MX9709340A - Inhibidores de proteasa de serina derivados de imidazo (1,5a) piridina. - Google Patents

Inhibidores de proteasa de serina derivados de imidazo (1,5a) piridina.

Info

Publication number
MX9709340A
MX9709340A MX9709340A MX9709340A MX9709340A MX 9709340 A MX9709340 A MX 9709340A MX 9709340 A MX9709340 A MX 9709340A MX 9709340 A MX9709340 A MX 9709340A MX 9709340 A MX9709340 A MX 9709340A
Authority
MX
Mexico
Prior art keywords
serine protease
imidazo
protease inhibitors
lower alkyl
derived serine
Prior art date
Application number
MX9709340A
Other languages
English (en)
Other versions
MXPA97009340A (es
Inventor
Henricus Carl Joseph Ottenheym
Anton Egbert Peter Adang
Jacobus Albertus Maria Peters
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of MXPA97009340A publication Critical patent/MXPA97009340A/es
Publication of MX9709340A publication Critical patent/MX9709340A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invencion se refiere a un inhibidor de proteasa de serina derivado de imidazo[1,5a]piridina que comprende una unidad que tiene la formula general (I), en donde R1 es hidrogeno, alquilo menor o un grupo acilo; R2 es hidrogeno o alquilo menor; R3 y R4 son independientemente hidrogeno, alquilo menor o juntos forman =CH-NR5R6 siendo R5 y R6 alquilos menores. Los compuestos son inhibidores de proteasa de serina y pueden usarse para el tratamiento y profilaxis de trombosis y enfermedades asociadas a la trombina.
MX9709340A 1995-06-02 1996-05-29 Inhibidores de proteasa de serina derivados de imidazo (1,5a) piridina. MX9709340A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95201448.4 1995-06-02
EP95201448 1995-06-02
PCT/EP1996/002298 WO1996038470A1 (en) 1995-06-02 1996-05-29 IMIDAZO[1,5a]PYRIDINE DERIVED SERINE PROTEASE INHIBITORS

Publications (2)

Publication Number Publication Date
MXPA97009340A MXPA97009340A (es) 1998-02-01
MX9709340A true MX9709340A (es) 1998-02-28

Family

ID=8220349

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9709340A MX9709340A (es) 1995-06-02 1996-05-29 Inhibidores de proteasa de serina derivados de imidazo (1,5a) piridina.

Country Status (26)

Country Link
US (1) US5916888A (es)
EP (1) EP0830371B1 (es)
JP (1) JPH11505859A (es)
KR (1) KR19990022162A (es)
AR (1) AR002752A1 (es)
AT (1) ATE198208T1 (es)
AU (1) AU704970B2 (es)
BR (1) BR9608978A (es)
CA (1) CA2222960A1 (es)
CZ (1) CZ287664B6 (es)
DE (1) DE69611298T2 (es)
DK (1) DK0830371T3 (es)
ES (1) ES2154408T3 (es)
GR (1) GR3035321T3 (es)
HU (1) HUP9801810A3 (es)
IL (1) IL118323A (es)
MX (1) MX9709340A (es)
NO (1) NO975534L (es)
NZ (1) NZ310438A (es)
PL (1) PL323730A1 (es)
PT (1) PT830371E (es)
RU (1) RU2175327C2 (es)
TR (1) TR199701483T1 (es)
TW (1) TW445146B (es)
WO (1) WO1996038470A1 (es)
ZA (1) ZA964008B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358928B1 (en) 1999-11-22 2002-03-19 Enzyme Systems Products Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases
KR100669498B1 (ko) * 2000-03-24 2007-01-15 주식회사 삼양제넥스 세린 프로테이즈 저해제 및 그것을 함유하는 패혈증 치료제
US20040018984A1 (en) * 2002-07-17 2004-01-29 Mizuo Miyazaki Methods for preventing adhesion formation using protease inhibitors
EP1479680A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Azaindole derivatives as Factor Xa inhibitors
WO2008070161A1 (en) * 2006-12-06 2008-06-12 The Research Foundation Of State University Of New York Azepans and methods for making and using same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1233860B (it) * 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa

Also Published As

Publication number Publication date
HK1009454A1 (en) 1999-06-04
EP0830371A1 (en) 1998-03-25
KR19990022162A (ko) 1999-03-25
PT830371E (pt) 2001-04-30
CZ287664B6 (en) 2001-01-17
TR199701483T1 (xx) 1998-03-21
PL323730A1 (en) 1998-04-14
WO1996038470A1 (en) 1996-12-05
TW445146B (en) 2001-07-11
ZA964008B (en) 1997-07-11
ATE198208T1 (de) 2001-01-15
US5916888A (en) 1999-06-29
AU6123396A (en) 1996-12-18
HUP9801810A3 (en) 1999-05-28
DK0830371T3 (da) 2001-02-26
NO975534L (no) 1998-01-30
ES2154408T3 (es) 2001-04-01
CA2222960A1 (en) 1996-12-05
JPH11505859A (ja) 1999-05-25
CZ381297A3 (cs) 1998-04-15
BR9608978A (pt) 1999-06-29
AR002752A1 (es) 1998-04-29
DE69611298T2 (de) 2001-05-31
IL118323A0 (en) 1996-09-12
NO975534D0 (no) 1997-12-01
IL118323A (en) 1999-11-30
DE69611298D1 (de) 2001-01-25
GR3035321T3 (en) 2001-04-30
NZ310438A (en) 1999-11-29
EP0830371B1 (en) 2000-12-20
HUP9801810A2 (hu) 1998-11-30
RU2175327C2 (ru) 2001-10-27
AU704970B2 (en) 1999-05-13

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees