IN2014DN09200A - - Google Patents

Info

Publication number
IN2014DN09200A
IN2014DN09200A IN9200DEN2014A IN2014DN09200A IN 2014DN09200 A IN2014DN09200 A IN 2014DN09200A IN 9200DEN2014 A IN9200DEN2014 A IN 9200DEN2014A IN 2014DN09200 A IN2014DN09200 A IN 2014DN09200A
Authority
IN
India
Prior art keywords
ampk
compounds
indole
activate
activation
Prior art date
Application number
Inventor
Samit Kumar Bhattacharya
Kimberly OKeefe CAMERON
Matthew Scott Dowling
David Christopher Ebner
Dilinie Prasadhini Fernando
Kevin James Filipski
Daniel Wei Shung Kung
Esther Cheng Yin Lee
Aaron Christopher Smith
Meihua Mike Tu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IN2014DN09200A publication Critical patent/IN2014DN09200A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to indole and indazole compounds of Formula (I) that activate 5 adenosine monophosphate activated protein kinase (AMPK). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases conditions or disorders ameliorated by activation of AMPK.
IN9200DEN2014 2012-04-10 2013-04-01 IN2014DN09200A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261622129P 2012-04-10 2012-04-10
PCT/IB2013/052604 WO2013153479A2 (en) 2012-04-10 2013-04-01 Indole and indazole compounds that activate ampk

Publications (1)

Publication Number Publication Date
IN2014DN09200A true IN2014DN09200A (en) 2015-07-10

Family

ID=48237173

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9200DEN2014 IN2014DN09200A (en) 2012-04-10 2013-04-01

Country Status (42)

Country Link
US (2) US8889730B2 (en)
EP (1) EP2836490B1 (en)
JP (1) JP6026642B2 (en)
KR (1) KR20150002782A (en)
CN (1) CN104245688A (en)
AP (1) AP2014007983A0 (en)
AR (1) AR090633A1 (en)
AU (1) AU2013246552A1 (en)
CA (1) CA2869692C (en)
CO (1) CO7091185A2 (en)
CR (1) CR20140411A (en)
CU (1) CU20140118A7 (en)
CY (1) CY1119194T1 (en)
DK (1) DK2836490T3 (en)
DO (1) DOP2014000228A (en)
EA (1) EA028564B1 (en)
EC (2) ECSP14020545A (en)
ES (1) ES2637238T3 (en)
GT (1) GT201400215A (en)
HK (1) HK1202547A1 (en)
HR (1) HRP20171028T1 (en)
HU (1) HUE033096T2 (en)
IL (1) IL234860A0 (en)
IN (1) IN2014DN09200A (en)
LT (1) LT2836490T (en)
MD (1) MD20140109A2 (en)
ME (1) ME02729B (en)
MX (1) MX2014012330A (en)
NI (1) NI201400121A (en)
NZ (1) NZ630700A (en)
PE (1) PE20142294A1 (en)
PH (1) PH12014502280A1 (en)
PL (1) PL2836490T3 (en)
PT (1) PT2836490T (en)
RS (1) RS56290B1 (en)
SG (1) SG11201405571SA (en)
SI (1) SI2836490T1 (en)
TN (1) TN2014000420A1 (en)
TW (1) TWI465431B (en)
UY (1) UY34736A (en)
WO (2) WO2013153479A2 (en)
ZA (1) ZA201406792B (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014121055A2 (en) * 2013-02-04 2014-08-07 Janssen Pharmaceutica Nv Flap modulators
TWI644899B (en) 2013-02-04 2018-12-21 健生藥品公司 Flap modulators
US9890119B2 (en) 2013-02-27 2018-02-13 Shionogi & Co., Ltd. Indole and azaindole derivative having AMPK-activating activity
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6435923B2 (en) * 2014-03-07 2018-12-12 Jnc株式会社 Dihydropyran compound, liquid crystal composition, and liquid crystal display device
WO2016031842A1 (en) 2014-08-27 2016-03-03 塩野義製薬株式会社 Azaindole derivative having ampk-activating effect
NZ768373A (en) 2014-10-06 2024-03-22 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
WO2016092413A1 (en) * 2014-12-10 2016-06-16 Pfizer Inc. Indole and indazole compounds that activate ampk
EP3224245B1 (en) * 2014-12-24 2018-09-12 National Institute Of Biological Sciences, Beijing Necrosis inhibitors
CN107847765B (en) 2015-06-18 2021-05-04 89生物有限公司 1,4-Substituted piperidine derivatives
MX379846B (en) 2015-06-18 2025-03-11 89Bio Ltd SUBSTITUTED 4-BENZYL AND 4-BENZOYL PIPERIDINE DERIVATIVES.
WO2017011917A1 (en) * 2015-07-23 2017-01-26 Thrasos Therapeutics Inc. Methods for treating and preventing polycystic kidney diseases (pkd) using amp-activated protein kinase (ampk) modulators and activators
CN109071536A (en) 2016-02-26 2018-12-21 盐野义制药株式会社 5- phenyl 7-azaindole derivatives with AMPK activation
AU2017240685B2 (en) 2016-03-31 2021-08-12 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
HRP20221051T8 (en) 2016-04-15 2023-07-21 Cancer Research Technology Limited Heterocyclic compounds as ret kinase inhibitors
MX387394B (en) 2016-04-15 2025-03-18 Cancer Research Tech Ltd HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS.
