ES2154408T3 - Inhibidores de serina proteasa derivados de imidazo(1,5a)piridina. - Google Patents

Inhibidores de serina proteasa derivados de imidazo(1,5a)piridina.

Info

Publication number
ES2154408T3
ES2154408T3 ES96918638T ES96918638T ES2154408T3 ES 2154408 T3 ES2154408 T3 ES 2154408T3 ES 96918638 T ES96918638 T ES 96918638T ES 96918638 T ES96918638 T ES 96918638T ES 2154408 T3 ES2154408 T3 ES 2154408T3
Authority
ES
Spain
Prior art keywords
sub
imidazo
piridina
inhibitors derived
lower rent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96918638T
Other languages
English (en)
Inventor
Henricus Carl Joseph Ottenheym
Anton Egbert Peter Adang
Jacobus Albertus Maria Peters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2154408T3 publication Critical patent/ES2154408T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A UN INHIBIDOR DE SERIN PROTEASA DERIVADO DE IMIDAZO[1,5A]PIRIDINA QUE COMPRENDE UNA UNIDAD DE FORMULA GENERAL (I) EN LA QUE R SUB,1} ES UN GRUPO HIDROGENO, ALQUILO INFERIOR O ACILO; R SUB,2} ES HIDROGENO O ALQUILO INFERIOR; R SUB,3} Y R SUB,4} SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO INFERIOR, O JUNTOS FORMAN =CH NR SUB,5}R SUB,6}, R SUB,5} Y R SUB,6} SON ALQUILO INFERIOR. LOS COMPUESTOS SON INHIBIDORES DE SERIN PROTEASAS Y PUEDEN UTILIZARSE PARA EL TRATAMIENTO Y PROFILAXIS DE LA TROMBOSIS Y ENFERMEDADES ASOCIADAS A TROMBINA.
ES96918638T 1995-06-02 1996-05-29 Inhibidores de serina proteasa derivados de imidazo(1,5a)piridina. Expired - Lifetime ES2154408T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95201448 1995-06-02

Publications (1)

Publication Number Publication Date
ES2154408T3 true ES2154408T3 (es) 2001-04-01

Family

ID=8220349

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96918638T Expired - Lifetime ES2154408T3 (es) 1995-06-02 1996-05-29 Inhibidores de serina proteasa derivados de imidazo(1,5a)piridina.

Country Status (26)

Country Link
US (1) US5916888A (es)
EP (1) EP0830371B1 (es)
JP (1) JPH11505859A (es)
KR (1) KR19990022162A (es)
AR (1) AR002752A1 (es)
AT (1) ATE198208T1 (es)
AU (1) AU704970B2 (es)
BR (1) BR9608978A (es)
CA (1) CA2222960A1 (es)
CZ (1) CZ287664B6 (es)
DE (1) DE69611298T2 (es)
DK (1) DK0830371T3 (es)
ES (1) ES2154408T3 (es)
GR (1) GR3035321T3 (es)
HU (1) HUP9801810A3 (es)
IL (1) IL118323A (es)
MX (1) MX9709340A (es)
NO (1) NO975534L (es)
NZ (1) NZ310438A (es)
PL (1) PL323730A1 (es)
PT (1) PT830371E (es)
RU (1) RU2175327C2 (es)
TR (1) TR199701483T1 (es)
TW (1) TW445146B (es)
WO (1) WO1996038470A1 (es)
ZA (1) ZA964008B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358928B1 (en) 1999-11-22 2002-03-19 Enzyme Systems Products Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases
KR100669498B1 (ko) * 2000-03-24 2007-01-15 주식회사 삼양제넥스 세린 프로테이즈 저해제 및 그것을 함유하는 패혈증 치료제
US20040018984A1 (en) * 2002-07-17 2004-01-29 Mizuo Miyazaki Methods for preventing adhesion formation using protease inhibitors
EP1479680A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Azaindole derivatives as Factor Xa inhibitors
WO2008070161A1 (en) * 2006-12-06 2008-06-12 The Research Foundation Of State University Of New York Azepans and methods for making and using same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1233860B (it) * 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa

Also Published As

Publication number Publication date
PL323730A1 (en) 1998-04-14
AR002752A1 (es) 1998-04-29
HK1009454A1 (en) 1999-06-04
WO1996038470A1 (en) 1996-12-05
EP0830371B1 (en) 2000-12-20
NO975534D0 (no) 1997-12-01
ZA964008B (en) 1997-07-11
NO975534L (no) 1998-01-30
CZ381297A3 (cs) 1998-04-15
HUP9801810A2 (hu) 1998-11-30
DE69611298D1 (de) 2001-01-25
CZ287664B6 (en) 2001-01-17
ATE198208T1 (de) 2001-01-15
KR19990022162A (ko) 1999-03-25
DK0830371T3 (da) 2001-02-26
RU2175327C2 (ru) 2001-10-27
TW445146B (en) 2001-07-11
AU6123396A (en) 1996-12-18
HUP9801810A3 (en) 1999-05-28
JPH11505859A (ja) 1999-05-25
DE69611298T2 (de) 2001-05-31
EP0830371A1 (en) 1998-03-25
AU704970B2 (en) 1999-05-13
MX9709340A (es) 1998-02-28
IL118323A0 (en) 1996-09-12
CA2222960A1 (en) 1996-12-05
IL118323A (en) 1999-11-30
GR3035321T3 (en) 2001-04-30
PT830371E (pt) 2001-04-30
US5916888A (en) 1999-06-29
TR199701483T1 (xx) 1998-03-21
BR9608978A (pt) 1999-06-29
NZ310438A (en) 1999-11-29

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