ES2014042A6 - Un procedimiento para la preparacion de una composicion de 1-(2'-desoxi -2' fluor -b- d- arabinofuranosil) -5-etiluracilo. - Google Patents

Un procedimiento para la preparacion de una composicion de 1-(2'-desoxi -2' fluor -b- d- arabinofuranosil) -5-etiluracilo.

Info

Publication number
ES2014042A6
ES2014042A6 ES8802716A ES8802716A ES2014042A6 ES 2014042 A6 ES2014042 A6 ES 2014042A6 ES 8802716 A ES8802716 A ES 8802716A ES 8802716 A ES8802716 A ES 8802716A ES 2014042 A6 ES2014042 A6 ES 2014042A6
Authority
ES
Spain
Prior art keywords
ethyluracil
deoxy
fluoro
beta
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8802716A
Other languages
English (en)
Inventor
Jack J Fox
Kyoichi A Watanabe
Carlos Lopez
Christian G Trepo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Sloan Kettering Institute for Cancer Research
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Sloan Kettering Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Sloan Kettering Institute for Cancer Research filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of ES2014042A6 publication Critical patent/ES2014042A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE UNA COMPOSICION DE 1-(2''-DESOXI-2''-FLUOR- D-ARABINOFURANOSIL)-5-ETILURACILO. COMPRENDE MEZCLAR EL INGREDIENTE ACTIVO CON UN VEHICULO FARMACEUTICAMENTE ACEPTABLE, MEDIANTE GRANULACION EN HUMEDO DE LA MEZCLA SEGUIDA O NO DE COMPRESION, COMPRESION DIRECTA DE LA MEZCLA, INCORPORACION DE LA MISMA EN CAPSULAS DE GELATINA DURA O BLANDA, DISOLUCION DE LA MEZCLA EN AGUA O SOLUCIONES ACUOSAS ESTERILES, FUSION DE UNA BASE GRASA PARA SUPOSITORIOS E INCORPORACION EN ELLA DE LA MEZCLA O INCORPORACION DEL INGREDIENTE ACTIVO EN GOMAS O PARAFINAS PARA LA OBTENCION DE UNGUENTOS Y PASTAS. LA COMPOSICION ASI OBTENIDA TIENE APLICACION EN EL TRATAMIENTO DE LAS INFECCIONES PRODUCIDAS POR EL VIRUS DE LA HEPATITIS.
ES8802716A 1987-09-03 1988-09-02 Un procedimiento para la preparacion de una composicion de 1-(2'-desoxi -2' fluor -b- d- arabinofuranosil) -5-etiluracilo. Expired - Lifetime ES2014042A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9244687A 1987-09-03 1987-09-03

Publications (1)

Publication Number Publication Date
ES2014042A6 true ES2014042A6 (es) 1990-06-16

Family

ID=22233256

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802716A Expired - Lifetime ES2014042A6 (es) 1987-09-03 1988-09-02 Un procedimiento para la preparacion de una composicion de 1-(2'-desoxi -2' fluor -b- d- arabinofuranosil) -5-etiluracilo.

Country Status (10)

Country Link
EP (1) EP0338042B1 (es)
JP (1) JPH02500524A (es)
KR (1) KR970011386B1 (es)
AU (1) AU2487688A (es)
CA (1) CA1328865C (es)
DE (1) DE3885090T2 (es)
ES (1) ES2014042A6 (es)
IL (1) IL87646A (es)
PT (1) PT88420B (es)
WO (1) WO1989001776A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
EP2390257A1 (en) * 1998-02-25 2011-11-30 Emory University 2'-fluoronucleosides
KR101005299B1 (ko) * 2000-10-18 2011-01-04 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211733A (en) * 1978-12-26 1980-07-08 Chang Shih Chih Gas-liquid mixing process and apparatus
AU575918B2 (en) * 1984-03-06 1988-08-11 Sloan-Kettering Institute For Cancer Research Hepatitis treatment with pyrimidine nucleoside compounds
US4666892A (en) * 1984-03-06 1987-05-19 Sloan-Kettering Memorial Cancer Center Method and composition for hepatitis treatment with pyrimidine nucleoside compounds

Also Published As

Publication number Publication date
KR890701112A (ko) 1989-12-19
JPH02500524A (ja) 1990-02-22
PT88420A (pt) 1989-07-31
DE3885090D1 (de) 1993-11-25
CA1328865C (en) 1994-04-26
DE3885090T2 (de) 1994-05-11
PT88420B (pt) 1993-12-31
EP0338042B1 (en) 1993-10-20
EP0338042A4 (en) 1990-09-26
WO1989001776A1 (en) 1989-03-09
EP0338042A1 (en) 1989-10-25
AU2487688A (en) 1989-03-31
IL87646A (en) 1994-07-31
KR970011386B1 (ko) 1997-07-10

Similar Documents

Publication Publication Date Title
EP0476054A4 (en) Method for treating viral infection
ZA896864B (en) Method and composition for the treatment and prevention of viral infections
PT80079A (en) Process for the preparation of antiviral pharmaceutical preparations containing 2-diethylamino-2,2',6'-acetoxyxylidide (lidocaine)
MD950114A (en) A Nucleoside analogs of 1,3-oxatiolan, method of its preparation, pharmaceutical composition, method of virus infection treatment
CA2197319A1 (en) Lipid analogs for treating viral infections
FI891338A0 (fi) Parannus menetelmään 2',3'-dideoksi-2',3'-didehydronukleosidien valmistamiseksi
EP0276279A4 (en) PREPARATION AND METHOD FOR IMMUNIZING AGAINST VIRAL AIDS AND ARC PATHOGENS.
AU5064985A (en) Methods and compositions for treating viral infection
EP0608212A4 (en) PROCESS FOR TREATING VIRAL INFECTIONS.
ES2014042A6 (es) Un procedimiento para la preparacion de una composicion de 1-(2'-desoxi -2' fluor -b- d- arabinofuranosil) -5-etiluracilo.
EP0177153A3 (en) Interferon-cyclaradine combination
PT87004A (pt) Process for the preparation of compositions for the treatment of viral infections and composites 3'-azide-2',3'-didesoxy-in osine and 3'-fluoro-2',3'-didesoxyguanosine
AU7515287A (en) Methods and compositions for treating viral infections
MD960168A (ro) Metodă şi compuşi pentru tratamentul infecţiilor virale
AU6796287A (en) Method and composition for prophylaxis and treatment of viral infections
BG102404A (en) The application of flupirtin for the prevention and treatment of diseases related to impairement of the haematopoeic cellular system
ES8704962A1 (es) Un procedimiento para preparar 1b-d-ribofuranosil, 1-2-4-triazol-3-carboxamida.
ZA87470B (en) Method and composition for prophylaxis and treatment of viral infections
NZ213370A (en) Method of treating viral infections of selected trees and field crops using ribavirin (1-b-d-ribofuranosyl-1,2,4-triazole-3-carboxamide) or the 2,3,5-triacetyl or 5'-butyryl derivative thereof
UA37251C2 (uk) Лікарський засіб для лікування або профілактики вірусної інфекції гепатиту в і спосіб лікування вірусної інфекції гепатиту в
HUT44439A (en) Process for inhibiting the reproduction of viruses and virus infections
GB2255718B (en) Pharmaceutical composition for treating bacterial and / or viral infection
EP0452360A4 (en) Methods and compositions for the prophylaxis and treatment of hepatitis b virus infections
ZA906605B (en) N,n'-bis-1,3,5-triazin-6-ylpiperazines,and process for their preparation
OA09507A (en) Compositions and methods for treating or preventing AIDS ARC and HIV infection

Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-09-02