PT3464272T (en) 2016-06-07 2022-03-11 Jacobio Pharmaceuticals Co Ltd Novel heterocyclic derivatives useful as shp2 inhibitors
US20190350955A1 (en) 2016-06-30 2019-11-21 Inserm (Institut National De La Sante Et De La Recherche Medicale Methods and pharmaceutical compositions for the treatment of cardiomyopathies
HUE056716T2 (en) 2016-09-30 2022-03-28 Vertex Pharma Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
LT3551622T (en) 2016-12-09 2021-02-25 Vertex Pharmaceuticals Incorporated Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
HUE068568T2 (en) 2017-03-23 2025-01-28 Jacobio Pharmaceuticals Co Ltd Novel heterocyclic derivatives useful as shp2 inhibitors
GB201705971D0 (en) 2017-04-13 2017-05-31 Cancer Res Tech Ltd Inhibitor compounds
WO2018227049A1 (en) 2017-06-08 2018-12-13 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
WO2019018395A1 (en) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
TWI799435B (en) 2017-08-02 2023-04-21 美商維泰克斯製藥公司 Processes for preparing compounds
EP3697774B1 (en) 2017-10-19 2025-09-24 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of cftr modulators
CN111757874B (en) 2017-12-08 2024-03-08 弗特克斯药品有限公司 Methods for preparing modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (en) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 Pharmaceutical compositions for treating cystic fibrosis
WO2019168874A1 (en) * 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
KR102224550B1 (en) * 2018-04-02 2021-03-09 울산대학교 산학협력단 Novel Ether Compounds, and Preparation Method of Ether Compounds from Activative Alkene Compounds using Photoredox Catalysts
EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
CN108572223B (en) * 2018-04-23 2021-01-26 南京明捷生物医药检测有限公司 Method for determining activity inducing substance in polypeptide
CN112955143B (en) * 2018-09-18 2023-10-13 北京强新生物科技有限公司 Treatment of non-alcoholic fatty liver disease
CN112839935A (en) 2018-09-26 2021-05-25 北京加科思新药研发有限公司 Novel heterocyclic derivatives useful as SHP2 inhibitors
EP3906027A4 (en) * 2018-12-31 2022-09-21 The Board of Trustees of the Leland Stanford Junior University METHODS AND FORMULATIONS FOR TREATING MITOCHONDRIAL DYSFUNCTION
WO2020201263A1 (en) 2019-04-01 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling
CN112441900B (en) * 2019-09-05 2024-07-23 浙江中科创越药业有限公司 Preparation method of 4-felbinac
CN111333486A (en) * 2020-04-08 2020-06-26 南京优氟医药科技有限公司 Production process of 2-methyl-2- (4-chlorphenyl) -1, 3-propylene glycol
WO2021236617A1 (en) 2020-05-19 2021-11-25 Kallyope, Inc. Ampk activators
CN111423379B (en) * 2020-05-21 2021-08-03 湖南科技大学 Substituted 3-indazole Mcl-1 protein inhibitor and preparation method and application
AU2021297323A1 (en) 2020-06-26 2023-02-16 Kallyope, Inc. AMPK activators
EP4221700A1 (en) 2020-09-30 2023-08-09 Bioverativ Therapeutics Inc. Ampk activators and methods of use thereof
WO2025021039A1 (en) * 2023-07-21 2025-01-30 深圳众格生物科技有限公司 Ampk agonist and use thereof
WO2025045185A1 (en) * 2023-08-31 2025-03-06 深圳众格生物科技有限公司 Aryl or heteroaryl substituted carbamate compound and derivative and use thereof

Family Cites Families (281)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010061B1 (en) 1978-09-25 1983-07-13 Stuart John Mc Farlane Pharmaceutical preparations containing a mollusc extract
JP2602037B2 (en) 1987-10-31 1997-04-23 持田製薬株式会社 1-acyl-2,3-dihydro-4 (1H) -quinolinone-4-oxime derivatives, process for preparing the same, and pharmaceutical compositions containing diuretic, antihypertensive, anti-edema and ascites removal based on them
GB8814277D0 (en) 1988-06-16 1988-07-20 Glaxo Group Ltd Chemical compounds
JPH02264757A (en) 1989-04-06 1990-10-29 Nippon Steel Chem Co Ltd Production of nitroindoles
US5210092A (en) 1990-09-25 1993-05-11 Fujisawa Pharmaceutical Co., Ltd. Angiotensin ii antagonizing heterocyclic derivatives
US5215994A (en) 1990-09-25 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Angiotenin II antagonizing heterocyclic derivatives
US5354759A (en) 1991-09-12 1994-10-11 Fujisawa Pharmaceutical Co., Ltd. Angiotenin II antagonizing heterocyclic compounds
WO1993006082A1 (en) 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
DE4136489A1 (en) 1991-11-06 1993-05-13 Bayer Ag NEW DIETHYLENTRIAMINE DERIVATIVES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
EP0548553A1 (en) 1991-11-25 1993-06-30 Takeda Chemical Industries, Ltd. Optically active azole compounds, their production and use
EP0545478A1 (en) 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
WO1993020065A1 (en) 1992-03-27 1993-10-14 Kyoto Pharmaceutical Industries, Ltd. Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor
JP3229654B2 (en) 1992-06-05 2001-11-19 ティーディーケイ株式会社 Compound for organic EL device and organic EL device
CA2116863A1 (en) 1992-07-03 1994-01-20 Sumio Yokota Condensed heterocyclic derivatives and herbicides
GB2271991A (en) 1992-11-02 1994-05-04 Merck Sharp & Dohme N-(2-oxo-1H-1,4-benzodiazepin-3-yl)-ureas
EP0639573A1 (en) 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Benzocondensed five membered heterocycles, process of their preparation, their use as drug, as diagnostic means and pharmaceuticals containing it
US5354763A (en) 1993-11-17 1994-10-11 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
JP2829788B2 (en) 1994-02-10 1998-12-02 ファイザー インク． 5-Heteroarylindole derivatives as benzodiazepine receptor site agonists and antagonists
MX9700696A (en) 1994-07-27 1997-04-30 Sankyo Co HETERO-CYCLIC COMPOUNDS USEFUL AS PRODUCERS OF ALOSTERIC EFFECT IN MUSCARINIC RECEPTORS.
FR2723739B1 (en) 1994-08-19 1997-02-14 Sanofi Sa GLYCINAMIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM.
JPH08225535A (en) 1994-11-15 1996-09-03 Dai Ichi Seiyaku Co Ltd Indazole derivative
EP0717143A1 (en) 1994-12-16 1996-06-19 Lignozym GmbH Multicomponents system for modifying decomposing or bleaching of lignin or materials containing it or similar components and the way to use it
CA2217707A1 (en) 1995-04-10 1996-10-17 Fujisawa Pharmaceutial Co., Ltd. Indole derivatives as cgmp-pde inhibitors
WO1997010214A1 (en) 1995-09-14 1997-03-20 Shionogi & Co., Ltd. Novel phenylacetic acid derivatives and medicinal composition containing the same
EP0914322A1 (en) 1996-05-27 1999-05-12 Fujisawa Pharmaceutical Co., Ltd. New indolyl and benzofuranyl carboxamides as inhibitors of nitric oxide production
US5629325A (en) 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
US5861398A (en) 1996-08-26 1999-01-19 Alanex Corporation Benzoperimidine-carboxylic acids and derivatives thereof
WO1998028292A1 (en) 1996-12-23 1998-07-02 Smithkline Beecham Corporation Novel piperidine containing compounds
WO1998043969A1 (en) 1997-03-31 1998-10-08 Dupont Pharmaceuticals Company Indazoles of cyclic ureas useful as hiv protease inhibitors
DK0901786T3 (en) 1997-08-11 2007-10-08 Pfizer Prod Inc Solid pharmaceutical dispersions with increased bioavailability
SE9704544D0 (en) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704545D0 (en) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
JP2002509149A (en) 1998-01-14 2002-03-26 ザ ユーエイビー リサーチ ファウンデイション Methods for synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections using inhibitors of bacterial NAD synthetase enzyme
CA2260499A1 (en) 1998-01-29 1999-07-29 Sumitomo Pharmaceuticals Company Limited Pharmaceutical compositions for the treatment of ischemic brain damage
EA003876B1 (en) * 1998-02-25 2003-10-30 Дженетикс Инститьют, Ллс Inhibitors of phospholipase enzymes
WO1999059973A1 (en) 1998-05-15 1999-11-25 Guilford Pharmaceuticals Inc. Carboxamide compounds, compositions, and methods for inhibiting parp activity
WO2000002550A2 (en) 1998-07-08 2000-01-20 Nortran Pharmaceuticals, Inc. Acetylpiperazines for modulating sexual activity
EE04904B1 (en) 1998-07-15 2007-10-15 Teijin Limited Thiobenzimidazole derivatives and a pharmaceutical composition
DE19842354A1 (en) 1998-09-16 2000-03-23 Bayer Ag New 3,4-dichloro-isothiazole-5-carboxamide derivatives, useful as resistance inducers and microbicides, especially fungicides, for protecting plants against microbial infection
FR2783520B1 (en) 1998-09-21 2000-11-10 Oreal NEW CATIONIC 4-HYDROXYINDOLES, THEIR USE FOR THE OXIDIZING DYE OF KERATINIC FIBERS, TINCTORIAL COMPOSITIONS AND DYING PROCESS
AU1738900A (en) 1998-11-19 2000-06-05 Nortran Pharmaceuticals Inc. Serotonin ligands as pro-erectile compounds
AR021509A1 (en) 1998-12-08 2002-07-24 Lundbeck & Co As H BENZOFURAN DERIVATIVES, ITS PREPARATION AND USE
CZ27399A3 (en) 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituted nitrogen heterocyclic derivatives process of their preparation, the derivatives employed as medicaments, pharmaceutical composition and a compound pharmaceutical preparation in which these derivatives are comprised as well as use of these derivatives for preparing medicaments
WO2001032621A1 (en) 1999-10-29 2001-05-10 Wakunaga Pharmaceutical Co., Ltd. Novel indole derivatives and drugs containing the same as the active ingredient
CN1105722C (en) 1999-11-12 2003-04-16 中国科学院上海药物研究所 Arteannuin derivant containing azacyclic radical and preparation process thereof
WO2001090074A2 (en) 2000-05-22 2001-11-29 Leo Pharma A/S BENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a)
AU2001275537A1 (en) 2000-06-20 2002-01-02 Wayne State University N-and o-substituted 4-(2-(diphenylmethoxy)-ethyl)-1-((phenyl)methyl)piperidine analogs and methods of treating cns disorders therewith
JP2002017386A (en) 2000-07-06 2002-01-22 Mitsubishi Rayon Co Ltd Method for producing indole-3-carboxylic acid derivative
JP2002017387A (en) 2000-07-06 2002-01-22 Mitsubishi Rayon Co Ltd Method for producing indole derivatives
WO2002018363A2 (en) 2000-08-29 2002-03-07 Abbott Laboratories 3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors
DE10046934A1 (en) 2000-09-21 2002-04-18 Consortium Elektrochem Ind Process for the fermentative production of non-proteinogenic L-amino acids
EP1332141A1 (en) 2000-10-25 2003-08-06 AstraZeneca AB Quinazoline derivatives
DE60136748D1 (en) 2000-11-01 2009-01-08 Merck Patent Gmbh METHOD AND COMPOSITIONS FOR THE TREATMENT OF EYE DISEASES
AU2002239277A1 (en) 2000-11-20 2002-05-27 Cor Therapeutics, Inc. Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof
US6387992B1 (en) 2000-11-27 2002-05-14 Ciba Specialty Chemicals Corporation Substituted 5-heteroaryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, a process for preparation thereof and compositions stabilized therewith
GB0031315D0 (en) 2000-12-21 2001-02-07 Glaxo Group Ltd Indole derivatives
JP4094955B2 (en) 2001-01-18 2008-06-04 塩野義製薬株式会社 Terphenyl compound having a substituted amino group
US20040087604A1 (en) 2001-01-22 2004-05-06 Tatsuo Tsuri Hetero-tricyclic compounds having substituted amino groups
SK9782003A3 (en) 2001-02-02 2004-01-08 Schering Corp 3,4-Di-substituted cyclobutene-1,2-diones as CXC chemokine receptor antagonists
CA2439152C (en) 2001-02-28 2008-06-17 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
US6951848B2 (en) 2001-03-12 2005-10-04 Millennium Pharmaceuticals, Inc., Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
GB0106586D0 (en) 2001-03-16 2001-05-09 Smithkline Beecham Plc Novel compounds
CA2444031C (en) 2001-04-16 2012-02-21 Schering Corporation 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands
US7199147B2 (en) 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
EP1844771A3 (en) 2001-06-20 2007-11-07 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
WO2003004027A1 (en) 2001-07-05 2003-01-16 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as mch selective antagonists
HUP0401605A3 (en) 2001-08-01 2012-09-28 Merck Patent Gmbh Integrin inhibitors for the treatment of eye diseases
EP1424336A4 (en) 2001-09-03 2004-11-10 Takeda Chemical Industries Ltd 1,3-BENZOTHIAZINONE DERIVATIVES AND THEIR USE
CN1599734A (en) 2001-10-12 2005-03-23 先灵公司 3,4-di-substituted maleimide compounds as CXC-chemokine receptor antagonists
CN1589269A (en) 2001-10-26 2005-03-02 康涅狄格大学 Heteroindanes: a new class of potent cannabimimetic ligands
AU2002334217B2 (en) 2001-10-26 2008-07-03 Aventis Pharmaceuticals Inc. Benzimidazoles and analogues and their use as protein kinases inhibitors
FR2831536A1 (en) 2001-10-26 2003-05-02 Aventis Pharma Sa NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS KDR INHIBITORS
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
TWI317634B (en) 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
SE0104331D0 (en) 2001-12-19 2001-12-19 Astrazeneca Ab Novel compounds
JP2003192716A (en) 2001-12-27 2003-07-09 Mitsui Chemicals Inc Olefin polymerization catalyst and method for polymerizing olefin by using the same
WO2003070686A1 (en) 2002-02-21 2003-08-28 Asahi Kasei Pharma Corporation Substituted phenylalkanoic acid derivative and use thereof
ES2246481T3 (en) 2002-02-27 2006-02-16 Pfizer Products Inc. ACC INHIBITORS
AU2003214462A1 (en) 2002-04-03 2003-10-13 Astrazeneca Ab Indole derivatives having anti-angiogenetic activity
EP1509226A4 (en) 2002-05-14 2008-04-09 Baylor College Medicine SMALL INHIBITORY MOLECULES OF HER2 GENE EXPRESSION
AU2003239508A1 (en) 2002-05-21 2003-12-12 Bristol-Myers Squibb Company Indole compounds useful as impdh inhibitors
WO2004004701A1 (en) 2002-07-09 2004-01-15 Fujisawa Pharmaceutical Co., Ltd. Remedy for urinary frequency and urinary incontinence
US6972336B2 (en) 2002-07-18 2005-12-06 Novartis Ag N-alkylation of indole derivatives
JP2006502133A (en) 2002-08-10 2006-01-19 アステックス、セラピューティックス、リミテッド 3- (Carbonyl) 1H-indazole compounds as cyclin dependent kinase (CDK) inhibitors
FR2845382A1 (en) 2002-10-02 2004-04-09 Sanofi Synthelabo INDAZOLECARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS
FR2846656B1 (en) 2002-11-05 2004-12-24 Servier Lab NOVEL IMIDAZOPYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES2375111T3 (en) 2002-11-21 2012-02-24 Novartis Ag PYRIMIDINES 2,4,6-TRISUSTITUIDAS AS INHIBITORS OF FOSFOTIDILINOSITOL (PI) 3-QUINASA AND ITS USE IN THE TREATMENT OF C�? NCER.
