CY2226B1 - Pyrimidine derivatives as hmg-coa reductase inhibitors - Google Patents

Pyrimidine derivatives as hmg-coa reductase inhibitors

Info

Publication number
CY2226B1
CY2226B1 CY0100015A CY0100015A CY2226B1 CY 2226 B1 CY2226 B1 CY 2226B1 CY 0100015 A CY0100015 A CY 0100015A CY 0100015 A CY0100015 A CY 0100015A CY 2226 B1 CY2226 B1 CY 2226B1
Authority
CY
Cyprus
Prior art keywords
hmg
coa reductase
reductase inhibitors
pyrimidine derivatives
hyperlipoproteinemia
Prior art date
Application number
CY0100015A
Other languages
English (en)
Inventor
Haruo Koike
Masamichi Watanabe
Kentaro Hirai
Teruyuki Ishiba
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16216169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2226(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of CY2226B1 publication Critical patent/CY2226B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CY0100015A 1991-07-01 2001-06-27 Pyrimidine derivatives as hmg-coa reductase inhibitors CY2226B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18801591 1991-07-01

Publications (1)

Publication Number Publication Date
CY2226B1 true CY2226B1 (en) 2003-04-18

Family

ID=16216169

Family Applications (2)

Application Number Title Priority Date Filing Date
CY0100015A CY2226B1 (en) 1991-07-01 2001-06-27 Pyrimidine derivatives as hmg-coa reductase inhibitors
CY2004008C CY2004008I2 (el) 1991-07-01 2015-06-15 ΠΑΡΑΓΩΓΑ ΠΥΡΙΜΙΔΙΝΗΣ ΣΑΝ ΑΝΑΣΤΟΛΕΙΣ HMG-CoA ΑΝΑΓΩΓΑΣΗΣ

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2004008C CY2004008I2 (el) 1991-07-01 2015-06-15 ΠΑΡΑΓΩΓΑ ΠΥΡΙΜΙΔΙΝΗΣ ΣΑΝ ΑΝΑΣΤΟΛΕΙΣ HMG-CoA ΑΝΑΓΩΓΑΣΗΣ

Country Status (19)

Country Link
US (2) US5260440A (fr)
EP (1) EP0521471B1 (fr)
JP (1) JP2648897B2 (fr)
KR (1) KR960005951B1 (fr)
AT (1) ATE197149T1 (fr)
CA (1) CA2072945C (fr)
CL (1) CL2010000113A1 (fr)
CY (2) CY2226B1 (fr)
DE (2) DE122009000017I2 (fr)
DK (1) DK0521471T3 (fr)
ES (1) ES2153824T3 (fr)
GE (1) GEP20022693B (fr)
GR (1) GR3035189T3 (fr)
HK (1) HK1011986A1 (fr)
HU (2) HU220624B1 (fr)
LU (1) LU91042I2 (fr)
NL (1) NL300125I2 (fr)
PT (1) PT521471E (fr)
TW (1) TW203044B (fr)

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