JP5719099B2 - 糖尿病治療における優れた血糖コントロール - Google Patents
糖尿病治療における優れた血糖コントロール Download PDFInfo
- Publication number
- JP5719099B2 JP5719099B2 JP2008504512A JP2008504512A JP5719099B2 JP 5719099 B2 JP5719099 B2 JP 5719099B2 JP 2008504512 A JP2008504512 A JP 2008504512A JP 2008504512 A JP2008504512 A JP 2008504512A JP 5719099 B2 JP5719099 B2 JP 5719099B2
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- glucose
- meal
- blood glucose
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66739305P | 2005-03-31 | 2005-03-31 | |
| US60/667,393 | 2005-03-31 | ||
| US11/329,686 US9006175B2 (en) | 1999-06-29 | 2006-01-10 | Potentiation of glucose elimination |
| US11/329,686 | 2006-01-10 | ||
| PCT/US2006/012366 WO2006105501A2 (en) | 2005-03-31 | 2006-03-31 | Control of blood glucose in diabetes treatment using pulmonarily administered insulin in combination with basal insulin |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012238430A Division JP5788374B2 (ja) | 2005-03-31 | 2012-10-29 | 糖尿病治療における優れた血糖コントロール |
| JP2015020034A Division JP2015110631A (ja) | 2005-03-31 | 2015-02-04 | 糖尿病治療における優れた血糖コントロール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008534622A JP2008534622A (ja) | 2008-08-28 |
| JP2008534622A5 JP2008534622A5 (https=) | 2009-05-14 |
| JP5719099B2 true JP5719099B2 (ja) | 2015-05-13 |
Family
ID=37054222
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504512A Expired - Fee Related JP5719099B2 (ja) | 2005-03-31 | 2006-03-31 | 糖尿病治療における優れた血糖コントロール |
| JP2012238430A Expired - Fee Related JP5788374B2 (ja) | 2005-03-31 | 2012-10-29 | 糖尿病治療における優れた血糖コントロール |
| JP2015020034A Pending JP2015110631A (ja) | 2005-03-31 | 2015-02-04 | 糖尿病治療における優れた血糖コントロール |
| JP2016048575A Pending JP2016147883A (ja) | 2005-03-31 | 2016-03-11 | 糖尿病治療における優れた血糖コントロール |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012238430A Expired - Fee Related JP5788374B2 (ja) | 2005-03-31 | 2012-10-29 | 糖尿病治療における優れた血糖コントロール |
| JP2015020034A Pending JP2015110631A (ja) | 2005-03-31 | 2015-02-04 | 糖尿病治療における優れた血糖コントロール |
| JP2016048575A Pending JP2016147883A (ja) | 2005-03-31 | 2016-03-11 | 糖尿病治療における優れた血糖コントロール |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US9006175B2 (https=) |
| EP (4) | EP2266597A1 (https=) |
| JP (4) | JP5719099B2 (https=) |
| KR (1) | KR101244028B1 (https=) |
| CN (1) | CN101151047A (https=) |
| AT (2) | ATE471154T1 (https=) |
| AU (2) | AU2006230576B2 (https=) |
| BR (1) | BRPI0608271A2 (https=) |
| CA (1) | CA2601860C (https=) |
| DE (2) | DE602006015005D1 (https=) |
| DK (2) | DK2027870T3 (https=) |
| ES (2) | ES2334258T3 (https=) |
| IL (1) | IL186182A (https=) |
| MX (1) | MX2007012102A (https=) |
| WO (1) | WO2006105501A2 (https=) |
Families Citing this family (53)
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|---|---|---|---|---|
| US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| ES2569916T3 (es) * | 1999-06-29 | 2016-05-13 | Mannkind Corporation | Formulaciones farmacéuticas que comprenden insulina complejada con una dicetopiperazina |
| US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
| US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
| US6923175B2 (en) | 2002-03-20 | 2005-08-02 | Mannkind Corporation | Inhalation apparatus |
| US20070027063A1 (en) * | 2004-01-12 | 2007-02-01 | Mannkind Corporation | Method of preserving the function of insulin-producing cells |
| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| MX373000B (es) | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| EP1986679B1 (en) | 2006-02-22 | 2017-10-25 | MannKind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| EP2211842B1 (en) * | 2007-10-24 | 2015-08-12 | MannKind Corporation | An inhalable dry powder formulation comprising glp-1 for use in the treatment of hyperglycemia and diabetes by pulmonary administration |
| US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
| WO2009121020A1 (en) * | 2008-03-27 | 2009-10-01 | Mannkind Corporation | A dry powder inhalation system |
| AU2015201158B2 (en) * | 2008-03-27 | 2017-04-13 | Mannkind Corporation | A dry powder inhalation system |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| AU2014200952B2 (en) * | 2008-06-13 | 2014-12-11 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
| CN101827626B (zh) | 2008-06-13 | 2015-03-18 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| AU2015275293B2 (en) * | 2008-06-13 | 2018-06-07 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
| ES2421385T3 (es) * | 2008-06-20 | 2013-09-02 | Mannkind Corp | Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación |
| TWI532497B (zh) * | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US11110151B2 (en) * | 2008-08-11 | 2021-09-07 | Mannkind Corporation | Composition and method for reducing hypoglycemia events in diabetes treatment |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| DK2379100T3 (en) * | 2009-01-08 | 2014-12-01 | Mannkind Corp | Treatment of hyperglycemia with GLP-1 |
| BRPI1008849B8 (pt) * | 2009-02-04 | 2021-06-22 | Sanofi Aventis Deutschland | dispositivo médico e método para controle glicêmico |
| AU2014200960B2 (en) * | 2009-03-04 | 2016-02-11 | Mannkind Corporation | An improved dry powder drug delivery system |
| CN102438602B (zh) * | 2009-03-04 | 2016-04-13 | 曼金德公司 | 改进的干燥粉末药物输送系统 |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| EP3556356B1 (en) * | 2009-06-12 | 2021-05-05 | MannKind Corporation | Diketopiperazine microparticles with defined isomer content |
| KR102584844B1 (ko) | 2009-06-12 | 2023-10-04 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| EP2496253B1 (en) | 2009-11-02 | 2019-01-09 | MannKind Corporation | Apparatus and method for cryogranulating a pharmaceutical composition |
| CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| CN102985125A (zh) | 2010-06-21 | 2013-03-20 | 曼金德公司 | 干粉药物输送系统和方法 |
| KR101798691B1 (ko) | 2010-09-06 | 2017-11-16 | 키에시 파르마슈티시 엣스. 피. 에이. | 계량된-투여량 흡입기 및 계량된-투여량 흡입기의 사용 방법 |
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| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| MX2014004983A (es) | 2011-10-24 | 2014-09-22 | Mannkid Corp | Metodos y composiciones para tratar dolor. |
| KR102264177B1 (ko) | 2012-07-12 | 2021-06-11 | 맨카인드 코포레이션 | 건조 분말 약물 전달 시스템 및 방법 |
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| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| WO2014152993A1 (en) * | 2013-03-14 | 2014-09-25 | The Board Of Regents Of The University Of Oklahoma | Use of klotho nucleic acids or proteins for treatment of diabetes and diabetes-related conditions |
| EP3587404B1 (en) | 2013-03-15 | 2022-07-13 | MannKind Corporation | Microcrystalline diketopiperazine compositions, methods for preparation and use thereof |
| MX375448B (es) | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
| CN113940627B (zh) * | 2013-08-05 | 2024-12-03 | 海吉雅有限公司 | 减轻糖毒性和恢复胰岛β细胞功能的系统、装置和方法 |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
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| JP2019516485A (ja) | 2016-05-19 | 2019-06-20 | マンカインド コーポレイション | 吸入を検出および監視するための機器、システム、および方法 |
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| BR112020025924A2 (pt) * | 2018-06-18 | 2021-03-23 | Biocon Limited | método e uso de controle de níveis de glicose pós-prandial em um indivíduo |
| WO2020077030A1 (en) * | 2018-10-11 | 2020-04-16 | The Cleveland Clinic Foundation | Aggf1 and aggf1-primed cells for treating diseases and conditions |
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