IS7839A (en) 2002-11-22 2004-05-23 Merck Frosst Canada Ltd. 4-Oxo-1- (3-substituted phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitor
DK1581492T3 (en) 2002-11-28 2008-11-10 Suven Life Sciences Ltd N-arylsulfonyl-3-substituted indoles with serotonin receptor affinity, process for their preparation and a pharmaceutical composition containing these
WO2004092131A1 (en) 2003-01-06 2004-10-28 Eli Lilly And Company Indole derivatives as ppar modulators
CA2509202A1 (en) 2003-01-06 2004-07-29 Eli Lilly And Company Fused heterocyclic derivatives as ppar modulators
CL2004000234A1 (en) 2003-02-12 2005-04-15 Biogen Idec Inc DERIVATIVE COMPOUNDS 3- (PIRIDIN-2-IL) -4-HETEROARIL-PIRAZOL SUBSTITUTED, ANTAGONISTS OF AIK5 AND / OR AIK4; PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOUND IN THE TREATMENT OF FIBROTIC DISORDERS AS SCLERODERMIA, LUPUS NEFRITICO, CICATRIZACION DE HERID
ITMI20030287A1 (en) 2003-02-18 2004-08-19 Acraf INDAZOLAMIDS EQUIPPED WITH ANALGESIC ACTIVITY METHOD, FOR
KR101088272B1 (en) 2003-02-21 2011-11-30 키에시 파르마슈티시 엣스. 피. 에이. 1-phenylalcancarboxylic acid extract for the treatment of neurodegenerative diseases
JP2004284997A (en) 2003-03-24 2004-10-14 Taoka Chem Co Ltd Method for producing high-purity indolecarboxylic acids
JP2004284998A (en) 2003-03-24 2004-10-14 Taoka Chem Co Ltd Method for producing 1-alkylindoles
EP1615667A2 (en) 2003-04-11 2006-01-18 Novo Nordisk A/S Combinations of an 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist
DK1615647T3 (en) 2003-04-11 2010-04-06 High Point Pharmaceuticals Llc Pharmaceutical use of condensed 1,2,4-triazoles
WO2004089471A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF
JP2006522750A (en) 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ Combination therapy using 11β-hydroxysteroid dehydrogenase type 1 inhibitors and antihypertensive agents to treat metabolic syndrome and related diseases and disorders
EP1615637A1 (en) 2003-04-11 2006-01-18 Novo Nordisk A/S Pharmaceutical use of substituted 1,2,4-triazoles
ATE482747T1 (en) 2003-04-11 2010-10-15 High Point Pharmaceuticals Llc NEW AMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USES
EP1628970A2 (en) 2003-04-30 2006-03-01 The Institutes of Pharmaceutical Discovery, LLC Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
US7119205B2 (en) 2003-05-16 2006-10-10 Abbott Laboratories Thienopyridones as AMPK activators for the treatment of diabetes and obesity
US7429596B2 (en) 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
JP2009513513A (en) 2003-07-04 2009-04-02 グラクソスミスクライン・ソシエタ・ペル・アチオニ Substituted indoles as ORL-1 receptor ligands
WO2005014554A1 (en) 2003-08-08 2005-02-17 Astex Therapeutics Limited 1h-indazole-3-carboxamide compounds as mapkap kinase modulators
CA2535665A1 (en) 2003-08-14 2005-02-24 Asahi Kasei Pharma Corporation Substituted arylalkanoic acid derivative and use thereof
JP4110324B2 (en) * 2003-10-15 2008-07-02 宇部興産株式会社 New indazole derivatives
JP4458819B2 (en) 2003-11-13 2010-04-28 株式会社リコー Azo-substituted indole compound and optical recording medium using the same
JP2005145859A (en) 2003-11-13 2005-06-09 Nippon Steel Chem Co Ltd Dehydrogenation method and method for producing aromatic heterocyclic compound
RS20060391A (en) 2003-12-22 2008-11-28 Memory Pharmaceuticals Corporation, Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2- benzisothiazoles, and preparation and uses thereof
CA2560741C (en) 2004-03-25 2013-08-06 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
WO2005097203A2 (en) 2004-04-01 2005-10-20 Cardiome Pharma Corp. Serum protein conjugates of ion channel modulating compounds and uses thereof
JP4510500B2 (en) 2004-04-15 2010-07-21 株式会社リコー Azo-substituted indole compound, azo metal chelate compound, and optical recording medium
ATE505470T1 (en) 2004-05-07 2011-04-15 Memory Pharm Corp 1H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZISOXAZOLES, 1, 2-BENZISOTHIAZOLES AND CHROMONES AND THEIR PRODUCTION AND USES
DE602005015699D1 (en) 2004-05-12 2009-09-10 Pfizer Prod Inc PROLIN DERIVATIVES AND THEIR USE AS DIPEPTIDYLPEPTIDASE IV INHIBITORS
CN1950374A (en) 2004-05-25 2007-04-18 辉瑞产品公司 Tetraazabenzo[e]azulene derivatives and analogs thereof
JP2008501689A (en) 2004-06-03 2008-01-24 ブランデイス ユニヴァーシティー Asymmetric Michael addition and aldol addition reaction using bifunctional catalysts based on cinchona alkaloids
ES2315877T3 (en) 2004-06-18 2009-04-01 Biolipox Ab USEFUL INDOLES IN THE TREATMENT OF INFLAMMATIONS.
DE602005014233D1 (en) 2004-06-18 2009-06-10 Biolipox Ab INDOORS SUITABLE FOR THE TREATMENT OF IGNITIONS
US20080146811A1 (en) 2004-07-23 2008-06-19 Hongfeng Deng Compounds and Methods For Treatment of Thrombosis
AU2005266312C1 (en) 2004-07-28 2011-06-16 Janssen Pharmaceutica N.V. Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
US20070015771A1 (en) 2004-07-29 2007-01-18 Threshold Pharmaceuticals, Inc. Lonidamine analogs
JP2006045119A (en) 2004-08-04 2006-02-16 Toray Ind Inc Pyrazine derivative and nephritis-treating agent using the same as active ingredient
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
ATE531367T1 (en) 2004-09-17 2011-11-15 Whitehead Biomedical Inst COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING A-SYNUKLEIN POISONING
EP1798224A1 (en) 2004-10-05 2007-06-20 Shionogi Co., Ltd. Biaryl derivative
JP2008516962A (en) 2004-10-15 2008-05-22 バイオジェン・アイデック・エムエイ・インコーポレイテッド How to treat vascular injury
JP2006131519A (en) 2004-11-04 2006-05-25 Idemitsu Kosan Co Ltd Fused ring-containing compound and organic electroluminescence device using the same
DE102004054666A1 (en) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh New substituted pyrazol-3-carboxamide derivatives useful to combat harmful plants and for growth regulation of plants
JPWO2006051937A1 (en) 2004-11-15 2008-05-29 塩野義製薬株式会社 Hetero 5-membered ring derivatives
WO2006069097A2 (en) 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
JP2008526734A (en) 2004-12-31 2008-07-24 エスケー ケミカルズ カンパニー リミテッド Quinazoline derivatives effective in preventing diabetes and obesity
PA8660701A1 (en) 2005-02-04 2006-09-22 Pfizer Prod Inc SMALL AGONISTS AND THEIR USES
FR2882054B1 (en) 2005-02-17 2007-04-13 Sanofi Aventis Sa 1,5-DIARYLPYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
KR101048535B1 (en) 2005-03-30 2011-07-11 주식회사 대웅제약 Antifungal Triazole Derivatives
WO2006110516A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories Acylhydrazide p2x7 antagonists and uses thereof
TW200642683A (en) 2005-04-22 2006-12-16 Sankyo Co Heterocyclic compound
CA2960117C (en) 2005-05-17 2018-01-30 Sarcode Bioscience Inc. Lfa-1 antagonists for the treatment of eye disorders
WO2006130453A1 (en) 2005-05-27 2006-12-07 Brandeis University Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts
WO2006130437A2 (en) 2005-05-27 2006-12-07 Brandeis University Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids
US7553964B2 (en) 2005-06-03 2009-06-30 Abbott Laboratories Cyclobutyl amine derivatives
EP1893562A4 (en) 2005-06-14 2010-04-28 Merck Frosst Canada Ltd Reversible inhibitors of monoamine oxidase a and b
US20080221088A1 (en) 2005-06-23 2008-09-11 Vijay Kumar Potluri 3,4-Substituted Thiazoles as Ampk Activators
CN101208340B (en) 2005-06-27 2010-12-22 塞诺菲-安万特股份有限公司 Pyrazolopyridine derivatives as inhibitors of beta-adrenergic receptor kinase 1
BRPI0613555A2 (en) 2005-07-04 2011-01-18 Reddys Lab Ltd Dr thiazole derivatives as ampk activator
JP2007015952A (en) 2005-07-06 2007-01-25 Shionogi & Co Ltd Naphthalene derivative
EP1754483A1 (en) 2005-08-18 2007-02-21 Merck Sante Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them
EP1931632A4 (en) 2005-08-18 2011-05-11 Microbia Inc Useful indole compounds
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
EP1951315A2 (en) 2005-11-03 2008-08-06 Ilypsa, Inc. Phospholipase inhibitors, including multi-valent phospholipase inhibitors, and use thereof, including as lumen-localized phospholipase inhibitors
MX2008005666A (en) 2005-11-03 2009-03-02 Ilypsa Inc Multivalent indole compounds and use thereof as phospholipase-a2 inhibitors.
JP2009514883A (en) 2005-11-03 2009-04-09 イリプサ， インコーポレイテッド Azaindole compounds and their use as phospholipase A2 inhibitors
EP1963332A1 (en) 2005-11-09 2008-09-03 Memory Pharmaceuticals Corporation 1 h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
WO2007058504A1 (en) 2005-11-21 2007-05-24 Lg Life Sciences, Ltd. Novel compounds as agonist for ppar gamma and ppar alpha, method for preparation of the same, and pharmaceutical composition containing the same
CN1978445B (en) 2005-12-02 2010-09-01 中国科学院上海药物研究所 Compound serving as human-derived adenoside mononucleoside activated protein kinase activator, and its preparing method and use
AU2006325754B2 (en) 2005-12-14 2012-04-12 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors
US8163749B2 (en) 2005-12-14 2012-04-24 Bristol-Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
WO2007079173A2 (en) 2005-12-30 2007-07-12 Emergent Biosolutions Inc. Novel 2-heteroaryloxy-phenol derivatives as antibacterial agents
BRPI0707427A2 (en) 2006-02-03 2011-05-03 Lilly Co Eli a compound or a pharmaceutically acceptable salt thereof, a method for treating dyslipidemia, atherosclerosis, and diabetes and complications thereof, to elevate plasma levels of hdl, and to decrease plasma triglycerides, pharmaceutical composition, and use of a compound or salt. pharmaceutically acceptable thereof
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
MX2008012529A (en) 2006-03-30 2008-10-14 Asahi Kasei Pharma Corp Substituted bicyclic cyclic derivative and use thereof.
CN101437519A (en) 2006-03-31 2009-05-20 艾博特公司 Indazole compounds
CN101426498A (en) 2006-04-18 2009-05-06 艾博特公司 Antagonists of vanilloid receptor subtype 1 (VR 1) and uses thereof
WO2007122482A1 (en) 2006-04-20 2007-11-01 Pfizer Products Inc. Fused phenyl amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases
HRP20110917T1 (en) 2006-05-19 2012-03-31 Abbott Laboratories Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives
CN101448791B (en) 2006-05-24 2011-11-16 伊莱利利公司 Fxr agonists
EP2025676A4 (en) 2006-06-08 2011-06-15 Ube Industries NEW INDAZOLE DERIVATIVE HAVING A SPIRO CYCLIC STRUCTURE IN A SIDE CHAIN
CN101484420B (en) 2006-07-03 2014-04-30 比奥维特罗姆上市公司 Indoles as 5-HT6 modulators
FR2903695B1 (en) 2006-07-13 2008-10-24 Merck Sante Soc Par Actions Si USE OF AMPAP ACTIVATOR IMIDAZOLE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
KR100826108B1 (en) 2006-08-04 2008-04-29 한국화학연구원 Furan-2-carboxylic acid derivative and its manufacturing method
MX2009001327A (en) 2006-08-07 2009-06-05 Ironwood Pharmaceuticals Inc Indole compounds.
JP2008063278A (en) 2006-09-07 2008-03-21 Fujifilm Finechemicals Co Ltd Method for producing 1-pyridin-4-yl-indole
JP2008106037A (en) 2006-09-29 2008-05-08 Osaka Prefecture Univ Method for producing indole compound and indole compound
WO2008054748A2 (en) 2006-10-31 2008-05-08 Arena Pharmaceuticals, Inc. Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
ATE552262T1 (en) 2006-11-29 2012-04-15 Pfizer Prod Inc SPIROKETONES AS INHIBITORS OF ACETYL COA CARBOXYLASE
WO2008070599A1 (en) 2006-12-05 2008-06-12 Chung-Ming Sun Indazole compounds
WO2008072850A1 (en) 2006-12-11 2008-06-19 Amorepacific Corporation Triazine derivatives having inhibitory activity against acetyl-coa carboxylase
JP2010513231A (en) 2006-12-14 2010-04-30 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト Dihydropyridine derivatives useful as protein kinase inhibitors
AU2007333737A1 (en) 2006-12-18 2008-06-26 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
CN101568530A (en) 2006-12-22 2009-10-28 诺瓦提斯公司 Indol-4-yl-pyrimidinyl-2-yl-amine derivatives and use thereof as cyclin dependant kinase inhibitors
JP5650404B2 (en) 2006-12-28 2015-01-07 ライジェル ファーマシューティカルズ， インコーポレイテッド N-substituted heterocycloalkyloxybenzamide compounds and methods of use thereof
PE20081559A1 (en) 2007-01-12 2008-11-20 Merck & Co Inc SPIROCHROMANONE DERIVATIVES SUBSTITUTED AS ACETYL COA CARBOXYLASE INHIBITORS
US7999001B2 (en) 2007-01-15 2011-08-16 The United States Of America As Represented By The Secretary Of The Army Antiviral compounds and methods of using thereof
DE102007002717A1 (en) 2007-01-18 2008-07-24 Merck Patent Gmbh Heterocyclic indazole derivatives
JP2008179567A (en) 2007-01-25 2008-08-07 Toray Ind Inc Anticancer agent containing pyrazine derivative as active ingredient
AR065093A1 (en) 2007-02-05 2009-05-13 Merck Frosst Canada Ltd PHARMACEUTICAL COMPOUNDS INHIBITING THE BIOSYNTHESIS OF LEUCOTRIENS
US20090047246A1 (en) 2007-02-12 2009-02-19 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
JP5107589B2 (en) 2007-02-13 2012-12-26 旭化成株式会社 Indole derivatives
JP2008208074A (en) 2007-02-27 2008-09-11 Toray Ind Inc Anticancer agent containing pyrazine derivative as active ingredient
JP2008222576A (en) 2007-03-09 2008-09-25 Japan Enviro Chemicals Ltd Method for producing indole compound
WO2008110863A1 (en) 2007-03-15 2008-09-18 Glenmark Pharmaceuticals S.A. Indazole derivatives and their use as vanilloid receptor ligands
WO2008118822A1 (en) 2007-03-23 2008-10-02 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
AU2008231695B2 (en) 2007-03-28 2013-03-28 Novartis Ag Purinyl derivatives and their use as potassium channel modulators
WO2008136642A1 (en) 2007-05-07 2008-11-13 Mazence Inc. Naphthoquinone-based pharmaceutical composition for treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases
WO2008150899A1 (en) 2007-05-29 2008-12-11 Emory University Combination therapies for treatment of cancer and inflammatory diseases
FR2917735B1 (en) 2007-06-21 2009-09-04 Sanofi Aventis Sa NEW SUBSTITUTED INDAZOLES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
TW200906823A (en) 2007-07-16 2009-02-16 Lilly Co Eli Compounds and methods for modulating FXR
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
EP2183233A1 (en) 2007-08-03 2010-05-12 Betagenon AB Dithiazolidine and thiazolidine derivatives as anticancer agents
KR20090016804A (en) 2007-08-13 2009-02-18 주식회사 티지 바이오텍 Novel benzyl ester compounds and compositions for the prevention and treatment of obesity, diabetes and hyperlipidemia containing them as active ingredients
US7705004B2 (en) 2007-08-17 2010-04-27 Portola Pharmaceuticals, Inc. Protein kinase inhibitors
US8143305B2 (en) 2007-08-29 2012-03-27 Schering Corporation 2,3-substituted indole derivatives for treating viral infections
AU2008295484B2 (en) 2007-08-29 2013-09-26 Merck Sharp & Dohme Llc Substituted indole derivatives and methods of use thereof
US8415358B2 (en) 2007-09-17 2013-04-09 Neurosearch A/S Pyrazine derivatives and their use as potassium channel modulators
WO2009053373A1 (en) 2007-10-26 2009-04-30 Janssen Pharmaceutica Nv Quinolinone derivatives as parp inhibitors
US20090124680A1 (en) 2007-10-31 2009-05-14 Mazence Inc. Use of prodrug composition containing naphthoquinone-based compound for manufacture of medicament for treatment or prevention of diseases involving metabolic syndrome
US8377928B2 (en) 2007-11-16 2013-02-19 Merck Sharp & Dohme Corp. 3-aminosulfonyl substituted indole derivatives and methods of use thereof
CA2705947C (en) 2007-11-16 2016-08-09 Rigel Pharmaceuticals, Inc. Carboxamide, sulfonamide and amine compounds for metabolic disorders
EP2226315A4 (en) 2007-12-28 2012-01-25 Carna Biosciences Inc 2-AMINOQUINAZOLINE DERIVATIVE
EP2258950A1 (en) 2008-01-31 2010-12-08 National University Corporation Yokohama National University Fluid machine
BRPI0905952A2 (en) 2008-02-04 2015-06-30 Mercury Therapeutics Compound and salts thereof and pharmaceutical composition
WO2009115874A2 (en) 2008-03-17 2009-09-24 Matrix Laboratories Ltd. Novel heterocyclic compounds, pharmaceutical compositions containing them and processes for their preparation
AU2009226868A1 (en) 2008-03-20 2009-09-24 F. Hoffmann-La Roche Ag Pyrrolidinyl derivatives and uses thereof
WO2009120783A1 (en) 2008-03-25 2009-10-01 The Johns Hopkins University High affinity inhibitors of hepatitis c virus ns3/4a protease
ES2395347T3 (en) 2008-03-27 2013-02-12 Janssen Pharmaceutica, N.V. Indolyl-alkylamino derivatives substituted with aza-bicyclohexyl as novel histone deacetylase inhibitors
EP2262500B1 (en) 2008-04-11 2016-04-27 Merck Patent GmbH Thienopyridone derivatives as amp-activated protein kinase (ampk) activators
KR101662333B1 (en) 2008-04-23 2016-10-04 리겔 파마슈티칼스, 인크. Carboxamide compounds for the treatment of metabolic disorders
ES2388485T3 (en) 2008-05-05 2012-10-15 Merck Patent Gmbh Thienopyridone derivatives as activators of AMP-activated protein kinase (AMPK)
GB0808282D0 (en) 2008-05-07 2008-06-11 Medical Res Council Compounds for use in stabilizing p53 mutants
CA2724774C (en) 2008-05-28 2013-06-25 Pfizer Inc. Pyrazolospiroketone acetyl-coa carboxylase inhibitors
US20110009443A1 (en) 2008-05-28 2011-01-13 Kevin Daniel Freeman-Cook Pyrazolospiroketone Acetyl-Coa Carboxylase Inhibitors
US8329698B2 (en) 2008-06-16 2012-12-11 MERCK Patent Gesellschaft mit beschränkter Haftung Quinoxalinedione derivatives which are activators of AMPK-activated protein kinase
TW201011013A (en) 2008-06-20 2010-03-16 Glaxo Group Ltd Compounds
DE102008031480A1 (en) 2008-07-03 2010-01-07 Merck Patent Gmbh Salts containing a Pyrimidincarbonsäure derivative
WO2010009190A1 (en) 2008-07-16 2010-01-21 King Pharmaceuticals Research And Development, Inc. Methods of treating atherosclerosis
WO2010010186A1 (en) 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
EP2318370A1 (en) 2008-07-29 2011-05-11 Pfizer Inc. Fluorinated heteroaryls
PT2334687E (en) 2008-08-28 2012-04-13 Pfizer Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives
MX2011002846A (en) 2008-09-26 2011-04-07 Hoffmann La Roche Pyrine or pyrazine derivatives for treating hcv.
WO2010036910A1 (en) 2008-09-26 2010-04-01 Yoshikazu Ohta Heart protection by administering an amp-activated protein kinase activator
MX2011004258A (en) 2008-10-22 2011-06-01 Merck Sharp & Dohme Novel cyclic benzimidazole derivatives useful anti-diabetic agents.
EP2352374B1 (en) 2008-10-29 2014-09-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010056041A2 (en) 2008-11-13 2010-05-20 주식회사 머젠스 Pharmaceutical composition for treating and preventing heart diseases caused by ischemia or ischemic reperfusion
KR101637337B1 (en) 2008-11-21 2016-07-07 라퀄리아 파마 인코포레이티드 Novel Pyrazole-3-carboxamide derivative having 5-HT2B receptor antagonist activity
KR101061599B1 (en) 2008-12-05 2011-09-02 한국과학기술연구원 Novel indazole derivatives that are protein kinase inhibitors for the treatment of abnormal cell growth diseases, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing the same as active ingredients
WO2010068287A2 (en) 2008-12-11 2010-06-17 Angion Biomedica Corp. Small molecule modulators of hepatocyte growth factor (scatter factor) activity
EA201170828A1 (en) 2008-12-18 2011-12-30 Мерк Сероно С.А. CONDENSED HETEROCYCLIC DERIVATIVES OF OXADIAZOL, SUITABLE FOR THE TREATMENT OF SCATTERED SCLEROSIS
EP2381775A4 (en) 2008-12-23 2012-08-15 Harvard College SMALL MOLECULAR NEKTROPTOSIS HEMMER
WO2010073011A2 (en) 2008-12-23 2010-07-01 Betagenon Ab Compounds useful as medicaments
AU2010208247B2 (en) 2009-01-28 2015-06-18 Rigel Pharmaceuticals, Inc. Carboxamide compounds and methods for using the same
WO2010086613A1 (en) 2009-01-30 2010-08-05 Betagenon Ab Compounds useful as inhibitors as ampk
WO2010086820A1 (en) 2009-02-02 2010-08-05 Pfizer Inc. 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof
US20100210682A1 (en) 2009-02-19 2010-08-19 Abbott Laboratories Repeated Dosing of TRPV1 Antagonists
EP2406230A1 (en) 2009-03-11 2012-01-18 Pfizer Inc. Substituted indazole amides and their use as glucokinase activators
MY151246A (en) 2009-03-11 2014-04-30 Pfizer Benzofuranyl derivatives
WO2010106457A2 (en) 2009-03-20 2010-09-23 Pfizer Inc. 3-oxa-7-azabicyclo[3.3.1]nonanes
CN102361878A (en) 2009-03-24 2012-02-22 住友化学株式会社 Process for preparing boronic acid ester compounds
US8785473B2 (en) 2009-03-31 2014-07-22 Renascience Co., Ltd. Plasminogen activator inhibitor-1 inhibitor
WO2010118009A1 (en) 2009-04-06 2010-10-14 Ptc Therapeutics, Inc. Hcv inhibitor and therapeutic agent combinations
CA2759843A1 (en) 2009-05-08 2010-11-10 Pfizer Inc. Gpr 119 modulators
WO2010128414A1 (en) 2009-05-08 2010-11-11 Pfizer Inc. Gpr 119 modulators
CN102459222B (en) 2009-06-05 2014-06-04 辉瑞大药厂 L-(piperidin-4-yl)-pyrazole derivatives as modulators of GPR119
AU2010270030B2 (en) 2009-07-08 2015-12-24 Baltic Bio Ab 1, 2, 4-thiazolidin-3-one derivatives and their use in the treatment of cancer
WO2011005611A1 (en) 2009-07-09 2011-01-13 Merck Sharp & Dohme Corp. Neuromedin u receptor agonists and uses thereof
US8742100B2 (en) 2009-07-30 2014-06-03 National University Of Singapore Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
GB0915892D0 (en) 2009-09-10 2009-10-14 Smithkline Beecham Corp Compounds
WO2011032320A1 (en) 2009-09-21 2011-03-24 F. Hoffmann-La Roche Ag Novel alkene oxindole derivatives
WO2011069298A1 (en) 2009-12-11 2011-06-16 F. Hoffmann-La Roche Ag Novel cyclopropane indolinone derivatives
JP2013047189A (en) 2009-12-25 2013-03-07 Kyorin Pharmaceutical Co Ltd Novel parabanic acid derivative, and medicine containing the same as effective component
HRP20140035T1 (en) 2009-12-29 2014-02-14 Poxel TIENO [2,3-B] PYRIDINDION AMPK ACTIVATORS AND THEIR THERAPY USES
JP2013520502A (en) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション Novel cyclic benzimidazole derivatives that are useful anti-diabetic drugs
WO2011123681A1 (en) 2010-03-31 2011-10-06 Rigel Pharmaceuticals, Inc. Methods for using carboxamide, sulfonamide and amine compounds
US8344137B2 (en) 2010-04-14 2013-01-01 Hoffman-La Roche Inc. 3,3-dimethyl tetrahydroquinoline derivatives
EP2566868A1 (en) 2010-05-05 2013-03-13 GlaxoSmithKline LLC Pyrrolo [3, 2 -d]pyrimidin-3 -yl derivatives used as activators of ampk
US8592594B2 (en) 2010-07-02 2013-11-26 Hoffmann-La Roche Inc. Tetrahydro-quinoline derivatives
NZ605692A (en) 2010-07-29 2015-04-24 Rigel Pharmaceuticals Inc Ampk-activating heterocyclic compounds and methods for using the same
KR101190141B1 (en) 2010-08-24 2012-10-12 서울대학교산학협력단 Pharmaceutical compositioin containing ampk-activating compound
WO2012027548A1 (en) 2010-08-25 2012-03-01 The Feinstein Institute For Medical Research Compounds and methods for prevention and treatment of alzheimer's and other diseases
JP2013230986A (en) 2010-08-25 2013-11-14 Kyorin Pharmaceutical Co Ltd Novel hydantoin derivative and medicinal agent comprising the same as active ingredient
CA2811025C (en) 2010-09-10 2018-07-17 Shionogi & Co., Ltd. Hetero ring-fused imidazole derivative having ampk activating effect
WO2012040499A2 (en) 2010-09-22 2012-03-29 Surface Logix, Inc. Metabolic inhibitors
US8546427B2 (en) 2010-10-20 2013-10-01 Hoffmann-La Roche Inc. Tetrahydroquinoline derivatives
US8809369B2 (en) 2011-01-26 2014-08-19 Hoffmann-La Roche Inc. Tetrahydroquinoline derivatives
ES2652662T3 (en) 2011-02-25 2018-02-05 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as antidiabetic agents
WO2012119978A1 (en) 2011-03-07 2012-09-13 Glaxosmithkline Llc Quinolinone derivatives
JP2014507453A (en) 2011-03-07 2014-03-27 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 1H-pyrrolo [3,2-d] pyrimidinedione derivative
JP5855253B2 (en) 2011-08-12 2016-02-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Indazole compounds, compositions and methods of use
CA2860250C (en) 2012-02-21 2020-11-10 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Also Published As

Publication number Publication date
AU2013246552A1 (en) 2014-09-25
HRP20171028T1 (en) 2017-10-06
PE20142294A1 (en) 2014-12-27
SI2836490T1 (en) 2017-08-31
ES2637238T3 (en) 2017-10-11
LT2836490T (en) 2017-08-10
MX2014012330A (en) 2015-01-12
AP2014007983A0 (en) 2014-10-31
JP2015512931A (en) 2015-04-30
NZ630700A (en) 2015-11-27
TW201402547A (en) 2014-01-16
DOP2014000228A (en) 2014-11-30
PH12014502280B1 (en) 2014-12-15
US8889730B2 (en) 2014-11-18
US20150038484A1 (en) 2015-02-05
EP2836490B1 (en) 2017-06-14
AR090633A1 (en) 2014-11-26
PL2836490T3 (en) 2017-10-31
RS56290B1 (en) 2017-12-29
HUE033096T2 (en) 2017-11-28
CA2869692A1 (en) 2013-10-17
ECSP14026271A (en) 2015-11-30
ME02729B (en) 2017-10-20
JP6026642B2 (en) 2016-11-16
EA028564B1 (en) 2017-12-29
EA201491592A1 (en) 2015-03-31
CR20140411A (en) 2014-10-14
TWI465431B (en) 2014-12-21
WO2014140704A1 (en) 2014-09-18
PT2836490T (en) 2017-08-23
DK2836490T3 (en) 2017-07-31
CY1119194T1 (en) 2018-02-14
CU20140118A7 (en) 2014-11-27
SG11201405571SA (en) 2014-10-30
CO7091185A2 (en) 2014-10-21
WO2013153479A2 (en) 2013-10-17
UY34736A (en) 2013-11-29
NI201400121A (en) 2015-03-05
IL234860A0 (en) 2014-12-31
CA2869692C (en) 2016-08-02
US20130267493A1 (en) 2013-10-10
PH12014502280A1 (en) 2014-12-15
HK1202547A1 (en) 2015-10-02
WO2013153479A3 (en) 2013-12-05
KR20150002782A (en) 2015-01-07
CN104245688A (en) 2014-12-24
TN2014000420A1 (en) 2016-03-30
ECSP14020545A (en) 2017-07-31
GT201400215A (en) 2015-10-15
MD20140109A2 (en) 2015-02-28
EP2836490A2 (en) 2015-02-18
ZA201406792B (en) 2016-01-27

Similar Documents

Publication Publication Date Title
IN2014DN09200A (en)
TN2013000348A1 (en) Compounds and compositions as trk inhibitors
EA033343B1 (en) Compounds inhibiting rip2 kinase, pharmaceutical composition based thereon and use thereof for the treatment of diseases mediated by rip2 kinase
PH12016501898A1 (en) Quinoxaline derivatives useful as fgfr kinase modulators
NZ700928A (en) Dna-pk inhibitors
TN2012000081A1 (en) Compounds and compositions as protein kinase inhibitors
EA024842B9 (en) Compounds as modulators of pi3k protein kinase
MX2013012981A (en) Substituted indazole derivatives active as kinase inhibitors.
PH12017500841A1 (en) 2-amino-6-(difluoromethyl)- 5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors
NZ727358A (en) Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
IN2014MN01875A (en)
TN2014000016A1 (en) 4 - piperidinyl compounds for use as tankyrase inhibitors
EA201691514A1 (en) CONNECTIONS
MX2014000964A (en) Substituted heterocyclic aza derivatives.
PH12015501053A1 (en) Oxazolidin-2-one-pyrimidine derivatives
MY176521A (en) Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof
MX2014003584A (en) Substituted methanesulfonamide derivatives as vanilloid receptor ligands.
MX2014003455A (en) Aryl or n-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands.
UA110793C2 (en) Pyrazolyl hinoksalinovi kinase inhibitors