DE20007303U1 - Kristalline Base von Citalopram - Google Patents
Kristalline Base von CitalopramInfo
- Publication number
- DE20007303U1 DE20007303U1 DE20007303U DE20007303U DE20007303U1 DE 20007303 U1 DE20007303 U1 DE 20007303U1 DE 20007303 U DE20007303 U DE 20007303U DE 20007303 U DE20007303 U DE 20007303U DE 20007303 U1 DE20007303 U1 DE 20007303U1
- Authority
- DE
- Germany
- Prior art keywords
- citalopram
- base
- salt
- crystalline
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title claims 12
- 229960001653 citalopram Drugs 0.000 title claims 12
- 239000002585 base Substances 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 9
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Laminated Bodies (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Description
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Der Beschreibungstext wurde nicht elektronisch erfaßt
Claims (10)
1. Kristalline Base der Verbindung Citalopram
(1-[3-(Dimethylamino)propyl]-1-(4-fluorphenyl)-1,3-
dihydro-5-isobenzofurancarbonitril) mit der Formel:
2. Kristalline Base gemäß Anspruch 1,
dadurch gekennzeichnet, daß
die Base die racemische Mischung von Citalopram ist.
3. Kristalline Base gemäß Anspruch 1 oder 2,
dadurch gekennzeichnet, daß
sie einen Schmelzpunkt von 90 bis 93°C besitzt, am
meisten bevorzugt 91 bis 92°C.
4. Kristalline Base gemäß einem der Ansprüche 1 bis 3,
dadurch gekennzeichnet, daß
sie eine Reinheit von mehr als 99,8 Gew.-% besitzt,
vorzugsweise mehr als 99,9 Gew.-%.
5. Kristallines Salz von Citalopram, hergestellt durch
Freisetzen der Base von Citalopram, Ausfällen der Base
in kristalliner Form und Überführen in das Salz.
6. Kristallines Salz, hergestellt durch Freisetzen der Base
von Citalopram aus einem rohen Salz von Citalopram,
Ausfällen der Base in kristalliner Form und Überführen
in das Salz.
7. Kristallines Salz, hergestellt durch Freisetzen der Base
von Citalopram aus einer Rohlösung von Citalopram-Base
oder -Salz, Ausfällen der Base in kristalliner Form und
Überführen in das Salz.
8. Kristallines Salz gemäß einem der Ansprüche 5 bis 7,
dadurch gekennzeichnet, daß es
das Hydrobromid- oder Hydrochloridsalz von Citalopram
ist.
9. Hydrochlorid- oder Hydrobromidsalz von Citalopram gemäß
Anspruch 8,
dadurch gekennzeichnet, daß
es eine Reinheit von mehr als 99,8 Gew.-% besitzt,
vorzugsweise mehr als 99,9 Gew.-%.
10. Pharmazeutische Formulierung der freien Base von
Citalopram gemäß einem der Ansprüche 1 bis 4,
vorzugsweise Tabletten oder ein Schmelzgranulat.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200000402 | 2000-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE20007303U1 true DE20007303U1 (de) | 2000-07-27 |
Family
ID=8159320
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE20007303U Ceased DE20007303U1 (de) | 2000-03-13 | 2000-04-20 | Kristalline Base von Citalopram |
DE10164687A Revoked DE10164687B4 (de) | 2000-03-13 | 2001-02-20 | Verfahren zur Herstellung von gereinigter Citalopram-Base oder eines gereinigten Salzes von Citalopram |
DE20121240U Ceased DE20121240U1 (de) | 2000-03-13 | 2001-02-20 | Kristalline Citalopram-Base |
DE10108042A Withdrawn DE10108042A1 (de) | 2000-03-13 | 2001-02-20 | Kristalline Citalopram-Base |
DE60100786T Revoked DE60100786T2 (de) | 2000-03-13 | 2001-02-28 | Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon |
DE1227088T Pending DE1227088T1 (de) | 2000-03-13 | 2001-02-28 | Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon |
DE60100022T Expired - Fee Related DE60100022T3 (de) | 2000-03-13 | 2001-02-28 | Verfahren zur herstellung von citalopram-salzen |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10164687A Revoked DE10164687B4 (de) | 2000-03-13 | 2001-02-20 | Verfahren zur Herstellung von gereinigter Citalopram-Base oder eines gereinigten Salzes von Citalopram |
DE20121240U Ceased DE20121240U1 (de) | 2000-03-13 | 2001-02-20 | Kristalline Citalopram-Base |
DE10108042A Withdrawn DE10108042A1 (de) | 2000-03-13 | 2001-02-20 | Kristalline Citalopram-Base |
DE60100786T Revoked DE60100786T2 (de) | 2000-03-13 | 2001-02-28 | Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon |
DE1227088T Pending DE1227088T1 (de) | 2000-03-13 | 2001-02-28 | Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon |
DE60100022T Expired - Fee Related DE60100022T3 (de) | 2000-03-13 | 2001-02-28 | Verfahren zur herstellung von citalopram-salzen |
Country Status (42)
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2806086A1 (fr) * | 2000-03-13 | 2001-09-14 | Lundbeck & Co As H | Base cristalline du citalopram |
EP1152000A1 (de) * | 2000-05-02 | 2001-11-07 | SUMIKA FINE CHEMICALS Co., Ltd. | Citalopramhydrobromidkristall und deren kristallisierungsverfahren |
EP1462447A2 (de) * | 2000-12-22 | 2004-09-29 | H. Lundbeck A/S | Verfahren zur Herstellung von reinem Citalopram |
WO2004094399A1 (en) * | 2003-04-21 | 2004-11-04 | Natco Pharma Ltd | An improved process for the preparation of citalopram hydrobromide |
US7560576B2 (en) | 2005-06-22 | 2009-07-14 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE237604T1 (de) * | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
AR021155A1 (es) * | 1999-07-08 | 2002-06-12 | Lundbeck & Co As H | Tratamiento de desordenes neuroticos |
US7708749B2 (en) | 2000-12-20 | 2010-05-04 | Fox Hollow Technologies, Inc. | Debulking catheters and methods |
US8328829B2 (en) | 1999-08-19 | 2012-12-11 | Covidien Lp | High capacity debulking catheter with razor edge cutting window |
US7713279B2 (en) | 2000-12-20 | 2010-05-11 | Fox Hollow Technologies, Inc. | Method and devices for cutting tissue |
US6299622B1 (en) | 1999-08-19 | 2001-10-09 | Fox Hollow Technologies, Inc. | Atherectomy catheter with aligned imager |
US7887556B2 (en) | 2000-12-20 | 2011-02-15 | Fox Hollow Technologies, Inc. | Debulking catheters and methods |
IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
IS6021A (is) * | 2000-08-10 | 2001-10-20 | H. Lundbeck A/S | Lyfjasamsetningar sem innihalda sítalópram |
GB2376233B (en) * | 2000-08-10 | 2003-09-10 | Lundbeck & Co As H | Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns |
ES2436668T3 (es) | 2000-12-20 | 2014-01-03 | Covidien Lp | Catéter para retirar material oclusivo ateromatoso o trombótico |
AU2001100195B4 (en) * | 2001-01-05 | 2001-12-20 | H Lundbeck As | Pharmaceutical composition containing citalopram. |
GB0105627D0 (en) * | 2001-03-07 | 2001-04-25 | Cipla Ltd | Preparation of phthalanes |
IL158031A0 (en) * | 2001-05-01 | 2004-03-28 | Lundbeck & Co As H | The use of enantiomeric pure escitalopram |
DE60217932T2 (de) | 2001-07-31 | 2007-08-30 | H. Lundbeck A/S, Valby | Kristalline Zusammensetzung enthaltend Escitalopram |
AU2003222435A1 (en) * | 2002-01-07 | 2003-07-24 | Sun Pharmaceutical Industries Limited | Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile |
GB2385848A (en) * | 2002-02-27 | 2003-09-03 | Cipla Ltd | Citalopram salts |
GB2386118A (en) * | 2002-02-27 | 2003-09-10 | Cipla Ltd | Citalopram |
GB0204607D0 (en) | 2002-02-27 | 2002-04-10 | Matrix Lab Ltd | Process |
GB2387596B (en) * | 2002-02-27 | 2004-02-11 | Matrix Lab Ltd | Process |
GB2386119A (en) * | 2002-02-27 | 2003-09-10 | Cipla Ltd | Purification of citalopram |
EP1346989A1 (de) * | 2002-03-21 | 2003-09-24 | Jubilant Organosys Limited | Verbessertes Verfahren zur Herstellung von Citalopram und Citalopram Hydrobromid |
GB0206708D0 (en) * | 2002-03-21 | 2002-05-01 | Cipla Ltd | Pharmaceutical salts |
US6812355B2 (en) | 2002-10-22 | 2004-11-02 | Sekhsaria Chemicals Limited | Process for the manufacture of citalopram hydrobromide from 5-bromophthalide |
US20050154052A1 (en) * | 2003-03-24 | 2005-07-14 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
US8246640B2 (en) | 2003-04-22 | 2012-08-21 | Tyco Healthcare Group Lp | Methods and devices for cutting tissue at a vascular location |
US7019153B2 (en) | 2003-06-10 | 2006-03-28 | Sun Pharmaceutical Industries Limited | Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid |
GB0317475D0 (en) * | 2003-07-25 | 2003-08-27 | Meditab Specialities Pvt Ltd | Product |
JP4025735B2 (ja) * | 2003-08-21 | 2007-12-26 | ローム アンド ハース カンパニー | 水性系を処理する方法 |
GB0320312D0 (en) | 2003-08-29 | 2003-10-01 | Novartis Ag | Purification process |
CN100569765C (zh) * | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
ITTO20050301A1 (it) * | 2005-05-05 | 2006-11-06 | Errekappa Euroterapici Spa | Formulazioni liquide orali contenenti citalopram |
WO2006123243A2 (en) * | 2005-05-20 | 2006-11-23 | Aurobindo Pharma Limited | Pharmaceutical dosage forms comprising escitalopram in form of granules |
TWI347942B (en) * | 2005-06-22 | 2011-09-01 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
EP2502621A1 (de) | 2005-06-27 | 2012-09-26 | Valeant International (Barbados) SRL | Kristalline Formen von Bupropion HBr |
US20070276419A1 (en) | 2006-05-26 | 2007-11-29 | Fox Hollow Technologies, Inc. | Methods and devices for rotating an active element and an energy emitter on a catheter |
US8784440B2 (en) | 2008-02-25 | 2014-07-22 | Covidien Lp | Methods and devices for cutting tissue |
US8414604B2 (en) | 2008-10-13 | 2013-04-09 | Covidien Lp | Devices and methods for manipulating a catheter shaft |
BRPI1014721A2 (pt) | 2009-04-29 | 2016-04-12 | Tyco Healthcare | métodos e dispositivos para cortar e raspar tecido |
JP5281195B2 (ja) | 2009-05-14 | 2013-09-04 | コヴィディエン リミテッド パートナーシップ | 簡単に清掃され得るアテレクトミー用カテーテルおよび使用の方法 |
KR20120079479A (ko) | 2009-12-02 | 2012-07-12 | 타이코 헬스케어 그룹 엘피 | 조직 절단 장치 및 방법 |
US20110144673A1 (en) | 2009-12-11 | 2011-06-16 | Fox Hollow Technologies, Inc. | Material removal device having improved material capture efficiency and methods of use |
EP2742881B1 (de) | 2010-06-14 | 2015-10-07 | Covidien LP | Materialentfernungsvorrichtung |
US8920450B2 (en) | 2010-10-28 | 2014-12-30 | Covidien Lp | Material removal device and method of use |
KR101518151B1 (ko) | 2010-11-11 | 2015-05-06 | 코비디엔 엘피 | 촬영용 가요성 디벌킹 카테터와, 사용 및 제조 방법 |
US8992717B2 (en) | 2011-09-01 | 2015-03-31 | Covidien Lp | Catheter with helical drive shaft and methods of manufacture |
US9532844B2 (en) | 2012-09-13 | 2017-01-03 | Covidien Lp | Cleaning device for medical instrument and method of use |
US9943329B2 (en) | 2012-11-08 | 2018-04-17 | Covidien Lp | Tissue-removing catheter with rotatable cutter |
WO2015200702A1 (en) | 2014-06-27 | 2015-12-30 | Covidien Lp | Cleaning device for catheter and catheter including the same |
US10314667B2 (en) | 2015-03-25 | 2019-06-11 | Covidien Lp | Cleaning device for cleaning medical instrument |
US10292721B2 (en) | 2015-07-20 | 2019-05-21 | Covidien Lp | Tissue-removing catheter including movable distal tip |
US10314664B2 (en) | 2015-10-07 | 2019-06-11 | Covidien Lp | Tissue-removing catheter and tissue-removing element with depth stop |
BR112022000992A2 (pt) | 2019-07-19 | 2022-06-14 | Arx Llc | Regimes de tratamento de dexmedetomidina não sedantes |
US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
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US2233970A (en) * | 1941-03-04 | Quinoline compound and process of | ||
US2584429A (en) * | 1950-12-29 | 1952-02-05 | Rohm & Haas | 1,1-diphenyl-4-tert.-amino-2-butyne-1-ols |
GB1143702A (de) * | 1965-03-18 | |||
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
IL63968A (en) * | 1980-10-01 | 1985-10-31 | Glaxo Group Ltd | Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it |
US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
DK213290D0 (da) | 1990-09-06 | 1990-09-06 | Lundbeck & Co As H | Treatment of cerebrovascular disorders |
US5296507A (en) * | 1990-09-06 | 1994-03-22 | H.Lundbeck A/S | Treatment of cerbrovascular disorders |
CA2120874E (en) * | 1994-04-08 | 2002-01-08 | Keshava Murthy | Form of form 1 ranitidine |
JP3526581B2 (ja) * | 1997-07-08 | 2004-05-17 | ハー・ルンドベック・アクティーゼルスカブ | シタロプラムの製造方法 |
UA62985C2 (en) * | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
CZ292911B6 (cs) * | 1997-11-11 | 2004-01-14 | H. Lundbeck A/S | Způsob výroby citalopramu |
PL199423B1 (pl) | 1998-10-20 | 2008-09-30 | Lundbeck & Co As H | Sposób wytwarzania citalopramu |
ATE237604T1 (de) | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
ITMI991581A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ITMI991579A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
US6433196B1 (en) * | 2000-02-17 | 2002-08-13 | Sumika Fine Chemicals Co., Ltd. | Production method of citalopram, intermediate therefor and production method of the intermediate |
GB2357762B (en) * | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
US6977306B2 (en) * | 2000-05-02 | 2005-12-20 | Sumitomo Chemical Company, Limited | Citalopram hydrobromide crystal and method for crystallization thereof |
-
2000
- 2000-04-13 GB GB0105982A patent/GB2357762B/en not_active Expired - Fee Related
- 2000-04-18 HU HU0001581A patent/HU0001581D0/hu unknown
- 2000-04-20 DE DE20007303U patent/DE20007303U1/de not_active Ceased
- 2000-10-18 NL NL1016435A patent/NL1016435C1/nl not_active IP Right Cessation
- 2000-11-09 IT IT2000MI002425A patent/IT1319645B1/it active
- 2000-12-05 US US09/730,490 patent/US20010031784A1/en not_active Abandoned
-
2001
- 2001-01-25 FI FI20010156A patent/FI20010156A0/fi unknown
- 2001-01-26 HU HU0100450A patent/HU0100450D0/hu unknown
- 2001-02-05 DK DK200100183A patent/DK173903B1/da not_active IP Right Cessation
- 2001-02-05 HU HU0100531A patent/HUP0100531A3/hu unknown
- 2001-02-05 IS IS5841A patent/IS5841A/is unknown
- 2001-02-05 GB GBGB0102797.8A patent/GB0102797D0/en not_active Ceased
- 2001-02-06 NO NO20010619A patent/NO312031B1/no active IP Right Review Request
- 2001-02-07 FI FI20010225A patent/FI109022B/fi active
- 2001-02-07 IE IE20010109A patent/IES20010109A2/en not_active IP Right Cessation
- 2001-02-12 GR GR20010100074A patent/GR1003796B/el unknown
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2806086A1 (fr) * | 2000-03-13 | 2001-09-14 | Lundbeck & Co As H | Base cristalline du citalopram |
GR1003796B (el) * | 2000-03-13 | 2002-02-08 | H. Lundbeck A/S | Κρυσταλλικη βαση κιταλοπραμης. |
EP1227088A1 (de) * | 2000-03-13 | 2002-07-31 | H.Lundbeck A/S | Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon |
EP1152000A1 (de) * | 2000-05-02 | 2001-11-07 | SUMIKA FINE CHEMICALS Co., Ltd. | Citalopramhydrobromidkristall und deren kristallisierungsverfahren |
US6977306B2 (en) | 2000-05-02 | 2005-12-20 | Sumitomo Chemical Company, Limited | Citalopram hydrobromide crystal and method for crystallization thereof |
EP1462447A2 (de) * | 2000-12-22 | 2004-09-29 | H. Lundbeck A/S | Verfahren zur Herstellung von reinem Citalopram |
EP1462447A3 (de) * | 2000-12-22 | 2004-11-17 | H. Lundbeck A/S | Verfahren zur Herstellung von reinem Citalopram |
WO2004094399A1 (en) * | 2003-04-21 | 2004-11-04 | Natco Pharma Ltd | An improved process for the preparation of citalopram hydrobromide |
US7560576B2 (en) | 2005-06-22 | 2009-07-14 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
US7723533B2 (en) | 2005-06-22 | 2010-05-25 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
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