EA199800907A1 - Производные карболина - Google Patents
Производные карболинаInfo
- Publication number
- EA199800907A1 EA199800907A1 EA199800907A EA199800907A EA199800907A1 EA 199800907 A1 EA199800907 A1 EA 199800907A1 EA 199800907 A EA199800907 A EA 199800907A EA 199800907 A EA199800907 A EA 199800907A EA 199800907 A1 EA199800907 A1 EA 199800907A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- carboline
- carbolic
- potent
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Карболиновые производные формулы (I) являются мощными и селективными ингибиторами циклической гуанозин 3',5'-монофосфат специфической фосфодиэстеразы (c GMP специфической PDE) и обладают полезными свойствами в различных терапевтических областях, где такое ингибирование, как полагается, является полезным, включая лечение сердечно-сосудистых нарушений.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9609777.9A GB9609777D0 (en) | 1996-05-10 | 1996-05-10 | Chemical compounds |
GBGB9609820.7A GB9609820D0 (en) | 1996-05-10 | 1996-05-10 | Chemical compounds |
PCT/EP1997/002277 WO1997043287A1 (en) | 1996-05-10 | 1997-05-05 | Carboline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
EA199800907A1 true EA199800907A1 (ru) | 1999-04-29 |
Family
ID=26309303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199800907A EA199800907A1 (ru) | 1996-05-10 | 1997-05-05 | Производные карболина |
Country Status (26)
Country | Link |
---|---|
US (2) | US6117881A (ru) |
EP (1) | EP0912567B1 (ru) |
JP (1) | JP3418405B2 (ru) |
KR (1) | KR20000010918A (ru) |
CN (1) | CN1067071C (ru) |
AP (1) | AP9801365A0 (ru) |
AT (1) | ATE215950T1 (ru) |
AU (1) | AU711885B2 (ru) |
BG (1) | BG102879A (ru) |
BR (1) | BR9709230A (ru) |
CA (1) | CA2253948C (ru) |
CZ (1) | CZ358598A3 (ru) |
DE (1) | DE69711882T2 (ru) |
EA (1) | EA199800907A1 (ru) |
EE (1) | EE9800390A (ru) |
ES (1) | ES2175404T3 (ru) |
HU (1) | HUP9901478A3 (ru) |
IL (1) | IL126951A0 (ru) |
IS (1) | IS4864A (ru) |
NO (1) | NO985222L (ru) |
OA (1) | OA10920A (ru) |
PL (1) | PL329875A1 (ru) |
SK (1) | SK154498A3 (ru) |
TR (1) | TR199802282T2 (ru) |
WO (1) | WO1997043287A1 (ru) |
YU (1) | YU49898A (ru) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3418405B2 (ja) * | 1996-05-10 | 2003-06-23 | アイコス コーポレイション | カルボリン誘導体 |
US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
DE19837069C1 (de) * | 1998-08-17 | 2000-01-05 | Bayer Ag | Substituierte Zimtsäuren und Zimtsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von substituierten Indanoncarbonsäureestern |
JP2002524564A (ja) * | 1998-09-16 | 2002-08-06 | アイコス コーポレイション | cGMPホスホジエステラーゼ阻害剤としてのカルボリン誘導体 |
DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
JP2002539247A (ja) | 1999-03-24 | 2002-11-19 | ハーバー ブランチ オーシャノグラフィック インスティテューション インク. | マンズアミンの抗炎症作用の使用 |
US6451807B1 (en) | 1999-04-30 | 2002-09-17 | Lilly Icos, Llc. | Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor |
HUP0001632A3 (en) | 1999-04-30 | 2001-12-28 | Lilly Icos Llc Wilmington | Pharmaceutical compositions comprising selective phosphodiestherase inhibitors |
JP2004500425A (ja) | 2000-04-19 | 2004-01-08 | リリー アイコス リミテッド ライアビリティ カンパニー | パーキンソン病の処置に対する環状gmp特異的ホスホジエステラーゼインヒビターの使用 |
UA74826C2 (en) * | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
AU2001263278A1 (en) | 2000-06-23 | 2002-01-08 | Lilly Icos Llc | Cyclic gmp-specific phosphodiesterase inhibitors |
US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
EP1360185B1 (en) | 2001-02-12 | 2005-08-24 | Lilly Icos LLC | Carboline derivatives |
WO2002064591A2 (en) * | 2001-02-12 | 2002-08-22 | Lilly Icos Llc | Carboline derivatives |
CA2441792C (en) * | 2001-04-25 | 2010-08-03 | Lilly Icos Llc | Carboline derivatives as inhibitors of phosphodiesterase 5 (pdes) for the treatment of cardiovascular diseases and erectile dysfunction |
JP2004536816A (ja) | 2001-06-05 | 2004-12-09 | リリー アイコス リミテッド ライアビリティ カンパニー | Pde5阻害剤としてのカルボリン誘導体 |
EP1397361B1 (en) * | 2001-06-21 | 2006-08-09 | Lilly Icos LLC | Carboline derivatives as pdev inhibitors |
EP1442042A1 (en) | 2001-11-09 | 2004-08-04 | Schering Corporation | Polycyclic guanine derivative phosphodiesterase v inhibitors |
US7335680B2 (en) * | 2001-12-20 | 2008-02-26 | Laboratoires Serono Sa | Pyrrolidine derivatives as prostaglandin modulators |
TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
US7595311B2 (en) | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
EP3342420A1 (en) * | 2003-06-13 | 2018-07-04 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
WO2004113300A1 (ja) * | 2003-06-23 | 2004-12-29 | Ono Pharmaceutical Co., Ltd. | 新規三環性複素環化合物 |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
EP1737461B1 (en) * | 2004-03-15 | 2012-12-12 | PTC Therapeutics, Inc. | Carboline derivatives useful in the inhibition of angiogenesis |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
ZA200609845B (en) * | 2004-05-26 | 2010-02-24 | Eisai R&D Man Co Ltd | Cinnamide compound |
KR101128065B1 (ko) | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
AU2005297966B2 (en) | 2004-10-26 | 2010-12-23 | Eisai R & D Management Co., Ltd. | Amorphous object of cinnamide compound |
EP1829874B1 (en) | 2004-12-22 | 2014-02-12 | Ono Pharmaceutical Co., Ltd. | Tricyclic compound and use thereof |
US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
NZ568694A (en) | 2005-11-09 | 2011-09-30 | Zalicus Inc | Method, compositions, and kits for the treatment of medical conditions |
WO2007058304A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド化合物の塩またはそれらの溶媒和物 |
WO2007058305A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド誘導体の製造方法 |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
NZ568050A (en) | 2005-11-24 | 2010-09-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
US20070117839A1 (en) * | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
SA07280403B1 (ar) | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | ملح رباعي لمركب سيناميد |
US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2008095136A2 (en) | 2007-01-31 | 2008-08-07 | Henkin Robert I | Methods for detection of biological substances |
TW200848054A (en) | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
JPWO2008140111A1 (ja) * | 2007-05-16 | 2010-08-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド誘導体のワンポット製造方法 |
US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
MX2010002098A (es) | 2007-08-31 | 2010-03-30 | Eisai R&D Man Co Ltd | Compuesto policiclico. |
CA2712095A1 (en) * | 2008-01-28 | 2009-08-06 | Eisai R&D Management Co., Ltd. | Crystalline cinnamide compounds or salts thereof |
US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
WO2014055801A1 (en) | 2012-10-05 | 2014-04-10 | Henkin Robert I | Phosphodiesterase inhibitors for treating taste and smell disorders |
CN106233141B (zh) | 2014-02-18 | 2018-08-21 | 罗伯特·I·汉金 | 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物 |
AU2016326718B2 (en) | 2015-09-23 | 2022-12-15 | Minerva Biotechnologies Corporation | Method of screening for agents for differentiating stem cells |
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US3917599A (en) * | 1973-03-30 | 1975-11-04 | Council Scient Ind Res | 2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles |
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IT1217190B (it) * | 1988-04-22 | 1990-03-14 | Recordati Chem Pharm | Composti utili per il trattamento e diagnosi di disfunzioni frettili |
FI892362A (fi) * | 1988-06-01 | 1989-12-02 | Eisai Co Ltd | Buten- eller propensyraderivat. |
EP0357122A3 (en) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties |
DE3830096A1 (de) * | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
FR2649613B1 (fr) * | 1989-07-11 | 1991-09-27 | Virag Ronald | Medicament vaso-actif |
JPH0344324A (ja) * | 1989-07-13 | 1991-02-26 | Kazuoki Tsuchiya | 性機能賦活剤 |
US5270323A (en) * | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
EP0459666B1 (en) * | 1990-05-31 | 1994-11-09 | Pfizer Inc. | Medicaments against impotence |
GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
GB9218322D0 (en) * | 1992-08-28 | 1992-10-14 | Pfizer Ltd | Therapeutic agents |
GB9301192D0 (en) * | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
JP3418405B2 (ja) * | 1996-05-10 | 2003-06-23 | アイコス コーポレイション | カルボリン誘導体 |
US5874437A (en) * | 1996-11-01 | 1999-02-23 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
US6043252A (en) * | 1997-05-05 | 2000-03-28 | Icos Corporation | Carboline derivatives |
-
1997
- 1997-05-05 JP JP54045697A patent/JP3418405B2/ja not_active Expired - Fee Related
- 1997-05-05 IL IL12695197A patent/IL126951A0/xx unknown
- 1997-05-05 ES ES97922960T patent/ES2175404T3/es not_active Expired - Lifetime
- 1997-05-05 PL PL97329875A patent/PL329875A1/xx unknown
- 1997-05-05 KR KR1019980709066A patent/KR20000010918A/ko not_active Application Discontinuation
- 1997-05-05 SK SK1544-98A patent/SK154498A3/sk unknown
- 1997-05-05 EE EE9800390A patent/EE9800390A/xx unknown
- 1997-05-05 DE DE69711882T patent/DE69711882T2/de not_active Expired - Fee Related
- 1997-05-05 CZ CZ983585A patent/CZ358598A3/cs unknown
- 1997-05-05 WO PCT/EP1997/002277 patent/WO1997043287A1/en not_active Application Discontinuation
- 1997-05-05 EP EP97922960A patent/EP0912567B1/en not_active Expired - Lifetime
- 1997-05-05 TR TR1998/02282T patent/TR199802282T2/xx unknown
- 1997-05-05 BR BR9709230A patent/BR9709230A/pt not_active IP Right Cessation
- 1997-05-05 YU YU49898A patent/YU49898A/sh unknown
- 1997-05-05 AT AT97922960T patent/ATE215950T1/de not_active IP Right Cessation
- 1997-05-05 CA CA002253948A patent/CA2253948C/en not_active Expired - Fee Related
- 1997-05-05 HU HU9901478A patent/HUP9901478A3/hu unknown
- 1997-05-05 CN CN97194508A patent/CN1067071C/zh not_active Expired - Fee Related
- 1997-05-05 EA EA199800907A patent/EA199800907A1/ru unknown
- 1997-05-05 US US09/155,811 patent/US6117881A/en not_active Expired - Fee Related
- 1997-05-05 AP APAP/P/1998/001365A patent/AP9801365A0/en unknown
- 1997-05-05 AU AU28910/97A patent/AU711885B2/en not_active Ceased
-
1998
- 1998-10-13 IS IS4864A patent/IS4864A/is unknown
- 1998-10-29 BG BG102879A patent/BG102879A/xx unknown
- 1998-11-09 NO NO985222A patent/NO985222L/no not_active Application Discontinuation
- 1998-11-09 OA OA9800218A patent/OA10920A/en unknown
-
2000
- 2000-06-12 US US09/592,514 patent/US6306870B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2175404T3 (es) | 2002-11-16 |
IS4864A (is) | 1998-10-13 |
YU49898A (sh) | 2000-03-21 |
NO985222L (no) | 1999-01-11 |
PL329875A1 (en) | 1999-04-12 |
EE9800390A (et) | 1999-06-15 |
US6117881A (en) | 2000-09-12 |
BR9709230A (pt) | 1999-08-10 |
CA2253948A1 (en) | 1997-11-20 |
JP3418405B2 (ja) | 2003-06-23 |
KR20000010918A (ko) | 2000-02-25 |
NO985222D0 (no) | 1998-11-09 |
WO1997043287A1 (en) | 1997-11-20 |
EP0912567A1 (en) | 1999-05-06 |
OA10920A (en) | 2003-02-21 |
HUP9901478A2 (hu) | 1999-08-30 |
SK154498A3 (en) | 2000-01-18 |
CA2253948C (en) | 2005-07-26 |
CN1067071C (zh) | 2001-06-13 |
US6306870B1 (en) | 2001-10-23 |
DE69711882D1 (en) | 2002-05-16 |
IL126951A0 (en) | 1999-09-22 |
EP0912567B1 (en) | 2002-04-10 |
JP2000513717A (ja) | 2000-10-17 |
AU2891097A (en) | 1997-12-05 |
CZ358598A3 (cs) | 1999-03-17 |
DE69711882T2 (de) | 2002-10-31 |
TR199802282T2 (xx) | 1999-03-22 |
AU711885B2 (en) | 1999-10-21 |
ATE215950T1 (de) | 2002-04-15 |
AP9801365A0 (en) | 1998-12-31 |
HUP9901478A3 (en) | 1999-11-29 |
BG102879A (en) | 1999-09-30 |
CN1218471A (zh) | 1999-06-02 |
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