DK2207565T3 - Immunoterapi-regimener afhængig af apoe-status - Google Patents
Immunoterapi-regimener afhængig af apoe-status Download PDFInfo
- Publication number
- DK2207565T3 DK2207565T3 DK08839961.3T DK08839961T DK2207565T3 DK 2207565 T3 DK2207565 T3 DK 2207565T3 DK 08839961 T DK08839961 T DK 08839961T DK 2207565 T3 DK2207565 T3 DK 2207565T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q99/00—Subject matter not provided for in other groups of this subclass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Business, Economics & Management (AREA)
- Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- General Physics & Mathematics (AREA)
- General Business, Economics & Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (13)
1. Humaniseret form af et 3D6-antistof omfattende en human tung kæde konstant region med L234A, L235A og G237A-mutationer, hvor mutationerne er nummereret med EU-nummereringssystemet, hvor 3D6 er et antistof fremstillet 5 ved ATCC accessionsnummer PTA-5130.
2. Humaniseret antistof ifølge krav 1, hvor isotypen er human IgGl, IgG2 eller IgG4, fortrinsvis IgGl.
3. Humaniseret antistof ifølge krav 1, omfattende en moden let kæde variabel regionsekvens ifølge SEQ ID NO:2, og en moden tung kæde variabel regionsekvens ifølge SEQ ID NO: 3, hvor antistoffet har human IgG-isotype.
4. Humaniseret antistof ifølge krav 1, omfattende en humaniseret let kæde med 15 en aminosyresekvens omfattende SEQ ID NO:48 og en humaniseret tung kæde med en aminosyresekvens omfattende SEQ ID NO:66 eller 67.
5. Farmaceutisk sammensætning omfattende det humaniserede antistof ifølge et hvilket som helst af kravene 1-4. 20
6. Isoleret nukleinsyre der koder for det humaniserede antistof ifølge et hvilket som helst af kravene 1-4, med en sekvens omfattende SEQ ID NO:68, forudsat at nukleotiderne 1-57 der koder for en signalsekvens kan eller ikke kan være til stede. 25
7. Humaniseret antistof ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til behandling eller fremkaldelse af profylakse af en amyloidogen sygdom kendetegnet ved amyloide deponeringer af Αβ i hjernen, hos en patient med nul ApoE4-alleller. 30
8. Humaniseret antistof ifølge krav 7, til anvendelse ifølge krav 7, hvor patienten der har nul ApoE4-alleller administreres med en dosis på 0,5-2 mg/kg af antistoffet.
9. Det humaniserede antistof ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til behandling eller fremkaldelse af profylakse af en amyloidogen sygdom kendetegnet ved amyloide deponeringer af Αβ i hjernen, hos en patient med én eller to ApoE4-alleller. 5
10. Humaniseret antistof ifølge krav 9, til anvendelse ifølge krav 9, hvor patienten der har én eller to ApoE4-alleller administreres med en dosis på 0.15-1 mg/kg af antistoffet.
11. Det humaniserede antistof ifølge et hvilket som helst af kravene 7 til 10, til anvendelsen af disse krav, hvor patienten overvåges for vasogent ødem, fortrinsvis ved MRI.
12. Det humaniserede antistof ifølge et hvilket som helst af kravene 7 til 11, til 15 anvendelsen af disse krav, hvor den amyloiodogene sygdom er kendetegnet ved amyloide deponeringer af Αβ i hjernen er Alzheimer's sygdom.
13. Antistof ifølge et hvilket som helst af kravene 1 til 4, til anvendelse i behandlingen eller profylakse afen sygdom kendetegnet ved amyloide 20 deponeringer i hjernen hos patienten, i mindst et af et første og et andet regimen, hvor en måling af ApoE4-kopiantal anvendes til at vælge de forskellige regimener.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99942307P | 2007-10-17 | 2007-10-17 | |
| US8382708P | 2008-07-25 | 2008-07-25 | |
| PCT/US2008/080382 WO2009052439A2 (en) | 2007-10-17 | 2008-10-17 | Immunotherapy regimes dependent on apoe status |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2207565T3 true DK2207565T3 (da) | 2015-07-13 |
Family
ID=40568093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08839961.3T DK2207565T3 (da) | 2007-10-17 | 2008-10-17 | Immunoterapi-regimener afhængig af apoe-status |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US9644025B2 (da) |
| EP (2) | EP2207565B1 (da) |
| JP (2) | JP5745853B2 (da) |
| KR (1) | KR101197839B1 (da) |
| CN (2) | CN101969988A (da) |
| AR (1) | AR071732A1 (da) |
| AU (1) | AU2008311823A1 (da) |
| BR (1) | BRPI0818000A2 (da) |
| CA (2) | CA2702617C (da) |
| CL (1) | CL2008003089A1 (da) |
| CO (1) | CO6331295A2 (da) |
| CY (1) | CY1116552T1 (da) |
| DK (1) | DK2207565T3 (da) |
| EA (2) | EA022307B1 (da) |
| ES (1) | ES2547230T3 (da) |
| HK (2) | HK1146234A1 (da) |
| HR (1) | HRP20150790T1 (da) |
| HU (1) | HUE025684T2 (da) |
| IL (1) | IL205127A (da) |
| JO (1) | JO3076B1 (da) |
| MX (1) | MX2010004250A (da) |
| MY (1) | MY156454A (da) |
| PA (1) | PA8800801A1 (da) |
| PE (1) | PE20090971A1 (da) |
| PL (1) | PL2207565T3 (da) |
| PT (1) | PT2207565E (da) |
| RS (1) | RS54130B1 (da) |
| SG (2) | SG10201607589XA (da) |
| SI (1) | SI2207565T1 (da) |
| TW (2) | TW201206479A (da) |
| WO (1) | WO2009052439A2 (da) |
| ZA (1) | ZA201002544B (da) |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| NZ567324A (en) * | 2003-02-01 | 2009-08-28 | Wyeth Corp | Active immunization to generate antibodies to soluble A-beta |
| CA2582194A1 (en) * | 2004-10-05 | 2006-04-20 | Neuralab Limited | Methods and compositions for improving recombinant protein production |
| AR052051A1 (es) | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
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| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
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