NO985222D0 - Karbolinderivater - Google Patents

Karbolinderivater

Info

Publication number
NO985222D0
NO985222D0 NO985222A NO985222A NO985222D0 NO 985222 D0 NO985222 D0 NO 985222D0 NO 985222 A NO985222 A NO 985222A NO 985222 A NO985222 A NO 985222A NO 985222 D0 NO985222 D0 NO 985222D0
Authority
NO
Norway
Prior art keywords
carboline
Prior art date
Application number
NO985222A
Other languages
English (en)
Other versions
NO985222L (no
Inventor
Agnes Bombrun
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609777.9A external-priority patent/GB9609777D0/en
Priority claimed from GBGB9609820.7A external-priority patent/GB9609820D0/en
Application filed by Icos Corp filed Critical Icos Corp
Publication of NO985222D0 publication Critical patent/NO985222D0/no
Publication of NO985222L publication Critical patent/NO985222L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO985222A 1996-05-10 1998-11-09 Karbolinderivater NO985222L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9609777.9A GB9609777D0 (en) 1996-05-10 1996-05-10 Chemical compounds
GBGB9609820.7A GB9609820D0 (en) 1996-05-10 1996-05-10 Chemical compounds
PCT/EP1997/002277 WO1997043287A1 (en) 1996-05-10 1997-05-05 Carboline derivatives

Publications (2)

Publication Number Publication Date
NO985222D0 true NO985222D0 (no) 1998-11-09
NO985222L NO985222L (no) 1999-01-11

Family

ID=26309303

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985222A NO985222L (no) 1996-05-10 1998-11-09 Karbolinderivater

Country Status (26)

Country Link
US (2) US6117881A (no)
EP (1) EP0912567B1 (no)
JP (1) JP3418405B2 (no)
KR (1) KR20000010918A (no)
CN (1) CN1067071C (no)
AP (1) AP9801365A0 (no)
AT (1) ATE215950T1 (no)
AU (1) AU711885B2 (no)
BG (1) BG102879A (no)
BR (1) BR9709230A (no)
CA (1) CA2253948C (no)
CZ (1) CZ358598A3 (no)
DE (1) DE69711882T2 (no)
EA (1) EA199800907A1 (no)
EE (1) EE9800390A (no)
ES (1) ES2175404T3 (no)
HU (1) HUP9901478A3 (no)
IL (1) IL126951A0 (no)
IS (1) IS4864A (no)
NO (1) NO985222L (no)
OA (1) OA10920A (no)
PL (1) PL329875A1 (no)
SK (1) SK154498A3 (no)
TR (1) TR199802282T2 (no)
WO (1) WO1997043287A1 (no)
YU (1) YU49898A (no)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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YU49898A (sh) * 1996-05-10 2000-03-21 Icos Corporation Hemijska jedinjenja
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
DE19837069C1 (de) 1998-08-17 2000-01-05 Bayer Ag Substituierte Zimtsäuren und Zimtsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von substituierten Indanoncarbonsäureestern
AU1025899A (en) * 1998-09-16 2000-04-03 Icos Corporation Carboline derivatives as cgmp phosphodiesterase inhibitors
DE19903087A1 (de) * 1999-01-27 2000-08-10 Forssmann Wolf Georg Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern
ATE256466T1 (de) * 1999-03-24 2004-01-15 Harbor Branch Oceanographic Verwendung von manzaminen als entzündungshemmende mittel
US6451807B1 (en) 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
IL135817A0 (en) 1999-04-30 2001-05-20 Lilly Icos Llc Phosphodiesterase enzyme inhibitors and their use in pharmaceutical articles
DE60124085D1 (de) 2000-04-19 2006-12-07 Lilly Icos Llc Pde-v hemmer zur behandlung von morbus parkinson
UA74826C2 (en) * 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
CA2412596C (en) * 2000-06-23 2007-07-31 Lilly Icos Llc Cyclic gmp-specific phosphodiesterase inhibitors
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
WO2002064590A2 (en) * 2001-02-12 2002-08-22 Lilly Icos Llc Carboline derivatives
JP4223285B2 (ja) * 2001-02-12 2009-02-12 リリー アイコス リミテッド ライアビリティ カンパニー 化合物
US7115621B2 (en) * 2001-04-25 2006-10-03 Lilly Icos Llc Chemical compounds
JP2004536816A (ja) 2001-06-05 2004-12-09 リリー アイコス リミテッド ライアビリティ カンパニー Ｐｄｅ５阻害剤としてのカルボリン誘導体
MXPA03011167A (es) * 2001-06-21 2004-02-26 Lilly Icos Llc Derivados de carbolina utiles como ihibidores de pdev.
CA2465893A1 (en) 2001-11-09 2003-05-22 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
ATE455758T1 (de) 2001-12-20 2010-02-15 Merck Serono Sa Pyrrolidin-derivatie als prostaglandin- modulatoren
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
EP2526958B1 (en) 2003-06-13 2017-10-18 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7872133B2 (en) 2003-06-23 2011-01-18 Ono Pharmaceutical Co., Ltd. Tricyclic heterocycle compound
SG184755A1 (en) 2004-03-15 2012-10-30 Ptc Therapeutics Inc Carboline derivatives useful in the inhibition of angiogenesis
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
ZA200609845B (en) * 2004-05-26 2010-02-24 Eisai R&D Man Co Ltd Cinnamide compound
KR101128065B1 (ko) 2004-05-26 2012-04-12 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 화합물
US7923563B2 (en) 2004-10-26 2011-04-12 Eisai R&D Management Co., Ltd. Amorphous object of cinnamide compound
WO2006068164A1 (ja) 2004-12-22 2006-06-29 Ono Pharmaceutical Co., Ltd. 三環式化合物およびその用途
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
JPWO2007058304A1 (ja) * 2005-11-18 2009-05-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物の塩またはそれらの溶媒和物
AU2006316005A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
JP5221144B2 (ja) 2005-11-24 2013-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 モルホリンタイプ・シンナミド化合物
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US7737141B2 (en) 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US8293489B2 (en) 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
US20080207900A1 (en) * 2007-02-28 2008-08-28 Teiji Kimura Two cyclic oxomorphorin derivatives
AU2008250119A1 (en) * 2007-05-16 2008-11-20 Eisai R & D Management Co., Ltd. One-pot production process for cinnamide derivative
CA2694401C (en) 2007-08-31 2012-12-04 Eisai R&D Management Co., Ltd. Polycyclic compound
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
CA2712095A1 (en) * 2008-01-28 2009-08-06 Eisai R&D Management Co., Ltd. Crystalline cinnamide compounds or salts thereof
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
EP2903619B1 (en) 2012-10-05 2019-06-05 Robert I. Henkin Phosphodiesterase inhibitors for treating taste and smell disorders
CN106233141B (zh) 2014-02-18 2018-08-21 罗伯特·I·汉金 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物
CA2999503A1 (en) 2015-09-23 2017-03-30 Minerva Biotechnologies Corporation Method of screening for agents for differentiating stem cells

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Also Published As

Publication number Publication date
NO985222L (no) 1999-01-11
TR199802282T2 (xx) 1999-03-22
PL329875A1 (en) 1999-04-12
YU49898A (sh) 2000-03-21
EP0912567A1 (en) 1999-05-06
KR20000010918A (ko) 2000-02-25
ES2175404T3 (es) 2002-11-16
HUP9901478A2 (hu) 1999-08-30
ATE215950T1 (de) 2002-04-15
AP9801365A0 (en) 1998-12-31
IL126951A0 (en) 1999-09-22
CA2253948A1 (en) 1997-11-20
EA199800907A1 (ru) 1999-04-29
BR9709230A (pt) 1999-08-10
IS4864A (is) 1998-10-13
US6306870B1 (en) 2001-10-23
JP3418405B2 (ja) 2003-06-23
JP2000513717A (ja) 2000-10-17
CN1218471A (zh) 1999-06-02
CN1067071C (zh) 2001-06-13
DE69711882T2 (de) 2002-10-31
AU2891097A (en) 1997-12-05
AU711885B2 (en) 1999-10-21
EP0912567B1 (en) 2002-04-10
WO1997043287A1 (en) 1997-11-20
OA10920A (en) 2003-02-21
CZ358598A3 (cs) 1999-03-17
US6117881A (en) 2000-09-12
BG102879A (en) 1999-09-30
HUP9901478A3 (en) 1999-11-29
SK154498A3 (en) 2000-01-18
EE9800390A (et) 1999-06-15
CA2253948C (en) 2005-07-26
DE69711882D1 (en) 2002-05-16

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application