MX2007012607A - Preparacion de intermedios de tadalafil. - Google Patents

Preparacion de intermedios de tadalafil.

Info

Publication number
MX2007012607A
MX2007012607A MX2007012607A MX2007012607A MX2007012607A MX 2007012607 A MX2007012607 A MX 2007012607A MX 2007012607 A MX2007012607 A MX 2007012607A MX 2007012607 A MX2007012607 A MX 2007012607A MX 2007012607 A MX2007012607 A MX 2007012607A
Authority
MX
Mexico
Prior art keywords
intermediates
tadalafil
preparation
converting
various solvents
Prior art date
Application number
MX2007012607A
Other languages
English (en)
Inventor
Dov Diller
Ben-Zion Dolitzky
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of MX2007012607A publication Critical patent/MX2007012607A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se proporciona un proceso para preparar el intermedio de tadalafil en diferentes solventes. Tambien se proporciona un metodo para convertir dichos intermedios en tadalafil.
MX2007012607A 2005-04-12 2006-04-12 Preparacion de intermedios de tadalafil. MX2007012607A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67123905P 2005-04-12 2005-04-12
PCT/US2006/014052 WO2006110893A2 (en) 2005-04-12 2006-04-12 Preparation of tadalafil intermediates

Publications (1)

Publication Number Publication Date
MX2007012607A true MX2007012607A (es) 2008-01-11

Family

ID=37056817

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007012607A MX2007012607A (es) 2005-04-12 2006-04-12 Preparacion de intermedios de tadalafil.

Country Status (11)

Country Link
US (1) US20060276652A1 (es)
EP (1) EP1812435A2 (es)
JP (1) JP2008538554A (es)
KR (1) KR20070110941A (es)
CN (1) CN101155809A (es)
CA (1) CA2601697A1 (es)
DE (1) DE06750162T1 (es)
ES (1) ES2278552T1 (es)
IL (1) IL185029A0 (es)
MX (1) MX2007012607A (es)
WO (1) WO2006110893A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2170880B1 (en) 2007-06-29 2012-08-15 Ranbaxy Laboratories Limited A process for the preparation of intermediates of tetracyclic compounds
EP2107059A1 (en) 2008-03-31 2009-10-07 LEK Pharmaceuticals D.D. Conversion of tryptophan into ß-carboline derivatives
PL385356A1 (pl) 2008-06-03 2009-12-07 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób wytwarzania tadalafilu
ES2541421T3 (es) 2011-02-10 2015-07-20 Interquim, S.A. Procedimiento de obtención de compuestos derivados de tetrahidro-ß-carbolina
CN103232451A (zh) * 2013-05-14 2013-08-07 张家港威胜生物医药有限公司 一种他达那非的简易制备工艺
CN104151313B (zh) * 2014-07-13 2019-04-09 浙江华海药业股份有限公司 一种纯化他达拉非中间体的方法
CN105753763A (zh) * 2014-12-18 2016-07-13 广州医药研究总院有限公司 他达那非中间体的制备方法
CN105541840B (zh) * 2015-12-31 2017-12-05 湖南千金湘江药业股份有限公司 关键中间体及其合成方法和在制备他达拉非方面的应用
CN110684025B (zh) * 2019-10-29 2020-09-04 株洲千金药业股份有限公司 一种他达拉非的制备方法
CN110790764B (zh) * 2019-11-27 2021-04-06 四川省通园制药集团有限公司 一种一锅法制备他达拉非的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
ATE330958T1 (de) * 2000-06-23 2006-07-15 Lilly Icos Llc Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
ES2318175T3 (es) * 2002-07-31 2009-05-01 Lilly Icos Llc Reaccion pictet-splenger modificada y productos preparados a partir de la misma.

Also Published As

Publication number Publication date
CA2601697A1 (en) 2006-10-19
DE06750162T1 (de) 2007-07-05
ES2278552T1 (es) 2007-08-16
IL185029A0 (en) 2007-12-03
KR20070110941A (ko) 2007-11-20
US20060276652A1 (en) 2006-12-07
EP1812435A2 (en) 2007-08-01
JP2008538554A (ja) 2008-10-30
WO2006110893A3 (en) 2007-05-10
WO2006110893A2 (en) 2006-10-19
CN101155809A (zh) 2008-04-02

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal