MX368314B - Inhibidores del mir-155 para tratar linfoma cutáneo de células t (ctcl). - Google Patents

Inhibidores del mir-155 para tratar linfoma cutáneo de células t (ctcl).

Info

Publication number
MX368314B
MX368314B MX2017015400A MX2017015400A MX368314B MX 368314 B MX368314 B MX 368314B MX 2017015400 A MX2017015400 A MX 2017015400A MX 2017015400 A MX2017015400 A MX 2017015400A MX 368314 B MX368314 B MX 368314B
Authority
MX
Mexico
Prior art keywords
mir
inhibitors
cell lymphoma
ctcl
treating cutaneous
Prior art date
Application number
MX2017015400A
Other languages
English (en)
Other versions
MX2017015400A (es
Inventor
Dalby Christina
Seto Anita
Jackson Aimee
Rodman David
BEATTY Xuan
Original Assignee
Miragen Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miragen Therapeutics Inc filed Critical Miragen Therapeutics Inc
Publication of MX2017015400A publication Critical patent/MX2017015400A/es
Publication of MX368314B publication Critical patent/MX368314B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3531—Hydrogen
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
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  • Wood Science & Technology (AREA)
  • Zoology (AREA)
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a inhibidores de oligonucleótidos del miR-155 y composiciones de los mismos. La invención proporciona además los métodos para tratar un cáncer tal como un linfoma de células T en un sujeto al administrar al sujeto un inhibidor de oligonucleótidos del miR-155. La invención también proporciona los métodos para reducir o inhibir la proliferación de células T malignas al administrar un inhibidor de oligonucleótidos del miR-155.
MX2017015400A 2015-06-05 2016-06-03 Inhibidores del mir-155 para tratar linfoma cutáneo de células t (ctcl). MX368314B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562171758P 2015-06-05 2015-06-05
PCT/US2016/035865 WO2016197024A2 (en) 2015-06-05 2016-06-03 Mir-155 inhibitors for treating cutaneous t cell lymphoma (ctcl)

Publications (2)

Publication Number Publication Date
MX2017015400A MX2017015400A (es) 2018-06-19
MX368314B true MX368314B (es) 2019-09-27

Family

ID=57441983

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017015400A MX368314B (es) 2015-06-05 2016-06-03 Inhibidores del mir-155 para tratar linfoma cutáneo de células t (ctcl).
MX2019011469A MX2019011469A (es) 2015-06-05 2017-11-29 Inhibidores del mir-155 para tratar linfoma cutaneo de celulas t (ctcl).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019011469A MX2019011469A (es) 2015-06-05 2017-11-29 Inhibidores del mir-155 para tratar linfoma cutaneo de celulas t (ctcl).

Country Status (14)

Country Link
US (5) US9771585B2 (es)
EP (1) EP3303590A4 (es)
JP (2) JP6721252B2 (es)
KR (2) KR20190118688A (es)
CN (1) CN108138180A (es)
AU (2) AU2016270434B2 (es)
BR (1) BR112017026201A2 (es)
CA (1) CA2986949C (es)
HK (1) HK1253405A1 (es)
IL (1) IL255896A (es)
MX (2) MX368314B (es)
NZ (1) NZ737542A (es)
RU (1) RU2718534C2 (es)
WO (1) WO2016197024A2 (es)

Families Citing this family (8)

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EP3303590A4 (en) 2015-06-05 2019-01-02 Miragen Therapeutics, Inc. Mir-155 inhibitors for treating cutaneous t cell lymphoma (ctcl)
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Also Published As

Publication number Publication date
JP2020094073A (ja) 2020-06-18
CN108138180A (zh) 2018-06-08
US20180037890A1 (en) 2018-02-08
US20160355814A1 (en) 2016-12-08
AU2016270434A1 (en) 2017-12-07
MX2019011469A (es) 2019-11-01
MX2017015400A (es) 2018-06-19
JP2018517412A (ja) 2018-07-05
KR20180005754A (ko) 2018-01-16
BR112017026201A2 (pt) 2018-08-14
NZ737542A (en) 2019-09-27
WO2016197024A2 (en) 2016-12-08
US20180127750A1 (en) 2018-05-10
US9994852B2 (en) 2018-06-12
US10316318B2 (en) 2019-06-11
AU2016270434B2 (en) 2019-07-11
WO2016197024A3 (en) 2017-02-09
EP3303590A4 (en) 2019-01-02
RU2017146374A (ru) 2019-07-09
EP3303590A2 (en) 2018-04-11
US9771585B2 (en) 2017-09-26
KR20190118688A (ko) 2019-10-18
JP6721252B2 (ja) 2020-07-08
CA2986949A1 (en) 2016-12-08
HK1253405A1 (zh) 2019-06-14
KR102034619B1 (ko) 2019-11-11
AU2019232918A1 (en) 2019-10-10
US20190106695A1 (en) 2019-04-11
CA2986949C (en) 2020-07-21
RU2017146374A3 (es) 2019-09-30
US20190359980A1 (en) 2019-11-28
RU2718534C2 (ru) 2020-04-08
IL255896A (en) 2018-01-31

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