MX9606192A - Inhibidores de lactama biciclica de la enzima que convierte la interleucina-1-beta. - Google Patents
Inhibidores de lactama biciclica de la enzima que convierte la interleucina-1-beta.Info
- Publication number
- MX9606192A MX9606192A MX9606192A MX9606192A MX9606192A MX 9606192 A MX9606192 A MX 9606192A MX 9606192 A MX9606192 A MX 9606192A MX 9606192 A MX9606192 A MX 9606192A MX 9606192 A MX9606192 A MX 9606192A
- Authority
- MX
- Mexico
- Prior art keywords
- interleukin
- bicycling
- converting enzyme
- beta converting
- lactam inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion se refiere a los compuestos, composiciones y métodos para inhibir la actividad de la proteasa de interleucina-1 beta, que tiene la formula A, en donde Y = (a) o (b) o (c), Z = varias lactamas bicíclicas con un puente superior de nitrogeno.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08255276 | 1994-06-08 | ||
US08/255,276 US5552400A (en) | 1994-06-08 | 1994-06-08 | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
MX9606192A true MX9606192A (es) | 1998-06-30 |
MXPA96006192A MXPA96006192A (es) | 1998-10-30 |
Family
ID=
Also Published As
Publication number | Publication date |
---|---|
US5639745A (en) | 1997-06-17 |
JPH10501244A (ja) | 1998-02-03 |
EP0764167B1 (en) | 2003-10-22 |
AU705882B2 (en) | 1999-06-03 |
CA2192360A1 (en) | 1995-12-14 |
DE69531990D1 (de) | 2003-11-27 |
ES2341949T3 (es) | 2010-06-30 |
JP4173536B2 (ja) | 2008-10-29 |
CA2192360C (en) | 2007-08-07 |
HU226979B1 (en) | 2010-04-28 |
EP0764167A1 (en) | 1997-03-26 |
PT764167E (pt) | 2004-03-31 |
EP0764167A4 (en) | 1997-09-17 |
HK1012630A1 (en) | 1999-08-06 |
EP1391461B1 (en) | 2010-04-14 |
AU2769995A (en) | 1996-01-04 |
HU9603376D0 (en) | 1997-01-28 |
DE69536064D1 (de) | 2010-05-27 |
ATE464314T1 (de) | 2010-04-15 |
ES2210294T3 (es) | 2004-07-01 |
ATE252585T1 (de) | 2003-11-15 |
HK1064102A1 (en) | 2005-01-21 |
WO1995033751A1 (en) | 1995-12-14 |
HUT76334A (en) | 1997-08-28 |
US5552400A (en) | 1996-09-03 |
DK0764167T3 (da) | 2004-02-09 |
EP1391461A1 (en) | 2004-02-25 |
DE69531990T2 (de) | 2004-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2192360A1 (en) | Bicyclic lactam inhibitor of interleukin-1-beta converting enzyme | |
CY2093B1 (en) | Dual action inhibitors | |
IL109901A (en) | Peptidic phosphinyloxymethyl ketones and pharmaceutical compositions containing them | |
WO2000059497A8 (en) | Pyrrolidine modulators of chemokine receptor activity | |
MY118498A (en) | Lactam derivatives | |
PL331900A1 (en) | 1,4-heterocyclic inhibitors of metaloprotease | |
HU9401679D0 (en) | Alpha-heteroaryloxymethyl-ketones as interleukin-1-beta converting enzyme inhibitors | |
PH31249A (en) | Inhibitors of hiv protease. | |
PL331838A1 (en) | 1,3-diheterocyclic inhibitors of metaloproteases | |
CA2266015A1 (en) | Tricyclic antitumor compounds being farnesyl protein transferase inhibitors | |
AU9298198A (en) | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity | |
EP0567088A3 (en) | Process for the preparation of an amylase inhibitor. | |
WO1996020210A3 (en) | Diastereomerically pure 3-oxo and 3-thioxo-4-aza-androstan derivatives and the use thereof as antiandrogens | |
TW223630B (en) | Retroviral protease inhibitors | |
ZA949148B (en) | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents | |
MX9605196A (es) | Halometilamidas como inhibidores de la proteasa il-1b. | |
DE3273628D1 (en) | Phosphonamidate compounds | |
HUP0004521A3 (en) | Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors and medicaments containing the compounds | |
MX9500228A (es) | N-oxidos de 4-arilpiperazinas y 4-arilpiperidinas. | |
EP0785786A4 (en) | MICROBIAL SYNTHESIS OF HIV PROTEASE INHIBITORS | |
EP0785989A4 (en) | MICROBIAL SYNTHESIS OF INHIBITORS OF THE HIV PROTEASE | |
ZA979867B (en) | 1-(3-Aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors | |
ES2065843A1 (es) | Aplicacion de ent-11 , 16-dihidroxi-18-nor-4a -carboximetil-oxido de manoilo como inhibidor de la adenilatociclasa. | |
MX9603347A (es) | Derivados de disulfuro de 1,3,4,5-tetrahidro-benzo[c] azepin-3-ona de mercaptoacetilamido novedosos, utiles como inhibidores de encefalinasa y de enzima convertidora de angiotensina. | |
HU9500944D0 (en) | N,n-substituted amino-methylen-imidazolinone derivatives as intermediates of 2-substituted 5-chloro-imidazol-4-carbaldeydes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
HC | Change of company name or juridical status |
Owner name: PHARMACORE AB |
|
PD | Change of proprietorship |
Owner name: VERTEX PHARMACEUTICALS INCORPORATED.* |
|
MM | Annulment or lapse due to non-payment of fees |