BR112017026201A2 - inibidores de mir-155 para o tratamento de linfoma cutâneo de células t (ctcl) - Google Patents
inibidores de mir-155 para o tratamento de linfoma cutâneo de células t (ctcl)Info
- Publication number
- BR112017026201A2 BR112017026201A2 BR112017026201-0A BR112017026201A BR112017026201A2 BR 112017026201 A2 BR112017026201 A2 BR 112017026201A2 BR 112017026201 A BR112017026201 A BR 112017026201A BR 112017026201 A2 BR112017026201 A2 BR 112017026201A2
- Authority
- BR
- Brazil
- Prior art keywords
- mir
- inhibitors
- cell lymphoma
- ctcl
- cutaneous
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3531—Hydrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
a presente invenção proporciona inibidores de oligonucleotídeo de mir-155 e composições dos mesmos. a invenção proporciona adicionalmente métodos para o tratamento de câncer, tal como um linfoma de células t em um indivíduo através da administração ao indivíduo de um inibidor de oligonucleotídeos de mir-155. a invenção também proporciona métodos para reduzir ou inibir a proliferação de células t malignas através da administração de um inibidor de oligonucleotídeos de mir-155.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562171758P | 2015-06-05 | 2015-06-05 | |
US62/171,758 | 2015-06-05 | ||
PCT/US2016/035865 WO2016197024A2 (en) | 2015-06-05 | 2016-06-03 | Mir-155 inhibitors for treating cutaneous t cell lymphoma (ctcl) |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017026201A2 true BR112017026201A2 (pt) | 2018-08-14 |
Family
ID=57441983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017026201-0A BR112017026201A2 (pt) | 2015-06-05 | 2016-06-03 | inibidores de mir-155 para o tratamento de linfoma cutâneo de células t (ctcl) |
Country Status (14)
Country | Link |
---|---|
US (5) | US9771585B2 (pt) |
EP (1) | EP3303590A4 (pt) |
JP (2) | JP6721252B2 (pt) |
KR (2) | KR20190118688A (pt) |
CN (1) | CN108138180A (pt) |
AU (2) | AU2016270434B2 (pt) |
BR (1) | BR112017026201A2 (pt) |
CA (1) | CA2986949C (pt) |
HK (1) | HK1253405A1 (pt) |
IL (1) | IL255896A (pt) |
MX (2) | MX368314B (pt) |
NZ (1) | NZ737542A (pt) |
RU (1) | RU2718534C2 (pt) |
WO (1) | WO2016197024A2 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108138180A (zh) | 2015-06-05 | 2018-06-08 | 米拉根医疗股份有限公司 | 用于治疗皮肤t细胞淋巴瘤(ctcl)的mir-155抑制剂 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
WO2018009855A1 (en) * | 2016-07-07 | 2018-01-11 | MiRagen Therapeutics, Inc. | Methods for treating cutaneous t-cell lymphoma (ctcl) with mir-155 inhibitors |
EP3494228B1 (en) * | 2016-08-03 | 2021-07-07 | CBmed GmbH Center for Biomarker Research in Medicine | Method for prognosing and diagnosing tumors |
US11478500B2 (en) * | 2018-08-16 | 2022-10-25 | The Regents Of The University Of California | Anticancer compositions and methods for making and using them |
JP2022511848A (ja) * | 2018-12-03 | 2022-02-01 | ミラゲン セラピューティクス,インコーポレイテッド | Mir-155阻害剤を使用した成人t細胞白血病/リンパ腫(atll)の治療 |
CN112661826B (zh) * | 2020-12-25 | 2022-03-29 | 中山大学 | 小肽ERpeptide及其在急性髓系白血病中的应用 |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1541463A (en) | 1975-10-11 | 1979-02-28 | Lion Dentifrice Co Ltd | Process for prparing a multiple emulsion having a dispersing form of water-phase/oil-phase/water-phase |
US4960764A (en) | 1987-03-06 | 1990-10-02 | Richardson-Vicks Inc. | Oil-in-water-in-silicone emulsion compositions |
US5260065A (en) | 1991-09-17 | 1993-11-09 | Micro Vesicular Systems, Inc. | Blended lipid vesicles |
US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
US5840710A (en) | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
WO1996031194A2 (en) | 1995-04-03 | 1996-10-10 | Johnson & Johnson Consumer Products, Inc. | Skin care compositions containing retinoids and liposomes |
US5783656A (en) | 1996-02-06 | 1998-07-21 | Japan Synthetic Rubber Co., Ltd. | Polyamic acid, polyimide and liquid crystal aligning agent |
US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
AU731909B2 (en) | 1997-07-01 | 2001-04-05 | Isis Pharmaceuticals, Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
SK17432000A3 (sk) | 1998-05-26 | 2001-07-10 | Icn Pharmaceuticals, Inc. | Zlúčenina, ktorá zahŕňa nukleozid s 2',4'-mostíkom a oligonukleotid z nej odvodený |
US6838283B2 (en) | 1998-09-29 | 2005-01-04 | Isis Pharmaceuticals Inc. | Antisense modulation of survivin expression |
US6693187B1 (en) | 2000-10-17 | 2004-02-17 | Lievre Cornu Llc | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge |
EP2428571B1 (en) | 2001-09-28 | 2018-07-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
JP4868739B2 (ja) | 2002-05-06 | 2012-02-01 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 核酸の送達法 |
CA2533701A1 (en) | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
WO2005054494A2 (en) | 2003-11-26 | 2005-06-16 | University Of Massachusetts | Sequence-specific inhibition of small rna function |
WO2005078139A2 (en) | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES |
CA2556435C (en) | 2004-02-13 | 2014-08-12 | The Rockefeller University | Anti-microrna oligonucleotide molecules |
EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP1791567B1 (en) | 2004-08-10 | 2015-07-29 | Alnylam Pharmaceuticals Inc. | Chemically modified oligonucleotides |
US8071306B2 (en) | 2005-01-25 | 2011-12-06 | Merck Sharp & Dohme Corp. | Methods for quantitating small RNA molecules |
EP1856286A2 (en) | 2005-02-11 | 2007-11-21 | Wisconsin Alumni Research Foundation | Mir-155 assay |
CN103882124B (zh) | 2005-08-01 | 2015-11-18 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
KR20080082956A (ko) | 2005-09-15 | 2008-09-12 | 노보솜 아게 | 양쪽성 리포솜의 개선 또는 양쪽성 리포솜에 관련된 개선 |
CA2633754C (en) | 2006-01-05 | 2013-06-18 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis and treatment of solid cancers |
EP2591794A1 (en) | 2006-01-05 | 2013-05-15 | The Ohio State University Research Foundation | MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors |
WO2007081720A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
EP1986697B1 (en) * | 2006-02-17 | 2016-06-29 | GE Healthcare Dharmacon, Inc. | Compositions and methods for inhibiting gene silencing by rna interference |
EP2371971B1 (en) | 2006-03-20 | 2013-11-27 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
CN101437942A (zh) * | 2006-04-03 | 2009-05-20 | 桑塔里斯制药公司 | 包含抗微小rna反义寡核苷酸的药物组合物 |
DK2666859T3 (en) * | 2006-04-03 | 2019-04-08 | Roche Innovation Ct Copenhagen As | PHARMACEUTICAL COMPOSITION CONTAINING ANTI-miRNA ANTISENSE OLIGONUCLEOTIDES |
CN102851291B (zh) * | 2006-04-03 | 2016-03-09 | 斯特拉有限责任公司 | 包含抗微小rna反义寡核苷酸的药物组合物 |
US8697672B2 (en) | 2007-05-16 | 2014-04-15 | California Institute Of Technology | Microrna inhibition for the treatment of inflammation and myeloproliferative disorders |
EP2173908B1 (en) | 2007-08-03 | 2016-01-06 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncrnas |
ES2873350T3 (es) | 2007-08-27 | 2021-11-03 | 1Globe Health Inst Llc | Composiciones de ARN interferente asimétrico y usos de las mismas |
US7993831B2 (en) | 2007-09-14 | 2011-08-09 | Asuragen, Inc. | Methods of normalization in microRNA detection assays |
ES2463665T3 (es) | 2007-10-04 | 2014-05-28 | Stella Aps | Tratamiento de combinación para el tratamiento de infección por virus de la hepatitis C |
CN101424640B (zh) | 2007-11-02 | 2012-07-25 | 江苏命码生物科技有限公司 | 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法 |
KR101026502B1 (ko) * | 2007-11-23 | 2011-04-01 | 주식회사 파나진 | 마이크로rna 안티센스 pna, 그를 포함하는 조성물, 및 그의 사용 및 평가 방법 |
CN102007408A (zh) | 2008-02-28 | 2011-04-06 | 俄亥俄州立大学研究基金会 | 与急性髓性白血病(aml)中的细胞遗传学和预后相关的微rna特征及其用途 |
CA2717792A1 (en) * | 2008-03-07 | 2009-09-11 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
DK2310505T3 (en) * | 2008-06-30 | 2017-10-16 | Roche Innovation Ct Copenhagen As | ANTIDOT oligomers |
WO2010012667A1 (en) | 2008-08-01 | 2010-02-04 | Santaris Pharma A/S | Micro-rna mediated modulation of colony stimulating factors |
WO2010091204A1 (en) * | 2009-02-04 | 2010-08-12 | Board Of Regents, The University Of Texas System | Dual targeting of mir-208 and mir-499 in the treatment of cardiac disorders |
WO2010129672A1 (en) | 2009-05-05 | 2010-11-11 | Miragen Therapeutics | Lipophilic polynucleotide conjugates |
EP2459742B1 (en) | 2009-07-29 | 2016-04-06 | Pharnext | New diagnostic tools for alzheimer disease |
WO2011070297A2 (fr) | 2009-12-08 | 2011-06-16 | Universite Joseph Fourier | Utilisation de miarns comme biomarqueurs dans le diagnostic de gliomes |
WO2011094683A2 (en) | 2010-01-29 | 2011-08-04 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method of identifying myelodysplastic syndromes |
CA2794142A1 (en) | 2010-03-26 | 2011-09-29 | The Ohio State University | Materials and methods related to modulation of mismatch repair and genomic stability by mir-155 |
WO2011121610A1 (en) | 2010-04-01 | 2011-10-06 | Department Of Biotechnology | Micrornas (mirna) as biomarkers for detecting different grades of gliomas and pathways of glioma progression |
US20120064122A1 (en) | 2010-09-13 | 2012-03-15 | David Baltimore | Treatment of autoimmune inflammation using mir-155 |
WO2012068400A2 (en) | 2010-11-17 | 2012-05-24 | Asuragen, Inc. | Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms |
EP2683387A4 (en) | 2011-03-07 | 2014-09-03 | Univ Ohio State | MUTATORY ACTIVITY INDUCED BY INFLAMMATION OF MICROARN-155 (MIR-155) BINDING AND CANCER |
EP3133147B1 (en) | 2011-04-18 | 2019-03-27 | DiamiR, LLC | Universal screening test based on mirna (ust) |
JP6029147B2 (ja) | 2011-06-03 | 2016-11-24 | 国立大学法人北海道大学 | miRNA機能抑制用オリゴヌクレオチド誘導体 |
ES2610245T3 (es) | 2011-07-15 | 2017-04-26 | Leo Pharma A/S | Perfilado de microARN para el diagnóstico en linfoma cutáneo de células T (CTCL) |
AU2012322788B2 (en) | 2011-10-11 | 2018-01-04 | The Brigham And Women's Hospital, Inc. | Micrornas in neurodegenerative disorders |
US9447471B2 (en) | 2011-12-29 | 2016-09-20 | Quest Diagnostics Investments Incorporated | Microrna profiling for diagnosis of dysplastic nevi and melanoma |
WO2013134403A1 (en) | 2012-03-06 | 2013-09-12 | The Washington University | Method of treating neurodegenerative diseases with microrna regulators |
US20130236453A1 (en) | 2012-03-12 | 2013-09-12 | The Ohio State University | Methods and Compositions for Modulating Acute Graft-versus-Host Disease using miR-155 Specific Inhibitors |
US20160002624A1 (en) | 2012-05-17 | 2016-01-07 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide compositions |
CN104582691A (zh) * | 2012-05-23 | 2015-04-29 | 俄亥俄州立大学 | 脂膜白蛋白纳米颗粒组合物以及制备和使用其的方法 |
US9603873B2 (en) | 2012-12-03 | 2017-03-28 | Ohio State Innovation Foundation | Activation of innate immunity by miRNA for cancer and infection treatment |
JP6446026B2 (ja) | 2013-03-15 | 2018-12-26 | ミラゲン セラピューティクス, インコーポレイテッド | 架橋二環式ヌクレオシド |
JP2018517704A (ja) | 2015-06-05 | 2018-07-05 | ミラゲン セラピューティクス, インコーポレイテッド | 筋萎縮性側索硬化症(ALS)を処置するためのmiR−155阻害剤 |
CN108138180A (zh) | 2015-06-05 | 2018-06-08 | 米拉根医疗股份有限公司 | 用于治疗皮肤t细胞淋巴瘤(ctcl)的mir-155抑制剂 |
WO2018009855A1 (en) | 2016-07-07 | 2018-01-11 | MiRagen Therapeutics, Inc. | Methods for treating cutaneous t-cell lymphoma (ctcl) with mir-155 inhibitors |
-
2016
- 2016-06-03 CN CN201680042052.2A patent/CN108138180A/zh active Pending
- 2016-06-03 AU AU2016270434A patent/AU2016270434B2/en not_active Ceased
- 2016-06-03 BR BR112017026201-0A patent/BR112017026201A2/pt not_active Application Discontinuation
- 2016-06-03 KR KR1020197029891A patent/KR20190118688A/ko active Application Filing
- 2016-06-03 US US15/173,368 patent/US9771585B2/en not_active Expired - Fee Related
- 2016-06-03 RU RU2017146374A patent/RU2718534C2/ru active
- 2016-06-03 KR KR1020187000338A patent/KR102034619B1/ko active IP Right Grant
- 2016-06-03 JP JP2017562663A patent/JP6721252B2/ja not_active Expired - Fee Related
- 2016-06-03 CA CA2986949A patent/CA2986949C/en not_active Expired - Fee Related
- 2016-06-03 NZ NZ73754216A patent/NZ737542A/en not_active IP Right Cessation
- 2016-06-03 WO PCT/US2016/035865 patent/WO2016197024A2/en active Application Filing
- 2016-06-03 EP EP16804580.5A patent/EP3303590A4/en not_active Withdrawn
- 2016-06-03 MX MX2017015400A patent/MX368314B/es active IP Right Grant
-
2017
- 2017-08-15 US US15/677,818 patent/US20180127750A1/en not_active Abandoned
- 2017-09-25 US US15/714,671 patent/US9994852B2/en not_active Expired - Fee Related
- 2017-11-26 IL IL255896A patent/IL255896A/en unknown
- 2017-11-29 MX MX2019011469A patent/MX2019011469A/es unknown
-
2018
- 2018-05-10 US US15/976,333 patent/US10316318B2/en not_active Expired - Fee Related
- 2018-10-04 HK HK18112703.3A patent/HK1253405A1/zh unknown
-
2019
- 2019-04-12 US US16/382,883 patent/US20190359980A1/en not_active Abandoned
- 2019-09-20 AU AU2019232918A patent/AU2019232918A1/en not_active Abandoned
-
2020
- 2020-03-25 JP JP2020054154A patent/JP2020094073A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112017026201A2 (pt) | inibidores de mir-155 para o tratamento de linfoma cutâneo de células t (ctcl) | |
CR20190478A (es) | Inhibidores de pd-1/pd-l1 | |
MX2020013649A (es) | Composiciones y metodos para inhibir la actividad de la arginasa. | |
PH12018500899A1 (en) | Compositions and methods for inhibiting arginase activity | |
MX2018008052A (es) | Inhibidores de desmetilasa especifica de lisina 1 (lsd1). | |
PH12017502141A1 (en) | Compounds and their methods of use | |
PH12018502234B1 (en) | Treatment of cancer with tor kinase inhibitors | |
EP4279087A3 (en) | Pd-1 / pd-l1 inhibitors for the treatment of cancer | |
BR112017020999A2 (pt) | inibidores de indolamina-2,3-dioxigenase para o tratamento de câncer | |
EP4252851A3 (en) | Ezh2 inhibitors for treating lymphoma | |
BR112016003201A2 (pt) | inibidores de grp94 seletivos e usos dos mesmos | |
EA034822B9 (ru) | Производные n-пиридинилацетамида в качестве ингибиторов сигнального пути wnt | |
PH12017501879A1 (en) | Methods for treating cancer | |
PH12015500867B1 (en) | Treatment of prostate cancer with tor kinase inhibitors | |
MX2017011018A (es) | Inhibicion de la actividad de olig2. | |
ZA201901367B (en) | Inhibition of olig2 activity | |
NZ740817A (en) | Pcna inhibitors | |
TN2014000086A1 (en) | Compositions and methods for treating cancer using pi3k beta inhibitor and mapk pathway inhibitor, including mek and raf inhibitors | |
PH12019501918A1 (en) | Methods of treating cancer with farnesyltransferase inhibitors | |
MX2018004977A (es) | Inhibidores heterociclicos de la proteina cinasa 1 dependiente de 3-fosfoinositido (pdk1) para usarse en el tratamiento del cancer. | |
BR112018012341A2 (pt) | compostos úteis como inibidores da quinase | |
NZ779757A (en) | Pcna inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B65X | Notification of requirement for priority examination of patent application | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |