DE60100786D1 - Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon - Google Patents

Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon

Info

Publication number
DE60100786D1
DE60100786D1 DE60100786T DE60100786T DE60100786D1 DE 60100786 D1 DE60100786 D1 DE 60100786D1 DE 60100786 T DE60100786 T DE 60100786T DE 60100786 T DE60100786 T DE 60100786T DE 60100786 D1 DE60100786 D1 DE 60100786D1
Authority
DE
Germany
Prior art keywords
citalopram
hydrochloride
hydrobromide salt
crystalline base
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE60100786T
Other languages
English (en)
Other versions
DE60100786T2 (de
Inventor
Hans Petersen
Klaus Peter Boegesoe
Per Holm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60100786(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of DE60100786D1 publication Critical patent/DE60100786D1/de
Application granted granted Critical
Publication of DE60100786T2 publication Critical patent/DE60100786T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Laminated Bodies (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60100786T 2000-03-13 2001-02-28 Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon Revoked DE60100786T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200000402 2000-03-13
DK200000402 2000-03-13
WOPCT/DK00/00183 2000-04-13
DKPCT/DK00/00183 2000-04-13

Publications (2)

Publication Number Publication Date
DE60100786D1 true DE60100786D1 (de) 2003-10-23
DE60100786T2 DE60100786T2 (de) 2004-07-15

Family

ID=8159320

Family Applications (7)

Application Number Title Priority Date Filing Date
DE20007303U Ceased DE20007303U1 (de) 2000-03-13 2000-04-20 Kristalline Base von Citalopram
DE10164687A Revoked DE10164687B4 (de) 2000-03-13 2001-02-20 Verfahren zur Herstellung von gereinigter Citalopram-Base oder eines gereinigten Salzes von Citalopram
DE20121240U Ceased DE20121240U1 (de) 2000-03-13 2001-02-20 Kristalline Citalopram-Base
DE10108042A Withdrawn DE10108042A1 (de) 2000-03-13 2001-02-20 Kristalline Citalopram-Base
DE60100786T Revoked DE60100786T2 (de) 2000-03-13 2001-02-28 Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon
DE1227088T Pending DE1227088T1 (de) 2000-03-13 2001-02-28 Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon
DE60100022T Expired - Fee Related DE60100022T3 (de) 2000-03-13 2001-02-28 Verfahren zur herstellung von citalopram-salzen

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DE20007303U Ceased DE20007303U1 (de) 2000-03-13 2000-04-20 Kristalline Base von Citalopram
DE10164687A Revoked DE10164687B4 (de) 2000-03-13 2001-02-20 Verfahren zur Herstellung von gereinigter Citalopram-Base oder eines gereinigten Salzes von Citalopram
DE20121240U Ceased DE20121240U1 (de) 2000-03-13 2001-02-20 Kristalline Citalopram-Base
DE10108042A Withdrawn DE10108042A1 (de) 2000-03-13 2001-02-20 Kristalline Citalopram-Base

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE1227088T Pending DE1227088T1 (de) 2000-03-13 2001-02-28 Kristalline Base von Citalopram, und Hydrochlorid- oder Hydrobromidsalz davon
DE60100022T Expired - Fee Related DE60100022T3 (de) 2000-03-13 2001-02-28 Verfahren zur herstellung von citalopram-salzen

Country Status (42)

Country Link
US (7) US20010031784A1 (de)
EP (2) EP1169314B2 (de)
JP (1) JP2003527383A (de)
KR (1) KR20020080486A (de)
CN (2) CN1258530C (de)
AR (1) AR029811A1 (de)
AT (3) ATE223396T1 (de)
AU (2) AU746664B2 (de)
BE (1) BE1013210A3 (de)
BG (1) BG107065A (de)
BR (1) BR0109373A (de)
CA (2) CA2360287C (de)
CH (2) CH691537A5 (de)
CZ (1) CZ292077B6 (de)
DE (7) DE20007303U1 (de)
DK (3) DK173903B1 (de)
EA (1) EA200200972A1 (de)
ES (3) ES2180471T3 (de)
FI (2) FI20010156A0 (de)
FR (1) FR2806086B1 (de)
GB (2) GB2357762B (de)
GR (1) GR1003796B (de)
HK (1) HK1054750A1 (de)
HR (1) HRP20020756A2 (de)
HU (3) HU0001581D0 (de)
IE (1) IES20010109A2 (de)
IL (2) IL147339A (de)
IS (1) IS5841A (de)
IT (2) IT1319645B1 (de)
MX (1) MXPA02008793A (de)
NL (2) NL1016435C1 (de)
NO (2) NO312031B1 (de)
PL (1) PL360158A1 (de)
PT (2) PT1227088E (de)
SE (2) SE517136C2 (de)
SI (2) SI1169314T2 (de)
SK (1) SK285528B6 (de)
TR (1) TR200202185T2 (de)
UA (1) UA74360C2 (de)
WO (1) WO2001068627A1 (de)
YU (1) YU68802A (de)
ZA (1) ZA200207148B (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100604156B1 (ko) 1999-04-14 2006-07-25 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
US7713279B2 (en) 2000-12-20 2010-05-11 Fox Hollow Technologies, Inc. Method and devices for cutting tissue
US6299622B1 (en) 1999-08-19 2001-10-09 Fox Hollow Technologies, Inc. Atherectomy catheter with aligned imager
US7708749B2 (en) 2000-12-20 2010-05-04 Fox Hollow Technologies, Inc. Debulking catheters and methods
US7771444B2 (en) 2000-12-20 2010-08-10 Fox Hollow Technologies, Inc. Methods and devices for removing material from a body lumen
US8328829B2 (en) 1999-08-19 2012-12-11 Covidien Lp High capacity debulking catheter with razor edge cutting window
US7887556B2 (en) 2000-12-20 2011-02-15 Fox Hollow Technologies, Inc. Debulking catheters and methods
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
US6977306B2 (en) * 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
CA2353693C (en) * 2000-08-10 2003-07-22 H. Lundbeck A/S Pharmaceutical composition containing citalopram
ATE277920T1 (de) * 2000-12-22 2004-10-15 Lundbeck & Co As H Verfahren zur vorbereitung von reinem citalopram
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
IL158031A0 (en) * 2001-05-01 2004-03-28 Lundbeck & Co As H The use of enantiomeric pure escitalopram
DE60202615T2 (de) 2001-07-31 2006-01-12 H. Lundbeck A/S Kristalline zusammensetzung mit escitalopram
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB2386118A (en) * 2002-02-27 2003-09-10 Cipla Ltd Citalopram
GB2387844B (en) * 2002-02-27 2005-05-11 Matrix Lab Ltd Separation of impurities from a crude mixture of citalopram
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2385848A (en) * 2002-02-27 2003-09-03 Cipla Ltd Citalopram salts
EP1346989A1 (de) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Verbessertes Verfahren zur Herstellung von Citalopram und Citalopram Hydrobromid
GB0206708D0 (en) * 2002-03-21 2002-05-01 Cipla Ltd Pharmaceutical salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
WO2004094399A1 (en) * 2003-04-21 2004-11-04 Natco Pharma Ltd An improved process for the preparation of citalopram hydrobromide
US8246640B2 (en) 2003-04-22 2012-08-21 Tyco Healthcare Group Lp Methods and devices for cutting tissue at a vascular location
EP1486492A3 (de) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. Ein Verfahren zur Hydrogenolyse von [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran
GB0317475D0 (en) * 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
JP4025735B2 (ja) * 2003-08-21 2007-12-26 ローム アンド ハース カンパニー 水性系を処理する方法
GB0320312D0 (en) 2003-08-29 2003-10-01 Novartis Ag Purification process
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
ITTO20050301A1 (it) * 2005-05-05 2006-11-06 Errekappa Euroterapici Spa Formulazioni liquide orali contenenti citalopram
EP1901714A2 (de) * 2005-05-20 2008-03-26 Aurobindo Pharma Limited Pharmazeutische dosierformen mit escitalopram in granulatform
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
WO2007002597A2 (en) 2005-06-27 2007-01-04 Biovail Laboratories International S.R.L. Modified-release formulations of a bupropion salt
US20070276419A1 (en) 2006-05-26 2007-11-29 Fox Hollow Technologies, Inc. Methods and devices for rotating an active element and an energy emitter on a catheter
US8784440B2 (en) 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
JP5555242B2 (ja) 2008-10-13 2014-07-23 コヴィディエン リミテッド パートナーシップ カテーテルシャフトを操作するデバイスおよび方法
JP5579830B2 (ja) 2009-04-29 2014-08-27 コヴィディエン リミテッド パートナーシップ 組織を切断および研磨する方法および装置
WO2010132748A1 (en) 2009-05-14 2010-11-18 Fox Hollow Technologies, Inc. Easily cleaned atherectomy catheters and methods of use
CA2781046C (en) 2009-12-02 2014-09-16 Tyco Healthcare Group Lp Methods and devices for cutting tissue
RU2520801C2 (ru) 2009-12-11 2014-06-27 ТАЙКО ХЕЛСКЕА ГРУП эЛПи Устройство для съема материала с улучшенной эффективностью захвата и способы применения
CA2800920C (en) 2010-06-14 2015-04-14 Covidien Lp Material removal device
US8920450B2 (en) 2010-10-28 2014-12-30 Covidien Lp Material removal device and method of use
US8808186B2 (en) 2010-11-11 2014-08-19 Covidien Lp Flexible debulking catheters with imaging and methods of use and manufacture
EP2750862B1 (de) 2011-09-01 2016-07-06 Covidien LP Katheter mit spiralförmiger antriebswelle und herstellungsverfahren
US9532844B2 (en) 2012-09-13 2017-01-03 Covidien Lp Cleaning device for medical instrument and method of use
US9943329B2 (en) 2012-11-08 2018-04-17 Covidien Lp Tissue-removing catheter with rotatable cutter
WO2015200702A1 (en) 2014-06-27 2015-12-30 Covidien Lp Cleaning device for catheter and catheter including the same
US10314667B2 (en) 2015-03-25 2019-06-11 Covidien Lp Cleaning device for cleaning medical instrument
US10292721B2 (en) 2015-07-20 2019-05-21 Covidien Lp Tissue-removing catheter including movable distal tip
US10314664B2 (en) 2015-10-07 2019-06-11 Covidien Lp Tissue-removing catheter and tissue-removing element with depth stop
CN114375191A (zh) 2019-07-19 2022-04-19 比奥克斯塞尔医疗股份有限公司 非镇静的右美托咪定治疗方案
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2233970A (en) * 1941-03-04 Quinoline compound and process of
US2584429A (en) * 1950-12-29 1952-02-05 Rohm & Haas 1,1-diphenyl-4-tert.-amino-2-butyne-1-ols
GB1143702A (de) * 1965-03-18
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
CA2120874E (en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine
AU737610B2 (en) * 1997-07-08 2001-08-23 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CA2291072C (en) * 1997-11-11 2002-08-20 H. Lundbeck A/S Method for the preparation of citalopram
NZ510858A (en) * 1998-10-20 2003-11-28 H Method for the preparation of citalopram
KR100604156B1 (ko) 1999-04-14 2006-07-25 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US6977306B2 (en) * 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof

Also Published As

Publication number Publication date
CH691537A5 (de) 2001-08-15
US20060247451A1 (en) 2006-11-02
ES2173054T3 (es) 2002-12-16
DE20121240U1 (de) 2002-07-04
CZ292077B6 (cs) 2003-07-16
ZA200207148B (en) 2003-04-23
NO312031B1 (no) 2002-03-04
HRP20020756A2 (en) 2004-12-31
FI109022B (fi) 2002-05-15
NL1016435C1 (nl) 2000-11-06
NO20020356L (no) 2001-09-14
HU0100531D0 (en) 2001-03-28
IS5841A (is) 2001-09-14
AT4364U1 (de) 2001-06-25
CA2411732A1 (en) 2001-09-20
TR200202185T2 (tr) 2002-12-23
GB0102797D0 (en) 2001-03-21
ES2159491B1 (es) 2002-05-01
IL147339A (en) 2004-09-27
EP1169314B2 (de) 2011-06-01
SI1169314T1 (en) 2002-12-31
ATE250050T1 (de) 2003-10-15
DE60100022T3 (de) 2011-11-17
CN1258530C (zh) 2006-06-07
EP1169314A1 (de) 2002-01-09
SE0103046D0 (sv) 2001-09-14
PL360158A1 (en) 2004-09-06
SK285528B6 (sk) 2007-03-01
IT1319645B1 (it) 2003-10-23
EP1169314B1 (de) 2002-09-04
WO2001068627A1 (en) 2001-09-20
HU0001581D0 (en) 2000-06-28
CN1680350A (zh) 2005-10-12
CZ2001808A3 (cs) 2002-01-16
UA74360C2 (uk) 2005-12-15
US20050165092A1 (en) 2005-07-28
EP1227088B1 (de) 2003-09-17
BR0109373A (pt) 2002-12-24
DE1227088T1 (de) 2003-02-06
FR2806086A1 (fr) 2001-09-14
ES2173054T1 (es) 2002-10-16
PT1169314E (pt) 2002-11-29
JP2003527383A (ja) 2003-09-16
AU3725201A (en) 2001-09-13
KR20020080486A (ko) 2002-10-23
IES20010109A2 (en) 2002-02-20
ES2180471T1 (es) 2003-02-16
AU2001100197B4 (en) 2001-12-06
SK13132002A3 (sk) 2003-01-09
SE0103046L (sv) 2001-11-14
FI20010156A0 (fi) 2001-01-25
CN1429220A (zh) 2003-07-09
US20040167210A1 (en) 2004-08-26
ES2180471T3 (es) 2004-05-01
CA2360287A1 (en) 2001-09-20
GB2357762B (en) 2002-01-30
SI1169314T2 (sl) 2011-08-31
HK1054750A1 (en) 2003-12-12
SE0200730L (sv) 2002-08-29
IL147339A0 (en) 2002-08-14
CH691477A5 (de) 2001-07-31
MXPA02008793A (es) 2003-02-12
NL1017413C1 (nl) 2001-09-13
DE10164687B4 (de) 2006-04-27
SI1227088T1 (en) 2003-12-31
HU0100450D0 (en) 2001-04-28
AU746664B2 (en) 2002-05-02
NO315851B1 (no) 2003-11-03
AR029811A1 (es) 2003-07-16
HUP0100531A3 (en) 2004-04-28
DK173903B1 (da) 2002-02-11
EA200200972A1 (ru) 2003-02-27
DE10108042A1 (de) 2001-10-18
NO20010619L (no) 2001-09-14
GR1003796B (el) 2002-02-08
GB2357762A (en) 2001-07-04
US20010031784A1 (en) 2001-10-18
DE60100786T2 (de) 2004-07-15
DE20007303U1 (de) 2000-07-27
NO20020356D0 (no) 2002-01-23
ITMI20002425A1 (it) 2002-05-09
SE517136C2 (sv) 2002-04-16
US20030078442A1 (en) 2003-04-24
DE60100022D1 (de) 2002-10-10
FI20010225A0 (fi) 2001-02-07
NO20010619D0 (no) 2001-02-06
ITMI20010406A1 (it) 2002-08-28
ATE223396T1 (de) 2002-09-15
BG107065A (bg) 2003-05-30
GB0105982D0 (en) 2001-05-02
IL158072A0 (en) 2004-03-28
US20050165244A1 (en) 2005-07-28
CA2360287C (en) 2003-09-09
FR2806086B1 (fr) 2003-05-09
DK1169314T3 (da) 2002-10-14
PT1227088E (pt) 2003-12-31
DE60100022T2 (de) 2003-03-06
EP1227088A1 (de) 2002-07-31
ES2159491A1 (es) 2001-10-01
YU68802A (sh) 2005-11-28
BE1013210A3 (fr) 2001-10-02
HUP0100531A2 (hu) 2002-01-28
AU2001100197A4 (en) 2001-09-20
US20040132808A1 (en) 2004-07-08
FI20010225A (fi) 2001-09-14
DK1227088T3 (da) 2003-12-22
SE0200730D0 (sv) 2002-03-12
SE526022C2 (sv) 2005-06-14

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