JP5395439B2 - 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物 - Google Patents

固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物 Download PDF

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JP5395439B2
JP5395439B2 JP2008549555A JP2008549555A JP5395439B2 JP 5395439 B2 JP5395439 B2 JP 5395439B2 JP 2008549555 A JP2008549555 A JP 2008549555A JP 2008549555 A JP2008549555 A JP 2008549555A JP 5395439 B2 JP5395439 B2 JP 5395439B2
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クローチェ,カーロ・エム
キャリン,ジョージ・エイ
ヴォリニア,ステファノ
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JP2008549555A 2006-01-05 2007-01-03 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物 Expired - Fee Related JP5395439B2 (ja)

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US75658506P 2006-01-05 2006-01-05
US60/756,585 2006-01-05
PCT/US2007/000159 WO2007081740A2 (en) 2006-01-05 2007-01-03 Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers

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JP5395439B2 true JP5395439B2 (ja) 2014-01-22

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JP2008549555A Expired - Fee Related JP5395439B2 (ja) 2006-01-05 2007-01-03 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物
JP2012183280A Expired - Fee Related JP5743982B2 (ja) 2006-01-05 2012-08-22 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物
JP2013216256A Expired - Fee Related JP5837909B2 (ja) 2006-01-05 2013-10-17 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物
JP2015141189A Pending JP2016025853A (ja) 2006-01-05 2015-07-15 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物

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JP2013216256A Expired - Fee Related JP5837909B2 (ja) 2006-01-05 2013-10-17 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物
JP2015141189A Pending JP2016025853A (ja) 2006-01-05 2015-07-15 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物

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Cited By (8)

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Publication number Priority date Publication date Assignee Title
JP2013046612A (ja) * 2006-01-05 2013-03-07 Ohio State Univ Research Foundation 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物
US8946187B2 (en) 2010-11-12 2015-02-03 The Ohio State University Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
US9085804B2 (en) 2007-08-03 2015-07-21 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
US9249468B2 (en) 2011-10-14 2016-02-02 The Ohio State University Methods and materials related to ovarian cancer
US9434995B2 (en) 2012-01-20 2016-09-06 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
US9481885B2 (en) 2011-12-13 2016-11-01 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
US10758619B2 (en) 2010-11-15 2020-09-01 The Ohio State University Controlled release mucoadhesive systems
WO2023190271A1 (ja) 2022-03-28 2023-10-05 株式会社リジェネシスサイエンス miR-140を含む医薬組成物及びその製造方法

Families Citing this family (301)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005013901A2 (en) 2003-07-31 2005-02-17 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for use in modulation of small non-coding rnas
EP1713938A2 (en) 2004-02-09 2006-10-25 Thomas Jefferson University DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
EP1771563A2 (en) 2004-05-28 2007-04-11 Ambion, Inc. METHODS AND COMPOSITIONS INVOLVING MicroRNA
EP1838852A2 (en) 2004-11-12 2007-10-03 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
US20090209621A1 (en) * 2005-06-03 2009-08-20 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
WO2007016548A2 (en) * 2005-08-01 2007-02-08 The Ohio State University Research Foundation Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer
EP2796554A3 (en) 2005-09-12 2014-12-10 The Ohio State University Research Foundation Compositions for use in treating BCL2-associated cancers
US8445198B2 (en) * 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
CN103361424A (zh) 2006-01-05 2013-10-23 俄亥俄州立大学研究基金会 胰腺内分泌和腺泡肿瘤中的微小rna表达异常
EP2514433B1 (en) 2006-01-05 2015-10-21 The Ohio State University Research Foundation MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer
EP2369011A1 (en) * 2006-03-20 2011-09-28 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis
ES2447850T3 (es) * 2006-07-13 2014-03-13 The Ohio State University Research Foundation Métodos y composiciones basados en micro-ARN para el pronóstico y tratamiento de enfermedades relacionadas con el colon
JP5426383B2 (ja) 2006-09-19 2014-02-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 慢性リンパ球性白血病におけるmiR−29およびmiR−181によって制御されるTCL1発現
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
US8975026B2 (en) * 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
WO2008094545A2 (en) 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
US20100144850A1 (en) * 2007-04-30 2010-06-10 The Ohio State University Research Foundation Methods for Differentiating Pancreatic Cancer from Normal Pancreatic Function and/or Chronic Pancreatitis
US8697672B2 (en) * 2007-05-16 2014-04-15 California Institute Of Technology Microrna inhibition for the treatment of inflammation and myeloproliferative disorders
EP2164990A4 (en) * 2007-05-21 2011-02-23 Dana Farber Cancer Inst Inc COMPOSITIONS, KITS AND METHODS OF IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF CANCER
ES2537349T3 (es) 2007-06-08 2015-06-05 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Métodos para determinar un subtipo de carcinoma hepatocelular
CA2690749A1 (en) 2007-06-15 2008-12-24 The Ohio State University Research Foundation Oncogenic all-1 fusion proteins for targeting drosha-mediated microrna processing
EP2176425A2 (en) * 2007-07-06 2010-04-21 Koninklijke Nederlandse Akademie van Wetenschappen Small rna molecules, precursors thereof, means and methods for detecting them, and uses thereof in typing samples
WO2009015071A1 (en) * 2007-07-23 2009-01-29 Dharmacon, Inc. Screening of micro-rna cluster inhibitor pools
AU2008282318B2 (en) 2007-07-31 2014-02-27 The Ohio State University Research Foundation Methods for reverting methylation by targeting methyltransferases
EP2182969B1 (en) 2007-07-31 2016-11-16 The Board of Regents of The University of Texas System A micro-rna family that modulates fibrosis and uses thereof
WO2009021235A2 (en) * 2007-08-09 2009-02-12 The Regents Of The University Of Colorado Methods and compositions for treating cancer
WO2009021325A1 (en) 2007-08-10 2009-02-19 British Columbia Cancer Agency Branch Microrna compositions and methods for the treatment of myelogenous leukemia
CA2926831A1 (en) 2007-08-22 2009-02-26 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
WO2009024790A1 (en) * 2007-08-23 2009-02-26 Isis Innovation Limited Method and kit for the prognosis of cancer by determining the level of mirna-210
CA2698771A1 (en) * 2007-09-06 2009-03-12 The Ohio State University Research Foundation Microrna signatures in human ovarian cancer
ES2419129T3 (es) 2007-09-14 2013-08-19 The Ohio State University Research Foundation Expresión de miARN en microvesículas de sangre periférica humana y usos del mismo
EP2198050A1 (en) 2007-09-14 2010-06-23 Asuragen, INC. Micrornas differentially expressed in cervical cancer and uses thereof
US20090136957A1 (en) * 2007-09-15 2009-05-28 Irena Ivanovska Methods and compositions for regulating cell cycle progression via the miR-106B family
US20100305188A1 (en) * 2007-10-03 2010-12-02 Kyowa Hakko Kirin Co., Ltd. Nucleic acid capable of regulating the proliferation of cell
CN103898069A (zh) 2007-10-26 2014-07-02 俄亥俄州立大学研究基金会 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途
JP2011501964A (ja) 2007-10-30 2011-01-20 ベリデックス・エルエルシー 扁平上皮細胞肺癌の予後予測プロセス
CN101424640B (zh) * 2007-11-02 2012-07-25 江苏命码生物科技有限公司 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
WO2009070805A2 (en) * 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2009085234A2 (en) * 2007-12-20 2009-07-09 Signal Pharmaceuticals, Inc. Use of micro-rna as a biomarker of immunomodulatory drug activity
WO2009082744A2 (en) * 2007-12-22 2009-07-02 Sloan-Kettering Institute For Cancer Research Prognosis and interference-mediated treatment of breast cancer
JP5116026B2 (ja) * 2008-01-23 2013-01-09 富士フイルム株式会社 癌の検出方法および癌抑制剤
AU2009219197B2 (en) * 2008-02-28 2014-04-10 The Govt. Of The U.S.A. As Represented By The Secretary Of The Dep. Of Health And Human Services MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of prostate related disorders
JP5662166B2 (ja) * 2008-02-28 2015-01-28 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation 胃癌の診断、予後診断及び治療のためのマイクロrnaに基づいた方法及び組成物
WO2009111643A2 (en) * 2008-03-06 2009-09-11 Asuragen, Inc. Microrna markers for recurrence of colorectal cancer
EP2285960B1 (en) 2008-05-08 2015-07-08 Asuragen, INC. Compositions and methods related to mir-184 modulation of neovascularization or angiogenesis
WO2009143379A2 (en) * 2008-05-21 2009-11-26 Fred Hutchinson Cancer Research Center Use of extracellular rna to measure disease
EP2123258A1 (en) 2008-05-23 2009-11-25 Liplasome Pharma A/S Liposomes for drug delivery
US9217155B2 (en) 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
WO2009143603A1 (en) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
WO2009147656A1 (en) * 2008-06-01 2009-12-10 Rosetta Genomics Ltd. Compositions and methods for prognosis of gastric cancer
CN102149827B (zh) 2008-06-11 2014-08-20 由卫生与公众服务部代表的美利坚合众国政府 MiR-26家族作为肝细胞癌和对治疗的应答性的预测性标志物的用途
MX2011003039A (es) * 2008-09-26 2011-08-15 Tocagen Inc Vectores de terapia genica y citosina deaminasas.
WO2010050328A1 (ja) * 2008-10-27 2010-05-06 国立がんセンター総長が代表する日本国 腫瘍の転移抑制剤
GB2465088C (en) * 2008-10-30 2016-01-27 Caris Mpi Inc miRNA expression in the characterisation and classification of cancer
WO2010062706A2 (en) 2008-10-30 2010-06-03 Caris Mpi, Inc. Methods for assessing rna patterns
WO2010055487A2 (en) * 2008-11-13 2010-05-20 Koninklijke Philips Electronics N.V. Compositions and methods for micro-rna expession profiling of colorectal cancer
WO2010058393A2 (en) * 2008-11-20 2010-05-27 Rosetta Genomics Ltd. Compositions and methods for the prognosis of colon cancer
WO2010065156A1 (en) * 2008-12-05 2010-06-10 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis and treatment of ovarian cancer
WO2010065961A2 (en) * 2008-12-05 2010-06-10 Whitehead Institute For Biomedical Research Compositions and methods relating to mir-31
WO2010066384A1 (en) * 2008-12-10 2010-06-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Compositions and methods for micro-rna expression profiling of cancer stem cells
EP2199412A1 (en) * 2008-12-10 2010-06-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Compositions and methods for micro-RNA expression profiling of cancer stem cells
EP2196542A1 (en) * 2008-12-15 2010-06-16 Koninklijke Philips Electronics N.V. Compositions and methods for micro-rna expression profiling of colorectal cancer
CN101475984A (zh) * 2008-12-15 2009-07-08 江苏命码生物科技有限公司 一种非小细胞肺癌检测标记物及其检测方法、相关生物芯片和试剂盒
US8492133B2 (en) 2009-01-20 2013-07-23 Ramot At Tel Aviv University, Ltd. MIR-21 promoter driven targeted cancer therapy
CN102272330B (zh) * 2009-02-23 2014-04-23 博奥生物有限公司 用于肺癌诊断、预后和提高生存率的试剂盒
EP2628803A3 (en) * 2009-02-25 2014-01-01 Cepheid Methods of detecting lung cancer
AU2010234806B2 (en) * 2009-03-31 2014-05-22 The United States Of America As Represented By The Secretary Department Of Health And Human Services Differentially expressed microRNAs as biomarkers for the diagnosis and treatment of Sjogren's syndrome
US8420800B2 (en) 2009-04-16 2013-04-16 Keio University Head-and-neck tumor proliferation inhibitor
KR101793615B1 (ko) 2009-04-30 2017-11-03 오스페달레 산 라파엘 에스.알.엘. 유전자 벡터
EP2432895A2 (en) * 2009-05-22 2012-03-28 Asuragen, INC. Mirna biomarkers of prostate disease
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
US20100322909A1 (en) * 2009-06-17 2010-12-23 The University Of Pittsburgh - Of The Commonwealth System Of Higher Education Th1-associated micrornas and their use for tumor immunotherapy
WO2011017089A1 (en) * 2009-07-27 2011-02-10 The Regents Of The University Of Colorado, A Body Corporate Mirna inhibition of six1 expression
CN101988061A (zh) * 2009-07-30 2011-03-23 江苏命码生物科技有限公司 乳腺癌检测标记物及其检测方法、试剂盒和生物芯片
EP2283846A1 (en) * 2009-08-12 2011-02-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. miRNA compounds for treatment of prostate carcinoma
EP2910650A1 (en) 2009-08-24 2015-08-26 National University Corporation Kanazawa University Detection of colorectal cancer by gene expression profiling
DK177532B1 (en) 2009-09-17 2013-09-08 Bio Bedst Aps Medical use of sPLA2 hydrolysable liposomes
JP6143041B2 (ja) * 2009-09-30 2017-06-07 公益財団法人ヒューマンサイエンス振興財団 大腸がん検査キット
EP2504452A4 (en) 2009-11-23 2014-06-11 Univ Ohio State Res Found MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS
WO2011076144A1 (en) * 2009-12-24 2011-06-30 Fudan University Compositions and methods for microrna expession profiling in plasma of lung cancer
WO2011076145A1 (en) * 2009-12-24 2011-06-30 Fudan University Tissue-based micro-rna methods for diagnosis of different subtypes of lung cancer
WO2011075873A1 (zh) * 2009-12-24 2011-06-30 北京命码生科科技有限公司 胰腺癌标记物及其检测方法、试剂盒和生物芯片
CN101942502B (zh) * 2009-12-24 2014-09-17 北京命码生科科技有限公司 胰腺癌标记物及其检测方法、试剂盒和生物芯片
CN102770561B (zh) * 2009-12-24 2015-05-06 复旦大学 用于诊断不同亚型肺癌的基于组织的微-rna方法
US8846631B2 (en) 2010-01-14 2014-09-30 Regulus Therapeutics Inc. MicroRNA compositions and methods
CN101875973B (zh) * 2010-04-01 2013-01-09 华中农业大学 与猪免疫性状相关的小rna分子标记与应用
WO2011128886A1 (en) 2010-04-12 2011-10-20 Ramot At Tel Aviv University Ltd. A micro-rna for cancer diagnosis, prognosis and therapy
EP2561075B1 (en) 2010-04-23 2018-06-27 University of Massachusetts Aav-based treatment of cholesterol-related disorders
WO2011135459A2 (en) 2010-04-29 2011-11-03 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy
CN102242080B (zh) * 2010-05-13 2014-03-05 北京大学第三医院 miR-24用于治疗或诊断心衰或患心衰倾向或者改善心肌细胞功能的方法
WO2011150855A1 (en) * 2010-06-04 2011-12-08 Fudan University Micro-rna biomarkers and methods for diagnosis of early colorectal carcinoma and high-grade adenoma
WO2011156777A1 (en) 2010-06-10 2011-12-15 Fred Hutchinson Cancer Research Center Use of blood mir-210 for cancer prognosis
CN109112097A (zh) * 2010-06-16 2019-01-01 米纳瓦生物技术公司 重编程癌细胞
EP3369817A1 (en) 2010-07-06 2018-09-05 InteRNA Technologies B.V. Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma , or in diseases or conditions with activated braf pathway
JP5775517B2 (ja) 2010-07-08 2015-09-09 武田薬品工業株式会社 糖尿病の予防・治療剤
EP2594644B1 (en) * 2010-07-12 2016-08-10 National University Corporation Tottori University Method for preparing novel hipsc by means of mirna introduction
EP2598657B1 (en) 2010-08-01 2016-10-05 Tel HaShomer Medical Research Infrastructure and Services Ltd. Microrna patterns for the diagnosis, prognosis and treatment of melanoma
CN102018965A (zh) * 2010-09-17 2011-04-20 天津医科大学 miRNA-10a在制备抑制结肠癌的侵袭和转移药物中的应用
CN102406653B (zh) * 2010-09-21 2015-05-06 中国人民解放军第二军医大学 一种miRNA的抗病毒作用、实施方法及用途
WO2012041959A1 (en) 2010-09-30 2012-04-05 University Of Zurich Treatment of b-cell lymphoma with microrna
EP2627766B1 (en) * 2010-10-17 2016-05-25 Yeda Research and Development Co. Ltd. Methods and compositions for the treatment of insulin-associated medical conditions
CN102031261B (zh) * 2010-10-27 2015-04-22 南京医科大学 一种与妊娠期糖尿病相关的血清/血浆miRNA标志物及其应用
US20130267443A1 (en) 2010-11-19 2013-10-10 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
US20130331291A1 (en) * 2010-12-01 2013-12-12 Assistance Publique -Hôpitaux De Paris (Aphp) Method for predicting the outcome of colon cancer by analysing mirna expression
CN102140466B (zh) * 2010-12-30 2013-03-27 苏州吉玛基因股份有限公司 人miR-1825反义核酸及其应用
CN102140467B (zh) * 2010-12-30 2013-05-15 苏州吉玛基因股份有限公司 人miR-365反义核酸及其应用
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
CN102146412B (zh) * 2011-01-11 2012-10-03 中山大学 一种小分子非编码RNA 基因hsa-miR-29b 及其应用
WO2012103355A2 (en) 2011-01-26 2012-08-02 Cepheid Methods of detecting lung cancer
RU2615117C2 (ru) 2011-02-03 2017-04-04 Мирна Терапетикс, Инк. ДВУХЦЕПОЧЕЧНАЯ МОЛЕКУЛА РНК ДЛЯ ОБЕСПЕЧЕНИЯ КЛЕТКИ АКТИВНОСТЬЮ miR-34a
EP2670849A1 (en) 2011-02-03 2013-12-11 Mirna Therapeutics, Inc. Synthetic mimics of mir-124
HK1197274A1 (en) * 2011-02-07 2015-01-09 Biomirna Holdings Ltd. Micro-rna biomarkers for identifying risk of and/or for diagnosing lung tumour and pharmaceutical compositions thereof
WO2012122239A1 (en) 2011-03-07 2012-09-13 The Ohio State University MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER
EP4086338A1 (en) 2011-03-17 2022-11-09 Minerva Biotechnologies Corporation Method for making pluripotent stem cells
CA2832899A1 (en) * 2011-04-12 2012-10-18 Beth Israel Deaconess Medical Center, Inc. Micro-rna inhibitors and their uses in disease
JP6021893B2 (ja) * 2011-04-18 2016-11-09 ディアミール, エルエルシーDiamir, Llc 軽度認知機能障害(MCI)およびアルツハイマー病(AD)の早期検出ならびにモニタリングのために体液からのmiRNAを使用する方法
CA2870511C (en) 2011-04-21 2023-08-08 University Of Massachusetts Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
WO2012174293A2 (en) 2011-06-14 2012-12-20 Nestec Sa Methods for identifying inflammatory bowel disease patients with dysplasia or cancer
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
CN103857796A (zh) 2011-09-16 2014-06-11 Lsip基金运营联合公司 膀胱癌细胞的检测方法、用于膀胱癌细胞的检测方法的引物及膀胱癌标记物
WO2013067048A1 (en) * 2011-10-31 2013-05-10 The Ohio State University Materials and methods related to mir-221 and hepatocellular carcinoma
JP2015501645A (ja) * 2011-12-10 2015-01-19 オハイオ・ステイト・イノベーション・ファウンデーション 肺がんの腫瘍発生および化学療法耐性を低減するために有用なmiRNAならびに関連する組成物および方法
CN102533976A (zh) * 2011-12-15 2012-07-04 苏州福英基因科技有限公司 各种癌症病理演变前期microrna-21原位杂交检测试剂盒及检测方法和应用
CN102533978A (zh) * 2011-12-15 2012-07-04 苏州福英基因科技有限公司 各种癌症病理演变前期microrna-373水平原位杂交检测试剂盒及检测方法和应用
CN102533977A (zh) * 2011-12-15 2012-07-04 苏州福英基因科技有限公司 各种癌症病理演变前期microrna-372水平原位杂交检测试剂盒及检测方法和应用
CN102533980A (zh) * 2011-12-15 2012-07-04 苏州福英基因科技有限公司 各种癌症病理演变前期microrna-10b水平原位杂交检测试剂盒及检测方法和应用
EP2800820B1 (en) * 2011-12-19 2020-04-08 Valley Health System Methods and kits for detecting subjects having pancreatic cancer
CN102533983A (zh) * 2011-12-19 2012-07-04 苏州福英基因科技有限公司 癌症病理演变前期microrna-330水平原位杂交检测试剂盒及检测方法和应用
CN102443644A (zh) * 2011-12-20 2012-05-09 苏州福英基因科技有限公司 结肠癌病理演变前期microrna-29a水平原位杂交检测试剂盒及检测方法和应用
CN102559884A (zh) * 2011-12-27 2012-07-11 芮屈生物技术(上海)有限公司 各种癌症病理演变前期let-7mirna水平原位杂交检测试剂盒及检测方法和应用
EP2809810B1 (en) 2012-01-06 2019-11-13 Viomics Inc. System and method of detecting rnas altered by lung cancer in peripheral blood
CN103372218B (zh) * 2012-04-19 2016-05-04 中国科学院上海生命科学研究院 自身免疫性疾病相关的microRNA及其应用
CN102676524B (zh) * 2012-05-16 2013-04-03 北京旷博生物技术有限公司 乳腺癌分子标志物miR-147a
CN102743765A (zh) * 2012-05-24 2012-10-24 上海大学 非小细胞肺癌中miR-10a基因的应用
WO2014012047A1 (en) * 2012-07-12 2014-01-16 University Of Louisville Research Foundation, Inc. Systems and methods for diagnosis, prognosis, and treatment of cancer
AU2013302365B2 (en) 2012-08-16 2019-03-21 Mayo Foundation For Medical Education And Research Cancer diagnostics using biomarkers
CN102816862A (zh) * 2012-09-19 2012-12-12 南开大学 miRNA 222在前列腺癌血清学诊断试剂盒中的应用
CN102827943A (zh) * 2012-09-19 2012-12-19 南开大学 miRNA 320a在前列腺癌血清学诊断试剂盒中的应用
EP2711430A1 (en) * 2012-09-24 2014-03-26 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. MicroRNA based method for diagnosis of colorectal tumors and of metastasis
CN104994861B (zh) * 2012-10-18 2019-10-11 西澳大学 使用miRNA的癌症疗法
EP2909324B1 (en) 2012-10-25 2020-02-26 Tocagen Inc. Retroviral vector with mini-promoter cassette
EP2922554B1 (en) 2012-11-26 2022-02-23 ModernaTX, Inc. Terminally modified rna
EP2931319B1 (en) 2012-12-13 2019-08-21 ModernaTX, Inc. Modified nucleic acid molecules and uses thereof
EP2746406B1 (en) * 2012-12-18 2017-08-23 Samsung Electronics Co., Ltd. Composition and kit for diagnosing breast cancer including miRNAs within vesicle, and method of diagnosing breast cancer using the same
EP3434774A1 (en) 2013-01-17 2019-01-30 ModernaTX, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
CN103224933A (zh) * 2013-02-22 2013-07-31 上海大学 非小细胞肺癌中miR-34a基因的应用
WO2014152646A1 (en) * 2013-03-14 2014-09-25 The Trustees Of Princeton University Micrornas as functional mediators and biomarkers of bone metastasis
CA2907377A1 (en) 2013-03-15 2014-09-18 Baylor Research Institute Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
KR20150043937A (ko) 2013-10-15 2015-04-23 삼성전자주식회사 개체의 간암 진단용 조성물, 개체의 간암 진단하는 방법 및 개체의 간암 진단에 필요한 정보를 얻는 방법
KR101685107B1 (ko) * 2013-10-16 2016-12-09 서울대학교산학협력단 개체의 조직 또는 장기 손상 진단용 조성물 및 키트, 개체의 조직 또는 장기 손상을 예측 또는 진단하는 방법 및 치료제를 탐색하는 방법
CN103805603B (zh) * 2014-01-20 2016-01-20 南京医科大学附属南京儿童医院 与常见型先天肠管无神经节细胞症发生相关的血浆miRNA标志物及其应用
CN103740848B (zh) * 2014-01-28 2015-10-28 厦门大学附属中山医院 基于AllGlo探针荧光定量PCR的hsa-miR-146检测试剂盒及其检测方法
US10632349B2 (en) 2017-11-03 2020-04-28 Parsons Xtreme Golf, LLC Golf club heads and methods to manufacture golf club heads
WO2015153679A1 (en) * 2014-03-31 2015-10-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Microrna assay for detection and management of pancreatic cancer precursors
US9631194B2 (en) 2014-04-04 2017-04-25 Beth Israel Deaconess Medical Center Methods and compositions for use in treatment of FOXP2-related cancers
CN103937888B (zh) * 2014-04-14 2016-08-17 上海交通大学 鉴别胃癌的血浆microRNA标志物的筛选与应用
BR112016024565A2 (pt) * 2014-04-25 2018-01-23 Children's Medical Center Corporation composições e métodos de tratar hemoglobinopatias
EP3444362B1 (en) * 2014-05-02 2020-12-09 Ruprecht-Karls-Universität Heidelberg Circulating mirnas as early detection marker and prognostic marker
ES2481819B1 (es) * 2014-06-12 2015-04-01 Sistemas Genómicos, S.L. Método de evaluación para evaluar una posibilidad de cáncer de mama
KR102669353B1 (ko) 2014-06-12 2024-05-28 국립연구개발법인 고쿠리츠간켄큐센터 전립선암 검출 키트 또는 디바이스 및 검출 방법
CN119220688A (zh) * 2014-06-13 2024-12-31 东丽株式会社 乳癌的检测试剂盒或装置以及检测方法
KR20240023185A (ko) 2014-06-13 2024-02-20 도레이 카부시키가이샤 대장암의 검출 키트 또는 디바이스 및 검출 방법
KR102585737B1 (ko) 2014-06-16 2023-10-10 국립연구개발법인 고쿠리츠간켄큐센터 위암의 검출 키트 또는 디바이스 및 검출 방법
JP5795115B1 (ja) * 2014-06-19 2015-10-14 アイリスオーヤマ株式会社 Led照明装置
US9623040B2 (en) 2014-07-14 2017-04-18 The Board Of Trustees Of The Leland Stanford Junior University Immunomodulation by controlling expression levels of microRNAs in dendritic cells
KR102604163B1 (ko) * 2014-08-07 2023-11-20 에이전시 포 사이언스, 테크놀로지 앤드 리서치 위암 진단용 microrna 바이오마커
CN104293923A (zh) * 2014-09-19 2015-01-21 浙江大学 荧光定量PCR检测组织中miR-100含量的试剂盒及其应用
DK3198035T3 (da) 2014-09-26 2023-01-30 Allarity Therapeutics Europe ApS Fremgangsmåder til forudsigelse af medicinrespons
JP6842410B2 (ja) 2014-10-03 2021-03-17 ユニバーシティ オブ マサチューセッツ 新規の高効率ライブラリーにより同定されるaavベクター
WO2016054554A1 (en) 2014-10-03 2016-04-07 University Of Massachusetts Heterologous targeting peptide grafted aavs
RU2738421C2 (ru) 2014-10-21 2020-12-14 Юниверсити Оф Массачусетс Варианты рекомбинантных aav и их применения
WO2016077125A1 (en) 2014-11-10 2016-05-19 Moderna Therapeutics, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof
CN104491880A (zh) * 2014-12-31 2015-04-08 中国人民解放军第三军医大学 MicroRNA-141作为抑制剂的用途
TWI571514B (zh) * 2015-01-09 2017-02-21 長庚大學 評估罹患大腸直腸癌風險的方法
TWI626314B (zh) * 2015-01-09 2018-06-11 長庚大學 評估罹患大腸直腸癌風險的方法
EP3256170B1 (en) 2015-02-13 2020-09-23 University of Massachusetts Compositions and methods for transient delivery of nucleases
EP3263714B1 (en) * 2015-02-24 2021-08-25 Theoria Science Inc. Method for diagnosing brain metastasis
WO2016138287A1 (en) * 2015-02-25 2016-09-01 Washington University METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs
JP6548184B2 (ja) * 2015-02-27 2019-07-24 国立大学法人北海道大学 がんの悪性度、予後及び/又は抗がん剤治療の有効性を判定するためのバイオマーカー、抗がん剤を選択するためのコンパニオン診断薬並びに抗がん剤
US11046955B2 (en) 2015-04-24 2021-06-29 University Of Massachusetts Modified AAV constructs and uses thereof
CN105497900A (zh) * 2015-04-30 2016-04-20 苏州大学 一种抗未分化甲状腺癌耐药靶点及其应用
US10533173B2 (en) * 2015-05-05 2020-01-14 Jiangsu Micromedmark Biotech Co., Ltd. Precursor miRNA and applications in tumor therapy thereof
HK1253405A1 (zh) 2015-06-05 2019-06-14 MiRagen Therapeutics, Inc. 用於治疗皮肤t细胞淋巴瘤(ctcl)的mir-155抑制剂
KR101814868B1 (ko) * 2015-06-18 2018-01-04 재단법인대구경북과학기술원 마이크로 rna와 nmda 수용체의 상관관계를 이용한 해마의 기능감소 판단 방법, 기능감소 억제 방법 및 기능감소 억제제 스크리닝 방법
WO2017070516A1 (en) * 2015-10-22 2017-04-27 University Of Massachusetts Prostate-targeting adeno-associated virus serotype vectors
EP3364997B1 (en) 2015-10-22 2024-01-17 University of Massachusetts Aspartoacylase gene therapy in the treatment of canavan disease
CN105238863A (zh) * 2015-10-29 2016-01-13 中国科学院近代物理研究所 miR-197在作为肝癌检测标志物中的应用
CN105219867B (zh) * 2015-11-02 2016-08-17 北京博奥医学检验所有限公司 用于胃癌诊断的miRNA生物标志物及检测试剂盒
KR102601499B1 (ko) * 2015-11-06 2023-11-13 연세대학교 산학협력단 miRNA 발현 수준으로부터 UQCRB 관련 질병을 진단하는 방법
CN105441448B (zh) * 2015-11-26 2018-05-22 中国农业科学院北京畜牧兽医研究所 miR-192对绵羊骨骼肌卫星细胞增殖分化调控应用
CN105586401A (zh) * 2015-12-14 2016-05-18 常州杰傲医学检验所有限公司 一种用于乳腺癌诊断的miRNA标志物、其应用及诊断试剂盒
US20180355442A1 (en) * 2015-12-15 2018-12-13 Inserm (Institute National De La Sante Et De La Recherche Medicale) Methods for diagnosing or prognosing prostate cancer
US20210206818A1 (en) 2016-01-22 2021-07-08 Modernatx, Inc. Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
US11826433B2 (en) 2016-02-02 2023-11-28 University Of Massachusetts Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system
EP3413928B1 (en) 2016-02-12 2022-04-20 University of Massachusetts Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
JP6670119B2 (ja) 2016-02-15 2020-03-18 Kyb株式会社 ベーンポンプ
WO2017147594A1 (en) * 2016-02-26 2017-08-31 Yale University COMPOSITIONS AND METHODS OF USING piRNAS IN CANCER DIAGNOSTICS AND THERAPEUTICS
CN109312341B (zh) 2016-03-07 2024-02-27 美国政府(由卫生和人类服务部的部长所代表) 微小rna及其使用方法
CN105755123A (zh) * 2016-03-21 2016-07-13 河北医科大学第医院 一种结直肠癌相关的标志物、其引物及应用
US11207426B2 (en) 2016-04-05 2021-12-28 University Of Massachusetts Compositions and methods for selective inhibition of grainyhead-like protein expression
EP3443001B1 (en) 2016-04-11 2025-04-30 Obsidian Therapeutics, Inc. REGULATED BIOCIRCUIT SYSTEMS
US11413356B2 (en) 2016-04-15 2022-08-16 University Of Massachusetts Methods and compositions for treating metabolic imbalance
ES2941411T3 (es) 2016-05-18 2023-05-22 Modernatx Inc Polinucleótidos que codifican interleucina-12 (IL12) y usos de los mismos
US10202604B2 (en) * 2016-05-26 2019-02-12 Stemirna Therapeutics Co., Ltd. Methods of using microRNA-141
EP3468537A1 (en) 2016-06-14 2019-04-17 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
US11882815B2 (en) 2016-06-15 2024-01-30 University Of Massachusetts Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
WO2018002762A1 (en) 2016-06-29 2018-01-04 Crispr Therapeutics Ag Materials and methods for treatment of amyotrophic lateral sclerosis (als) and other related disorders
ES2989940T3 (es) 2016-06-29 2024-11-28 Crispr Therapeutics Ag Materiales y métodos para el tratamiento de la ataxia de Friedreich y otros trastornos relacionados
WO2018002812A1 (en) 2016-06-29 2018-01-04 Crispr Therapeutics Ag Materials and methods for treatment of myotonic dystrophy type 1 (dm1) and other related disorders
EP3481857A1 (en) 2016-07-06 2019-05-15 Crispr Therapeutics AG Materials and methods for treatment of pain related disorders
AU2017292169B2 (en) 2016-07-06 2021-12-23 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
US10801025B2 (en) 2016-07-26 2020-10-13 Indiana University Research And Technology Corporation MicroRNA therapy for pancreatic cancer
CN106244679B (zh) * 2016-07-27 2019-11-22 中国医学科学院基础医学研究所 miR-100抑制剂在降低癌症转移中的用途
CN106237344A (zh) * 2016-08-04 2016-12-21 北京信生元生物医学科技有限公司 miR‑1255在制备治疗膀胱癌药物中的应用
CN110506127B (zh) 2016-08-24 2024-01-12 维拉科特Sd公司 基因组标签预测前列腺癌患者对术后放射疗法应答性的用途
US10457940B2 (en) 2016-09-22 2019-10-29 University Of Massachusetts AAV treatment of Huntington's disease
CN106381298A (zh) * 2016-09-27 2017-02-08 和泓(厦门)生物技术有限公司 一种rna抑制剂及其应用
US9725769B1 (en) 2016-10-07 2017-08-08 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
WO2018071831A1 (en) 2016-10-13 2018-04-19 University Of Massachusetts Aav capsid designs
AU2017347837A1 (en) 2016-10-26 2019-06-06 Modernatx, Inc. Messenger ribonucleic acids for enhancing immune responses and methods of use thereof
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
EP3538067A1 (en) 2016-11-08 2019-09-18 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
AU2017258901A1 (en) 2016-12-30 2018-07-19 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
CA3050984A1 (en) 2017-01-20 2018-07-26 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
AU2018214556A1 (en) 2017-02-01 2019-08-15 Modernatx, Inc. Immunomodulatory therapeutic mRNA compositions encoding activating oncogene mutation peptides
CN119351474A (zh) 2017-02-22 2025-01-24 克里斯珀医疗股份公司 用于基因编辑的组合物和方法
US11407997B2 (en) 2017-02-22 2022-08-09 Crispr Therapeutics Ag Materials and methods for treatment of primary hyperoxaluria type 1 (PH1) and other alanine-glyoxylate aminotransferase (AGXT) gene related conditions or disorders
EP3585900B1 (en) 2017-02-22 2022-12-21 CRISPR Therapeutics AG Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
US20200040061A1 (en) 2017-02-22 2020-02-06 Crispr Therapeutics Ag Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
US11559588B2 (en) 2017-02-22 2023-01-24 Crispr Therapeutics Ag Materials and methods for treatment of Spinocerebellar Ataxia Type 1 (SCA1) and other Spinocerebellar Ataxia Type 1 Protein (ATXN1) gene related conditions or disorders
US11873532B2 (en) 2017-03-09 2024-01-16 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
US12215388B2 (en) 2017-05-03 2025-02-04 Lee Moffitt Cancer Center and Research Institute, Inc. Theranostic tools for management of pancreatic cancer and its precursors
CA3062716A1 (en) 2017-05-12 2018-11-15 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
WO2018231990A2 (en) 2017-06-14 2018-12-20 Modernatx, Inc. Polynucleotides encoding methylmalonyl-coa mutase
AU2018293544A1 (en) * 2017-06-29 2019-12-19 The University Of Sydney Cell-free microRNA signatures of pancreatic islet beta cell death
US12497660B2 (en) 2017-08-04 2025-12-16 Veracyte SD, Inc. Use of immune cell-specific gene expression for prognosis of prostate cancer and prediction of responsiveness to radiation therapy
CA3073211A1 (en) 2017-08-31 2019-03-07 Modernatx, Inc. Methods of making lipid nanoparticles
CN107746886B (zh) * 2017-09-11 2019-10-01 朱伟 一种与结直肠癌辅助诊断相关的血浆miRNA标志物及其应用
CN107488734B (zh) * 2017-10-10 2019-11-05 广州医科大学附属第二医院 miR-19a-3p在制备前列腺癌骨转移诊断试剂和治疗药物中的应用
CN107904301A (zh) * 2017-10-26 2018-04-13 宁波市微循环与莨菪类药研究所 miR‑181a作为海洛因成瘾的生物标记物及其在制备抗海洛因复吸药物中的应用
WO2019102381A1 (en) 2017-11-21 2019-05-31 Casebia Therapeutics Llp Materials and methods for treatment of autosomal dominant retinitis pigmentosa
CN107815492A (zh) * 2017-12-08 2018-03-20 武汉科技大学 一种基于qpcr诊断乳腺癌的检测方法
JP7298913B2 (ja) * 2017-12-13 2023-06-27 国立大学法人広島大学 乳がんの検出を補助する方法
CA3084633A1 (en) 2017-12-21 2019-06-27 Crispr Therapeutics Ag Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp)
JP7402163B2 (ja) 2017-12-21 2023-12-20 クリスパー セラピューティクス アーゲー 2a型アッシャー症候群の処置のための材料および方法
CN107881239B (zh) * 2017-12-27 2021-04-13 广西壮族自治区肿瘤防治研究所 血浆中与结直肠癌转移相关的miRNA标志物及其应用
EP3746052A1 (en) 2018-01-30 2020-12-09 Modernatx, Inc. Compositions and methods for delivery of agents to immune cells
US20210163928A1 (en) 2018-04-11 2021-06-03 Modernatx, Inc. Messenger rna comprising functional rna elements
CN108559773A (zh) * 2018-04-18 2018-09-21 江苏省人民医院(南京医科大学第附属医院) miR-218在制备治疗骨质疏松症药物中的应用
US20210071180A1 (en) * 2018-04-23 2021-03-11 Board Of Regents, The Universy Of Texas System Microrna 584-5p compositions and methods for treating cancer
WO2019241315A1 (en) 2018-06-12 2019-12-19 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
US11535899B2 (en) 2018-08-10 2022-12-27 Toray Industries, Inc. Kit, device and method for detecting prostate cancer
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
WO2020086742A1 (en) 2018-10-24 2020-04-30 Obsidian Therapeutics, Inc. Er tunable protein regulation
WO2020132494A2 (en) * 2018-12-21 2020-06-25 Baylor Research Institute Methods for prognosing, diagnosing, and treating gastric cancer
CN109971851A (zh) * 2019-01-22 2019-07-05 宁波大学 MiR-125b-2-3p作为鉴别诊断肾癌亚型的分子标志物及其在肿瘤转移中的用途
CN113939282A (zh) 2019-01-31 2022-01-14 摩登纳特斯有限公司 制备脂质纳米颗粒的方法
CN109913454B (zh) * 2019-03-05 2021-08-10 上海珑欣生物医学科技有限公司 一种生物活性提高的microRNA及其应用
AU2020235865A1 (en) 2019-03-08 2021-09-23 Obsidian Therapeutics, Inc. Human carbonic anhydrase 2 compositions and methods for tunable regulation
EP3965895A4 (en) * 2019-05-08 2023-10-25 Nova Southeastern University Regulation of nucleotide excision repair (ner) by microrna for treatment of breast cancer
JP2022538004A (ja) * 2019-06-19 2022-08-31 セルラリティ インク. 疾患治療用エキソソーム
EP3987027A1 (en) 2019-06-24 2022-04-27 ModernaTX, Inc. Endonuclease-resistant messenger rna and uses thereof
MA56517A (fr) 2019-06-24 2022-04-27 Modernatx Inc Arn messager comprenant des éléments d'arn fonctionnels et leurs utilisations
CN110354137B (zh) * 2019-08-20 2023-08-04 中山大学附属第六医院 miRNA-197-3p在制备抗前列腺癌药物中的应用
US20220348937A1 (en) 2019-09-06 2022-11-03 Obsidian Therapeutics, Inc. Compositions and methods for dhfr tunable protein regulation
CN110791560B (zh) * 2019-11-06 2021-09-14 中国医学科学院医药生物技术研究所 一种用于阿尔茨海默病诊断和/或治疗的miRNA标志物
MX2022009410A (es) 2020-01-31 2022-10-18 Modernatx Inc Metodos de preparacion de nanoparticulas lipidicas.
JP2023512688A (ja) * 2020-02-03 2023-03-28 ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー 脊髄損傷後の機能回復を促進するためのマイクロrna-7組成物およびその使用方法
CN111349704B (zh) * 2020-03-17 2020-11-24 河北医科大学第三医院 肝癌的诊断产品和治疗组合物
KR20230023612A (ko) 2020-04-02 2023-02-17 마이레큘, 인크. 조작된 올리고뉴클레오티드를 사용한 표적화된 억제
CN111471683B (zh) * 2020-04-15 2021-09-07 湖南省科域生物医药科技有限公司 miR-93-5p作为诊断和治疗胃癌标志物的应用
CN111575374B (zh) * 2020-04-29 2023-06-27 大连凯伦生物科技咨询有限公司 用于早期胰腺肿瘤检测分子标志物、其检测方法及应用
WO2021240533A1 (en) * 2020-05-29 2021-12-02 National Institute Of Immunology Dna damage dependent microrna signature for cancers, methods and uses related thereto
CN111500739B (zh) * 2020-06-15 2022-05-17 南通大学附属医院 一种用于检测鼻咽癌预后的生物标志物及其应用
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
CN112048554A (zh) * 2020-06-29 2020-12-08 浙江大学 脂质体纳米颗粒芯片及其在制备胰腺癌诊断产品中的应用和相应标志物
WO2022020811A1 (en) 2020-07-24 2022-01-27 Strand Therapeutics, Inc. Lipidnanoparticle comprising modified nucleotides
CN111944809B (zh) * 2020-07-28 2022-07-29 武汉睿健医药科技有限公司 帕金森病的诊断标志物及其应用
US20230277457A1 (en) 2020-08-06 2023-09-07 Modernatx, Inc. Methods of preparing lipid nanoparticles
CN112138161B (zh) * 2020-08-28 2022-01-14 中国人民解放军总医院 一种抑制剂的用途以及一种药物的用途
CN112226514B (zh) * 2020-11-23 2021-08-03 苏州京脉生物科技有限公司 用于早期胃癌检测的标志物组合、试剂盒及其应用
EP4012047A1 (en) * 2020-12-11 2022-06-15 Fondazione di Religione e di Culto "Casa Sollievo Della Sofferenza" - Opera di San Pio da Pietrelcina Prognostic method for aggressive lung adenocarcinomas
CN112575088B (zh) * 2020-12-29 2022-07-05 浙江大学医学院附属妇产科医院 一种血浆外泌体miRNA生物标记物及其应用
US20240166707A1 (en) 2021-01-08 2024-05-23 Strand Therapeutics Inc. Expression constructs and uses thereof
KR102548285B1 (ko) * 2021-02-10 2023-06-28 영남대학교 산학협력단 특발성 신증후군 진단용 바이오마커 조성물 및 이의 용도
CA3171589A1 (en) 2021-05-03 2022-11-03 Moritz THRAN Improved nucleic acid sequence for cell type specific expression
CN113322237B (zh) * 2021-06-16 2022-05-13 中国医学科学院肿瘤医院 一种vav2基因缺失的肿瘤细胞系
CN114081896B (zh) * 2021-11-22 2023-03-14 新乡医学院 let-7i-3p在制备治疗结直肠癌的药物中的应用及方法
US12037616B2 (en) 2022-03-01 2024-07-16 Crispr Therapeutics Ag Methods and compositions for treating angiopoietin-like 3 (ANGPTL3) related conditions
US20250191759A1 (en) 2022-03-11 2025-06-12 Adriana DE SIERVI Breast Cancer Diagnostic and Treatment
KR20250004731A (ko) 2022-04-26 2025-01-08 스트랜드 세러퓨틱스 인코포레이티드 베네수엘라 말 뇌염 (vee) 레플리콘을 포함하는 지질 나노입자 및 이의 용도
CN115044676B (zh) * 2022-06-17 2025-08-26 连云港市第一人民医院 外泌体miRNA在预测非小细胞肺癌患者免疫治疗效果中的应用
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
EP4561546A1 (en) 2022-07-29 2025-06-04 ModernaTX, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024222859A1 (zh) 2023-04-28 2024-10-31 深圳深信生物科技有限公司 经修饰的递送载体及其应用
WO2024259373A1 (en) 2023-06-14 2024-12-19 Modernatx, Inc. Compounds and compositions for delivery of therapeutic agents
WO2025160381A1 (en) 2024-01-26 2025-07-31 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2025166202A1 (en) 2024-01-31 2025-08-07 Modernatx, Inc. Lipid nanoparticle compositions comprising sialic acid derivatives and the uses thereof
ES3048857A1 (es) * 2024-06-10 2025-12-11 Fundacion Para La Investig E Innovacion Biosanitaria Del Principado De Asturias Finba FIRMA DE miRNA UTILES EN LA DISCRIMINACION DE TUMORES
CN120643588B (zh) * 2025-08-13 2025-10-24 四川大学华西医院 miR-30d-5p与CYP24A1抑制物在激素性股骨头坏死中的应用

Family Cites Families (235)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4172124A (en) 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
US4608337A (en) 1980-11-07 1986-08-26 The Wistar Institute Human hybridomas and the production of human monoclonal antibodies by human hybridomas
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4701409A (en) 1984-11-15 1987-10-20 The Wistar Institute Detection of B-cell neoplasms
US4693975A (en) 1984-11-20 1987-09-15 The Wistar Institute Human hybridroma fusion partner for production of human monoclonal antibodies
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5015568A (en) 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5202429A (en) 1986-07-09 1993-04-13 The Wistar Institute DNA molecules having human BCL-2 gene sequences
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
ATE120497T1 (de) 1988-05-09 1995-04-15 Univ Temple Verfahren zur voraussage der wirksamkeit einer antineoplastichen behandlung bei einzelnen patienten.
US5198338A (en) 1989-05-31 1993-03-30 Temple University Molecular probing for human t-cell leukemia and lymphoma
US5149628A (en) 1989-11-15 1992-09-22 Temple University Methods for detecting bcl-3 gene in human leukemias
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
US5633135A (en) 1991-12-11 1997-05-27 Thomas Jefferson University Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities
US6040140A (en) 1991-12-11 2000-03-21 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
WO1993012136A1 (en) 1991-12-11 1993-06-24 Thomas Jefferson University Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
US5674682A (en) 1992-10-29 1997-10-07 Thomas Jefferson University Nucleic acid primers for detecting micrometastasis of prostate cancer
EP0667920B1 (en) 1992-10-29 2003-01-15 Thomas Jefferson University Methods of detecting micrometastasis of prostate cancer
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
US5985598A (en) 1994-10-27 1999-11-16 Thomas Jefferson University TCL-1 gene and protein and related methods and compositions
US7175995B1 (en) 1994-10-27 2007-02-13 Thomas Jefferson University TCL-1 protein and related methods
US5695944A (en) 1995-05-05 1997-12-09 Thomas Jefferson University Modulation of bcl-2 phosphorylation
US5567586A (en) 1995-05-18 1996-10-22 Thomas Jefferson University Methods of indentifying solid tumors with chromosome abnormalities in the ALL-1 region
US5928884A (en) 1996-02-09 1999-07-27 Croce; Carlo M. FHIT proteins and nucleic acids and methods based thereon
US6242212B1 (en) 1996-02-09 2001-06-05 Thomas Jefferson University Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins
US5849902A (en) 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
WO1998035707A1 (en) 1997-02-18 1998-08-20 Thomas Jefferson University Compositions that bind to pancreatic cancer cells and methods of using the same
AU6951098A (en) 1997-04-04 1998-10-30 The Texas A & M University System Noninvasive detection of colonic biomarkers using fecal messenger rna
US6303323B1 (en) 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
CO5080817A1 (es) 1997-10-21 2001-09-25 Cancer Res Campaign Tech Ltd Determinacion de anormalidades en el crecimiento celular
CA2335315A1 (en) 1998-07-20 2000-01-27 Thomas Jefferson University Nitrilase homologs
US6255293B1 (en) 1998-07-24 2001-07-03 Yeda Research And Development Co., Ltd. Prevention of metastasis with 5-aza-2′-deoxycytidine
WO2000046364A1 (en) 1999-02-05 2000-08-10 The Uab Research Foundation Fiber receptor-independent system for the propagation of adenoviral vectors
US7141417B1 (en) 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
WO2000055169A1 (en) 1999-03-15 2000-09-21 Thomas Jefferson University TCL-1b GENE AND PROTEIN AND RELATED METHODS AND COMPOSITIONS
AU6227400A (en) 1999-07-26 2001-02-13 Childrens Hospital Los Angeles Research Institute Fenretinide increases antibody cellular toxicity
US7163801B2 (en) 1999-09-01 2007-01-16 The Burnham Institute Methods for determining the prognosis for cancer patients using tucan
US20030206958A1 (en) 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
US6891031B2 (en) 2000-02-18 2005-05-10 The Regents Of The University Of California Coordinate cytokine regulatory sequences
US20010026796A1 (en) 2000-03-14 2001-10-04 Croce Carlo M. TCL1 enhances Akt kinase activity and mediates its nuclear translocation
DE60140676D1 (de) 2000-03-30 2010-01-14 Massachusetts Inst Technology Mediatoren von rns-interferenz, die rns-sequenzspezifisch sind
CA2406366A1 (en) 2000-04-11 2001-10-18 Thomas Jefferson University Muir-torre-like syndrome infhit deficient mice
US20020086331A1 (en) 2000-05-16 2002-07-04 Carlo Croce Crystal structure of worm NitFhit reveals that a Nit tetramer binds two Fhit dimers
US7060811B2 (en) 2000-10-13 2006-06-13 Board Of Regents, The University Of Texas System WWOX: a tumor suppressor gene mutated in multiple cancers
US20020173478A1 (en) 2000-11-14 2002-11-21 The Trustees Of The University Of Pennsylvania Post-transcriptional gene silencing by RNAi in mammalian cells
US20040033502A1 (en) 2001-03-28 2004-02-19 Amanda Williams Gene expression profiles in esophageal tissue
US20050176025A1 (en) 2001-05-18 2005-08-11 Sirna Therapeutics, Inc. RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
CA2462144C (en) 2001-09-28 2016-09-20 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Micro-rna molecules
US7371736B2 (en) 2001-11-07 2008-05-13 The Board Of Trustees Of The University Of Arkansas Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss
WO2003040347A2 (en) 2001-11-09 2003-05-15 The Ohio State University Research Foundation Baalc expression as a diagnostic marker for acute leukemia
GB0128898D0 (en) 2001-12-03 2002-01-23 Biotech Res Ventures Pte Ltd Materials and methods relating to the stabilization and activation of a tumour suppressor protein
AU2002231843A1 (en) 2002-02-12 2003-09-04 Nokia Corporation Method for controlling data transmission, and data transmission system
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
CA2463595A1 (en) 2002-02-20 2003-08-28 Sirna Therapeutics, Inc. Rna interference mediated inhibition of bcl2 gene expression using short interfering nucleic acid (sina)
MXPA04008722A (es) 2002-03-08 2005-07-13 Eisai Co Ltd Compuestos macrociclicos utiles como farmaceuticos.
ATE529535T1 (de) * 2002-03-13 2011-11-15 Genomic Health Inc Genexpressionsprofilierung in einer biopsie unterzogenem tumorgewebe
EP1496928A4 (en) 2002-04-08 2005-08-10 Ciphergen Biosystems Inc SERUM BIOMARKERS IN HEPATOCELLULAR CARCINOMA
DE60329836D1 (de) 2002-04-29 2009-12-10 Univ Jefferson Humane chronische lymphozytische leukämie im mausmodell durch gezielte expression von tcl1
US8119610B2 (en) 2002-05-31 2012-02-21 The Regents Of The University Of California Method for efficient RNA interference in mammalian cells
EP1530418A4 (en) 2002-05-31 2005-10-12 Univ Leland Stanford Junior METHOD FOR IDENTIFYING AND INSULATING STEM CELLS AND CANCER STAMPS
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
US20050260639A1 (en) 2002-09-30 2005-11-24 Oncotherapy Science, Inc. Method for diagnosing pancreatic cancer
US20050266443A1 (en) 2002-10-11 2005-12-01 Thomas Jefferson University Novel tumor suppressor gene and compositions and methods for making and using the same
JP2006512908A (ja) 2002-10-11 2006-04-20 トーマス ジェファーソン ユニバーシティー 腫瘍抑制遺伝子および組成物ならびにその作製法および使用法
CA2504605C (en) 2002-11-13 2016-01-19 Thomas Jefferson University Treatment of chronic lymphocytic leukemia and prostate cancer with microrna mir15
CN1719973A (zh) 2002-11-13 2006-01-11 托马斯杰斐逊大学 用于癌症诊断和治疗的组合物和方法
US7250496B2 (en) 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US20040102421A1 (en) 2002-11-21 2004-05-27 Children's Hospital Research Center At Oakland Tocopherol and tocotrienol anti-inflammatory medicaments
WO2004071464A2 (en) 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
WO2004079013A1 (en) 2003-03-03 2004-09-16 Arizona Board Of Regents On Behalf Of The University Of Arizona Ecto-5’-nucleotidase (cd73) used in the diagnosis and the treatment of pancreatic cancer
US7183384B2 (en) 2003-03-06 2007-02-27 A & G Pharmaceutical, Inc. Monoclonal antibody 7H11 reactive with human cancer
WO2004081196A2 (en) 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
AU2003286741A1 (en) 2003-05-02 2004-11-26 Thomas Jefferson University Methods and compositions for diagnosis and therapy of parkin-associated disorders
US20050069918A1 (en) 2003-05-29 2005-03-31 Francois Claret JAB1 as a prognostic marker and a therapeutic target for human cancer
MXPA05013879A (es) 2003-06-18 2006-06-27 Genelux Corp Virus de la vaccinia recombinantes modificados y otros microorganismos, y usos de los mismos.
WO2005013901A2 (en) * 2003-07-31 2005-02-17 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for use in modulation of small non-coding rnas
US8106180B2 (en) 2003-08-07 2012-01-31 Whitehead Institute For Biomedical Research Methods and products for expression of micro RNAs
US20050037362A1 (en) 2003-08-11 2005-02-17 Eppendorf Array Technologies, S.A. Detection and quantification of siRNA on microarrays
US8412541B2 (en) 2003-08-14 2013-04-02 Edda Technology, Inc. Method and system for intelligent qualitative and quantitative analysis for medical diagnosis
US20050084883A1 (en) 2003-08-25 2005-04-21 The Johns Hopkins University School Of Medicine Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differential gene expression analysis
EP1670955A2 (en) 2003-09-22 2006-06-21 Rosetta Inpharmatics LLC. Synthetic lethal screen using rna interference
JPWO2005028648A1 (ja) 2003-09-22 2007-11-15 愛知県 リンパ腫の病型および予後診断方法
US20070054849A1 (en) 2003-09-24 2007-03-08 Oncotherapy Science, Inc. Method for diagnosing hepatocellular carcinomas
US20050186589A1 (en) 2003-11-07 2005-08-25 University Of Massachusetts Interspersed repetitive element RNAs as substrates, inhibitors and delivery vehicles for RNAi
US20050164252A1 (en) 2003-12-04 2005-07-28 Yeung Wah Hin A. Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell
AU2004305075A1 (en) 2003-12-19 2005-07-07 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies
JP4120002B2 (ja) 2004-01-07 2008-07-16 愛知県 miRNAを用いた癌の予後判定方法、癌の遺伝子治療ベクター及び癌治療用医薬組成物
US20050256072A1 (en) 2004-02-09 2005-11-17 University Of Massachusetts Dual functional oligonucleotides for use in repressing mutant gene expression
EP1713938A2 (en) 2004-02-09 2006-10-25 Thomas Jefferson University DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
WO2005079397A2 (en) 2004-02-13 2005-09-01 Rockefeller University Anti-microrna oligonucleotide molecules
JP4980878B2 (ja) 2004-02-23 2012-07-18 エラスムス ユニバーシティ メディカル センター ロッテルダム 遺伝子発現プロファイリングによる急性骨髄性白血病の分類、診断、および予後
WO2005094263A2 (en) 2004-03-23 2005-10-13 Pintex Pharmaceuticals, Inc. Methods of determining the prognosis and treatment of subjects with colon cancer
US20060134639A1 (en) 2004-04-06 2006-06-22 Huffel Christophe V Method for the determination of cellular transcriptional regulation
US7365058B2 (en) 2004-04-13 2008-04-29 The Rockefeller University MicroRNA and methods for inhibiting same
KR20070004957A (ko) 2004-04-20 2007-01-09 제나코 바이오메디컬 프로덕츠, 인코포레이티드 ncRNA 검출 방법
IL179285A (en) * 2004-05-14 2011-04-28 Rosetta Genomics Ltd Micrornas and uses thereof
EP1771563A2 (en) * 2004-05-28 2007-04-11 Ambion, Inc. METHODS AND COMPOSITIONS INVOLVING MicroRNA
US7635563B2 (en) 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
KR20070058441A (ko) 2004-07-01 2007-06-08 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 면역억제성 엑소솜
US20060037088A1 (en) 2004-08-13 2006-02-16 Shulin Li Gene expression levels as predictors of chemoradiation response of cancer
EP1797183B1 (en) 2004-09-02 2012-08-01 Yale University Regulation of oncogenes by micrornas
US7642348B2 (en) 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
US7592441B2 (en) 2004-10-04 2009-09-22 Rosetta Genomics Ltd Liver cancer-related nucleic acids
FR2877350B1 (fr) 2004-11-03 2010-08-27 Centre Nat Rech Scient IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE
EP1838852A2 (en) * 2004-11-12 2007-10-03 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
WO2008073922A2 (en) 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
EP1662259A1 (en) 2004-11-25 2006-05-31 Cellzome Ag Use of Eph receptor inhibitors for the treatment of neurodegenerative diseases
ATE544774T1 (de) 2004-12-14 2012-02-15 Alnylam Pharmaceuticals Inc Rnai-modulation von mll-af4 und verwendungen dafür
US20060185027A1 (en) 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
WO2006069584A2 (en) 2004-12-29 2006-07-06 Exiqon A/S NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF microRNAs AND THEIR TARGET mRNAs
DE602006016739D1 (de) 2005-01-25 2010-10-21 Rosetta Inpharmatics Llc Verfahren zur quantifizierung kleiner rna-moleküle
US8071306B2 (en) 2005-01-25 2011-12-06 Merck Sharp & Dohme Corp. Methods for quantitating small RNA molecules
WO2006086737A2 (en) 2005-02-11 2006-08-17 Wisconsin Alumni Reasearch Foundation Mir-155 assay
ES2440481T3 (es) 2005-02-23 2014-01-29 Genentech, Inc. Prolongación del tiempo hasta la progresión de la enfermedad o supervivencia en pacientes de cáncer de ovario usando pertuzumab
US20070065840A1 (en) 2005-03-23 2007-03-22 Irena Naguibneva Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS
GB2425311A (en) 2005-04-15 2006-10-25 Ist Superiore Sanita Micro RNA against kit protein
JP5173793B2 (ja) 2005-04-29 2013-04-03 ザ ロックフェラー ユニバーシティ マイクロrna及びそれを阻害する方法
US8071559B2 (en) 2005-05-02 2011-12-06 Cold Spring Harbor Laboratory Compositions and methods for cancer diagnosis and treatment
US20090209621A1 (en) 2005-06-03 2009-08-20 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
US20070065844A1 (en) 2005-06-08 2007-03-22 Massachusetts Institute Of Technology Solution-based methods for RNA expression profiling
US20060292616A1 (en) 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods
WO2007016548A2 (en) * 2005-08-01 2007-02-08 The Ohio State University Research Foundation Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer
US20070123482A1 (en) 2005-08-10 2007-05-31 Markus Stoffel Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
US20070213292A1 (en) 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
EP2796554A3 (en) 2005-09-12 2014-12-10 The Ohio State University Research Foundation Compositions for use in treating BCL2-associated cancers
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
EP1940456A4 (en) 2005-10-05 2009-10-21 Univ Ohio State Res Found WWOX GENE, VECTORS COMPRISING THE SAME, AND USES THEREOF IN THE TREATMENT OF CANCER
US20070092882A1 (en) 2005-10-21 2007-04-26 Hui Wang Analysis of microRNA
US8445198B2 (en) 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
US7390792B2 (en) 2005-12-15 2008-06-24 Board Of Regents, The University Of Texas System MicroRNA1 therapies
EP1966390A1 (en) 2005-12-29 2008-09-10 Exiqon A/S Detection of tissue origin of cancer
EP2514433B1 (en) 2006-01-05 2015-10-21 The Ohio State University Research Foundation MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer
CN103361424A (zh) 2006-01-05 2013-10-23 俄亥俄州立大学研究基金会 胰腺内分泌和腺泡肿瘤中的微小rna表达异常
EP2468895B1 (en) 2006-01-05 2014-09-24 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
US20090007281A1 (en) 2006-01-13 2009-01-01 Battelle Memorial Institute Animal Model for Assessing Copd-Related Diseases
EP2369011A1 (en) 2006-03-20 2011-09-28 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis
WO2007112097A2 (en) 2006-03-24 2007-10-04 Children's Medical Center Corporation Novel signature self renewal gene expression programs
AU2007233155B2 (en) 2006-03-29 2012-04-26 Scitech Development Llc Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery
EP2007889A2 (en) 2006-04-03 2008-12-31 Santaris Pharma A/S Pharmaceutical compositions comprising anti-mirna antisense oligonucleotides
CA2650026C (en) 2006-04-24 2013-01-22 The Ohio State University Research Foundation Pre-b cell proliferation and lymphoblastic leukemia/high-grade lymphoma in mir155 transgenic mice
WO2008002672A2 (en) 2006-06-28 2008-01-03 The Cleveland Clinic Foundation Targets for use in diagnosis, prognosis and therapy of cancer
WO2008029295A2 (en) 2006-06-30 2008-03-13 Rosetta Genomics Ltd A method for detecting nucleic acids
ES2447850T3 (es) 2006-07-13 2014-03-13 The Ohio State University Research Foundation Métodos y composiciones basados en micro-ARN para el pronóstico y tratamiento de enfermedades relacionadas con el colon
EA016145B1 (ru) 2006-08-30 2012-02-28 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Новые низкомолекулярные ингибиторы mdm2 и их применение
US20080193943A1 (en) 2006-09-05 2008-08-14 Abbott Laboratories Companion diagnostic assays for cancer therapy
AU2007299748A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. miR-15, miR-26, miR -31,miR -145, miR-147, miR-188, miR-215, miR-216 miR-331, mmu-miR-292-3p regulated genes and pathways as targets for therapeutic intervention
AU2007299804A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. MiR-200 regulated genes and pathways as targets for therapeutic intervention
JP5426383B2 (ja) 2006-09-19 2014-02-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 慢性リンパ球性白血病におけるmiR−29およびmiR−181によって制御されるTCL1発現
EP2115138A2 (en) 2006-09-19 2009-11-11 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
JP2008086201A (ja) 2006-09-29 2008-04-17 Gifu Prefecture Kenkyu Kaihatsu Zaidan マイクロrna生成の検出方法と癌の診断・治療およびマイクロrna生成調整剤
US8202968B2 (en) 2006-10-20 2012-06-19 Washington University Predicting lung cancer survival using gene expression
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
JP2010510769A (ja) 2006-11-28 2010-04-08 キャピタルバイオ コーポレーション 食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物
US8293684B2 (en) 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
WO2008070082A2 (en) 2006-12-04 2008-06-12 The Johns Hopkins University Stem-progenitor cell specific micro-ribonucleic acids and uses thereof
GB0624302D0 (en) 2006-12-05 2007-01-17 Istituto Superiore Di Sanito Micro RNA
AU2007333107A1 (en) 2006-12-08 2008-06-19 Asuragen, Inc. miR-21 regulated genes and pathways as targets for therapeutic intervention
WO2008073919A2 (en) 2006-12-08 2008-06-19 Asuragen, Inc. Mir-20 regulated genes and pathways as targets for therapeutic intervention
CN101622350A (zh) 2006-12-08 2010-01-06 奥斯瑞根公司 作为干预治疗靶标的miR-126调控基因和通路
CA2671270A1 (en) 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
WO2008094545A2 (en) 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
US8765702B2 (en) 2007-02-27 2014-07-01 Rosetta Genomics Ltd. Composition and methods for modulating cell proliferation and cell death
WO2008113758A1 (en) 2007-03-16 2008-09-25 Covalx Ag Direct mass spectrometric analysis of drug candidates targeting protein complexes
RU2009141359A (ru) 2007-04-10 2011-05-20 Нэйшнл Тайвань Юниверсити (Tw) Посттерапевтический прогноз выживания больных раком с использованием микрорнк
US20100144850A1 (en) 2007-04-30 2010-06-10 The Ohio State University Research Foundation Methods for Differentiating Pancreatic Cancer from Normal Pancreatic Function and/or Chronic Pancreatitis
US20090005336A1 (en) 2007-05-08 2009-01-01 Zhiguo Wang Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions
US20090131354A1 (en) 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090232893A1 (en) 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090099034A1 (en) 2007-06-07 2009-04-16 Wisconsin Alumni Research Foundation Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers
ES2537349T3 (es) 2007-06-08 2015-06-05 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Métodos para determinar un subtipo de carcinoma hepatocelular
AU2008261951A1 (en) 2007-06-08 2008-12-18 Asuragen, Inc. miR-34 regulated genes and pathways as targets for therapeutic intervention
CA2690749A1 (en) 2007-06-15 2008-12-24 The Ohio State University Research Foundation Oncogenic all-1 fusion proteins for targeting drosha-mediated microrna processing
EP2613149B1 (en) 2007-07-25 2014-09-17 University Of Louisville Research Foundation, Inc. Exosome-associated microRNA as a diagnostic marker
AU2008282318B2 (en) 2007-07-31 2014-02-27 The Ohio State University Research Foundation Methods for reverting methylation by targeting methyltransferases
EP2650383A1 (en) 2007-08-03 2013-10-16 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
CA2926831A1 (en) 2007-08-22 2009-02-26 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
US20090061424A1 (en) 2007-08-30 2009-03-05 Sigma-Aldrich Company Universal ligation array for analyzing gene expression or genomic variations
CA2698771A1 (en) 2007-09-06 2009-03-12 The Ohio State University Research Foundation Microrna signatures in human ovarian cancer
US20090239818A1 (en) 2007-09-07 2009-09-24 Cheng Jin Q Effective treatment of ovarian cancer using triciribine and related compounds
ES2419129T3 (es) 2007-09-14 2013-08-19 The Ohio State University Research Foundation Expresión de miARN en microvesículas de sangre periférica humana y usos del mismo
US20100305188A1 (en) 2007-10-03 2010-12-02 Kyowa Hakko Kirin Co., Ltd. Nucleic acid capable of regulating the proliferation of cell
MX2010003299A (es) 2007-10-04 2010-04-14 Santaris Pharma As Oligonucleotidos muy cortos (micromirs).
CN101861401B (zh) 2007-10-11 2014-03-12 俄亥俄州立大学研究基金会 用于诊断和治疗食管腺癌的方法和组合物
CN103898069A (zh) 2007-10-26 2014-07-02 俄亥俄州立大学研究基金会 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途
JP5535076B2 (ja) 2007-10-29 2014-07-02 レグルス・セラピューティクス・インコーポレイテッド 肝臓癌を治療するための標的化ミクロrna
US20090123933A1 (en) 2007-11-12 2009-05-14 Wake Forest University Health Sciences Microrna biomarkers in lupus
AU2008321253B2 (en) 2007-11-12 2014-01-16 Masaryk Memorial Cancer Institute Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
CN101918594A (zh) 2007-11-30 2010-12-15 俄亥俄州立大学研究基金会 肺癌中外周血中的微rna表达特征谱和靶向
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
US20090192114A1 (en) 2007-12-21 2009-07-30 Dmitriy Ovcharenko miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
CN101215560B (zh) 2007-12-26 2010-09-29 暨南大学 一种具有抗白血病作用的miR-21反义寡核苷酸及其应用
KR20100127768A (ko) 2008-02-01 2010-12-06 더 제너럴 하스피탈 코포레이션 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도
EP2260110B1 (en) 2008-02-08 2014-11-12 Asuragen, INC. miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
CA2717030A1 (en) 2008-02-28 2009-09-03 The Ohio State University Research Foundation Microrna signatures associated with cytogenetics and prognosis in acute myeloid leukemia (aml) and uses thereof
AU2009219197B2 (en) 2008-02-28 2014-04-10 The Govt. Of The U.S.A. As Represented By The Secretary Of The Dep. Of Health And Human Services MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of prostate related disorders
CN102015027A (zh) 2008-02-28 2011-04-13 俄亥俄州立大学研究基金会 与人慢性淋巴细胞性白血病(ccl)相关的微rna特征和其用途
JP5662166B2 (ja) 2008-02-28 2015-01-28 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation 胃癌の診断、予後診断及び治療のためのマイクロrnaに基づいた方法及び組成物
US20090220589A1 (en) 2008-03-01 2009-09-03 Abraxis Bioscience, Llc Treatment, diagnostic, and method for discovering antagonist using sparc specific mirnas
WO2009111643A2 (en) 2008-03-06 2009-09-11 Asuragen, Inc. Microrna markers for recurrence of colorectal cancer
US20090253780A1 (en) 2008-03-26 2009-10-08 Fumitaka Takeshita COMPOSITIONS AND METHODS RELATED TO miR-16 AND THERAPY OF PROSTATE CANCER
WO2009131887A2 (en) 2008-04-24 2009-10-29 Merck & Co., Inc. Methods of using mir210 as a biomarker for hypoxia and as a therapeutic agent for treating cancer
EP2285960B1 (en) 2008-05-08 2015-07-08 Asuragen, INC. Compositions and methods related to mir-184 modulation of neovascularization or angiogenesis
US20110107440A1 (en) 2008-06-04 2011-05-05 Andor Pivarcsi Skin cancer associated micrornas
US8900627B2 (en) 2008-06-06 2014-12-02 Mirna Therapeutics, Inc. Compositions for the in vivo delivery of RNAi agents
CN102149827B (zh) 2008-06-11 2014-08-20 由卫生与公众服务部代表的美利坚合众国政府 MiR-26家族作为肝细胞癌和对治疗的应答性的预测性标志物的用途
US20100021734A1 (en) 2008-07-22 2010-01-28 Covalent Materials Corporation Ceramic particles and producing method thereof
KR101031305B1 (ko) 2008-07-23 2011-04-29 국립암센터 마이크로rna-21 저해제를 포함하는 방사선 민감성증진용 조성물
EP2315832B1 (en) 2008-08-01 2015-04-08 Roche Innovation Center Copenhagen A/S Micro-rna mediated modulation of colony stimulating factors
JP2012500389A (ja) 2008-08-12 2012-01-05 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 多発性脊髄腫の診断、予後および治療のためのマイクロrnaに基づく組成物および方法
ES2663698T3 (es) 2008-09-04 2018-04-16 Ventana Medical Systems, Inc. Procedimiento para la predicción del riesgo de progresión de tumores
WO2010056737A2 (en) 2008-11-11 2010-05-20 Mirna Therapeutics, Inc. Methods and compositions involving mirnas in cancer stem cells
WO2010059779A1 (en) 2008-11-21 2010-05-27 The Ohio State University Research Foundation Tcl1 AS A TRANSCRIPTIONAL REGULATOR
WO2010065156A1 (en) 2008-12-05 2010-06-10 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis and treatment of ovarian cancer
AU2010218147A1 (en) 2009-02-26 2011-10-20 The Government Of The United States Of America As Represented By The Secretary Of The Dept. Of Health & Human Services MicroRNAs in never-smokers and related materials and methods
US20110136124A1 (en) 2009-09-23 2011-06-09 Wilson Roa Microrna expression profiles associated with lung cancer
EP2521541A2 (en) 2009-10-28 2012-11-14 ReVision Therapeutics, Inc. Prophylaxis of skin cancer with retinamides
WO2011057304A2 (en) 2009-11-09 2011-05-12 Yale University Microrna signatures differentiating uterine and ovarian papillary serous tumors
EP2504452A4 (en) 2009-11-23 2014-06-11 Univ Ohio State Res Found MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS
EP2354246A1 (en) 2010-02-05 2011-08-10 febit holding GmbH miRNA in the diagnosis of ovarian cancer
CN102844661B (zh) 2010-02-11 2014-06-25 香港理工大学 胃癌的生物标志物及其应用
WO2011119553A1 (en) 2010-03-26 2011-09-29 The Ohio State University Materials and methods related to modulation of mismatch repair and genomic stability by mir-155
US20130139273A1 (en) 2010-06-24 2013-05-30 The Ohio State University Chronic Lymphocytic Leukemia Modeled in Mouse by Targeted miR-29 Expression
US20130150430A1 (en) 2010-08-04 2013-06-13 The Ohio State University Methods for Impairing the P53/HDM2 Auto-Regulatory Loop in Multiple Myeloma Development Using mIR-192, mIR-194 and mIR-215
ES2606146T3 (es) 2010-11-12 2017-03-22 The Ohio State University Research Foundation Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal
WO2012097047A1 (en) 2011-01-11 2012-07-19 The Ohio State University Research Foundation Methods to identify chronic lymphocytic leukemia disease progression
WO2012122239A1 (en) 2011-03-07 2012-09-13 The Ohio State University MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013046612A (ja) * 2006-01-05 2013-03-07 Ohio State Univ Research Foundation 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物
JP2014060993A (ja) * 2006-01-05 2014-04-10 Ohio State Univ Research Foundation:The 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物
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US8946187B2 (en) 2010-11-12 2015-02-03 The Ohio State University Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
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US9434995B2 (en) 2012-01-20 2016-09-06 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
WO2023190271A1 (ja) 2022-03-28 2023-10-05 株式会社リジェネシスサイエンス miR-140を含む医薬組成物及びその製造方法

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