ES2001056A6 - Un procedimiento para la preparacion de polipeptidos y sus derivados que contienen oxa- y azahomocicloestatina. - Google Patents
Un procedimiento para la preparacion de polipeptidos y sus derivados que contienen oxa- y azahomocicloestatina.Info
- Publication number
- ES2001056A6 ES2001056A6 ES8600783A ES8600783A ES2001056A6 ES 2001056 A6 ES2001056 A6 ES 2001056A6 ES 8600783 A ES8600783 A ES 8600783A ES 8600783 A ES8600783 A ES 8600783A ES 2001056 A6 ES2001056 A6 ES 2001056A6
- Authority
- ES
- Spain
- Prior art keywords
- intermediates therefor
- renin inhibiting
- inhibiting polypeptides
- polypeptides
- renin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA PREPARACION DE POLIPEPTIDOS Y SUS DERIVADOS QUE CONTIENEN OXA- Y AZAHOMOCICLOESTANINA DE FORMULA GENERAL QUE COMPRENDE LA ACILACION DEL GRUPO A-AMINO NO PROTEGIDO DE UN RESTO AMINOACIDO CON UN AMINOACIDO QUE CONTIENE UNA FUNCION CARBOXILICA ACTIVADA (PARA LA ACILACION) Y UN GRUPO PROTECTOR ADECUADO UNIDO A SU PROPIO A-NITROGENO PARA FORMAR UNA UNION PEPTIDICA ENTRE LOS DOS RESTOS AMINOACIDOS, SEGUIDO DE ELIMINACION DEL CITADO GRUPO PROTECTOR. LOS COMPUESTOS ASI OBTENIDOS SON UTILES PARA INHIBIR LA ACCION ESCINDIDORA DEL ANGIOTENSINOGENO DEL ENZIMA RENINA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/762,099 US4668769A (en) | 1985-08-02 | 1985-08-02 | Oxa- and azahomocyclostatine polypeptides |
US06/780,353 US4599198A (en) | 1985-08-02 | 1985-09-26 | Intermediates in polypeptide synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2001056A6 true ES2001056A6 (es) | 1988-04-16 |
Family
ID=27117072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8600783A Expired ES2001056A6 (es) | 1985-08-02 | 1986-07-31 | Un procedimiento para la preparacion de polipeptidos y sus derivados que contienen oxa- y azahomocicloestatina. |
Country Status (14)
Country | Link |
---|---|
US (1) | US4599198A (es) |
EP (1) | EP0211580A3 (es) |
KR (1) | KR890003602B1 (es) |
AU (3) | AU569821B2 (es) |
CA (1) | CA1305175C (es) |
DK (1) | DK366686A (es) |
ES (1) | ES2001056A6 (es) |
FI (1) | FI863153A (es) |
GR (1) | GR862009B (es) |
HU (1) | HU204284B (es) |
IE (1) | IE862072L (es) |
IL (1) | IL79570A0 (es) |
NZ (2) | NZ217067A (es) |
PT (1) | PT83123B (es) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4727060A (en) * | 1984-11-13 | 1988-02-23 | Ciba-Geigy Corporation | Novel 5-amino-4-hydroxyvaleryl derivatives |
US5214129A (en) * | 1985-01-23 | 1993-05-25 | Abbott Laboratories | Peptidylaminodiols |
HU200473B (en) * | 1985-11-01 | 1990-06-28 | Pfizer | Process for producing polypeptides containing difluorocyclostatine and pharmaceutical compositions comprising same |
CA1282549C (en) * | 1985-11-12 | 1991-04-02 | Eric M. Gordon | Aminocarbonyl renin inhibitors |
US4757050A (en) * | 1985-12-23 | 1988-07-12 | E. R. Squibb Sons, Inc. | Ureido renin inhibitors |
CA1297631C (en) * | 1985-12-23 | 1992-03-17 | Sesha I. Natarajan | Ureido renin inhibitors |
IL81234A (en) * | 1986-01-16 | 1992-09-06 | Abbott Lab | Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them |
US4885292A (en) * | 1986-02-03 | 1989-12-05 | E. R. Squibb & Sons, Inc. | N-heterocyclic alcohol renin inhibitors |
DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
DE3635907A1 (de) * | 1986-10-22 | 1988-04-28 | Merck Patent Gmbh | Hydroxy-aminosaeurederivate |
US4931429A (en) * | 1987-10-01 | 1990-06-05 | G. D. Searle & Co. | α-aminoacyl β-aminoacyl aminodiols as anti-hypertensive agents |
US5166400A (en) * | 1989-01-19 | 1992-11-24 | Pfizer Inc. | Intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates |
US5036155A (en) * | 1989-06-29 | 1991-07-30 | Pfizer Inc. | Process for isopropyl 3S-amino-2R-hydroxy-alkanoates |
US4965372A (en) * | 1989-01-19 | 1990-10-23 | Pfizer Inc. | Process and intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates |
EP0472077A3 (en) * | 1990-08-24 | 1993-03-31 | Bayer Ag | Phosphonate containing hydroxyethylamin- and norstatin-type pseudopeptides |
US5583238A (en) * | 1990-11-19 | 1996-12-10 | G. D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
US5614522A (en) * | 1990-11-19 | 1997-03-25 | G.D. Searle & Co. | Retroviral protease inhibitors |
DE69132423T2 (de) | 1990-11-19 | 2001-04-26 | Monsanto Co | Inhibitoren retroviraler Proteasen |
US5482947A (en) * | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
US5475027A (en) * | 1990-11-19 | 1995-12-12 | G.D. Searle & Co. | Retroviral protease inhibitors |
US5648511A (en) * | 1990-11-19 | 1997-07-15 | G.D. Searle & Co. | Method for making intermediates useful in the synthesis of retroviral protease inhibitors |
US5510378A (en) * | 1990-11-19 | 1996-04-23 | G.D. Searle & Co. | Retroviral protease inhibitors |
DE69118907T2 (de) * | 1990-11-19 | 1996-11-14 | Monsanto Co | Retrovirale proteaseinhibitoren |
US5475013A (en) * | 1990-11-19 | 1995-12-12 | Monsanto Company | Retroviral protease inhibitors |
JPH0572071A (ja) * | 1991-04-15 | 1993-03-23 | Toshiba Corp | 圧力測定装置 |
WO1993023379A1 (en) | 1992-05-21 | 1993-11-25 | Monsanto Company | Retroviral protease inhibitors |
US6022994A (en) * | 1992-08-25 | 2000-02-08 | G. D. Searle &. Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
ES2177868T3 (es) * | 1992-08-25 | 2002-12-16 | Searle & Co | Hidroxietilaminosulfonamidas de alfa- y beta-aminoacidos utiles como inhibidores de proteasas retroviricas. |
US6046190A (en) * | 1992-08-25 | 2000-04-04 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
WO1994004493A1 (en) * | 1992-08-25 | 1994-03-03 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
KR100296461B1 (ko) * | 1992-08-25 | 2001-11-14 | 죤 에이치. 뷰센 | 레트로바이러스프로테아제저해제로서유용한n-(알카노일아미노-2-히드록시프로필)-술폰아미드 |
US6743929B1 (en) * | 1992-08-25 | 2004-06-01 | G. D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5760076A (en) * | 1992-08-25 | 1998-06-02 | G.D Searle & Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5968942A (en) * | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5830897A (en) * | 1992-08-27 | 1998-11-03 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
DK0666843T3 (da) * | 1992-10-30 | 2000-03-20 | Searle & Co | Sulfonylalkanoylaminohydroxyethylaminosulfaminsyrer, der kan anvendes som inhibitorer af retrovirale proteaser |
US5756498A (en) * | 1992-10-30 | 1998-05-26 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
ES2170305T3 (es) | 1992-10-30 | 2002-08-01 | Searle & Co | Derivados de acido hidroxietilaminosulfamico n-sustituidos utiles como inhibidores de proteasas retroviricas. |
US5578606A (en) * | 1992-10-30 | 1996-11-26 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
US6337398B1 (en) | 1992-10-30 | 2002-01-08 | G.D. Searle & Co. | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
US5830888A (en) * | 1993-04-16 | 1998-11-03 | Monsanto Company | Macrocyclic retroviral protease inhibitors |
US5750648A (en) * | 1993-08-20 | 1998-05-12 | G.D. Searle & Co. | Retroviral protease inhibitors and combinations thereof |
US5602119A (en) * | 1993-10-29 | 1997-02-11 | Vazquez; Michael L. | Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors |
US6133444A (en) * | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
CA2180021A1 (en) * | 1994-11-04 | 1996-05-17 | Yoichi Kawashima | Novel 1,3-dialkylurea derivatives having a hydroxyl group |
US5831117A (en) * | 1995-01-20 | 1998-11-03 | G. D. Searle & Co. | Method of preparing retroviral protease inhibitor intermediates |
US6143747A (en) | 1995-01-20 | 2000-11-07 | G. D. Searle & Co. | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors |
US6140505A (en) * | 1995-03-10 | 2000-10-31 | G. D. Searle & Co. | Synthesis of benzo fused heterocyclic sulfonyl chlorides |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5985870A (en) * | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
WO1996028465A1 (en) | 1995-03-10 | 1996-09-19 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6861539B1 (en) * | 1995-03-10 | 2005-03-01 | G. D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US7339078B2 (en) * | 1995-03-10 | 2008-03-04 | G.D. Searle Llc | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6407134B1 (en) * | 1995-03-10 | 2002-06-18 | G. D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
EP1188766A1 (en) | 1995-03-10 | 2002-03-20 | G.D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6667307B2 (en) | 1997-12-19 | 2003-12-23 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6169085B1 (en) | 1995-03-10 | 2001-01-02 | G. D. Searle & Company | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5776971A (en) * | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
ES2158997T3 (es) * | 1995-10-04 | 2001-09-16 | Ajinomoto Kk | Esteres alfa-aciloxi-beta-aminotiolcarboxilicos y metodo e intermedios para su produccion. |
CA2236236A1 (en) * | 1995-11-15 | 1997-05-22 | G.D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
CZ292996B6 (cs) * | 1996-02-08 | 2004-01-14 | Nippon Kayaku Kabushiki Kaisha | Způsob přípravy opticky aktivního kyanhydrinu |
WO1997046514A1 (en) * | 1996-05-31 | 1997-12-11 | Novartis Ag | Process for the preparation of hydrazine derivatives useful as intermediates for the preparation of peptide analogues |
US6711297B1 (en) * | 1998-07-03 | 2004-03-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and apparatus for dynamic transfer of image data |
US6538006B1 (en) | 1998-07-08 | 2003-03-25 | Pharmacia Corporation | Retroviral protease inhibitors |
AU2001281250A1 (en) | 2000-08-11 | 2002-02-25 | The Brigham And Women's Hospital, Inc. | (hydroxyethyl)ureas as inhibitors of alzheimer's beta-amyloid production |
GB0021831D0 (en) * | 2000-09-06 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
GB0205165D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205175D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205162D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205166D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205176D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0318463D0 (en) * | 2003-08-07 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
GB0318464D0 (en) * | 2003-08-07 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
GB0319759D0 (en) * | 2003-08-22 | 2003-09-24 | Astrazeneca Ab | Chemical compounds |
GB0319690D0 (en) * | 2003-08-22 | 2003-09-24 | Astrazeneca Ab | Chemical compounds |
US20050064076A1 (en) * | 2003-09-22 | 2005-03-24 | Fmc Technologies, Inc. | Method of measuring volatile components of foods |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1108180A (en) * | 1976-07-21 | 1981-09-01 | Hamao Umezawa | Analogs of bestatin |
US4479941A (en) * | 1981-12-10 | 1984-10-30 | Merck & Co., Inc. | Renin inhibitory peptides having PHE13 delection |
FR2531951A1 (fr) * | 1982-08-17 | 1984-02-24 | Sanofi Sa | Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent |
AU573735B2 (en) * | 1983-02-07 | 1988-06-23 | Aktiebolaget Hassle | Peptide analogue enzyme inhibitors |
IL74272A (en) * | 1984-02-16 | 1991-06-10 | Poudres & Explosifs Ste Nale | Preparation of carbamic acid derivatives |
DK34086A (da) * | 1985-01-23 | 1986-07-24 | Abbott Lab | Peptidylaminodioler |
CA1286846C (en) * | 1985-02-12 | 1991-07-23 | Catherine Cazaubon | Peptide derivatives which inhibit renin and acid proteases |
HU200473B (en) * | 1985-11-01 | 1990-06-28 | Pfizer | Process for producing polypeptides containing difluorocyclostatine and pharmaceutical compositions comprising same |
CA1297631C (en) * | 1985-12-23 | 1992-03-17 | Sesha I. Natarajan | Ureido renin inhibitors |
-
1985
- 1985-09-26 US US06/780,353 patent/US4599198A/en not_active Expired - Fee Related
-
1986
- 1986-07-25 EP EP86305722A patent/EP0211580A3/en not_active Withdrawn
- 1986-07-29 GR GR862009A patent/GR862009B/el unknown
- 1986-07-30 IL IL79570A patent/IL79570A0/xx not_active IP Right Cessation
- 1986-07-31 ES ES8600783A patent/ES2001056A6/es not_active Expired
- 1986-08-01 NZ NZ217067A patent/NZ217067A/xx unknown
- 1986-08-01 PT PT83123A patent/PT83123B/pt not_active IP Right Cessation
- 1986-08-01 AU AU60790/86A patent/AU569821B2/en not_active Ceased
- 1986-08-01 NZ NZ228380A patent/NZ228380A/xx unknown
- 1986-08-01 DK DK366686A patent/DK366686A/da not_active Application Discontinuation
- 1986-08-01 IE IE862072A patent/IE862072L/xx unknown
- 1986-08-01 FI FI863153A patent/FI863153A/fi not_active Application Discontinuation
- 1986-08-01 HU HU863358A patent/HU204284B/hu not_active IP Right Cessation
- 1986-08-02 KR KR1019860006442A patent/KR890003602B1/ko not_active IP Right Cessation
-
1988
- 1988-02-29 AU AU12392/88A patent/AU598913B2/en not_active Ceased
-
1990
- 1990-10-05 AU AU63850/90A patent/AU633629B2/en not_active Ceased
-
1991
- 1991-01-04 CA CA000615970A patent/CA1305175C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT83123A (en) | 1986-09-01 |
AU1239288A (en) | 1988-06-02 |
EP0211580A3 (en) | 1989-08-09 |
AU6385090A (en) | 1991-01-10 |
IE862072L (en) | 1987-02-02 |
NZ228380A (en) | 1990-08-28 |
KR870002161A (ko) | 1987-03-30 |
IL79570A0 (en) | 1986-10-31 |
HU204284B (en) | 1991-12-30 |
DK366686D0 (da) | 1986-08-01 |
FI863153A (fi) | 1987-02-03 |
US4599198A (en) | 1986-07-08 |
AU6079086A (en) | 1987-05-14 |
AU569821B2 (en) | 1988-02-18 |
FI863153A0 (fi) | 1986-08-01 |
PT83123B (pt) | 1989-03-30 |
EP0211580A2 (en) | 1987-02-25 |
KR890003602B1 (ko) | 1989-09-27 |
NZ217067A (en) | 1990-08-28 |
HUT41815A (en) | 1987-05-28 |
CA1305175C (en) | 1992-07-14 |
GR862009B (en) | 1986-12-23 |
DK366686A (da) | 1987-03-20 |
AU598913B2 (en) | 1990-07-05 |
AU633629B2 (en) | 1993-02-04 |
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