DE69531990D1 - Bicyclischer lactaminhibitor des interleukin-1-beta-konvertierenden enzyms - Google Patents

Bicyclischer lactaminhibitor des interleukin-1-beta-konvertierenden enzyms

Info

Publication number
DE69531990D1
DE69531990D1 DE69531990T DE69531990T DE69531990D1 DE 69531990 D1 DE69531990 D1 DE 69531990D1 DE 69531990 T DE69531990 T DE 69531990T DE 69531990 T DE69531990 T DE 69531990T DE 69531990 D1 DE69531990 D1 DE 69531990D1
Authority
DE
Germany
Prior art keywords
beta
interleukin
lactamine
hibitor
bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69531990T
Other languages
English (en)
Other versions
DE69531990T2 (de
Inventor
E Dolle
Prasad V Chaturvedula
Ross Tina Morgan
J Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69531990D1 publication Critical patent/DE69531990D1/de
Publication of DE69531990T2 publication Critical patent/DE69531990T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69531990T 1994-06-08 1995-06-08 Bicyclischer lactaminhibitor des interleukin-1-beta-konvertierenden enzyms Expired - Lifetime DE69531990T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/255,276 US5552400A (en) 1994-06-08 1994-06-08 Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US255276 1994-06-08
PCT/US1995/007314 WO1995033751A1 (en) 1994-06-08 1995-06-08 Bicycling lactam inhibitor of interleukin-1-beta converting enzyme

Publications (2)

Publication Number Publication Date
DE69531990D1 true DE69531990D1 (de) 2003-11-27
DE69531990T2 DE69531990T2 (de) 2004-09-02

Family

ID=22967606

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69531990T Expired - Lifetime DE69531990T2 (de) 1994-06-08 1995-06-08 Bicyclischer lactaminhibitor des interleukin-1-beta-konvertierenden enzyms
DE69536064T Expired - Lifetime DE69536064D1 (de) 1994-06-08 1995-06-08 Bizyklischer Lactaminhibitor des Interleukin-1-beta-konvertierenden Enzyms

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69536064T Expired - Lifetime DE69536064D1 (de) 1994-06-08 1995-06-08 Bizyklischer Lactaminhibitor des Interleukin-1-beta-konvertierenden Enzyms

Country Status (13)

Country Link
US (2) US5552400A (de)
EP (2) EP1391461B1 (de)
JP (1) JP4173536B2 (de)
AT (2) ATE252585T1 (de)
AU (1) AU705882B2 (de)
CA (1) CA2192360C (de)
DE (2) DE69531990T2 (de)
DK (1) DK0764167T3 (de)
ES (2) ES2341949T3 (de)
HK (2) HK1012630A1 (de)
HU (1) HU226979B1 (de)
PT (1) PT764167E (de)
WO (1) WO1995033751A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
KR100856767B1 (ko) * 1966-11-26 2009-06-16 버텍스 파마슈티칼스 인코포레이티드 인터류킨-1 베타 전환효소의 억제제
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) * 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6245764B1 (en) * 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
WO1996030395A2 (en) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
US5744451A (en) * 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
AU756253B2 (en) * 1995-12-20 2003-01-09 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1beta converting enzyme
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
EP0894003A4 (de) * 1996-04-12 2000-10-04 Bristol Myers Squibb Co N-Formyl Hydroxylamin enthaltende Verbindungen als ACE und/oder NEP Inhibitoren
US6117896A (en) 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
CA2268103A1 (en) * 1996-10-11 1998-04-23 Warner-Lambert Company Sulfonamide substituted aspartic acid interleukin-1.beta. converting enzyme inhibitors
US5919790A (en) * 1996-10-11 1999-07-06 Warner-Lambert Company Hydroxamate inhibitors of interleukin-1β converting enzyme
KR20000049047A (ko) 1996-10-11 2000-07-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 술폰아미드 인터루킨-1β 전환 효소 억제제
EP1062210B1 (de) * 1998-03-09 2005-06-01 Vertex Pharmaceuticals Incorporated 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
RU2274642C2 (ru) 1998-03-19 2006-04-20 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы каспаз
FR2777279B1 (fr) * 1998-04-08 2004-08-13 Hoechst Marion Roussel Inc Nouvelles formes cristallines du 1s-[1alpha(2s*,3r*), 9 alpha] 6,10-dioxo-n-(2-ethoxy-5-oxo-tetrahydro-3-furanyl) -9[[(1-isoquinolyl)carbonyl]amino]octohydro-6h-pyridazino [1,2-a][1,2]diazepine-1-carboxamide
CA2327185A1 (en) * 1998-04-08 1999-10-14 Abbott Laboratories Pyrazole inhibitors of cytokine production
FR2777889B1 (fr) 1998-04-27 2004-07-09 Hoechst Marion Roussel Inc Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
AU2003200034B2 (en) * 1998-04-27 2006-07-20 Aventis Pharma S.A. New derivatives of octahydro-6, 10-dioxo-6H-pyridazino [1,2-A][1,2]diazepine-1-carboxylic acid, their preparation process and their use in the preparation of therapeutically active compounds
FR2802927B1 (fr) * 1999-12-28 2002-03-01 Hoechst Marion Roussel Inc Nouveaux derives de diazepine carboxamide, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et leur nouvelle utilisation
EP1712239A3 (de) * 2000-05-12 2007-08-22 Immunex Corporation Interleukin-1 Inhibitoren zur Behandlung von Erkrankungen
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
AU7527901A (en) 2000-06-07 2001-12-17 Vertex Pharma Caspase inhibitors and uses thereof
AU2003211052A1 (en) * 2002-02-11 2003-09-04 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
WO2003068237A1 (en) * 2002-02-14 2003-08-21 Myriad Genetics, Inc. Beta-sheet mimetics and composition and methods relating thereto
WO2004031144A2 (en) * 2002-10-01 2004-04-15 Musc Foundation For Research Development Use of caspase inhibitors as therapeutic agent against radiation-induced injury
JP4848367B2 (ja) * 2004-05-15 2011-12-28 バーテックス ファーマシューティカルズ インコーポレイテッド Ｉｃｅインヒビターを使用した発作の処置
CN1980658A (zh) * 2004-05-27 2007-06-13 沃泰克斯药物股份有限公司 治疗自身炎性疾病的ice抑制剂
EP2635906A4 (de) 2010-11-05 2014-04-02 Univ Brandeis Ice-hemmende verbindungen und ihre verwendungen
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
MX2014003705A (es) * 2011-10-10 2014-07-22 Hoffmann La Roche Compuestos antivirales.

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
EP0025941B1 (de) * 1979-09-19 1983-05-04 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyridazopyridazinderivate, Verfahren zu deren Herstellung und Arzneimittel enthaltend solche Pyridazopyridazinderivate
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions
JP2543503B2 (ja) * 1986-07-01 1996-10-16 綜研化学株式会社 分岐構造を有する共重合体を分散安定剤として用いた乳化重合法
DE69226820T2 (de) * 1991-06-21 1999-05-12 Merck & Co Inc Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen
GB9123326D0 (en) * 1991-11-04 1991-12-18 Sandoz Ltd Improvements in or relating to organic compounds
EP0627926B1 (de) * 1992-02-21 1998-08-05 Merck & Co., Inc. (a New Jersey corp.) Peptidylderivate und inhibitoren des interleukin-1-g(b)-konvertierenden enzyms
DE69325904T2 (de) * 1992-05-15 1999-12-09 Merrell Pharma Inc MERCAPTOACETYLAMIDE VON PYRIDAZO[1,2-a][1,2]-DIAZEPIN -DERIVATEN ALS EUKEPHALINASE UND ACE-INHIBITOREN
EP0618223A3 (de) * 1993-03-08 1996-06-12 Sandoz Ltd Peptide, die Freisetzung vom Interleukin 1-Bêta, nützlich als entzündungshemmende Wirkstoffe.

Also Published As

Publication number Publication date
DK0764167T3 (da) 2004-02-09
PT764167E (pt) 2004-03-31
EP0764167B1 (de) 2003-10-22
JPH10501244A (ja) 1998-02-03
EP1391461B1 (de) 2010-04-14
WO1995033751A1 (en) 1995-12-14
AU2769995A (en) 1996-01-04
DE69531990T2 (de) 2004-09-02
US5552400A (en) 1996-09-03
DE69536064D1 (de) 2010-05-27
CA2192360C (en) 2007-08-07
ATE252585T1 (de) 2003-11-15
HUT76334A (en) 1997-08-28
ES2210294T3 (es) 2004-07-01
AU705882B2 (en) 1999-06-03
ES2341949T3 (es) 2010-06-30
US5639745A (en) 1997-06-17
JP4173536B2 (ja) 2008-10-29
EP0764167A1 (de) 1997-03-26
HU226979B1 (en) 2010-04-28
ATE464314T1 (de) 2010-04-15
CA2192360A1 (en) 1995-12-14
HK1064102A1 (en) 2005-01-21
EP0764167A4 (de) 1997-09-17
EP1391461A1 (de) 2004-02-25
HU9603376D0 (en) 1997-01-28
MX9606192A (es) 1998-06-30
HK1012630A1 (en) 1999-08-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition