NO991903D0 - Naftyridinderivater - Google Patents

Naftyridinderivater

Info

Publication number
NO991903D0
NO991903D0 NO991903A NO991903A NO991903D0 NO 991903 D0 NO991903 D0 NO 991903D0 NO 991903 A NO991903 A NO 991903A NO 991903 A NO991903 A NO 991903A NO 991903 D0 NO991903 D0 NO 991903D0
Authority
NO
Norway
Prior art keywords
naphthyridine
Prior art date
Application number
NO991903A
Other languages
English (en)
Other versions
NO312677B1 (no
NO991903L (no
Inventor
Rene Hersperger
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO991903D0 publication Critical patent/NO991903D0/no
Publication of NO991903L publication Critical patent/NO991903L/no
Publication of NO312677B1 publication Critical patent/NO312677B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
NO19991903A 1996-10-28 1999-04-21 Naftyridinderivater, fremgangsmåte for deres fremstilling, mellomprodukter, anvendelse av derivatene samt farmasöytiskemidler omfattende disse NO312677B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9622386.2A GB9622386D0 (en) 1996-10-28 1996-10-28 Organic compounds
PCT/EP1997/005898 WO1998018796A1 (en) 1996-10-28 1997-10-24 Naphthyridine derivatives

Publications (3)

Publication Number Publication Date
NO991903D0 true NO991903D0 (no) 1999-04-21
NO991903L NO991903L (no) 1999-04-21
NO312677B1 NO312677B1 (no) 2002-06-17

Family

ID=10802050

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19991903A NO312677B1 (no) 1996-10-28 1999-04-21 Naftyridinderivater, fremgangsmåte for deres fremstilling, mellomprodukter, anvendelse av derivatene samt farmasöytiskemidler omfattende disse

Country Status (32)

Country Link
US (1) US6136821A (no)
EP (1) EP0934320B1 (no)
JP (1) JP4451496B2 (no)
KR (1) KR100524329B1 (no)
CN (1) CN1103773C (no)
AR (1) AR009128A1 (no)
AT (1) ATE236155T1 (no)
AU (1) AU724471B2 (no)
BR (1) BR9713280B1 (no)
CA (1) CA2269946C (no)
CO (1) CO4910164A1 (no)
CZ (1) CZ146699A3 (no)
DE (1) DE69720493T2 (no)
DK (1) DK0934320T3 (no)
ES (1) ES2196377T3 (no)
GB (1) GB9622386D0 (no)
HK (1) HK1022305A1 (no)
HU (1) HUP9904204A3 (no)
ID (1) ID18623A (no)
IL (2) IL129502A0 (no)
MY (1) MY132642A (no)
NO (1) NO312677B1 (no)
NZ (1) NZ335363A (no)
PE (1) PE10899A1 (no)
PL (1) PL189280B1 (no)
PT (1) PT934320E (no)
SI (1) SI0934320T1 (no)
SK (1) SK283562B6 (no)
TR (1) TR199900920T2 (no)
TW (1) TW399052B (no)
WO (1) WO1998018796A1 (no)
ZA (1) ZA979593B (no)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
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CA2359449A1 (en) 1999-01-15 2000-07-20 Beate Gutterer Phenanthridine-n-oxides with pde-iv inhibiting activity
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EP2193808A1 (en) 1999-08-21 2010-06-09 Nycomed GmbH Synergistic combination
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
HUP0401305A2 (hu) 2001-01-31 2004-10-28 Pfizer Products Inc. Tiazolil-, oxazolil-, pirrolil- és imidazolil-savamid-származékok, mint PDE4 izozimek inhibitorai és az ezeket tartalmazó gyógyszerkészítmények
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
JP2004520386A (ja) 2001-01-31 2004-07-08 ファイザー・プロダクツ・インク Ｐｄｅ４アイソザイムの阻害剤として有用なニコチンアミドビアリール誘導体
PL364910A1 (en) 2001-01-31 2004-12-27 Pfizer Products Inc. Ether derivatives useful as inhibitors of pde4 isozymes
JP4510383B2 (ja) * 2001-05-23 2010-07-21 田辺三菱製薬株式会社 軟骨疾患修復治療用組成物
IL161317A0 (en) * 2001-10-16 2004-09-27 Memory Pharm Corp 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes
MY130622A (en) * 2001-11-05 2007-07-31 Novartis Ag Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors
BRPI0117198B1 (pt) 2001-12-14 2018-03-13 Merck Serono S.A. Usos de composição compreendendo um inibidor seletivo de uma isoforma 4 de fosfodiesterase
NZ540138A (en) 2002-11-19 2008-07-31 Memory Pharm Corp Pyridine n-oxide compounds as phosphodiesterase 4 inhibitors
GB0229281D0 (en) * 2002-12-16 2003-01-22 Novartis Ag Organic compounds
BRPI0410235A (pt) * 2003-04-16 2006-05-09 Memory Pharm Corp inibição de pde4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento
KR20060005375A (ko) * 2003-04-18 2006-01-17 메모리 파마슈티칼스 코포레이션 포스포디에스테라제 4 억제제로서의 피라졸 유도체
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
MY141255A (en) 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
WO2006073413A1 (en) * 2004-02-20 2006-07-13 The Board Of Trustees Of The University Of Illinois Blood pressure reduction in salt-sensitive
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
EP1758873A1 (en) * 2004-06-22 2007-03-07 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
CA2577171A1 (en) * 2004-09-14 2006-03-23 Novartis Ag Process for the preparation of 6, 8-substituted `1, 7 naphthpyridin derivatives by reacting the 8-halo-`1, 7 naphthpyridin-derivate with an organic boronic acid derivatives and intermadiates of this process
CN101166733A (zh) 2004-10-15 2008-04-23 记忆药物公司 作为磷酸二酯酶4抑制剂的吡唑衍生物
AU2005295350A1 (en) * 2004-10-20 2006-04-27 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
JP2006241111A (ja) * 2005-03-04 2006-09-14 Univ Nihon 新規ベンゾフロキサン及びその合成法
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512695A (ja) * 2005-10-21 2009-03-26 グラクソ グループ リミテッド 化合物
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
WO2007045477A2 (en) 2005-10-21 2007-04-26 Novartis Ag Human antibodies against il-13 and therapeutic uses
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP1963324B1 (en) 2005-12-22 2010-04-21 Glaxo Group Limited Heterocyclic compounds, their preparation and their use as antibacterials
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0601951D0 (en) * 2006-01-31 2006-03-15 Novartis Ag Organic compounds
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
ATE549337T1 (de) 2006-04-21 2012-03-15 Novartis Ag Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
AU2007302263A1 (en) 2006-09-29 2008-04-03 Novartis Ag Pyrazolopyrimidines as P13K lipid kinase inhibitors
WO2008052734A1 (en) 2006-10-30 2008-05-08 Novartis Ag Heterocyclic compounds as antiinflammatory agents
JP2010515729A (ja) 2007-01-10 2010-05-13 アイアールエム・リミテッド・ライアビリティ・カンパニー チャネル活性化プロテアーゼ阻害剤としての化合物および組成物
BRPI0811562A2 (pt) 2007-05-07 2014-12-09 Novartis Ag Compostos orgânicos
TWI439462B (zh) 2007-12-10 2014-06-01 Novartis Ag 作為ｅｎａｃ阻抑劑之螺環胍化合物
PT2231642E (pt) 2008-01-11 2014-03-12 Novartis Ag Pirimidinas como inibidores de quinase
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
CN102112130A (zh) 2008-06-10 2011-06-29 诺瓦提斯公司 作为上皮钠通道阻滞剂的吡嗪衍生物
WO2010088335A1 (en) 2009-01-29 2010-08-05 Novartis Ag Substituted benzimidazoles for the treatment of astrocytomas
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
BR112012003262A8 (pt) 2009-08-12 2016-05-17 Novartis Ag compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
CN105078978A (zh) 2009-08-17 2015-11-25 因特利凯公司 杂环化合物及其用途
WO2011020861A1 (en) 2009-08-20 2011-02-24 Novartis Ag Heterocyclic oxime compounds
EP2813227A1 (en) 2009-10-22 2014-12-17 Vertex Pharmaceuticals Incorporated Compositions for treatment of cystic fibrosis and other chronic diseases
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
CN103097385B (zh) 2010-07-14 2016-08-03 诺华股份有限公司 Ip受体激动剂杂环化合物
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
US20130324526A1 (en) 2011-02-10 2013-12-05 Novartis Ag [1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン， エルエルシー 複素環化合物およびその使用
CA2828219A1 (en) 2011-02-25 2012-08-30 Irm Llc Pyrazolo [1,5-a] pyridines as trk inhibitors
UY34305A (es) 2011-09-01 2013-04-30 Novartis Ag Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
CA2848809A1 (en) 2011-09-15 2013-03-21 Novartis Ag 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
EP2755652B1 (en) 2011-09-16 2021-06-02 Novartis AG N-substituted heterocyclyl carboxamides
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
JP5886433B2 (ja) 2011-09-16 2016-03-16 ノバルティス アーゲー 嚢胞性線維症処置のためのヘテロ環式化合物
EP2793893A4 (en) 2011-11-23 2015-07-08 Intellikine Llc IMPROVED TREATMENT REGIMES USING MTOR INHIBITORS
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
TW201335160A (zh) 2012-01-13 2013-09-01 Novartis Ag Ｉｐ受體激動劑之雜環化合物
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
WO2013149581A1 (en) 2012-04-03 2013-10-10 Novartis Ag Combination products with tyrosine kinase inhibitors and their use
JP5907005B2 (ja) * 2012-09-04 2016-04-20 エヌ・イーケムキャット株式会社 ビフェニル化合物の合成方法
JP5907006B2 (ja) * 2012-09-04 2016-04-20 エヌ・イーケムキャット株式会社 ビフェニル化合物の合成方法
WO2014125413A1 (en) 2013-02-13 2014-08-21 Novartis Ag Ip receptor agonist heterocyclic compounds
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
CN105246482A (zh) 2013-03-15 2016-01-13 因特利凯有限责任公司 激酶抑制剂的组合及其用途
WO2015084804A1 (en) 2013-12-03 2015-06-11 Novartis Ag Combination of mdm2 inhibitor and braf inhibitor and their use
MX2016013812A (es) 2014-04-24 2017-03-09 Novartis Ag Derivados de amino-pirazina como inhibidores de fosfatidil-inositol-3-cinasa.
EA033571B1 (ru) 2014-04-24 2019-11-06 Novartis Ag Производные пиразина в качестве ингибиторов фосфатидилинозитол 3-киназы
WO2015162456A1 (en) 2014-04-24 2015-10-29 Novartis Ag Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
US9741941B2 (en) 2014-04-29 2017-08-22 Universal Display Corporation Organic electroluminescent materials and devices
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
WO2016016822A1 (en) 2014-07-31 2016-02-04 Novartis Ag Combination therapy
MX2021015133A (es) 2019-06-10 2022-01-24 Novartis Ag Derivado de piridina y pirazina para el tratamiento de la fibrosis quistica, enfermedad pulmonar obstructiva cronica y bronquiectasia.
JOP20220044A1 (ar) 2019-08-28 2023-01-30 Novartis Ag مشتقات 1، 3- فينيل أريل غير متجانسة بها استبدال واستخدامها في معالجة مرض
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

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Also Published As

Publication number Publication date
IL129502A0 (en) 2000-02-29
PT934320E (pt) 2003-07-31
SK55799A3 (en) 1999-10-08
DK0934320T3 (da) 2003-07-14
TW399052B (en) 2000-07-21
EP0934320B1 (en) 2003-04-02
ZA979593B (en) 1998-04-28
JP4451496B2 (ja) 2010-04-14
ID18623A (id) 1998-04-30
BR9713280A (pt) 1999-11-03
DE69720493D1 (de) 2003-05-08
ES2196377T3 (es) 2003-12-16
KR20000052832A (ko) 2000-08-25
IL129502A (en) 2006-10-05
MY132642A (en) 2007-10-31
US6136821A (en) 2000-10-24
TR199900920T2 (xx) 1999-06-21
CA2269946C (en) 2007-01-23
AU6908498A (en) 1998-05-22
CO4910164A1 (es) 2000-04-24
GB9622386D0 (en) 1997-01-08
NO312677B1 (no) 2002-06-17
CN1234800A (zh) 1999-11-10
CA2269946A1 (en) 1998-05-07
SK283562B6 (sk) 2003-09-11
PL332738A1 (en) 1999-10-11
HK1022305A1 (en) 2000-08-04
HUP9904204A3 (en) 2000-06-28
WO1998018796A1 (en) 1998-05-07
DE69720493T2 (de) 2003-12-24
NZ335363A (en) 2000-11-24
NO991903L (no) 1999-04-21
PL189280B1 (pl) 2005-07-29
JP2001502717A (ja) 2001-02-27
CN1103773C (zh) 2003-03-26
SI0934320T1 (en) 2003-08-31
CZ146699A3 (cs) 1999-08-11
BR9713280B1 (pt) 2010-12-14
EP0934320A1 (en) 1999-08-11
AR009128A1 (es) 2000-03-08
KR100524329B1 (ko) 2005-11-01
AU724471B2 (en) 2000-09-21
PE10899A1 (es) 1999-03-03
HUP9904204A2 (hu) 2000-05-28
ATE236155T1 (de) 2003-04-15

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