ES2175404T3 - Derivados de carbolina. - Google Patents

Derivados de carbolina.

Info

Publication number
ES2175404T3
ES2175404T3 ES97922960T ES97922960T ES2175404T3 ES 2175404 T3 ES2175404 T3 ES 2175404T3 ES 97922960 T ES97922960 T ES 97922960T ES 97922960 T ES97922960 T ES 97922960T ES 2175404 T3 ES2175404 T3 ES 2175404T3
Authority
ES
Spain
Prior art keywords
carboline derivatives
specific
those
cgmp
cyclical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97922960T
Other languages
English (en)
Inventor
Agnes Bombrun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icos Corp
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609777.9A external-priority patent/GB9609777D0/en
Priority claimed from GBGB9609820.7A external-priority patent/GB9609820D0/en
Application filed by Icos Corp filed Critical Icos Corp
Application granted granted Critical
Publication of ES2175404T3 publication Critical patent/ES2175404T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

LOS DERIVADOS DE CARBOLINA DE FORMULA (I) SON INHIBIDORES POTENTES Y SELECTIVOS DE FOSFODIESTERASAS ESPECIFICAS AL 3'',5'' MONOFOSFATO DE GUANOSINA CICLICO (PDE ESPECIFICA AL CGMP) Y SON UTILES EN UNA AMPLIA VARIEDAD DE AREAS TERAPEUTICAS EN LAS QUE SE PIENSA ES CONVENIENTE TAL INHIBICION, INCLUIDO EL TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES.
ES97922960T 1996-05-10 1997-05-05 Derivados de carbolina. Expired - Lifetime ES2175404T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9609777.9A GB9609777D0 (en) 1996-05-10 1996-05-10 Chemical compounds
GBGB9609820.7A GB9609820D0 (en) 1996-05-10 1996-05-10 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2175404T3 true ES2175404T3 (es) 2002-11-16

Family

ID=26309303

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97922960T Expired - Lifetime ES2175404T3 (es) 1996-05-10 1997-05-05 Derivados de carbolina.

Country Status (26)

Country Link
US (2) US6117881A (es)
EP (1) EP0912567B1 (es)
JP (1) JP3418405B2 (es)
KR (1) KR20000010918A (es)
CN (1) CN1067071C (es)
AP (1) AP9801365A0 (es)
AT (1) ATE215950T1 (es)
AU (1) AU711885B2 (es)
BG (1) BG102879A (es)
BR (1) BR9709230A (es)
CA (1) CA2253948C (es)
CZ (1) CZ358598A3 (es)
DE (1) DE69711882T2 (es)
EA (1) EA199800907A1 (es)
EE (1) EE9800390A (es)
ES (1) ES2175404T3 (es)
HU (1) HUP9901478A3 (es)
IL (1) IL126951A0 (es)
IS (1) IS4864A (es)
NO (1) NO985222L (es)
OA (1) OA10920A (es)
PL (1) PL329875A1 (es)
SK (1) SK154498A3 (es)
TR (1) TR199802282T2 (es)
WO (1) WO1997043287A1 (es)
YU (1) YU49898A (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3418405B2 (ja) * 1996-05-10 2003-06-23 アイコス コーポレイション カルボリン誘導体
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
DE19837069C1 (de) * 1998-08-17 2000-01-05 Bayer Ag Substituierte Zimtsäuren und Zimtsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von substituierten Indanoncarbonsäureestern
JP2002524564A (ja) * 1998-09-16 2002-08-06 アイコス コーポレイション ｃＧＭＰホスホジエステラーゼ阻害剤としてのカルボリン誘導体
DE19903087A1 (de) * 1999-01-27 2000-08-10 Forssmann Wolf Georg Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern
JP2002539247A (ja) 1999-03-24 2002-11-19 ハーバー ブランチ オーシャノグラフィック インスティテューション インク． マンズアミンの抗炎症作用の使用
US6451807B1 (en) 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
HUP0001632A3 (en) 1999-04-30 2001-12-28 Lilly Icos Llc Wilmington Pharmaceutical compositions comprising selective phosphodiestherase inhibitors
JP2004500425A (ja) 2000-04-19 2004-01-08 リリー　アイコス　リミテッド　ライアビリティ　カンパニー パーキンソン病の処置に対する環状ｇｍｐ特異的ホスホジエステラーゼインヒビターの使用
UA74826C2 (en) * 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
AU2001263278A1 (en) 2000-06-23 2002-01-08 Lilly Icos Llc Cyclic gmp-specific phosphodiesterase inhibitors
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
EP1360185B1 (en) 2001-02-12 2005-08-24 Lilly Icos LLC Carboline derivatives
WO2002064591A2 (en) * 2001-02-12 2002-08-22 Lilly Icos Llc Carboline derivatives
CA2441792C (en) * 2001-04-25 2010-08-03 Lilly Icos Llc Carboline derivatives as inhibitors of phosphodiesterase 5 (pdes) for the treatment of cardiovascular diseases and erectile dysfunction
JP2004536816A (ja) 2001-06-05 2004-12-09 リリー アイコス リミテッド ライアビリティ カンパニー Ｐｄｅ５阻害剤としてのカルボリン誘導体
EP1397361B1 (en) * 2001-06-21 2006-08-09 Lilly Icos LLC Carboline derivatives as pdev inhibitors
EP1442042A1 (en) 2001-11-09 2004-08-04 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
US7335680B2 (en) * 2001-12-20 2008-02-26 Laboratoires Serono Sa Pyrrolidine derivatives as prostaglandin modulators
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
EP3342420A1 (en) * 2003-06-13 2018-07-04 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004113300A1 (ja) * 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. 新規三環性複素環化合物
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
EP1737461B1 (en) * 2004-03-15 2012-12-12 PTC Therapeutics, Inc. Carboline derivatives useful in the inhibition of angiogenesis
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
ZA200609845B (en) * 2004-05-26 2010-02-24 Eisai R&D Man Co Ltd Cinnamide compound
KR101128065B1 (ko) 2004-05-26 2012-04-12 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 화합물
AU2005297966B2 (en) 2004-10-26 2010-12-23 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
EP1829874B1 (en) 2004-12-22 2014-02-12 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
WO2007058304A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド化合物の塩またはそれらの溶媒和物
WO2007058305A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド誘導体の製造方法
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
NZ568050A (en) 2005-11-24 2010-09-30 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
SA07280403B1 (ar) 2006-07-28 2010-12-01 إيساي أر أند دي منجمنت كو. ليمتد ملح رباعي لمركب سيناميد
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008095136A2 (en) 2007-01-31 2008-08-07 Henkin Robert I Methods for detection of biological substances
TW200848054A (en) 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
JPWO2008140111A1 (ja) * 2007-05-16 2010-08-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド誘導体のワンポット製造方法
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
MX2010002098A (es) 2007-08-31 2010-03-30 Eisai R&D Man Co Ltd Compuesto policiclico.
CA2712095A1 (en) * 2008-01-28 2009-08-06 Eisai R&D Management Co., Ltd. Crystalline cinnamide compounds or salts thereof
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2014055801A1 (en) 2012-10-05 2014-04-10 Henkin Robert I Phosphodiesterase inhibitors for treating taste and smell disorders
CN106233141B (zh) 2014-02-18 2018-08-21 罗伯特·I·汉金 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物
AU2016326718B2 (en) 2015-09-23 2022-12-15 Minerva Biotechnologies Corporation Method of screening for agents for differentiating stem cells

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644384A (en) * 1969-06-09 1972-02-22 Sterling Drug Inc Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives
US3717638A (en) * 1971-03-11 1973-02-20 Sterling Drug Inc 1,2,3,4,6,7,12,12A-OCTAHYDRO-2-PHENYLPYRAZINO[2',1':6,1]PYRIDO[3,4-b]INDOLES AND INTERMEDIATES THEREFOR
US3917599A (en) * 1973-03-30 1975-11-04 Council Scient Ind Res 2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles
GB1454171A (en) * 1973-10-19 1976-10-27 Council Scient Ind Res Tetracyclic compounds
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
US4656174A (en) * 1982-07-24 1987-04-07 Pfizer Inc. Quinoline therapeutic agents
IT1217190B (it) * 1988-04-22 1990-03-14 Recordati Chem Pharm Composti utili per il trattamento e diagnosi di disfunzioni frettili
FI892362A (fi) * 1988-06-01 1989-12-02 Eisai Co Ltd Buten- eller propensyraderivat.
EP0357122A3 (en) * 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
DE3830096A1 (de) * 1988-09-03 1990-03-15 Hoechst Ag Piperazindione mit psychotroper wirkung
FR2649613B1 (fr) * 1989-07-11 1991-09-27 Virag Ronald Medicament vaso-actif
JPH0344324A (ja) * 1989-07-13 1991-02-26 Kazuoki Tsuchiya 性機能賦活剤
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
EP0459666B1 (en) * 1990-05-31 1994-11-09 Pfizer Inc. Medicaments against impotence
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9218322D0 (en) * 1992-08-28 1992-10-14 Pfizer Ltd Therapeutic agents
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
JP3418405B2 (ja) * 1996-05-10 2003-06-23 アイコス コーポレイション カルボリン誘導体
US5874437A (en) * 1996-11-01 1999-02-23 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6043252A (en) * 1997-05-05 2000-03-28 Icos Corporation Carboline derivatives

Also Published As

Publication number Publication date
IS4864A (is) 1998-10-13
YU49898A (sh) 2000-03-21
NO985222L (no) 1999-01-11
PL329875A1 (en) 1999-04-12
EE9800390A (et) 1999-06-15
US6117881A (en) 2000-09-12
BR9709230A (pt) 1999-08-10
CA2253948A1 (en) 1997-11-20
JP3418405B2 (ja) 2003-06-23
KR20000010918A (ko) 2000-02-25
NO985222D0 (no) 1998-11-09
WO1997043287A1 (en) 1997-11-20
EP0912567A1 (en) 1999-05-06
OA10920A (en) 2003-02-21
HUP9901478A2 (hu) 1999-08-30
SK154498A3 (en) 2000-01-18
CA2253948C (en) 2005-07-26
CN1067071C (zh) 2001-06-13
US6306870B1 (en) 2001-10-23
DE69711882D1 (en) 2002-05-16
IL126951A0 (en) 1999-09-22
EP0912567B1 (en) 2002-04-10
EA199800907A1 (ru) 1999-04-29
JP2000513717A (ja) 2000-10-17
AU2891097A (en) 1997-12-05
CZ358598A3 (cs) 1999-03-17
DE69711882T2 (de) 2002-10-31
TR199802282T2 (xx) 1999-03-22
AU711885B2 (en) 1999-10-21
ATE215950T1 (de) 2002-04-15
AP9801365A0 (en) 1998-12-31
HUP9901478A3 (en) 1999-11-29
BG102879A (en) 1999-09-30
CN1218471A (zh) 1999-06-02

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