BRPI0606170A2 - purificação diastereomérica de rosuvastatina - Google Patents
purificação diastereomérica de rosuvastatinaInfo
- Publication number
- BRPI0606170A2 BRPI0606170A2 BRPI0606170-2A BRPI0606170A BRPI0606170A2 BR PI0606170 A2 BRPI0606170 A2 BR PI0606170A2 BR PI0606170 A BRPI0606170 A BR PI0606170A BR PI0606170 A2 BRPI0606170 A2 BR PI0606170A2
- Authority
- BR
- Brazil
- Prior art keywords
- rosuvastatin
- purification
- diastereomeric
- diastereomeric purification
- diastereomerically pure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
PURIFICAçãO DIASTEREOMéRICA DE ROSUVASTATINA. A invenção refere-se a rosuvastatina diastereomericamente pura e processos para preparação de rosuvastatina diastereomericamente pura e seus intermediários. Fórmula (I)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72349105P | 2005-10-03 | 2005-10-03 | |
US73297905P | 2005-11-02 | 2005-11-02 | |
PCT/US2006/035711 WO2007040940A1 (en) | 2005-10-03 | 2006-09-12 | Diastereomeric purification of rosuvastatin |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0606170A2 true BRPI0606170A2 (pt) | 2009-06-02 |
Family
ID=37731511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0606170-2A BRPI0606170A2 (pt) | 2005-10-03 | 2006-09-12 | purificação diastereomérica de rosuvastatina |
Country Status (9)
Country | Link |
---|---|
US (2) | US20090187026A1 (pt) |
EP (1) | EP1817293A1 (pt) |
JP (1) | JP2008526897A (pt) |
KR (2) | KR20090113920A (pt) |
BR (1) | BRPI0606170A2 (pt) |
CA (1) | CA2624801A1 (pt) |
IL (1) | IL187949A0 (pt) |
TW (1) | TW200804305A (pt) |
WO (1) | WO2007040940A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
WO2007125547A2 (en) | 2006-05-03 | 2007-11-08 | Manne Satyanarayana Reddy | Novel process for statins and its pharmaceutically acceptable salts thereof |
ES2567171T3 (es) | 2006-10-09 | 2016-04-20 | Msn Laboratories Private Limited | Nuevo procedimiento para la preparación de estatinas y sus sales farmacéuticamente aceptables |
WO2008053334A2 (en) * | 2006-10-31 | 2008-05-08 | Aurobindo Pharma Limited | An improved process for preparing rosuvastatin calcium |
WO2008096257A1 (en) * | 2007-02-08 | 2008-08-14 | Aurobindo Pharma Limited | An improved process for preparation of rosuvastatin calcium |
US7884226B2 (en) | 2007-07-12 | 2011-02-08 | Teva Pharmaceutical Industries, Ltd. | Purification of rosuvatatin intermediate by thin film evaporation and chemical method |
EP2022784A1 (en) * | 2007-08-08 | 2009-02-11 | LEK Pharmaceuticals D.D. | Process for the preparation of methyl ester of rosuvastatin |
WO2009143776A1 (zh) * | 2008-05-27 | 2009-12-03 | 常州制药厂有限公司 | 瑞舒伐他汀钙盐的制备方法及其中间体 |
WO2010035284A2 (en) * | 2008-09-26 | 2010-04-01 | Matrix Laboratories Ltd | An improved process for the preparation of rosuvastatin calcium |
US8487105B2 (en) | 2009-01-19 | 2013-07-16 | Msn Laboratories Limited | Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof |
EP2467363A1 (en) | 2009-08-17 | 2012-06-27 | Aurobindo Pharma Limited | Process for the manufacture of rosuvastatin calcium using crystalline rosuvastatin ethyl ester |
WO2011086584A2 (en) | 2010-01-18 | 2011-07-21 | Msn Laboratories Limited | Improved process for the preparation of amide intermediates and their use thereof |
EP2383260A3 (en) * | 2010-04-30 | 2011-12-28 | Dipharma Francis S.r.l. | Process for the preparation of statins |
ITMI20100753A1 (it) * | 2010-04-30 | 2011-10-31 | Dipharma Francis Srl | Procedimento per la preparazione di statine |
HU230987B1 (hu) * | 2010-11-29 | 2019-08-28 | Egis Gyógyszergyár Nyrt. | Eljárás nagy tisztaságú gyógyszeripari intermedierek előállítására |
CN104230817B (zh) * | 2013-06-19 | 2016-09-14 | 南京欧信医药技术有限公司 | 3,5-二羟基庚-6-烯酸衍生物的制备方法 |
CN109580789B (zh) * | 2017-09-28 | 2021-06-22 | 安徽省庆云医药股份有限公司 | 一种液相色谱法分离测定瑞舒伐他汀叔丁酯及其光学异构体的方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5189164A (en) * | 1989-05-22 | 1993-02-23 | Sandoz Ltd. | Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof |
JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
US5218138A (en) * | 1992-09-02 | 1993-06-08 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihydroxylated compounds |
JPH08301864A (ja) * | 1995-05-09 | 1996-11-19 | Toyobo Co Ltd | α−オキシ酸の分子間環状ジエステルの精製方法 |
US5741934A (en) * | 1996-04-10 | 1998-04-21 | Sandler; Stanley R. | Preparation of primary mercaptans |
DE19841342A1 (de) * | 1998-09-10 | 2000-04-20 | Merck Patent Gmbh | Neue Reaktivsysteme aus polymerisierbaren Monomeren , die Peroxide und stabilisierten Boralkylverbindungen enthalten |
JP4565208B2 (ja) * | 2000-03-31 | 2010-10-20 | 株式会社クレハ | グリコリドの精製方法 |
KR100511533B1 (ko) * | 2002-04-09 | 2005-08-31 | 임광민 | 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법 |
US20050222415A1 (en) * | 2002-05-21 | 2005-10-06 | Yatendra Kumar | Process for the preparation of rosuvastatin |
JP2004277396A (ja) * | 2003-01-23 | 2004-10-07 | Teijin Chem Ltd | 芳香族ポリカーボネートから芳香族ジヒドロキシ化合物と炭酸ジアルキルを得る方法 |
WO2004103977A2 (en) * | 2003-05-21 | 2004-12-02 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of pyrimidine derivatives |
CA2537271A1 (en) * | 2003-08-28 | 2005-03-17 | Teva Pharmaceutical Industries, Ltd. | Process for preparation of rosuvastatin calcium |
CN1886383A (zh) * | 2003-10-22 | 2006-12-27 | 兰贝克赛实验室有限公司 | 无定形罗苏伐他汀钙的制备方法 |
CA2550742A1 (en) * | 2003-12-24 | 2005-07-14 | Teva Pharmaceutical Industries Ltd. | Process for preparation of statins with high syn to anti ratio |
US20070179166A1 (en) * | 2003-12-24 | 2007-08-02 | Valerie Niddam-Hildesheim | Process for preparation of statins with high syn to anti ratio |
US7851624B2 (en) * | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
JP2007508379A (ja) * | 2004-07-13 | 2007-04-05 | テバ ファーマシューティカル インダストリーズ リミティド | Tempo媒介型酸化段階を包含するロスバスタチンの調製方法 |
-
2006
- 2006-09-12 BR BRPI0606170-2A patent/BRPI0606170A2/pt not_active IP Right Cessation
- 2006-09-12 CA CA002624801A patent/CA2624801A1/en not_active Abandoned
- 2006-09-12 EP EP06790220A patent/EP1817293A1/en not_active Withdrawn
- 2006-09-12 TW TW095133788A patent/TW200804305A/zh unknown
- 2006-09-12 KR KR1020097020950A patent/KR20090113920A/ko active IP Right Grant
- 2006-09-12 WO PCT/US2006/035711 patent/WO2007040940A1/en active Application Filing
- 2006-09-12 KR KR1020077012477A patent/KR101019450B1/ko not_active IP Right Cessation
- 2006-09-12 JP JP2007550593A patent/JP2008526897A/ja not_active Withdrawn
-
2007
- 2007-12-06 IL IL187949A patent/IL187949A0/en unknown
-
2009
- 2009-02-26 US US12/380,419 patent/US20090187026A1/en not_active Abandoned
-
2010
- 2010-02-02 US US12/698,871 patent/US20100197916A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2007040940A1 (en) | 2007-04-12 |
KR20090113920A (ko) | 2009-11-02 |
KR20070085667A (ko) | 2007-08-27 |
TW200804305A (en) | 2008-01-16 |
EP1817293A1 (en) | 2007-08-15 |
IL187949A0 (en) | 2008-03-20 |
US20100197916A1 (en) | 2010-08-05 |
KR101019450B1 (ko) | 2011-03-07 |
CA2624801A1 (en) | 2007-04-12 |
US20090187026A1 (en) | 2009-07-23 |
JP2008526897A (ja) | 2008-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A E 5A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |