co NEW ADENINE COMPOUND
EP2138497A4 (en) 2007-03-20 2012-01-04 Dainippon Sumitomo Pharma Co Novel adenine compound
WO2008135791A1 (en) * 2007-05-08 2008-11-13 Astrazeneca Ab Imidazoquinolines with immuno-modulating properties
US8003692B2 (en) * 2007-06-15 2011-08-23 Board Of Regents, The University Of Texas System Methods and compositions to inhibit edema factor and adenylyl cyclase
PE20091156A1 (en) 2007-12-17 2009-09-03 Astrazeneca Ab SALTS OF (3 - {[[3- (6-AMINO-2-BUTOXY-8-OXO-7,8-DIHIDRO-9H-PURIN-9-IL) PROPYL] (3-MORFOLIN-4-ILPROPIL) AMINO] METHYL} PHENYL) METHYL ACETATE
US8865896B2 (en) * 2008-01-17 2014-10-21 Astrazeneca Aktiebolag Method for preparing adenine compound
JPWO2009091031A1 (en) * 2008-01-17 2011-05-26 大日本住友製薬株式会社 Method for producing adenine compound
WO2011068233A1 (en) * 2009-12-03 2011-06-09 Dainippon Sumitomo Pharma Co., Ltd. Imidazoquinolines which act via toll - like receptors (tlr)
ES2575688T3 (en) 2010-12-16 2016-06-30 Sumitomo Dainippon Pharma Co., Ltd. Imidazo [4,5-c] quinolin-1-yl derivative useful in therapy
US8895570B2 (en) 2010-12-17 2014-11-25 Astrazeneca Ab Purine derivatives
US10893824B2 (en) * 2010-12-20 2021-01-19 Cardiac Pacemakers, Inc. Heart failure detection with a sequential classifier
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
CN106414446A (en) * 2014-03-13 2017-02-15 新加坡科技研究局 Fused pyrimidine-based hydroxamate derivatives
CN108558882B (en) * 2018-04-12 2020-08-04 河南师范大学 Method for synthesizing chiral five-membered carbocyclic purine nucleoside through [3+2] cycloaddition based on allenoic acid ester

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224438A (en) * 1970-07-14 1980-09-23 Boehringer Mannheim Gmbh Adenosine-5'-carboxylic acid amides
US3855206A (en) * 1973-04-11 1974-12-17 Abbott Lab Adenosine-5{40 -carbohydroxamic esters
US4479942A (en) * 1981-08-10 1984-10-30 Fujisawa Pharmaceutical Co., Ltd. Tetrahydrofurnancarboxylic acid derivatives, processes for preparation thereof and pharmaceutical compositions thereof
US5310731A (en) * 1984-06-28 1994-05-10 Whitby Research, Inc. N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
DE19741739B4 (en) * 1997-09-22 2006-04-27 Nanogen Recognomics Gmbh Supramolecular mating system, its production and use

Also Published As

Publication number Publication date
US20020068745A1 (en) 2002-06-06
WO2002040481A2 (en) 2002-05-23
US6887880B2 (en) 2005-05-03
WO2002040481A3 (en) 2003-03-13

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