MX2018004977A - Inhibidores heterociclicos de la proteina cinasa 1 dependiente de 3-fosfoinositido (pdk1) para usarse en el tratamiento del cancer. - Google Patents
Inhibidores heterociclicos de la proteina cinasa 1 dependiente de 3-fosfoinositido (pdk1) para usarse en el tratamiento del cancer.Info
- Publication number
- MX2018004977A MX2018004977A MX2018004977A MX2018004977A MX2018004977A MX 2018004977 A MX2018004977 A MX 2018004977A MX 2018004977 A MX2018004977 A MX 2018004977A MX 2018004977 A MX2018004977 A MX 2018004977A MX 2018004977 A MX2018004977 A MX 2018004977A
- Authority
- MX
- Mexico
- Prior art keywords
- heterocyclic
- treat cancer
- pdk1 inhibitors
- pdk1
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen los métodos de uso de los compuestos que inhiben el enlace del sustrato mediado por PIF, de PDK1, que son útiles como inhibidores del crecimiento o la proliferación del cáncer que es dependiente de RSK2 o independiente de AKT. Tambión se describen las composiciones de tales compuestos para usarse en tales métodos de tratamiento del cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562245606P | 2015-10-23 | 2015-10-23 | |
PCT/US2016/058255 WO2017070565A1 (en) | 2015-10-23 | 2016-10-21 | Heterocyclic pdk1 inhibitors for use to treat cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018004977A true MX2018004977A (es) | 2018-07-06 |
Family
ID=57209945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018004977A MX2018004977A (es) | 2015-10-23 | 2016-10-21 | Inhibidores heterociclicos de la proteina cinasa 1 dependiente de 3-fosfoinositido (pdk1) para usarse en el tratamiento del cancer. |
Country Status (14)
Country | Link |
---|---|
US (3) | US20190015410A1 (es) |
EP (2) | EP3763368A1 (es) |
JP (1) | JP7094879B2 (es) |
KR (1) | KR20180101329A (es) |
CN (1) | CN108697699A (es) |
AU (2) | AU2016342352B2 (es) |
BR (1) | BR112018008025A2 (es) |
CA (1) | CA3002907A1 (es) |
DK (1) | DK3364971T3 (es) |
ES (1) | ES2820770T3 (es) |
MX (1) | MX2018004977A (es) |
PL (1) | PL3364971T3 (es) |
RU (1) | RU2018118786A (es) |
WO (1) | WO2017070565A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4323356A1 (en) | 2021-04-13 | 2024-02-21 | Nuvalent, Inc. | Amino-substituted heterocycles for treating cancers with egfr mutations |
WO2024040241A1 (en) | 2022-08-19 | 2024-02-22 | Viracta Therapeutics, Inc. | Pharmaceutical formulations, processes for preparation, and methods of use |
WO2024040242A1 (en) * | 2022-08-19 | 2024-02-22 | Viracta Therapeutics, Inc. | Combinations of pdk1 inhibitors and kinase inhibitors |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
DE102005061655A1 (de) * | 2005-12-22 | 2007-06-28 | Merck Patent Gmbh | Diazepinone |
SI2485731T1 (sl) | 2009-10-06 | 2016-09-30 | Millennium Pharmaceuticals, Inc. | Heterociklične spojine, ki se uporabljajo kot inhibitorji pdk1 |
EP2507244B1 (en) * | 2009-12-04 | 2014-11-05 | Nerviano Medical Sciences S.r.l. | Tricyclopyrazole derivatives |
WO2019094779A1 (en) * | 2017-11-09 | 2019-05-16 | Sunesis Pharmaceuticals, Inc. | Pharmaceutical formulations, processes for preparation, and methods of use |
-
2016
- 2016-10-21 ES ES16788389T patent/ES2820770T3/es active Active
- 2016-10-21 CN CN201680072623.7A patent/CN108697699A/zh active Pending
- 2016-10-21 EP EP20180303.8A patent/EP3763368A1/en active Pending
- 2016-10-21 WO PCT/US2016/058255 patent/WO2017070565A1/en active Application Filing
- 2016-10-21 BR BR112018008025-0A patent/BR112018008025A2/pt not_active Application Discontinuation
- 2016-10-21 KR KR1020187014416A patent/KR20180101329A/ko not_active Application Discontinuation
- 2016-10-21 DK DK16788389.1T patent/DK3364971T3/da active
- 2016-10-21 MX MX2018004977A patent/MX2018004977A/es unknown
- 2016-10-21 AU AU2016342352A patent/AU2016342352B2/en not_active Ceased
- 2016-10-21 PL PL16788389T patent/PL3364971T3/pl unknown
- 2016-10-21 JP JP2018520428A patent/JP7094879B2/ja active Active
- 2016-10-21 US US15/770,369 patent/US20190015410A1/en not_active Abandoned
- 2016-10-21 EP EP16788389.1A patent/EP3364971B1/en active Active
- 2016-10-21 RU RU2018118786A patent/RU2018118786A/ru unknown
- 2016-10-21 CA CA3002907A patent/CA3002907A1/en active Pending
-
2022
- 2022-05-12 AU AU2022203204A patent/AU2022203204A1/en not_active Abandoned
- 2022-06-02 US US17/831,041 patent/US20230099829A1/en not_active Abandoned
-
2024
- 2024-03-11 US US18/600,974 patent/US20240207258A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20180101329A (ko) | 2018-09-12 |
AU2016342352A1 (en) | 2018-05-10 |
WO2017070565A1 (en) | 2017-04-27 |
EP3364971B1 (en) | 2020-06-17 |
JP2018538244A (ja) | 2018-12-27 |
JP7094879B2 (ja) | 2022-07-04 |
RU2018118786A (ru) | 2019-11-26 |
EP3763368A1 (en) | 2021-01-13 |
CA3002907A1 (en) | 2017-04-27 |
BR112018008025A2 (pt) | 2018-10-23 |
AU2016342352B2 (en) | 2022-06-02 |
US20190015410A1 (en) | 2019-01-17 |
CN108697699A (zh) | 2018-10-23 |
EP3364971A1 (en) | 2018-08-29 |
US20240207258A1 (en) | 2024-06-27 |
RU2018118786A3 (es) | 2020-02-25 |
AU2022203204A1 (en) | 2022-06-02 |
US20230099829A1 (en) | 2023-03-30 |
PL3364971T3 (pl) | 2021-05-31 |
DK3364971T3 (da) | 2020-09-21 |
ES2820770T3 (es) | 2021-04-22 |
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