DE68921918T2 - Verfahren zur Voraussage der Wirksamkeit einer antineoplastichen Behandlung bei einzelnen Patienten. - Google Patents
Verfahren zur Voraussage der Wirksamkeit einer antineoplastichen Behandlung bei einzelnen Patienten.Info
- Publication number
- DE68921918T2 DE68921918T2 DE68921918T DE68921918T DE68921918T2 DE 68921918 T2 DE68921918 T2 DE 68921918T2 DE 68921918 T DE68921918 T DE 68921918T DE 68921918 T DE68921918 T DE 68921918T DE 68921918 T2 DE68921918 T2 DE 68921918T2
- Authority
- DE
- Germany
- Prior art keywords
- effectiveness
- individual patients
- predicting
- procedure
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19144988A | 1988-05-09 | 1988-05-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68921918D1 DE68921918D1 (de) | 1995-05-04 |
DE68921918T2 true DE68921918T2 (de) | 1995-09-07 |
Family
ID=22705545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68921918T Expired - Fee Related DE68921918T2 (de) | 1988-05-09 | 1989-05-04 | Verfahren zur Voraussage der Wirksamkeit einer antineoplastichen Behandlung bei einzelnen Patienten. |
Country Status (5)
Country | Link |
---|---|
US (1) | US5427916A (de) |
EP (1) | EP0341904B1 (de) |
JP (1) | JPH0636759B2 (de) |
AT (1) | ATE120497T1 (de) |
DE (1) | DE68921918T2 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR930703462A (ko) * | 1990-09-24 | 1993-11-30 | 로저 브렌트 | 검색 분석 방법 |
ES2092056T3 (es) * | 1991-09-23 | 1996-11-16 | Pfizer | Procedimiento para detectar arnm y adn especificos en celulas. |
US5411860A (en) * | 1992-04-07 | 1995-05-02 | The Johns Hopkins University | Amplification of human MDM2 gene in human tumors |
JPH07507926A (ja) * | 1992-06-16 | 1995-09-07 | ホイツテイアー・インステイテユート・フオー・ダイアビテイーズ・アンド・エンドクリノロジー | サポリン含有タンパク質の組換え産生 |
DK0646182T3 (da) * | 1992-06-18 | 1996-09-16 | Whittier Inst Diabetes & Endoc | Fremgangsmåde til påvisning af neoplastiske sygdomme |
GB9220777D0 (en) * | 1992-10-02 | 1992-11-18 | Univ Leicester | Oligonucleotide probes |
US5763198A (en) * | 1994-07-22 | 1998-06-09 | Sugen, Inc. | Screening assays for compounds |
ATE423852T1 (de) | 1996-04-05 | 2009-03-15 | Antonio Giordano | Methoden zur diagnose und prognose von krebs |
US5955269A (en) * | 1996-06-20 | 1999-09-21 | Rutgers, The State University Of New Jersey | Methods of screening foods for nutraceuticals |
WO2001023615A1 (en) * | 1999-09-29 | 2001-04-05 | Lifespan Biosciences, Inc. | Anti-aging nucleic acid and protein targets |
WO2002039121A2 (en) * | 2000-11-03 | 2002-05-16 | Board Of Regents, The University Of Texas System | Methods for detecting the efficacy of anticancer treatments |
WO2005078139A2 (en) | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES |
US7012200B2 (en) * | 2004-02-13 | 2006-03-14 | Sonion Roskilde A/S | Integrated volume control and switch assembly |
WO2005112924A2 (en) * | 2004-04-27 | 2005-12-01 | California Institute Of Technology | Methods of treating cancer by inhibiting histone gene expression |
JP2008503206A (ja) * | 2004-05-25 | 2008-02-07 | 日立化成工業株式会社 | 癌感受性を測定する方法 |
US20090011410A1 (en) * | 2004-10-20 | 2009-01-08 | Masato Mitsuhashi | Method for tailoring administration of drugs by quantitation of mrna |
WO2006086681A2 (en) * | 2005-02-09 | 2006-08-17 | Beth Israel Deaconess Medical Center, Inc. | Methods of inhibiting smooth muscle cell migration and proliferation |
WO2006116721A1 (en) * | 2005-04-28 | 2006-11-02 | Hitachi Chemical Research Center, Inc. | Ex vivo gene expression in whole blood as a model of assessment of individual variation to dietary supplements |
EP1907855A4 (de) * | 2005-07-12 | 2009-11-11 | Univ Temple | Genetische und epigenetische änderungen bei der diagnose und behandlung von krebs |
EP1937280B1 (de) | 2005-09-12 | 2014-08-27 | The Ohio State University Research Foundation | Zusammensetzungen zur Therapie von Bcl2-assoziierten Tumoren |
EP2591794A1 (de) | 2006-01-05 | 2013-05-15 | The Ohio State University Research Foundation | Anomalien bei Mikro-RNA-Expressionen in endokrinen und azinösen Pankreastumoren |
ES2536423T3 (es) | 2006-01-05 | 2015-05-25 | The Ohio State University Research Foundation | Métodos basados en microARN para el diagnóstico de cáncer de próstata |
ES2429404T3 (es) | 2006-01-05 | 2013-11-14 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico y el pronóstico del cáncer de pulmón |
EP2522746B1 (de) | 2006-03-02 | 2014-11-12 | The Ohio State University Research Foundation | Mikro-RNA-Expressionsprofil im Zusammenhang mit Bauchspeicheldrüsenkrebs |
EP1996731A2 (de) | 2006-03-20 | 2008-12-03 | The Ohio State University Research Foundation | Mikrorna-fingerabdrücke während humaner megakaryozytopoiese |
US20090298071A1 (en) * | 2006-05-08 | 2009-12-03 | Masato Mitsuhashi | Method for testing drug sensitivity in solid tumors by quantifying mrna expression in thinly-sliced tumor tissue |
WO2007134142A2 (en) * | 2006-05-11 | 2007-11-22 | University College Dublin | Methods and compositions for identifying and using p21-regulated proteins |
AU2007272947B2 (en) | 2006-07-13 | 2013-06-06 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Micro-RNA-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
US8841436B2 (en) * | 2007-03-15 | 2014-09-23 | University Hospitals Cleveland Medical Center | Screening, diagnosing, treating and prognosis of pathophysiologic status by RNA regulation |
CN101711287B (zh) | 2007-06-08 | 2016-04-27 | 由卫生与公众服务部代表的美利坚合众国政府 | 确定肝细胞癌亚型和检测肝癌干细胞的方法 |
WO2009012263A2 (en) * | 2007-07-18 | 2009-01-22 | The Trustees Of Columbia University In The City Of New York | Tissue-specific micrornas and compositions and uses thereof |
CN101809169B (zh) | 2007-07-31 | 2013-07-17 | 俄亥俄州立大学研究基金会 | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
EP2650383A1 (de) | 2007-08-03 | 2013-10-16 | The Ohio State University Research Foundation | Ultrakonservierte Bereiche zur Codierung von ncRNA |
CA2926831A1 (en) | 2007-08-22 | 2009-02-26 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
JP5401460B2 (ja) | 2007-09-06 | 2014-01-29 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | ヒト卵巣癌中のマイクロrnaシグネチャー |
JP5723156B2 (ja) | 2007-10-11 | 2015-05-27 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation | 食道腺癌の診断及び治療のための方法及び組成物 |
CN101855367A (zh) * | 2007-11-14 | 2010-10-06 | 日立化成工业株式会社 | 外周血白细胞中FC受体介导的肿瘤坏死因子超家族mRNA表达 |
US20090215064A1 (en) * | 2008-02-27 | 2009-08-27 | Hitachi Chemical Co., Ltd. | Quantitative assessment of individual cancer susceptibility by measuring dna damage-induced mrna in whole blood |
US9181315B2 (en) | 2009-01-08 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for induced brown fat differentiation |
US8492133B2 (en) | 2009-01-20 | 2013-07-23 | Ramot At Tel Aviv University, Ltd. | MIR-21 promoter driven targeted cancer therapy |
WO2010105096A2 (en) | 2009-03-11 | 2010-09-16 | University Of Massachusetts | Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212) |
WO2010149666A1 (en) | 2009-06-22 | 2010-12-29 | Medexis S.A. | Methods for treating neoplasia |
WO2011023413A1 (en) | 2009-08-31 | 2011-03-03 | Alcedo Biotech Gmbh | Microrna-based methods and compositions for reprogramming cells |
US20120238488A1 (en) | 2009-09-08 | 2012-09-20 | Konstantinos Alevizopoulos | Compounds and methods for treating neoplasia |
WO2011109637A1 (en) | 2010-03-03 | 2011-09-09 | Koo Foundation Sun Yat-Sen Cancer Center | Methods for classifying and treating breast cancers |
US20130303500A1 (en) | 2010-07-30 | 2013-11-14 | Medexis S.A. | Compounds and methods for treating neoplasia |
WO2012025633A1 (en) | 2010-08-27 | 2012-03-01 | University Of Zurich | A novel diagnostic and therapeutic target in inflammatory and/or cardiovascular diseases |
EP2546358A1 (de) | 2011-07-15 | 2013-01-16 | Laboratorios Del. Dr. Esteve, S.A. | Verfahren und Reagenzien zur effizienten Steuerung des HIV-Fortschritts |
JP2014530612A (ja) | 2011-10-14 | 2014-11-20 | ジ・オハイオ・ステート・ユニバーシティ | 卵巣がんに関する方法および材料 |
EP2971129B1 (de) | 2013-03-15 | 2018-05-09 | Sutter Bay Hospitals | Falz zur verwendung als target für therapien zur behandlung von krebs |
WO2015006543A1 (en) | 2013-07-10 | 2015-01-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for predicting and detecting tumor metastasis in kidney cancer |
US11028443B2 (en) | 2015-08-31 | 2021-06-08 | Showa Denko Materials Co., Ltd. | Molecular methods for assessing urothelial disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI76119C (fi) * | 1986-02-27 | 1988-09-09 | Orion Yhtymae Oy | Kvantitativ bestaemning av nukleinsyramolekyler och reagensfoerpackning som anvaends vid foerfarandet. |
EP0290144A1 (de) * | 1987-05-05 | 1988-11-09 | City of Hope | Verfahren zum Nachweis von beginnender Widerstandsfähigkeit gegen therapeutische Agenzien bei Krebskranken |
-
1989
- 1989-05-04 DE DE68921918T patent/DE68921918T2/de not_active Expired - Fee Related
- 1989-05-04 EP EP89304494A patent/EP0341904B1/de not_active Expired - Lifetime
- 1989-05-04 AT AT89304494T patent/ATE120497T1/de active
- 1989-05-08 JP JP1113875A patent/JPH0636759B2/ja not_active Expired - Lifetime
-
1994
- 1994-08-10 US US08/288,151 patent/US5427916A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH0213400A (ja) | 1990-01-17 |
DE68921918D1 (de) | 1995-05-04 |
JPH0636759B2 (ja) | 1994-05-18 |
US5427916A (en) | 1995-06-27 |
ATE120497T1 (de) | 1995-04-15 |
EP0341904B1 (de) | 1995-03-29 |
EP0341904A3 (de) | 1991-11-27 |
EP0341904A2 (de) | 1989-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |