ES2122543T3 - Derivados tetraciclicos, proceso de preparacion y utilizacion. - Google Patents
Derivados tetraciclicos, proceso de preparacion y utilizacion.Info
- Publication number
- ES2122543T3 ES2122543T3 ES95907565T ES95907565T ES2122543T3 ES 2122543 T3 ES2122543 T3 ES 2122543T3 ES 95907565 T ES95907565 T ES 95907565T ES 95907565 T ES95907565 T ES 95907565T ES 2122543 T3 ES2122543 T3 ES 2122543T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- sup
- alquilo
- represents hydrogen
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 abstract 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229940029575 guanosine Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9401090A GB9401090D0 (en) | 1994-01-21 | 1994-01-21 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2122543T3 true ES2122543T3 (es) | 1998-12-16 |
Family
ID=10749089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95907565T Expired - Lifetime ES2122543T3 (es) | 1994-01-21 | 1995-01-19 | Derivados tetraciclicos, proceso de preparacion y utilizacion. |
Country Status (48)
Families Citing this family (218)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9514465D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
| GB9511220D0 (en) * | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
| US6232312B1 (en) | 1995-06-07 | 2001-05-15 | Cell Pathways, Inc. | Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides |
| US5874440A (en) | 1995-06-07 | 1999-02-23 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with phenyl pyrimidinone derivatives |
| US6046216A (en) | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives |
| US6200980B1 (en) | 1995-06-07 | 2001-03-13 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with phenyl purinone derivatives |
| US6262059B1 (en) | 1995-06-07 | 2001-07-17 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with quinazoline derivatives |
| US6060477A (en) | 1995-06-07 | 2000-05-09 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives |
| GB9514473D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| GB9514464D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Medicaments |
| ES2175404T3 (es) | 1996-05-10 | 2002-11-16 | Icos Corp | Derivados de carbolina. |
| US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| US6071934A (en) | 1997-03-25 | 2000-06-06 | Cell Pathways, Inc. | Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions |
| CA2294480C (en) * | 1997-06-23 | 2008-05-20 | Queen's University At Kingston | Microdose therapy of female sexual dysfunction by no, co, and their donors |
| US6403597B1 (en) * | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
| US6046199A (en) * | 1998-01-14 | 2000-04-04 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives |
| US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
| US6268372B1 (en) | 1998-09-11 | 2001-07-31 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones |
| US6326379B1 (en) | 1998-09-16 | 2001-12-04 | Bristol-Myers Squibb Co. | Fused pyridine inhibitors of cGMP phosphodiesterase |
| IL132406A0 (en) * | 1998-10-21 | 2001-03-19 | Pfizer Prod Inc | Treatment of bph with cgmp elevators |
| US6133271A (en) | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
| US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
| US6348032B1 (en) | 1998-11-23 | 2002-02-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with benzimidazole derivatives |
| US6211220B1 (en) | 1998-11-23 | 2001-04-03 | Cell Pathways, Inc. | Method for treating neoplasia with amino or pyridylamino cyclobutene derivatives |
| US6420410B1 (en) | 1998-11-24 | 2002-07-16 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to N,N′-substituted benzimidazol-2-ones |
| US6211177B1 (en) | 1998-11-24 | 2001-04-03 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives |
| US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
| US6358992B1 (en) | 1998-11-25 | 2002-03-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with indole derivatives |
| DE60007289T2 (de) * | 1999-03-24 | 2004-10-21 | Harbor Branch Oceanographic | Verwendung von manzaminen als entzündungshemmende mittel |
| SV2002000055A (es) | 1999-04-30 | 2002-07-03 | Lilly Icos Llc | Articulos de manufactura ref. n0. 29342/36212 sv |
| US6451807B1 (en) | 1999-04-30 | 2002-09-17 | Lilly Icos, Llc. | Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor |
| US6943166B1 (en) | 1999-04-30 | 2005-09-13 | Lilly Icos Llc. | Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction |
| US7235625B2 (en) | 1999-06-29 | 2007-06-26 | Palatin Technologies, Inc. | Multiple agent therapy for sexual dysfunction |
| US7182958B1 (en) | 1999-08-03 | 2007-02-27 | Lilly Icos Llc. | β-carboline pharmaceutical compositions |
| US6821975B1 (en) | 1999-08-03 | 2004-11-23 | Lilly Icos Llc | Beta-carboline drug products |
| CZ20021151A3 (cs) | 1999-10-11 | 2003-03-12 | Pfizer Inc. | 5-(2-substituovaný-5-heterocyklylsulfonylpyrid-3-yl)-dihydropyrazolo[4,3-d]-pyrimidin-7-ony jako inhibitory fosfodiesterasy |
| TWI224966B (en) * | 1999-11-02 | 2004-12-11 | Pfizer | Pharmaceutical composition (I) useful for treating or preventing pulmonary hypertension in a patient |
| US6562830B1 (en) | 1999-11-09 | 2003-05-13 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with phenyl quinazolinone derivatives |
| US6376489B1 (en) * | 1999-12-23 | 2002-04-23 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US20020013327A1 (en) * | 2000-04-18 | 2002-01-31 | Lee Andrew G. | Compositions and methods for treating female sexual dysfunction |
| DE60124085D1 (de) | 2000-04-19 | 2006-12-07 | Lilly Icos Llc | Pde-v hemmer zur behandlung von morbus parkinson |
| UA72611C2 (uk) * | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
| UA74826C2 (en) * | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
| JP2004501124A (ja) * | 2000-06-07 | 2004-01-15 | リリー アイコス リミテッド ライアビリティ カンパニー | 化合物 |
| CA2412596C (en) | 2000-06-23 | 2007-07-31 | Lilly Icos Llc | Cyclic gmp-specific phosphodiesterase inhibitors |
| DE60121048T2 (de) | 2000-06-23 | 2007-01-25 | Lilly Icos Llc, Wilmington | PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE |
| CA2413510C (en) | 2000-06-26 | 2007-12-11 | Lilly Icos Llc | Condensed pyrazindione derivatives |
| US7176228B2 (en) * | 2000-07-24 | 2007-02-13 | Bayer Cropscience Ag | Pyrazole biphenylcarboxamides |
| CA2423357C (en) * | 2000-08-02 | 2008-05-27 | Lilly Icos Llc | Fused heterocyclic derivatives as phosphodiesterase inhibitors |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US6821978B2 (en) * | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
| CA2423280C (en) * | 2000-10-02 | 2009-01-13 | Lilly Icos Llc | Inhibitors of cyclic guanosine 3', 5'-monophosphates specific phosphodiesterase |
| DE60112960T2 (de) | 2000-10-02 | 2006-02-09 | Lilly Icos Llc, Wilmington | Kondensierte pyridoindolderivate |
| US6548508B2 (en) | 2000-10-20 | 2003-04-15 | Pfizer, Inc. | Use of PDE V inhibitors for improved fecundity in mammals |
| EP1211313A3 (en) * | 2000-11-01 | 2003-04-23 | Pfizer Limited | Modulation of PDE11A activity |
| US6828473B2 (en) | 2000-11-01 | 2004-12-07 | Pfizer Inc. | Modulation of PDE11A activity |
| AU2002211493A1 (en) | 2000-11-06 | 2002-05-15 | Lilly Icos Llc | Indole derivatives as pde5-inhibitors |
| EP1383765B1 (en) * | 2001-04-25 | 2006-12-13 | Lilly Icos LLC | Carboline derivatives as inhibitors of phosphodiesterase 5 (PDE5) for the treatment of cardiovascular diseases and erectile dysfunction |
| FR2824829B1 (fr) * | 2001-05-16 | 2005-06-03 | Macef | Nouveaux derives de dihydroimidazo [5,1-a]-beta-carboline, leur procede de preparation et leur application a titre de medicament |
| WO2002098875A1 (en) * | 2001-06-05 | 2002-12-12 | Lilly Icos Llc | Carboline derivatives as pde-5 inhibitors |
| JP4217605B2 (ja) * | 2001-06-05 | 2009-02-04 | リリー アイコス リミテッド ライアビリティ カンパニー | ピラジノ［１’，２’：１，６］ピリド［３，４−ｂ］インドール−１，４−ジオン誘導体 |
| WO2002098428A1 (en) * | 2001-06-05 | 2002-12-12 | Lilly Icos Llc | Tetracyclic compounds as pde5-inhibitors |
| US6984641B2 (en) | 2001-06-21 | 2006-01-10 | Lilly Icos Llc. | Carboline derivatives as PDE5 inhibitors |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| JP2005509038A (ja) * | 2001-11-09 | 2005-04-07 | シェーリング コーポレイション | 多環式グアニン誘導体ホスホジエステラーゼｖ阻害剤 |
| DE60221425T2 (de) * | 2001-11-14 | 2008-06-26 | Ortho-Mcneil Pharmaceutical, Inc. | Substituierte tetrazyklische pyrrolochinolonderivate als phosphodiesterase-inhibitoren |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7208516B2 (en) | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US7276529B2 (en) | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| AU2003223071A1 (en) * | 2002-05-23 | 2003-12-12 | Pfizer Inc. | Pharmaceutical combination of PDE5 inhibitors with ACE inhibitors |
| EP1719772A1 (en) | 2002-05-31 | 2006-11-08 | Schering Corporation | Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof |
| GB0214784D0 (en) * | 2002-06-26 | 2002-08-07 | Pfizer Ltd | Novel combination |
| DE60324949D1 (de) | 2002-07-31 | 2009-01-08 | Lilly Icos Llc | Modifizierte pictet-spengler-reaktion und damit hergestellte verbindungen |
| GB0219961D0 (en) | 2002-08-28 | 2002-10-02 | Pfizer Ltd | Oxytocin inhibitors |
| US7323462B2 (en) | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
| DK1572173T3 (da) | 2002-12-13 | 2010-06-14 | Warner Lambert Co | Alpha-2-delta-ligand til behandling af symptomer i den nedre urinvej |
| BRPI0409229A (pt) | 2003-04-01 | 2006-03-28 | Applied Research Systems | inibidores das fosfodiesterases na infertilidade |
| DK1620437T3 (da) | 2003-04-29 | 2009-08-24 | Pfizer Ltd | 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension |
| BRPI0410326A (pt) * | 2003-05-22 | 2006-05-23 | Altana Pharma Ag | composição compreendendo um inibidor pde4 e inibidor pde5 |
| DK1644021T3 (da) * | 2003-06-13 | 2012-10-29 | Ironwood Pharmaceuticals Inc | Fremgangsmåder og sammensætninger til behandlingen af gastrointestinale sygdomme |
| WO2004113300A1 (ja) * | 2003-06-23 | 2004-12-29 | Ono Pharmaceutical Co., Ltd. | 新規三環性複素環化合物 |
| US7291640B2 (en) | 2003-09-22 | 2007-11-06 | Pfizer Inc. | Substituted triazole derivatives as oxytocin antagonists |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| EP1699436A2 (en) * | 2003-12-12 | 2006-09-13 | Myogen, Inc. | Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure |
| WO2005068464A2 (en) * | 2003-12-15 | 2005-07-28 | Cadila Healthcare Limited | Process for preparing tadalafil and its intermediates |
| BRPI0506994A (pt) | 2004-01-22 | 2007-07-03 | Pfizer | derivados de triazol que inibem a atividade antagonista da vasopressina |
| US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
| JP2007530563A (ja) * | 2004-03-22 | 2007-11-01 | ミオゲン インコーポレイティッド | （ｓ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用 |
| WO2005092333A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
| US7569572B2 (en) | 2004-04-07 | 2009-08-04 | Pfizer Inc | Pyrazolo[4,3-D]pyrimidines |
| WO2005116030A1 (en) * | 2004-05-31 | 2005-12-08 | Matrix Laboratories Ltd | A process for the preparation of tadalafil |
| EP1776108A1 (en) * | 2004-06-23 | 2007-04-25 | Myogen, Inc. | Enoximone formulations and their use in the treatment of pde-iii mediated diseases |
| CA2577442A1 (en) | 2004-08-17 | 2006-03-02 | The Johns Hopkins University | Pde5 inhibitor compositions and methods for treating cardiac indications |
| WO2006049986A1 (en) * | 2004-10-28 | 2006-05-11 | Dr. Reddy's Laboratories Ltd. | Polymorphic forms of tadalafil |
| US20060111571A1 (en) * | 2004-11-02 | 2006-05-25 | Shlomit Wizel | Tadalafil crystal forms and processes for preparing them |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| PT1829874E (pt) | 2004-12-22 | 2014-04-10 | Ono Pharmaceutical Co | Composto tricíclico e sua utilização |
| WO2006091980A1 (en) * | 2005-02-25 | 2006-08-31 | Teva Pharmaceutical Industries Ltd. | Process of purifying tadalafil |
| KR20070099035A (ko) * | 2005-02-25 | 2007-10-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 입도가 큰 타달라필 및 이의 제조 방법 |
| EP1851222A1 (en) * | 2005-02-25 | 2007-11-07 | Teva Pharmaceutical Industries Ltd | Process of synthesizing tadalafil |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| MX2007012607A (es) * | 2005-04-12 | 2008-01-11 | Teva Pharma | Preparacion de intermedios de tadalafil. |
| SI2366393T1 (sl) | 2005-04-19 | 2013-12-31 | Takeda Gmbh | Roflumilast za zdravljenje pljučne hipertenzije |
| US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
| DE602006019231D1 (en) | 2005-05-12 | 2011-02-10 | Pfizer | Wasserfreie kristalline formen von n-ä1,2-ethoxyethyl)-5-(n-ethyl-n-methylaminoü-7-(4-methylpyridin-2-yl-aminoü-1h-pyrazoloä4,3-düpyrimidin-3-carbonylümethansulfonsäureamid |
| US20070010525A1 (en) * | 2005-06-27 | 2007-01-11 | Meyer Jackson | Method and compositions for modulating neuropeptide hormone secretion |
| US7863274B2 (en) * | 2005-07-29 | 2011-01-04 | Concert Pharmaceuticals Inc. | Deuterium enriched analogues of tadalafil as PDE5 inhibitors |
| WO2007016361A2 (en) * | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| JP2009503020A (ja) | 2005-08-03 | 2009-01-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肥満症の治療におけるフリバンセリンの使用 |
| WO2007025177A2 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP1937217A2 (en) * | 2005-09-13 | 2008-07-02 | Elan Pharma International Limited | Nanoparticulate tadalafil formulations |
| BRPI0617294B8 (pt) | 2005-10-12 | 2021-05-25 | Besins Healthcare Lu Sarl | composição farmacêutica em gel hidroalcóolico e uso de testosterona |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US7923449B2 (en) | 2005-10-29 | 2011-04-12 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| WO2007100387A2 (en) * | 2005-11-03 | 2007-09-07 | Dr. Reddy's Laboratories Ltd. | Process for preparing tadalafil |
| TWI435729B (zh) | 2005-11-09 | 2014-05-01 | Combinatorx Inc | 治療病症之方法，組合物及套組 |
| US7202229B1 (en) * | 2005-12-30 | 2007-04-10 | Alan James Group, Llc. | Aspirin formulation for cardiovascular health |
| US7201929B1 (en) * | 2005-12-30 | 2007-04-10 | Alan James Group, Llc. | Aspirin formulation for cardiovascular health |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| US20100216734A1 (en) * | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| CA2643199A1 (en) * | 2006-03-08 | 2007-09-13 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007110734A1 (en) * | 2006-03-24 | 2007-10-04 | Glenmark Pharmaceuticals Limited | Process for the preparation of tadalafil |
| WO2007124045A2 (en) * | 2006-04-20 | 2007-11-01 | Ampla Pharmaceuticals, Inc. | Piperidine and piperazine compounds for use in the treatment of obesity, eating disorders and sexual dysfunction by potentiation of mc4 receptor activity |
| US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| CA2651862A1 (en) * | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| US20090291958A1 (en) * | 2006-06-08 | 2009-11-26 | Auspex Pharmaceuticals, Inc. | Substituted PDE5 inhibitors |
| ES2336719T3 (es) | 2006-06-30 | 2010-04-15 | Boehringer Ingelheim International Gmbh | Flibanserina para el tratamiento de la incontinencia urinaria y las enfermedades relacionadas. |
| MX2008016569A (es) * | 2006-07-07 | 2009-01-30 | Teva Pharma | Composiciones solidas que contienen tadalafil y al menos un portador. |
| WO2008011154A2 (en) | 2006-07-21 | 2008-01-24 | Novartis Ag | Formulations for benzimidazolyl pyridyl ethers |
| EP2054041A2 (en) | 2006-08-14 | 2009-05-06 | Boehringer Ingelheim International GmbH | Formulations of flibanserin and method for manufacturing the same |
| CN101505736A (zh) | 2006-08-25 | 2009-08-12 | 贝林格尔.英格海姆国际有限公司 | 控制释放系统及其制造方法 |
| AR062501A1 (es) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas |
| BRPI0716604A2 (pt) * | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
| US20080103165A1 (en) * | 2006-09-19 | 2008-05-01 | Braincells, Inc. | Ppar mediated modulation of neurogenesis |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2101777B1 (en) | 2006-12-12 | 2015-05-20 | Gilead Sciences, Inc. | Composition for treating a pulmonary hypertension |
| WO2008095136A2 (en) | 2007-01-31 | 2008-08-07 | Henkin Robert I | Methods for detection of biological substances |
| EP2486927A1 (en) | 2007-02-12 | 2012-08-15 | DMI Biosciences, Inc. | Treatment of Comorbid Premature Ejaculation and Erectile Dysfunction |
| WO2008100933A2 (en) | 2007-02-12 | 2008-08-21 | Dmi Biosciences, Inc. | Reducing side effects of tramadol |
| WO2008103470A2 (en) * | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
| KR20100012867A (ko) * | 2007-04-25 | 2010-02-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 타다라필을 포함하는 고체 제형 |
| FR2916200A1 (fr) * | 2007-05-18 | 2008-11-21 | Fourtillan Snc | Nouveaux derives des 1,2,3,4,6,7,12,12a-octahydro pyrazino[1',2':1,6]pyrido[3,4-b]indoles, leur preparation et leur utilisation en therapeutique |
| DE102007028869A1 (de) | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
| PL2170880T3 (pl) | 2007-06-29 | 2012-11-30 | Ranbaxy Laboratories Ltd | Sposób wytwarzania związków pośrednich dla związków tetracyklicznych |
| EP2033962A1 (en) * | 2007-08-22 | 2009-03-11 | 4Sc Ag | Tetracyclic indolopyridines as EG5 inhibitors |
| PE20091188A1 (es) | 2007-09-12 | 2009-08-31 | Boehringer Ingelheim Int | Compuesto 1-[2-(4-(3-trifluorometil-fenil)piperazin-1-il)etil]-2,3-dihidro-1h-benzimidazol-2-ona (flibanserina), sus sales de adicion y composiciones farmaceuticas que los contienen |
| WO2009091777A1 (en) * | 2008-01-15 | 2009-07-23 | Forest Laboratories Holdings Limited | Nebivolol in the treatment of sexual dysfunction |
| ITMI20080285A1 (it) * | 2008-02-22 | 2009-08-23 | Endura Spa | Procedimento per la preparazione di esteri di acidi tetraidro-1h-betacarbolin-3-carbossilici |
| EP2107059A1 (en) | 2008-03-31 | 2009-10-07 | LEK Pharmaceuticals D.D. | Conversion of tryptophan into ß-carboline derivatives |
| PL385356A1 (pl) | 2008-06-03 | 2009-12-07 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Sposób wytwarzania tadalafilu |
| US8580801B2 (en) * | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
| EP2181997A1 (en) | 2008-10-30 | 2010-05-05 | Chemo Ibérica, S.A. | A process for the preparation of tadalafil |
| DE102008063992A1 (de) | 2008-12-19 | 2010-09-02 | Lerner, Zinoviy, Dipl.-Ing. | Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung |
| JP2012513464A (ja) | 2008-12-23 | 2012-06-14 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | ホスホジエステラーゼ阻害剤及びその使用 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US8586587B2 (en) | 2009-02-26 | 2013-11-19 | Thar Pharmaceuticals, Inc. | Crystalline molecular complex of tadalafil and methylparaben |
| GB0903493D0 (en) | 2009-02-27 | 2009-04-08 | Vantia Ltd | New compounds |
| DE102009033396A1 (de) | 2009-07-16 | 2011-01-20 | Ratiopharm Gmbh | Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung |
| UY33041A (es) | 2009-11-27 | 2011-06-30 | Bayer Schering Pharma Aktienegesellschaft | Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| US20110136815A1 (en) * | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| EP2556820A4 (en) | 2010-04-05 | 2015-01-21 | Sk Chemicals Co Ltd | COMPOSITION CONTAINING PDE5 INHIBITOR FOR MITIGATION OF SKIN WRINKLES |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| WO2012051559A2 (en) | 2010-10-15 | 2012-04-19 | Gilead Sciences, Inc. | Compositions and methods of treating pulmonary hypertension |
| WO2012107092A1 (en) | 2011-02-10 | 2012-08-16 | Synthon Bv | Pharmaceutical composition comprising tadalafil and a cyclodextrin |
| EP2673275B1 (en) | 2011-02-10 | 2015-04-08 | Interquim, S.A. | Process for obtaining compounds derived from tetrahydro-beta-carboline |
| EP2672959A1 (en) | 2011-02-10 | 2013-12-18 | Synthon BV | Granulated composition comprising tadalafil and a disintegrant |
| RU2013141446A (ru) | 2011-02-10 | 2015-03-20 | Синтон Бв | Фармацевтическая композиция, содержащая тадалафил и циклодекстрин |
| US20120123124A1 (en) * | 2011-04-22 | 2012-05-17 | Drug Process Licensing Associates, LLC | Manufacturing process for Tadalafil from racemic or L-tryptophan |
| CN102180876B (zh) * | 2011-05-28 | 2016-05-18 | 浙江华海药业股份有限公司 | 一种他达那非晶型i的制备方法 |
| EP2535049A1 (en) | 2011-06-17 | 2012-12-19 | Proyecto de Biomedicina Cima, S.L. | Tadalafil for the treatment of dementia |
| CN102367253B (zh) * | 2011-09-20 | 2016-04-06 | 浙江华海药业股份有限公司 | 一种制备他达拉非晶型a的方法 |
| US9402877B2 (en) | 2011-11-04 | 2016-08-02 | Xion Pharmaceuticals Corporation | Methods and compositions for oral administration of melanocortin receptor agonist compounds |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| WO2013109738A1 (en) | 2012-01-17 | 2013-07-25 | The Trustees Of Columbia University In The City Of New York | Novel phosphodiesterase inhibitors and uses thereof |
| WO2013109223A1 (en) | 2012-01-18 | 2013-07-25 | Mahmut Bilgic | Particulate formulations of tadalafil in effervescent form |
| WO2013109227A1 (en) | 2012-01-18 | 2013-07-25 | Mahmut Bilgic | Pharmaceutical compositions comprising ceftibuten |
| WO2014092661A1 (en) | 2012-01-18 | 2014-06-19 | Mahmut Bilgic | Particulate formulations of tadalafil in effervescent form |
| US10092651B2 (en) | 2012-02-28 | 2018-10-09 | Seoul Pharma Co., Ltd. | High-content fast dissolving film with masking of bitter taste comprising sildenafil as active ingredient |
| WO2014055801A1 (en) | 2012-10-05 | 2014-04-10 | Henkin Robert I | Phosphodiesterase inhibitors for treating taste and smell disorders |
| KR102146673B1 (ko) | 2012-12-04 | 2020-08-21 | 주식회사 아리바이오 | 포스포디에스테라제 타입 ５ 저해제를 포함하는 신경세포의 아폽토시스 억제용 조성물 |
| KR101953735B1 (ko) | 2012-12-14 | 2019-03-04 | 한미약품 주식회사 | 포스포다이에스터라제-5 억제제를 포함하는 츄정 |
| EP2938343B1 (en) | 2012-12-21 | 2018-09-12 | Mayo Foundation For Medical Education And Research | Methods and materials for treating calcific aortic valve stenosis |
| MX2015010725A (es) | 2013-02-21 | 2016-05-31 | Adverio Pharma Gmbh | Formas de metil {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato. |
| CN103232451A (zh) * | 2013-05-14 | 2013-08-07 | 张家港威胜生物医药有限公司 | 一种他达那非的简易制备工艺 |
| ES2776353T3 (es) | 2013-07-17 | 2020-07-30 | Univ Columbia | Inhibidores de la fosfodiesterasa novedosos y usos de los mismos |
| US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| EP3108245B1 (en) | 2014-02-18 | 2020-07-22 | Robert I. Henkin | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
| AR099416A1 (es) | 2014-02-28 | 2016-07-20 | Lilly Co Eli | Terapia combinada para la hipertensión resistente |
| JP6687550B2 (ja) | 2014-06-23 | 2020-04-22 | セルジーン コーポレイション | 肝疾患又は肝機能異常を治療するためのアプレミラスト |
| EP2962684A1 (en) | 2014-06-30 | 2016-01-06 | Sanovel Ilac Sanayi ve Ticaret A.S. | Orally disintegrating formulations of tadalafil |
| ES2784251T3 (es) | 2014-06-30 | 2020-09-23 | Montero Gida Sanayi Ve Ticaret As | Formulaciones de disgregación por vía oral de tadalafilo |
| CN104086546B (zh) * | 2014-07-14 | 2016-08-17 | 福建广生堂药业股份有限公司 | 他达拉非的药用酸盐及其制备方法 |
| SI3172207T1 (sl) | 2014-07-23 | 2019-06-28 | Krka D.D., Novo Mesto | Proces za pripravo zaviralca CGMP-fosfodiesteraze in oralne farmacevtske formulacije, ki obsega koprecipitate tadalafila |
| KR101645652B1 (ko) | 2014-11-03 | 2016-08-08 | (주)퓨젠바이오농업회사법인 | 세리포리아 락세라타에 의해 생산되는 세포외다당체를 유효성분으로 함유하는 성기능개선용 조성물 |
| KR102457316B1 (ko) * | 2015-06-26 | 2022-10-20 | 총킹 디캉 에릴 파마 씨오. 엘티디. | 새로운 5형포스포디에스테라아제 억제제 및 그 용도 |
| CN105541835B (zh) * | 2015-12-31 | 2017-12-05 | 湖南千金湘江药业股份有限公司 | 顺式四氢咔啉中间体及其合成方法和在制备他达拉非方面的应用 |
| CN105541840B (zh) * | 2015-12-31 | 2017-12-05 | 湖南千金湘江药业股份有限公司 | 关键中间体及其合成方法和在制备他达拉非方面的应用 |
| CN110381951A (zh) | 2016-12-14 | 2019-10-25 | 瑞必治公司 | 用于治疗肺性高血压和其他肺病症的方法及组合物 |
| CN106977516B (zh) * | 2017-03-02 | 2019-06-18 | 山东裕欣药业有限公司 | 一种他达拉非的制备方法 |
| AU2020273183A1 (en) | 2019-04-10 | 2021-10-14 | Mayo Foundation For Medical Education And Research | Methods and materials for gender-dependent treatment of cardiovascular dysfunction |
| RU2692764C1 (ru) | 2019-04-26 | 2019-06-27 | Общество с ограниченной ответственностью "Балтфарма" | Способ получения тадалафила |
| CN111995658B (zh) * | 2019-05-27 | 2022-08-02 | 首都医科大学 | Ldv修饰的五环哌嗪二酮及其制备和应用 |
| US20220296590A1 (en) | 2019-07-15 | 2022-09-22 | Biolab Sanus Farmaceutica Ltda | Stereoisomers of the compound 3-(benzo[d][1,3]dioxol-5-yl)-7-(1-hydroxypropan-2-yl)-1-(1h-indol-3-yl)-6,7-dihydro-3h-oxazol[3,4-a]pyrazine-5,8-dione and use thereof as an antitumor agent and phosphodiesterase enzyme inhibitor |
| CN110606847A (zh) * | 2019-07-30 | 2019-12-24 | 中国医药集团总公司四川抗菌素工业研究所 | 一种他达拉非顺式中间体的制备方法及其应用 |
| US11590209B2 (en) | 2020-01-21 | 2023-02-28 | Palatin Technologies, Inc. | Use of bremelanotide in patients with controlled hypertension |
| WO2021245192A1 (en) | 2020-06-04 | 2021-12-09 | Topadur Pharma Ag | Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof |
| WO2024173675A1 (en) | 2023-02-16 | 2024-08-22 | University Of Rochester | Improving glymphatic-lymphatic efflux |
| CN116715667A (zh) * | 2023-06-20 | 2023-09-08 | 常州制药厂有限公司 | 一种他达拉非新晶型b及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3644384A (en) * | 1969-06-09 | 1972-02-22 | Sterling Drug Inc | Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives |
| US3717638A (en) * | 1971-03-11 | 1973-02-20 | Sterling Drug Inc | 1,2,3,4,6,7,12,12A-OCTAHYDRO-2-PHENYLPYRAZINO[2',1':6,1]PYRIDO[3,4-b]INDOLES AND INTERMEDIATES THEREFOR |
| US3917599A (en) * | 1973-03-30 | 1975-11-04 | Council Scient Ind Res | 2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles |
| GB1454171A (en) * | 1973-10-19 | 1976-10-27 | Council Scient Ind Res | Tetracyclic compounds |
| US4273773A (en) * | 1979-09-24 | 1981-06-16 | American Home Products Corporation | Antihypertensive tricyclic isoindole derivatives |
| EP0357122A3 (en) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties |
| DE3830096A1 (de) * | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
| GB9514465D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| US6046199A (en) * | 1998-01-14 | 2000-04-04 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives |
| US6225315B1 (en) * | 1998-11-30 | 2001-05-01 | Pfizer Inc | Method of treating nitrate-induced tolerance |
-
1994
- 1994-01-21 GB GB9401090A patent/GB9401090D0/en active Pending
-
1995
- 1995-01-17 IS IS4252A patent/IS1888B/is unknown
- 1995-01-17 HR HR950023A patent/HRP950023B1/xx not_active IP Right Cessation
- 1995-01-18 MY MYPI95000109A patent/MY114663A/en unknown
- 1995-01-18 TW TW084100415A patent/TW378210B/zh not_active IP Right Cessation
- 1995-01-19 PE PE1995259855A patent/PE49495A1/es not_active IP Right Cessation
- 1995-01-19 AU AU15748/95A patent/AU689205B2/en not_active Expired
- 1995-01-19 AT AT95907565T patent/ATE169018T1/de active
- 1995-01-19 WO PCT/EP1995/000183 patent/WO1995019978A1/en active Search and Examination
- 1995-01-19 SK SK940-96A patent/SK280879B6/sk not_active IP Right Cessation
- 1995-01-19 SG SG1996007328A patent/SG49184A1/en unknown
- 1995-01-19 MX MX9602904A patent/MX9602904A/es unknown
- 1995-01-19 HU HU9601982A patent/HU222494B1/hu active IP Right Grant
- 1995-01-19 RO RO96-01454A patent/RO117794B1/ro unknown
- 1995-01-19 IL IL11238495A patent/IL112384A/en active Protection Beyond IP Right Term
- 1995-01-19 EE EE9600093A patent/EE03231B1/xx active Protection Beyond IP Right Term
- 1995-01-19 DE DE2003199006 patent/DE10399006I2/de active Active
- 1995-01-19 RU RU96117127A patent/RU2142463C1/ru active
- 1995-01-19 PL PL95315559A patent/PL179744B1/pl unknown
- 1995-01-19 AP APAP/P/1995/000712A patent/AP556A/en active
- 1995-01-19 ZA ZA95424A patent/ZA95424B/xx unknown
- 1995-01-19 JP JP51933995A patent/JP3808095B2/ja not_active Expired - Lifetime
- 1995-01-19 EG EG4795A patent/EG25852A/xx active
- 1995-01-19 EP EP95907565A patent/EP0740668B1/en not_active Expired - Lifetime
- 1995-01-19 CN CN95192078A patent/CN1045777C/zh not_active Expired - Lifetime
- 1995-01-19 ES ES95907565T patent/ES2122543T3/es not_active Expired - Lifetime
- 1995-01-19 CA CA002181377A patent/CA2181377C/en not_active Expired - Lifetime
- 1995-01-19 SI SI9530162T patent/SI0740668T1/xx unknown
- 1995-01-19 CO CO95001858A patent/CO4340684A1/es unknown
- 1995-01-19 KR KR1019960703922A patent/KR100357411B1/ko not_active Expired - Lifetime
- 1995-01-19 DK DK95907565T patent/DK0740668T3/da active
- 1995-01-19 NZ NZ279199A patent/NZ279199A/en not_active IP Right Cessation
- 1995-01-19 CZ CZ19962116A patent/CZ286566B6/cs not_active IP Right Cessation
- 1995-01-19 US US08/669,389 patent/US5859006A/en not_active Expired - Lifetime
- 1995-01-19 BR BRPI9506559A patent/BR9506559C8/pt not_active IP Right Cessation
- 1995-01-19 DE DE69503753T patent/DE69503753T2/de not_active Expired - Lifetime
- 1995-01-20 UY UY23893A patent/UY23893A1/es not_active IP Right Cessation
- 1995-01-20 SV SV1995000002A patent/SV1995000002A/es active IP Right Grant
- 1995-01-20 IN IN77DE1995 patent/IN183942B/en unknown
- 1995-01-20 MA MA23760A patent/MA23433A1/fr unknown
- 1995-01-20 TN TNTNSN95004A patent/TNSN95004A1/fr unknown
- 1995-01-31 SA SA95150475A patent/SA95150475B1/ar unknown
-
1996
- 1996-07-10 LV LVP-96-228A patent/LV11690B/lv unknown
- 1996-07-17 OA OA60864A patent/OA10584A/en unknown
- 1996-07-18 BG BG100727A patent/BG62733B1/bg unknown
- 1996-07-19 NO NO963015A patent/NO306465B1/no not_active IP Right Cessation
- 1996-07-19 FI FI962927A patent/FI113176B/fi not_active IP Right Cessation
-
1998
- 1998-06-26 AU AU73912/98A patent/AU707055B2/en not_active Expired
- 1998-08-12 US US09/133,078 patent/US6025494A/en not_active Expired - Lifetime
- 1998-12-01 CN CN98122779A patent/CN1070492C/zh not_active Expired - Lifetime
-
1999
- 1999-09-21 US US09/399,667 patent/US6127542A/en not_active Expired - Lifetime
-
2000
- 2000-08-07 US US09/633,431 patent/US6369059B1/en not_active Expired - Lifetime
-
2002
- 2002-02-05 US US10/068,114 patent/US6784179B2/en not_active Expired - Fee Related
-
2003
- 2003-01-22 NO NO2003002C patent/NO2003002I2/no not_active IP Right Cessation
- 2003-03-26 LU LU91017C patent/LU91017I2/fr unknown
- 2003-04-23 NL NL300124C patent/NL300124I2/nl unknown
-
2004
- 2004-04-21 JP JP2004125881A patent/JP4347125B2/ja not_active Expired - Lifetime
-
2009
- 2009-01-15 JP JP2009006669A patent/JP2009102386A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2122543T3 (es) | Derivados tetraciclicos, proceso de preparacion y utilizacion. | |
| ES2159758T3 (es) | Nuevas n-aminoalquilfluorenocarboxamidas; una nueva clase de ligandos especificos a subtipos del receptor de la dopamina. | |
| ES2176471T3 (es) | Inhibidores ciclicos gmp-especificos de la fosfodiesterasa. | |
| ES2131116T3 (es) | Analogos de nucleotidos enantiomericos antirretrovirales. | |
| ECSP941146A (es) | Derivados de benzofurano | |
| ES2111654T3 (es) | Derivados de piperazina como antagonistas de 5-ht1a. | |
| ES2058809T3 (es) | Derivados heterociclicos. | |
| ES2077643T3 (es) | Compuestos antivirales. | |
| DE60228436D1 (de) | Verwendung von castanospermine derivaten in der behandlung von hepatitis c | |
| DK0587645T3 (da) | Benzo- og pyridopyranderivater med anxiolytisk og antikonvulsiv aktivitet | |
| ES2009720A4 (es) | Agentes para tenir los cabellos. | |
| ES2140652T3 (es) | Uso de n-alquil-derivados de 1,5-didesoxi-1,5-imino-d-glucitol para el tratamiento de infecciones por el virus de la hepatitis b. | |
| ES2071479T3 (es) | Derivados de indano. | |
| KR890014112A (ko) | 퀴놀리진 및 퀴놀리지논 유도체의 심장 부정맥 치료용 의약품 제조에 있어서의 용도 | |
| ES2184343T3 (es) | Composiciones farmaceuticas a base de dalfopristina y de quinupristina y su preparacion. | |
| MX9301721A (es) | Derivados, composiciones de carbinol de bis-arilo sin puente, y metodos de uso. | |
| DK0413289T3 (da) | Oxadiazolyl-phenoxyalkyl-isoxazoler og deres anvendelse som antivirale midler | |
| ES2031606T3 (es) | Derivados de tiofeno | |
| ES2159098T3 (es) | Nuevos derivados de elipticina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
| IT224767Z2 (it) | Portapacchi per biciclette. | |
| UY27024A1 (es) | Métodos de tratamiento de condiciones asociadas con la cinasa p38 y compuestos de pirrolotriazina útiles como inhibidores de cinasa |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 740668 Country of ref document: ES |
|
| SPCF | Request for supplementary protection certificate filed |
Free format text: TADALAFILO (CIALIS) Spc suppl protection certif: C200300012 Filing date: 20030416 |
|
| SPCG | Supplementary protection certificate granted |
Free format text: TADALAFILO (CIALIS). Spc suppl protection certif: C200300012 Filing date: 20030416 Expiry date: 20171112 Effective date: 20040614 |