ES2140652T3 - Uso de n-alquil-derivados de 1,5-didesoxi-1,5-imino-d-glucitol para el tratamiento de infecciones por el virus de la hepatitis b. - Google Patents

Uso de n-alquil-derivados de 1,5-didesoxi-1,5-imino-d-glucitol para el tratamiento de infecciones por el virus de la hepatitis b.

Info

Publication number
ES2140652T3
ES2140652T3 ES95905416T ES95905416T ES2140652T3 ES 2140652 T3 ES2140652 T3 ES 2140652T3 ES 95905416 T ES95905416 T ES 95905416T ES 95905416 T ES95905416 T ES 95905416T ES 2140652 T3 ES2140652 T3 ES 2140652T3
Authority
ES
Spain
Prior art keywords
glucitol
hepatitis
treatment
alkyl
virus infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95905416T
Other languages
English (en)
Inventor
Timothy M Block
Baruch S Blumberg
Raymond A Dwek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
GD Searle LLC
Original Assignee
Monsanto Co
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co, GD Searle LLC filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2140652T3 publication Critical patent/ES2140652T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE PRESENTA UN METODO PARA EL TRATAMIENTO DE LAS INFECCIONES POR EL VIRUS DE LA HEPATITIS B (HBV) QUE COMPRENDE LA ADMINISTRACION AL ANFITRION INFECTADO DE UN DERIVADO DE N-ALQUILO DE 1,5-DIDEOXI-1,5-AMINO-D-GLUCITOL EN EL CUAL EL GRUPO DE ALQUILO CONTIENE ENTRE 3 Y 6 ATOMOS DE CARBONO.
ES95905416T 1994-01-13 1994-12-23 Uso de n-alquil-derivados de 1,5-didesoxi-1,5-imino-d-glucitol para el tratamiento de infecciones por el virus de la hepatitis b. Expired - Lifetime ES2140652T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18151994A 1994-01-13 1994-01-13

Publications (1)

Publication Number Publication Date
ES2140652T3 true ES2140652T3 (es) 2000-03-01

Family

ID=22664619

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95905416T Expired - Lifetime ES2140652T3 (es) 1994-01-13 1994-12-23 Uso de n-alquil-derivados de 1,5-didesoxi-1,5-imino-d-glucitol para el tratamiento de infecciones por el virus de la hepatitis b.

Country Status (14)

Country Link
US (1) US6037351A (es)
EP (1) EP0739205B1 (es)
JP (1) JP3628021B2 (es)
KR (1) KR100348657B1 (es)
CN (1) CN1074921C (es)
AT (1) ATE186836T1 (es)
AU (1) AU1403795A (es)
CA (1) CA2181033C (es)
DE (1) DE69421828T2 (es)
DK (1) DK0739205T3 (es)
ES (1) ES2140652T3 (es)
GR (1) GR3032527T3 (es)
PT (1) PT739205E (es)
WO (1) WO1995019172A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
AU753336B2 (en) 1997-11-10 2002-10-17 G.D. Searle & Co. Use of alkylated iminosugars to treat multidrug resistance
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
EP1714676A3 (en) * 1998-02-12 2006-11-15 G.D. Searle LLC. Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
WO1999040916A1 (en) * 1998-02-12 1999-08-19 G.D. Searle & Co. Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
US6274597B1 (en) 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
CA2362785A1 (en) * 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
EP1658846B1 (en) * 1999-02-12 2008-07-30 United Therapeutics Corporation N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol for treating hepatitis virus infections
WO2000047198A2 (en) * 1999-02-12 2000-08-17 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
DE60037664T2 (de) 1999-08-10 2008-12-24 The Chancellor, Masters And Scholars Of The University Of Oxford Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel
CN1422156A (zh) * 2000-02-14 2003-06-04 法马西亚公司 N－取代的－1,5－二脱氧－1,5－亚氨基－d－葡萄糖醇化合物在治疗肝炎病毒感染中的用途
CA2576425A1 (en) * 2004-08-13 2006-08-17 Migenix Inc. Compositions and methods for treating or preventing hepadnaviridae infection
EP2023927B1 (en) 2006-05-24 2015-02-25 United Therapeutics Corporation Deoxynojirimycin and d-arabinitol analogs and methods of using
WO2008063727A2 (en) * 2006-08-21 2008-05-29 United Therapeutics Corporation Combination therapy for treatment of viral infections
US8097728B2 (en) 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
JP2013233113A (ja) * 2012-05-09 2013-11-21 Osaka Univ 物理的負荷への耐性が向上した細胞の製造方法
RU2743694C1 (ru) * 2019-12-04 2021-02-24 Общество с ограниченной ответственностью "29 февраля" Миглустат N-бутил-1,5-дидезокси-1,5-имино-D-глюцит

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus
US4957926A (en) * 1988-12-22 1990-09-18 Monsanto Company Method of treating herpesviruses
US5030638A (en) * 1990-02-26 1991-07-09 G. D. Searle & Co. Method of antiviral enhancement

Also Published As

Publication number Publication date
KR100348657B1 (ko) 2003-08-02
DE69421828D1 (de) 1999-12-30
JP3628021B2 (ja) 2005-03-09
US6037351A (en) 2000-03-14
AU1403795A (en) 1995-08-01
CN1149253A (zh) 1997-05-07
EP0739205B1 (en) 1999-11-24
EP0739205A1 (en) 1996-10-30
GR3032527T3 (en) 2000-05-31
DK0739205T3 (da) 2000-05-01
JPH09508111A (ja) 1997-08-19
WO1995019172A1 (en) 1995-07-20
CA2181033C (en) 2007-09-04
ATE186836T1 (de) 1999-12-15
CN1074921C (zh) 2001-11-21
DE69421828T2 (de) 2000-04-20
CA2181033A1 (en) 1995-07-20
PT739205E (pt) 2000-04-28

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