ATE535252T1 - Peptid-konjugat-zusammensetzungen und -verfahren zur prävention und behandlung von alzheimer- krankheit - Google Patents
Peptid-konjugat-zusammensetzungen und -verfahren zur prävention und behandlung von alzheimer- krankheitInfo
- Publication number
- ATE535252T1 ATE535252T1 AT06751930T AT06751930T ATE535252T1 AT E535252 T1 ATE535252 T1 AT E535252T1 AT 06751930 T AT06751930 T AT 06751930T AT 06751930 T AT06751930 T AT 06751930T AT E535252 T1 ATE535252 T1 AT E535252T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- disease
- preventing
- immunogenic fragment
- peptide conjugate
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000000863 peptide conjugate Substances 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 4
- 230000002163 immunogen Effects 0.000 abstract 4
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003028 elevating effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67788605P | 2005-05-05 | 2005-05-05 | |
| PCT/US2006/016481 WO2006121656A2 (en) | 2005-05-05 | 2006-05-01 | Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE535252T1 true ATE535252T1 (de) | 2011-12-15 |
Family
ID=37019042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06751930T ATE535252T1 (de) | 2005-05-05 | 2006-05-01 | Peptid-konjugat-zusammensetzungen und -verfahren zur prävention und behandlung von alzheimer- krankheit |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7850973B2 (de) |
| EP (2) | EP1879613B1 (de) |
| JP (1) | JP2008540417A (de) |
| KR (1) | KR20080005260A (de) |
| CN (1) | CN101171031B (de) |
| AT (1) | ATE535252T1 (de) |
| AU (1) | AU2006246382A1 (de) |
| BR (1) | BRPI0610093A2 (de) |
| CA (1) | CA2607868A1 (de) |
| IL (1) | IL186793A0 (de) |
| MX (1) | MX2007013825A (de) |
| NO (1) | NO20076239L (de) |
| NZ (1) | NZ562434A (de) |
| RU (1) | RU2406529C2 (de) |
| WO (1) | WO2006121656A2 (de) |
| ZA (1) | ZA200708635B (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| PE20061329A1 (es) | 2004-12-15 | 2006-12-08 | Neuralab Ltd | Anticuerpos ab humanizados para mejorar la cognicion |
| BRPI0619249A2 (pt) | 2005-11-30 | 2011-09-20 | Abbott Lab | anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos |
| PT1976877E (pt) | 2005-11-30 | 2014-04-29 | Abbvie Inc | Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações |
| WO2007064917A2 (en) * | 2005-11-30 | 2007-06-07 | Abbott Laboratories | Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (de) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Verfahren zur behandlung von amyloidosen |
| PE20090329A1 (es) * | 2007-05-30 | 2009-03-27 | Abbott Lab | Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos |
| EP2527366B1 (de) * | 2007-06-12 | 2017-08-16 | AC Immune S.A. | Monoklonaler Anti-Beta-Amyloid-Antikörper |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
| EP2020602A1 (de) * | 2007-08-02 | 2009-02-04 | Araclon Biotech | Hochempfindliche Immuntests und Kits zur Bestimmung biologisch interessanter Peptide und Proteine |
| EP2586795B1 (de) | 2007-10-05 | 2018-05-16 | Genentech, Inc. | Verwendung eines Anti-Amyloid-Beta-Antikörpers bei Augenkrankheiten |
| ITMI20071975A1 (it) * | 2007-10-12 | 2009-04-13 | Fond I R C C S Istituto Neur O | Prodotti e loro uso per la diagnosi prevenzione e-o cura di patologie umane e-o animali caraterizzate dalla anomala deposizione di sostanza b-amiloide e-o similamiloide in organi e tesstui umani e-o animali e metodo di screening per la determinazione |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| WO2009054537A1 (ja) | 2007-10-25 | 2009-04-30 | Kagoshima University | アミロイドβペプチドのミミック分子を用いたペプチドワクチン |
| CA2729414C (en) * | 2008-07-01 | 2017-08-22 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Vaccine against amyloid folding intermediate |
| JP2011527681A (ja) * | 2008-07-08 | 2011-11-04 | メルク・シャープ・エンド・ドーム・コーポレイション | アルツハイマー病治療用ワクチン |
| EP2149380A1 (de) * | 2008-07-29 | 2010-02-03 | Medivet Pharma, S.L. | Tierärztliche Immuntherapiezusammensetzung für altersbedingte kognitive Dysfunktion |
| US8524863B2 (en) * | 2008-10-06 | 2013-09-03 | Commonwealth Scientific And Industrial Research Organisation | Amyloid-beta peptide crystal structure |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| EP2258398A1 (de) * | 2009-05-26 | 2010-12-08 | Araclón Biotech, S. L. | Albumin/Amyloidpeptid-Konjugate und deren Verwendungen |
| CA3239368A1 (en) * | 2009-06-10 | 2010-12-16 | New York University | Immunological targeting of pathological tau proteins |
| WO2011106732A1 (en) | 2010-02-25 | 2011-09-01 | Wyeth Llc | Pet monitoring of ab-directed immunotherapy |
| EP2558494B1 (de) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta-bindende proteine |
| AU2011282536B2 (en) | 2010-07-30 | 2015-12-24 | Ac Immune S.A. | Safe and functional humanized anti beta-amyloid antibody |
| CN105348387B (zh) | 2010-08-14 | 2020-08-25 | Abbvie 公司 | β淀粉样蛋白结合蛋白 |
| US20120328605A1 (en) * | 2010-10-27 | 2012-12-27 | Daniel Larocque | Compositions and uses |
| WO2012072611A1 (de) * | 2010-11-29 | 2012-06-07 | Philipps-Universität Marburg | SYNTHETISCHE LIGANDEN FÜR HUMANE ANTI-Aβ-ANTIKÖRPER |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| WO2013059322A2 (en) * | 2011-10-17 | 2013-04-25 | Lawrence Steinman | Amyloid beta peptide as a therapy for inflammation |
| CN106794236B (zh) * | 2014-04-15 | 2021-09-03 | 格里菲斯大学 | A群链球菌疫苗 |
| JP6913018B2 (ja) | 2014-07-08 | 2021-08-04 | ニューヨーク・ユニバーシティ | タウイメージングリガンド、ならびにタウ異常症の診断および治療におけるそれらの使用 |
| CN108135986B (zh) | 2015-08-13 | 2022-07-29 | 纽约大学 | 对于Tau的截短的Asp421表位特异性的基于抗体的分子和它们在诊断和治疗Tau疾病中的用途 |
| ES2571055B1 (es) * | 2016-02-15 | 2016-12-28 | Araclon Biotech, S.L. | Conjugado amiloide y usos y procedimientos del mismo |
| WO2017179646A1 (ja) * | 2016-04-14 | 2017-10-19 | Ｔａｏヘルスライフファーマ株式会社 | アミロスフェロイド（ａｓｐｄ）様構造体及び医薬組成物 |
| KR101898623B1 (ko) | 2016-11-10 | 2018-09-13 | 주식회사 브레인숲 | 종이 완구블록 |
| EP3658172A4 (de) | 2017-07-25 | 2021-05-05 | TrueBinding, Inc. | Behandlung von krebs durch blockierung der interaktion von tim-3 und seinem liganden |
| EA202091012A1 (ru) | 2017-10-25 | 2020-08-27 | Янссен Фармасьютикалз, Инк. | Композиции фосфорилированных тау-пептидов и их применения |
| RU2679059C1 (ru) * | 2018-04-17 | 2019-02-05 | Александр Олегович Морозов | Пептид и способ лечения болезни альцгеймера |
| RU2679080C1 (ru) * | 2018-04-17 | 2019-02-05 | Александр Олегович Морозов | Пептид и способ лечения болезни альцгеймера |
| CN113711036B (zh) | 2019-01-30 | 2025-03-18 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| CN113710269A (zh) | 2019-02-08 | 2021-11-26 | Ac免疫有限公司 | 磷酸化Tau肽疫苗的安全施用方法 |
| CN116157151A (zh) | 2020-05-26 | 2023-05-23 | 真和制药有限公司 | 通过阻断半乳凝素-3治疗炎性疾病的方法 |
| CN116063382B (zh) * | 2022-11-17 | 2024-11-05 | 山东大学 | 一种具有三阶非线性光学性能的多肽材料及其制备方法与应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5494808A (en) | 1994-09-15 | 1996-02-27 | Merck & Co., Inc. | Defined medium OMPC fermentation process |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6905686B1 (en) * | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
| JP3854481B2 (ja) * | 2000-11-17 | 2006-12-06 | 三菱重工業株式会社 | 湿式排煙脱硫装置、及び、湿式排煙脱硫方法 |
| ES2279869T3 (es) * | 2001-06-20 | 2007-09-01 | Ramot At Tel Aviv University Ltd. | Peptido antigenico comprendido por mulitples copias de un epitope de un polipeptido implicado en enfermedades de formacion de placas y los procedimientos de uso correspondientes. |
| MY144532A (en) * | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| MXPA05008156A (es) | 2003-02-01 | 2005-09-30 | Neuralab Ltd | Inmunizacion activa para generar anticuerpos para beta-a soluble. |
| UA93854C2 (ru) * | 2003-12-17 | 2011-03-25 | Вайет Ллк | Иммуногенный конъюгат и способ его получения |
-
2006
- 2006-05-01 AU AU2006246382A patent/AU2006246382A1/en not_active Abandoned
- 2006-05-01 MX MX2007013825A patent/MX2007013825A/es active IP Right Grant
- 2006-05-01 CN CN2006800153890A patent/CN101171031B/zh not_active Expired - Fee Related
- 2006-05-01 EP EP06751930A patent/EP1879613B1/de not_active Expired - Lifetime
- 2006-05-01 NZ NZ562434A patent/NZ562434A/en not_active IP Right Cessation
- 2006-05-01 CA CA002607868A patent/CA2607868A1/en not_active Abandoned
- 2006-05-01 BR BRPI0610093-7A patent/BRPI0610093A2/pt not_active IP Right Cessation
- 2006-05-01 AT AT06751930T patent/ATE535252T1/de active
- 2006-05-01 US US11/919,897 patent/US7850973B2/en not_active Expired - Fee Related
- 2006-05-01 EP EP10181823A patent/EP2269633A1/de not_active Withdrawn
- 2006-05-01 RU RU2007145052/10A patent/RU2406529C2/ru not_active IP Right Cessation
- 2006-05-01 JP JP2008510087A patent/JP2008540417A/ja active Pending
- 2006-05-01 KR KR1020077025682A patent/KR20080005260A/ko not_active Ceased
- 2006-05-01 WO PCT/US2006/016481 patent/WO2006121656A2/en not_active Ceased
-
2007
- 2007-10-10 ZA ZA2007/08635A patent/ZA200708635B/en unknown
- 2007-10-18 IL IL186793A patent/IL186793A0/en unknown
- 2007-12-04 NO NO20076239A patent/NO20076239L/no not_active Application Discontinuation
-
2010
- 2010-11-08 US US12/907,493 patent/US20110052611A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080005260A (ko) | 2008-01-10 |
| JP2008540417A (ja) | 2008-11-20 |
| NZ562434A (en) | 2010-04-30 |
| US20110052611A1 (en) | 2011-03-03 |
| US20090098155A1 (en) | 2009-04-16 |
| US7850973B2 (en) | 2010-12-14 |
| RU2406529C2 (ru) | 2010-12-20 |
| ZA200708635B (en) | 2008-10-29 |
| AU2006246382A1 (en) | 2006-11-16 |
| CN101171031B (zh) | 2011-09-28 |
| BRPI0610093A2 (pt) | 2008-12-09 |
| WO2006121656A3 (en) | 2007-01-04 |
| CA2607868A1 (en) | 2006-11-16 |
| EP1879613B1 (de) | 2011-11-30 |
| EP2269633A1 (de) | 2011-01-05 |
| WO2006121656A2 (en) | 2006-11-16 |
| IL186793A0 (en) | 2008-02-09 |
| NO20076239L (no) | 2008-01-30 |
| MX2007013825A (es) | 2008-01-18 |
| EP1879613A2 (de) | 2008-01-23 |
| CN101171031A (zh) | 2008-04-30 |
| RU2007145052A (ru) | 2009-06-10 |
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